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Endothelin receptor antagonists have been proposed for the treatment of a variety of disorders in which the endothelins may act as pathogenic mediators, such as congestive heart failure, systemic and pulmonary hypertension, and cerebral vasospasm. Bosentan (Ro 47-0203) is a nonpeptide competitive antagonist, which can be a good tool for studying the endothelin system because it may be administered either acutely or chronically. It is specific for the endothelin system and blocks the actions of endothelin at both mammalian receptors (A and B). In experimental models of heart failure bosentan acts as a vasodilator and neurohormonal blocker that improves overall left ventricular performance and reduces renal dysfunction. Furthermore, in chronic studies, bosentan attenuates cardiac remodeling and significantly improves survival. In patients with chronic heart failure bosentan produces pulmonary and systemic vasodilation and may enhance conventional treatment with angiotensin-converting enzyme inhibitors. Long-term studies are being conducted to characterize the full therapeutic potential of bosentan in chronic heart failure. In experimental models bosentan reverses established pulmonary hypertension. Preclinical efficacy has also been demonstrated in essential hypertension, where bosentan can reduce blood pressure and end-organ damage. Clinical trials in hypertensive patients indicate that bosentan reduces blood pressure without heart rate increase or neurohumoral stimulation. Finally, bosentan is being considered for the treatment of cerebral vasospasm following subarachnoid hemorrhage. Bosentan reverses experimentally induced vasospasm of the basilar artery, and preliminary trials indicate that it can increase cerebral blood flow after aneurysmal subarachnoid hemorrhage.

We present some highlights of two ongoing investigations that deal with the dynamics of planetary systems. Firstly, until recently, observed eccentric patterns in debris disks were found in young systems. However recent observations of Gyr-old eccentric debris disks leads to question the survival timescale of this type of asymmetry. One such disk was recently observed in the far-IR by the Herschel Space Observatory around ζ2 Reticuli. Secondly, as a binary companion orbits a circumprimary disk, it creates regions where planet formation is strongly handicapped. However, some planets were detected in this zone in tight binary systems (γ Cep, HD 196885). We aim to determine whether a binary companion can affect migration such that planets are brought in these regions and focus in particular on the planetesimal-driven migration mechanism.

Exozodiacal dust clouds are thought to be the extrasolar analogs of the Solar System's zodiacal dust. Studying these systems provides insights in the architecture of the innermost regions of planetary systems, including the Habitable Zone. Furthermore, the mere presence of the dust may result in major obstacles for direct imaging of earth-like planets. Our EXOZODI project aims to detect and study exozodiacal dust and to explain its origin. We are carrying out the first large, near-infrared interferometric survey in the northern (CHARA/FLUOR) and southern (VLTI/PIONIER) hemispheres. Preliminary results suggest a detection rate of up to 30% around A to K type stars and interesting trends with spectral type and age. We focus here on presenting the observational work carried out by our team.

Active galactic nuclei (AGNs) are a key component of galaxy evolution owing to feedback on the host from its supermassive black hole. The morphology of warm inflowing and outflowing dusty material can reveal the nature of the onset of feedback, AGN feeding and the unified model of AGN. Here we use the Large Binocular Telescope Interferometer (LBTI) to image the dense, obscuring disk and extended dusty outflow region of NGC 1068. In Fizeau imaging mode, the LBTI synthesizes the equivalent resolution of a 22.8 m telescope. The 8.7 μm Fizeau images of NGC 1068 have an effective resolution of 47 × 90 mas (3.3 × 6.2 pc) in a 5″ field of view after performing point spread function deconvolution techniques described here. This is the only extragalactic source to be Fizeau imaged using the LBTI, and the images bridge the scales measured with the Very Large Telescope Interferometer (0.5–5 pc) and those of single telescopes such as James Webb Space Telescope and Keck (>15 pc). The images detect and spatially resolve the low surface brightness mid-infrared features in the AGN disk/wind region that are overresolved by the Very Large Telescope Interferometer. The images show strong correlation between mid-infrared dust emission and near-infrared emission of highly excited atomic lines observed by SINFONI. Such LBTI imaging is a precursor to infrared imaging using the upcoming generation of extremely large telescopes, with angular resolutions up to six times better than James Webb Space Telescope, the largest space telescope in orbit. Detailed infrared images of the region around the supermassive black hole of NGC 1068 from the Large Binocular Telescope Interferometer reveal a dense disk, dusty outflow and emissions linked to radio jets, suggesting that active galactic nucleus torus models should include jet interactions.

