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Motion is an essential process for many living organisms and for artificial robots and machines. To date, creating self-propelled motion in nano-to-macroscopic-sized objects has been a challenging issue for scientists. Herein, we report the directional and continuous motion of crystals on a glass surface when irradiated simultaneously with two different wavelengths, using simple azobenzenes as a photoresponsive organic compound. The direction of the motion can be controlled by the position of the light sources, and the crystals can even climb vertical surfaces. The motion is driven by crystallization and melting at the front and rear edges of the crystal, respectively, via photochemical conversion between the crystal and liquid phases induced by the trans – cis isomerization of azobenzenes. This finding could lead to remote-controlled micrometre-sized vehicles and valves on solid substrates. Creating the motion of nanosized or microsized objects is essential for building robots at small scales. Here, Uchida et al. move photoresponsive organic crystals on a glass substrate using two lamps, which crystallize and melt the crystal front and the rear, respectively, to generate the moving force.

This paper aims to demonstrate the relationship between economic growth and the urban core area in order to help urban planners reach a better understanding of the pressures that are leading to changes in land use. Using a unique panel dataset with measures of China's land use, it is shown that, during the late 1980s and 1990s, China's urban land area rose significantly. Descriptive statistics and multivariate analysis are then used to identify the determinants of urban land use change. In addition to using more standard regression approaches such as ordinary least squares, the analysis is augmented with spatial statistical analysis. The analysis demonstrates the overwhelming importance of economic growth in the determination of urban land use. Overall, it is found that urban land expands by 3 per cent when the economy, measured by gross domestic product, grows by 10 per cent. It is also shown that the expansion of the urban core is associated with changes in China's economic structure. If urban planners have access to forecasts of economic growth, using these results they should be able to have a better basis for planning the expansion of the built-up area in the urban core.

The socio-ecological systems (SESs) framework provides cross-disciplinary insight into complex environmental problems. Numerous studies have applied the SES framework to coastal and marine environments over the last two decades. We review and analyze 98 of those studies to (i) describe how SES concepts were examined and measured, (ii) describe how the studies included feedbacks and thresholds, and (iii) identify and analyze elements unique to coastal and marine SES frameworks. We find that progress has been made in understanding key SES properties in coastal and marine ecosystems, which include resilience, adaptive capacity, vulnerability, and governance. A variety of methods has been developed and applied to analyze these features qualitatively and quantitatively. We also find that recent studies have incorporated land-based stressors in their analyses of coastal issues related to nutrient runoff, bacterial pollution, and management of anadromous species to represent explicit links in land-to-sea continuums. However, the literature has yet to identify methods and data that can be used to provide causal evidence of non-linearities and thresholds within SES. In addition, our findings suggest that greater alignment and consistency are needed in models with regard to metrics and spatial boundaries between ecological and social systems to take full advantage of the SES framework and improve coastal and marine management.

Making decisions about future environmental alternatives such as aging dams can be complex, technical, and challenging for the public. This study uses a split sample, labeled choice experiment to examine how information delivery method—combinations of text, images, and video—affects willingness to pay (WTP) for alternative scenarios for an aging dam. The results indicate that the still image treatment leads to higher WTP across all dam modification alternatives compared to keeping the dam in its current condition. In contrast, the video treatment leads in lower WTP for most alternatives and results in different preference ranking for dam management, i.e., higher WTP to maintain the dam over removing it. Our study suggests that preferences are sensitive to how information is delivered and reinforces the need for credible and legitimate visualizations that can correctly capture the projected future alternatives.

Effective management of ecosystem services requires understanding the biophysical relationships governing the trade-offs, as well as stakeholder preferences for the trade-offs. However, useful tools to guide the complex decision-making process are often lacking. This study demonstrates an approach that combines biophysical and economic models to identify socially preferred solutions. We demonstrate in the context of dam-removal decisions across thousands of dams in Maine, U.S. The results demonstrate the practical usability of this framework for identifying key trade-offs, areas in which people are in agreement and conflicted, along with solutions that are more preferred by society overall. The results also reveal a 30–47% welfare gain from optimizing across all ecosystem services, compared to a more common, visual approach of optimizing two services at a time. This approach may be useful to identify restoration projects that are likely to garner broad public support, particularly when there are trade-offs between ecosystem services, numerous potential solutions, and communities with diverging preferences.

This study evaluates the labor response of rural households participating in the Grain-for-Green program in China, the largest payments for ecosystem services program in the developing world. Using a panel data set that we designed and implemented, we find that the participating households are increasingly shifting their labor endowment from on-farm work to the off-farm labor market. However, the effects vary depending on the initial level of human and physical capital. The results support the view that one reason why the participants are more likely to find off-farm employment is because the program is relaxing households' liquidity constraints.

