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The Ionospheric Connection Explorer, or ICON, is a new NASA Explorer mission that will explore the boundary between Earth and space to understand the physical connection between our world and our space environment. This connection is made in the ionosphere, which has long been known to exhibit variability associated with the sun and solar wind. However, it has been recognized in the 21st century that equally significant changes in ionospheric conditions are apparently associated with energy and momentum propagating upward from our own atmosphere. ICON’s goal is to weigh the competing impacts of these two drivers as they influence our space environment. Here we describe the specific science objectives that address this goal, as well as the means by which they will be achieved. The instruments selected, the overall performance requirements of the science payload and the operational requirements are also described. ICON’s development began in 2013 and the mission is on track for launch in 2018. ICON is developed and managed by the Space Sciences Laboratory at the University of California, Berkeley, with key contributions from several partner institutions.

Version 5 (v05) of the thermospheric wind data from the Michelson Interferometer for Global High‐resolution Thermospheric Imaging (MIGHTI) instrument on the Ionospheric Connection Explorer (ICON) mission has been recently released, which largely avoids local‐time dependent artificial baseline drifts that are found in previous versions of the ICON/MIGHTI wind data. This paper describes monthly climatologies of zonal‐mean winds and tides based on the v05 ICON/MIGHTI data under geomagnetically quiet conditions (Hp30 < 3o) during April 2020–March 2022. Green‐line winds in the lower thermosphere (90–110 km) and red‐line winds in the middle thermosphere (200–300 km) are analyzed, as these data cover both daytime and nighttime. The latitude and height structures of zonal‐mean winds and tides are presented for each month, and the results are compared with the widely used empirical model, Horizontal Wind Model 2014 (HWM14). The ICON/MIGHTI and HWM14 results are in general agreement, providing a validation of the v05 ICON/MIGHTI data. The agreement is especially good for the zonal‐mean winds. Amplitudes of lower thermospheric tides from ICON/MIGHTI tend to be larger than those from HWM14 as well as from an empirical model, Climatological Tidal Model of the Thermosphere (CTMT). This could be due to the influence of interannual variability of the tides. The amplitude structure of lower thermospheric tides in HWM14 does not match those from ICON/MIGHTI and CTMT in some months. Also, HWM14 underestimates the meridional‐wind amplitude of the migrating diurnal tide in the middle thermosphere. These results highlight the need for improved tidal representation in HWM14. Key Points Monthly climatologies of zonal‐mean winds and tides at 90–110 km and 200–300 km are determined using v05 Ionospheric Connection Explorer/Michelson Interferometer for Global High‐resolution Thermospheric Imaging (ICON/MIGHTI) observations ICON/MIGHTI and Horizontal Wind Model 2014 results are in general agreement, providing a validation of the Version 5 ICON/MIGHTI data The agreement is especially good for the zonal‐mean winds, while some discrepancies are found in tidal amplitudes

The Michelson Interferometer for Global High-resolution Thermospheric Imaging (MIGHTI) was launched aboard NASA’s Ionospheric Connection (ICON) Explorer satellite in October 2019 to measure winds and temperatures on the limb in the upper mesosphere and lower thermosphere (MLT). Temperatures are observed using the molecular oxygen atmospheric band near 763 nm from 90–127 km altitude in the daytime and 90–108 km in the nighttime. Here we describe the measurement approach and methodology of the temperature retrieval, including unique on-orbit operations that allow for a better understanding of the instrument response. The MIGHTI measurement approach for temperatures is distinguished by concurrent observations from two different sensors, allowing for two self-consistent temperature products. We compare the MIGHTI temperatures against existing MLT space-borne and ground-based observations. The MIGHTI temperatures are within 7 K of these observations on average from 90–95 km throughout the day and night. In the daytime on average from 99–105 km, MIGHTI temperatures are higher than coincident observations by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument on NASA’s TIMED satellite by 18 K. Because the difference between the MIGHTI and SABER observations is predominantly a constant bias at a given altitude, conclusions of scientific analyses that are based on temperature variations are largely unaffected.

We develop a phenomenological formalism for mixing effects between the Standard Model and hidden-sector fields, motivated by dark matter in the Universe as well as string theories. The scheme includes multiple Higgs-portal interactions in the scalar sector as well as multiple gauge-kinetic mixings in the abelian gauge sector. While some of the mixing effects can be cast in closed form, other elements can be controlled analytically only by means of perturbative expansions in the ratio of standard scales over large hidden scales. Higgs and vector-boson masses and mixings are illustrated numerically for characteristic processes.

