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As the cost of satellite missions grow, government agencies are working to increase the relevance and usefulness of the Earth science data that they produce. The US National Aeronautics and Space Administration’s (NASA) early adopter program seeks to formalize partnerships with users of data early within the satellite planning process to ensure the greatest value of the mission. Scientists who are designing the satellite observing system, those who are developing mission data products, and the community who will use them need to work together to determine how satellite data can better inform decision making. NASA is working to initiate engagement with data users much earlier in the satellite program life so that the user needs can be prioritized, continue to engage with users throughout the development cycle, and then include analysis on societal impact after nominal mission life. The Early Adopter Program allows for broad and early engagement with decision makers by encouraging individuals and institutions with clear uses of data to engage with the mission. Early adopters facilitate feedback on mission products during pre-launch and accelerate the utilization of these products post-launch. This paper provides background and detail on how NASA is working to engage with early adopters, describes the partnership between early adopters and NASA missions, and connects the program to improved societal impacts of its satellite missions.

Carbon cycle science is at the heart of research on global climate change and its long-term impacts, as it examines the exchange of carbon between the atmosphere, oceans, land, and the impact of fossil fuel emissions on this cycling. Given the urgency of the climate challenge, NASA’s Carbon Monitoring System (CMS) requires all funded investigators to identify and work with stakeholder organizations at project inception to accelerate the transfer of the products developed by funded research into decision making systems. In this study, we contribute to the literature through the implementation of a quantitative analysis of 908 unique survey responses from funded investigators to explore the maturity of the scientist-stakeholder engagement. The paper employs multiple correspondence analysis to provide evidence to support policy options to increase stakeholder integration into research programs. Despite limitations of the dataset used, we demonstrated that multiple funding rounds, long-standing relationships between the stakeholder and scientist, and the scientific productivity of the PI, including the ability to produce datasets and research papers on these datasets, all contribute to carbon products moving from research to operational use. The maturity of relationships between scientists and stakeholders was shown to result improved stakeholder engagement. The use of carbon products should be identified in every stage of the program, and that capacity building is needed to support both existing and newly identified stakeholders better understand and use CMS products. As Federal, State, and local policy on climate adaptation and mitigation matures, the need for information on carbon will expand. Building of stakeholder-scientist relationships in CMS results in an effective generation and use of datasets to support this need and prototype ways that improved information needed for decision making can be created.

Underlying policy efforts to address global climate change is the scientific need to develop the methods to accurately measure and model carbon stocks and fluxes across the wide range of spatial and temporal scales in the Earth system. Initiated in 2010, the NASA Carbon Monitoring System is one of the most ambitious relevant science initiatives to date, exploiting the satellite remote sensing resources, computational capabilities, scientific knowledge, airborne science capabilities, and end-to-end system expertise that are major strengths of the NASA Earth Science program. Here we provide a synthesis of ‘Phase 2’ activities (2011–2019), encompassing 79 projects, 482 publications, and 136 data products. Our synthesis addresses four key questions: What has been attempted? What major results have been obtained? What major gaps and uncertainties remain? and What are the recommended next steps? Through this review, we take stock of what has been accomplished and identify future priorities toward meeting the nation’s needs for carbon monitoring reporting and verification.

Aims To describe the main characteristics of patients who were readmitted to hospital within 1 month after an index episode for acute decompensated heart failure (ADHF). Methods and results This is a nested case–control study in the ReIC cohort, cases being consecutive patients readmitted after hospitalization for an episode of ADHF and matched controls selected from those who were not readmitted. We collected clinical data and also patient-reported outcome measures, including dyspnea, Minnesota Living with Heart Failure Questionnaire (MLHFQ), Tilburg Frailty Indicator (TFI) and Hospital Anxiety and Depression Scale scores, as well as symptoms during a transition period of 1 month after discharge. We created a multivariable conditional logistic regression model. Despite cases consulted more than controls, there were no statistically significant differences in changes in treatment during this first month. Patients with chronic decompensated heart failure were 2.25 [1.25, 4.05] more likely to be readmitted than de novo patients. Previous diagnosis of arrhythmia and time since diagnosis ≥ 3 years, worsening in dyspnea, and changes in MLWHF and TFI scores were significant in the final model. Conclusion We present a model with explanatory variables for readmission in the short term for ADHF. Our study shows that in addition to variables classically related to readmission, there are others related to the presence of residual congestion, quality of life and frailty that are determining factors for readmission for heart failure in the first month after discharge. Trial Registration : ClinicalTrials.gov Identifier: NCT03300791. First registration: 03/10/2017.

Sin embargo, eso que parecía un sueño apenas alcanzable por unos pocos, ha comenzado a ser una realidad para muchos jóvenes que le quieren seguir apostando a la educación como medio de transformación social y motor para la consolidación de sus proyectos de vida en los territorios que habitan. Desde la Alianza ERA se resalta que, el objetivo principal es abrir trochas y caminos, tocando otras puertas de entidades e instituciones que se den cuenta de las grandes fortalezas de la ruralidad, las cuales muchas veces no llegan a ser visibilizadas por falta de oportunidades. A través de dicho programa se busca que cada uno de estos jóvenes tenga ta oportunidad de seguir conociendo y reconociendo desde otras perspectivas, esos maravittosos tugares que habitan, con un programa que tes permitirá desempeñarse en tas áreas de ta satud animat, producción pecuaria, y satud púbtica veterinaria; enmarcados en un compromiso ético y de responsabitidad sociat en armonía con et bienestar animat y et desarrotto rurat sostenibte.