Protected areas are used to sustain biodiversity and ecosystem services. However, protected areas can create tradeoffs spatially and temporally among ecosystem services, which can affect the welfare of dependent local communities. This study examines the effect of a protected area on the tradeoff between two extractive ecosystem services from mangrove forests: cutting mangroves (fuelwood) and harvesting the shrimp and fish that thrive if mangroves are not cut. We demonstrate the effect in the context of Saadani National Park (SANAPA) in Tanzania, where enforcement of prohibition of mangrove harvesting was strengthened to preserve biodiversity. Remote sensing data of mangrove cover over time are integrated with georeferenced household survey data in an econometric framework to identify the causal effect of mangrove protection on income components directly linked to mangrove ecosystem services. Our findings suggest that many households experienced an immediate loss in the consumption of mangrove firewood, with the loss most prevalent in richer households. However, all wealth classes appear to benefit from long-term sustainability gains in shrimping and fishing that result from mangrove protection. On average, we find that a 10% increase in the mangrove cover within SANAPA boundaries in a 5-km2 radius of the subvillage increases shrimping income by approximately twofold. The creation of SANAPA shifted the future trajectory of the area from one in which mangroves were experiencing uncontrolled cutting to one in which mangrove conservation is providing gains in income for the local villages as a result of the preservation of nursery habitat and biodiversity.

Although treatment of chronic myeloid leukemia (CML) has improved with the development of tyrosine kinase inhibitors (TKIs), patients develop fatal blast crisis (BC) whilst receiving TKI treatment. Alternative treatments for cases resistant to TKIs are required. A serine/threonine protein kinase, T-lymphokine-activated killer cell-originated protein kinase (TOPK), is highly expressed in various malignant tumors. Binding of peptides to human leukocyte antigen was assessed via mass spectrometry in K562 CML cells. TOPK expression was assessed in various CML cell lines and in clinical samples obtained from patients with CML using reverse transcription-quantitative polymerase chain reaction and western blot assays. It was observed that TOPK was expressed abundantly in BCR/ABL-positive cell lines and at significantly higher levels in CML clinical samples compared with healthy donor samples. Overexpression of BCR/ABL or the presence of its inhibitor imatinib upregulated and downregulated TOPK expression, respectively, indicating that TOPK may be a target of BCR/ABL. TOPK inhibitor OTS514 suppressed proliferation of BCR/ABL-positive cell lines and colony formation of CD34-positive cells from patients with CML compared with lymphoma patients without bone marrow involvement. Furthermore, phosphorylation of TOPK was increased by protein phosphatase 2A (PP2A) inhibitor okadaic acid and was decreased in the presence of PP2A activator FTY720 compared with untreated samples. As constitutive BCR/ABL activity and inhibition of PP2A are key mechanisms of CML development, TOPK may be a crucial signaling molecule for this disease. Inhibition of TOPK may control disease status of CML, even in cases resistant to TKIs.

The Fanconi anemia pathway is involved in the signaling of DNA damage. Several Fanconi anemia proteins have been identified, but how the pathway is actually activated was unclear. Now, work on chicken DT40 cells indicates that phosphorylation of FANCI at multiple sites triggers FANCD2 monoubiquitination and DNA-damage repair. In response to DNA damage or replication fork stress, the Fanconi anemia pathway is activated, leading to monoubiquitination of FANCD2 and FANCI and their colocalization in foci. Here we show that, in the chicken DT40 cell system, multiple alanine-substitution mutations in six conserved and clustered Ser/Thr-Gln motifs of FANCI largely abrogate monoubiquitination and focus formation of both FANCI and FANCD2, resulting in loss of DNA repair function. Conversely, FANCI carrying phosphomimic mutations on the same six residues induces constitutive monoubiquitination and focus formation of FANCI and FANCD2, and protects against cell killing and chromosome breakage by DNA interstrand cross-linking agents. We propose that the multiple phosphorylation of FANCI serves as a molecular switch in activation of the Fanconi anemia pathway. Mutational analysis of putative phosphorylation sites in human FANCI indicates that this switch is evolutionarily conserved.

Since 1999, China has pursued Grain for Green, an ambitious conservation set-aside program to prevent soil erosion. This paper evaluates its cost-effectiveness and sustainability. The results indicate that while the program has made a clear attempt to retire plots that are susceptible to soil erosion, there is room for better targeting. The government also may be able to generate fiscal savings if the payments more accurately reflect the differences in the opportunity costs of each plot. The study finds that some farmers may reconvert the land back to cultivation after program ends. (JEL Q23, H43)