Ixodes (Afrixodes) ambohitantelensisn. sp. (Acari: Ixodidae) is described based on females ex endemic shrew tenrecs (Afrosoricida: Tenrecidae) and an introduced rodent (Rodentia: Muridae) from Madagascar. Females of this new species are similar to those of other species of the subgenus Afrixodes Morel, 1966, known from Madagascar, from which they can be distinguished by the size of scutum, size of scutal setae, shape of alloscutal setae, development of genital apron, size of auriculae, size of anterior angle of basis capituli, size of palpi, dental formula on hypostome, development of syncoxae, and size and development of spurs on coxae I and IV.

The Brazilian free-tailed bat (Tadarida brasiliensis) is an exceptionally social and gregarious species of chiropteran known to roost in assemblages that can number in the millions. Chemical recognition of roostmates within these assemblages has not been extensively studied despite the fact that an ability to chemically recognize individuals could play an important role in forming and stabilizing complex suites of social interactions. Individual bats were given a choice between three roosting pouches: one permeated with the scent of a group of roostmates, one permeated with the scent of non-roostmates, and a clean control. Subjects rejected non-roostmate pouches with greater frequency than roostmate pouches or blank control pouches. Also, bats chose to roost in the roostmate scented pouches more often than the non-roostmate or control pouches. We demonstrated that T. brasiliensis has the ability to chemically recognize roostmates from non-roostmates and a preference for roosting in areas occupied by roostmates. It is important to investigate these behaviors because of their potential importance in colony dynamics and roost choice.

WT1 encodes a zinc-finger protein, expressed as distinct isoforms, that is inactivated in a subset of Wilms tumors. Both constitutional and somatic mutations disrupting the DNA-binding domain of WT1 result in a potentially dominant-negative phenotype. In generating inducible cell lines expressing wild-type isoforms of WT1 and WT1 mutants, we observed dramatic differences in the subnuclear localization of the induced proteins. The WT1 isoform that binds with high affinity to a defined DNA target, WT1(-KTS), was diffusely localized throughout the nucleus. In contrast, expression of an alternative splicing variant with reduced DNA binding affinity, WT1(+KTS), or WT1 mutants with a disrupted zinc-finger domain resulted in a speckled pattern of expression within the nucleus. Although similar in appearance, the localization of WT1 variants to subnuclear clusters was clearly distinct from that of the essential splicing factor SC35, suggesting that WT1 is not directly involved in pre-mRNA splicing. Localization to subnuclear clusters required the N terminus of WT1, and coexpression of a truncated WT1 mutant and wild-type WT1(-KTS) resulted in their physical association, the redistribution of WT1(-KTS) from a diffuse to a speckled pattern, and the inhibition of its transactivational activity. These observations suggest that different WT1 isoforms and WT1 mutants have distinct subnuclear compartments. Dominant-negative WT1 proteins physically associate with wild-type WT1 in vivo and may result in its sequestration within subnuclear structures.

Agitation has been linked to higher fall rates in demented elderly; music has been shown to diminish agitation. This study tested the hypothesis that music will also reduce falls in institutionalized persons with dementia. A quasi-experimental 1-group time-series design was conducted on a 55-bed dementia unit. Falls were recorded for 4 3-month periods. The data from 3 of these quarters were compared using a paired sample t-test. No significant difference was found. For descriptive purposes, falls from the previous autumn were reviewed retrospectively to detect a possible seasonal pattern. Falls increased in both winter quarters compared to autumn.

Background Deception can distort psychological tests on socially sensitive topics. Understanding the cerebral processes that are involved in such faking can be useful in detection and prevention of deception. Previous research shows that faking a brief implicit association test (BIAT) evokes a characteristic ERP response. It is not yet known whether temporarily available self-control resources moderate this response. We randomly assigned 22 participants (15 females, 24.23 ± 2.91 years old) to a counterbalanced repeated-measurements design. Participants first completed a Brief-IAT (BIAT) on doping attitudes as a baseline measure and were then instructed to fake a negative doping attitude both when self-control resources were depleted and non-depleted. Cerebral activity during BIAT performance was assessed using high-density EEG. Results Compared to the baseline BIAT, event-related potentials showed a first interaction at the parietal P1, while significant post hoc differences were found only at the later occurring late positive potential. Here, significantly decreased amplitudes were recorded for ‘normal’ faking, but not in the depletion condition. In source space, enhanced activity was found for ‘normal’ faking in the bilateral temporoparietal junction. Behaviorally, participants were successful in faking the BIAT successfully in both conditions. Conclusions Results indicate that temporarily available self-control resources do not affect overt faking success on a BIAT. However, differences were found on an electrophysiological level. This indicates that while on a phenotypical level self-control resources play a negligible role in deliberate test faking the underlying cerebral processes are markedly different.