Exocomets are small bodies that evaporate when they approach their host star. They are detected through variability of non-photospheric features with spectroscopy and/or asymmetric transits in time-series photometry. In the past four decades ~30 systems have shown such variations, and were therefore classified as exocomet host stars. However, some publications have pointed out mechanisms that might mimic exocometary features, and therefore, careful monitoring is needed to confirm the origin of the observed variability. With this paper we aim to investigate the exocomet nature of the non-photospheric variable features observed in the exocomet candidate stars HD 36546, HD 42111 and HD 85905. All of them have shown some degree of variability, particularly in their Ca II K line. We analysed the non-photospheric Ca II K line features from high-resolution spectra obtained using new NOT/FIES and Mercator/HERMES, and some additional archival spectra of the target stars. The variability was quantified through the changes in the equivalent widths of those features, which are assumed to be of circumstellar origin. Column densities were also estimated for each variable feature. Strong variability was found for HD 85905, consistent with a potential link to exocometary activity. However, the binarity of the system, which we confirmed through interferometric VLTI/PIONIER observations, complicates the interpretation of these signatures and prevents us from drawing definitive conclusions. The remaining two sources do not show any significant variability, but due to the sporadic nature of the exocometary events, we cannot discard the exocomet hypothesis. Further monitoring of the stars will be necessary to carry out a robust determination of the variability patterns and timescales that would completely rule out other scenarios.

Exocomets are small bodies that evaporate when they approach their host star. They are detected through variability of non-photospheric features with spectroscopy and/or asymmetric transits in time-series photometry. In the past four decades ~30 systems have shown such variations, and were therefore classified as exocomet host stars. However, some publications have pointed out mechanisms that might mimic exocometary features, and therefore, careful monitoring is needed to confirm the origin of the observed variability. With this paper we aim to investigate the exocomet nature of the non-photospheric variable features observed in the exocomet candidate stars HD 36546, HD 42111 and HD 85905. All of them have shown some degree of variability, particularly in their Ca II K line. We analysed the non-photospheric Ca II K line features from high-resolution spectra obtained using new NOT/FIES and Mercator/HERMES, and some additional archival spectra of the target stars. The variability was quantified through the changes in the equivalent widths of those features, which are assumed to be of circumstellar origin. Column densities were also estimated for each variable feature. Strong variability was found for HD 85905, consistent with a potential link to exocometary activity. However, the binarity of the system, which we confirmed through interferometric VLTI/PIONIER observations, complicates the interpretation of these signatures and prevents us from drawing definitive conclusions. The remaining two sources do not show any significant variability, but due to the sporadic nature of the exocometary events, we cannot discard the exocomet hypothesis. Further monitoring of the stars will be necessary to carry out a robust determination of the variability patterns and timescales that would completely rule out other scenarios.

An infrared excess over the stellar photospheric emission of main-sequence stars has been found in interferometric surveys, commonly attributed to the presence of hot exozodiacal dust (HEZD). While submicrometer-sized grains in close vicinity to their host star have been inferred to be responsible for the found near-infrared excesses, the presence and amount of larger grains as part of the dust distributions are weakly constrained. We quantify how many larger grains (above-micrometer-sized) could be present in addition to submicrometer-sized grains, while being consistent with observational constraints. This is important in order to distinguish between various scenarios for the origin of HEZD and to better estimate its observational appearance when observed with future instruments. We extended a model suitable to reproduce current observations of HEZD to investigate a bimodal size distribution. By deriving the characteristics of dust distributions whose observables are consistent with observational limits from interferometric measurements in the \\(K\\) and \\(N\\) bands we constrained the radii of sub- and above-micrometer-sized grains as well as their mass, number, and flux density ratios. In the most extreme cases of some of the investigated systems, large grains \\( 10\\,\\)m might dominate the mass budget of HEZD while contributing up to 25\\(\\,\\)% of the total flux density originating from the dust at a wavelength of 2.13\\(\\,\\)m and up to 50\\(\\,\\)% at a wavelength of 4.1\\(\\,\\)m; at a wavelength of 11.1\\(\\,\\)m their emission might clearly dominate over the emission of small grains. While it is not possible to detect such hot-dust distributions using ALMA, the ngVLA might allow us to detect HEZD at millimeter wavelengths. Large dust grains might have a more important impact on the observational appearance of HEZD than previously assumed, especially at longer wavelengths.