Book review

Abstract Disclosure: F. Korkmaz: None. P. Savani: None. S. Kim: None. V. Escobar Barboza: None. Background: Metformin use in patients with type 2 diabetes (T2D) is associated with lactic acidosis, although exceedingly rare. However, the risk of lactic acidosis is high in patients with underlying CKD. SGLT2 inhibitors have been increasingly used in patients with CKD in recent years due to their benefit in preventing the progression of diabetic nephropathy. In this case, we present the case of a 79-year-old elderly patient with T2D using both Metformin and an SGLT2 inhibitor who was admitted for life-threatening lactic acidosis. Clinical Case: A 79-year-old female with T2D and co-morbidities including CKD 3b, HTN HLD, and dementia, presented with altered mental status. Her home medications included Dapagliflozin 5 mg (started 6 months ago), Metformin XR 500 mg BID (started 8 years ago), Amlodipine, Atenolol, Hydrochlorothiazide, Olmesartan, and Rosuvastatin. Upon admission, she exhibited severe hypotension (BP: 74/35 mmHg), bradycardia (HR: 54 bpm), and hypothermia (Temp: 34.4°C), while maintaining normal oxygen saturation. Laboratory results showed glucose at 94 mg/dL, potassium at 6.8 mEq/L, BUN at 45 mg/dL, creatinine at 8.86 mg/dL (baseline: 1.3 mg/dL), anion gap at 37.4, pH at 6.8, HCO3 at 2.6 mmol/L, PCO2 at 15 mmHg, lactate at 19.9 mmol/L (reference range < 2), and urine positive for ketones. Despite intensive care with intravenous hydration, a bicarbonate drip, and three vasopressors, her hypotension persisted, and lactate levels rose to 24 mmol/L. Emergent continuous renal replacement therapy (CRRT) was initiated, which improved her hemodynamics and lactic acidosis—all potential causes of lactic acidosis, including infection work-ups such as blood cultures, were negative. Conclusion: Although it is often challenging to identify the exact cause of lactic acidosis, her clinical picture raised suspicion of metformin-induced lactic acidosis due to the initial failure to respond to fluid resuscitation and pressors, followed by improvement after CRRT, and a negative work-up for infection and other causes.There is a similar case presenting severe euglycemic ketoacidosis and lactic acidosis in a diabetic patient on chronic Dapagliflozin and Metformin therapy, which was triggered by poor oral intake and dehydration, ultimately requiring dialysis. Our case underscores the caution needed when using a combination of metformin and SGLT-2 inhibitors, especially in elderly T2D patients with decreased Presentation: Saturday, July 12, 2025

The state entities of a country have the responsibility of applying and promoting in their territory, the fulfillment of theSustainable Development Goals proposed by the United Nations. Among these, is the “guaranteeing sustainableconsumption and production modalities” [1]; one of its goals is that, by 2030, the generation of waste should be“considerably reduced through prevention, reduction, recycling and reuse activities”. In the case of the Senate of theRepublic of Colombia, interested in meeting these objectives, a consistent methodology is presented for thestandardization of the consumables process (waste associated with office products such as paper, plastic, cardboard,mixers, glasses, etc.), which has an important role within the institution in relation to the optimization of resources. Theapplied method was based on engineering tools that allowed the analysis and evaluation of the procedures that have the greatest influence, which resulted in the completion of all the documentation of the process, with their respectiveexecution times, indicators and impact evaluation. The application of these guidelines will allow greater control over themanagement and final disposal of the remaining products, which constitutes progress and development in the proceduraland environmental aspects aimed at being a sustainable organization.

Foodborne pathogens present a serious issue around the world due to the remarkably high number of illnesses they cause every year. In an effort to narrow the gap between monitoring needs and currently implemented classical detection methodologies, the last decades have seen an increased development of highly accurate and reliable biosensors. Peptides as recognition biomolecules have been explored to develop biosensors that combine simple sample preparation and enhanced detection of bacterial pathogens in food. This review first focuses on the selection strategies for the design and screening of sensitive peptide bioreceptors, such as the isolation of natural antimicrobial peptides (AMPs) from living organisms, the screening of peptides by phage display and the use of in silico tools. Subsequently, an overview on the state-of-the-art techniques in the development of peptide-based biosensors for foodborne pathogen detection based on various transduction systems was given. Additionally, limitations in classical detection strategies have led to the development of innovative approaches for food monitoring, such as electronic noses, as promising alternatives. The use of peptide receptors in electronic noses is a growing field and the recent advances of such systems for foodborne pathogen detection are presented. All these biosensors and electronic noses are promising alternatives for the pathogen detection with high sensitivity, low cost and rapid response, and some of them are potential portable devices for on-site analyses.

Additionally, soil moisture touches upon human lives in a number of ways-from the ravages of flooding to the needs for monitoring agricultural and hydrologic droughts. Because of their relevance to weather, climate, science, and society, accurate and timely measurements of soil moisture and freeze/thaw state with global coverage are critically important. The SMAP science objectives are to acquire space-based hydrosphere state measurements to 1) understand processes that link the terrestrial water, energy, and carbon cycles; 2) estimate global water and energy fluxes at the land surface; 3) quantify net carbon flux in boreal landscapes; 4) enhance weather and climate forecast abilities; and 5) develop improved flood prediction and drought-monitoring capabilities.