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"Estep, Jennifer"
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Kiss of frost : a Mythos Academy novel
Now in her second year as a warrior-in-training at Mythos Academy, Gwen Frost learns that one of her fellow students is secretly a Reaper who wants her dead.
Book
BRIEF: Recommended Reading: 'The Bourne Betrayal'
Jul. 19--If you like spy thrillers, check out \"Robert Ludlum's The Bourne Betrayal\" by Eric Van Lustbader (paperback, $9.99, 2008).
Newsletter
Kill the queen
\"Gladiator meets Game of Thrones: a royal woman becomes a skilled warrior to destroy her murderous cousin, avenge her family, and save her kingdom in this first entry in a dazzling fantasy epic from the New York Times and USA Today bestselling author of the Elemental Assassin series--an enthralling tale that combines magic, murder, intrigue, adventure, and a hint of romance. In a realm where one's magical power determines one's worth, Lady Everleigh's lack of obvious ability relegates her to the shadows of the royal court of Bellona, a kingdom steeped in gladiator tradition. Seventeenth in line for the throne, Evie is nothing more than a ceremonial fixture, overlooked and mostly forgotten. But dark forces are at work inside the palace. When her cousin Vasilia, the crown princess, assassinates her mother the queen and takes the throne by force, Evie is also attacked, along with the rest of the royal family. Luckily for Evie, her secret immunity to magic helps her escape the massacre. Forced into hiding to survive, she falls in with a gladiator troupe. Though they use their talents to entertain and amuse the masses, the gladiators are actually highly trained warriors skilled in the art of war, especially Lucas Sullivan, a powerful magier with secrets of his own. Uncertain of her future--or if she even has one--Evie begins training with the troupe until she can decide her next move. But as the bloodthirsty Vasilia exerts her power, pushing Bellona to the brink of war, Evie's fate becomes clear: she must become a fearsome gladiator herself ... and kill the queen.\"--Provided by publisher.
Book
Surfing the Web for Engineering Info
One Web site that can open the door to many others is the World Wide Web Virtual Library: Engineering at arioch.gsfc.nasa.gov/wwwvl/engineering.html. This site contains hundreds of links to other engineering sites. Another general engineering Web site is The Edinburgh Engineering Virtual Library at www.eevl.ac.uk/. One of the most informative Web sites about product development is The Engineering Zone at www.flinthills.com/~ramsdale/EngZone/design.htm. The Industrial Designers Society of America at www.idsa.org is another good site that focuses on industrial design.
Magazine Article
ConceptWorks
RealityWave Inc. has released a new version of its real-time collaboration add-in for SolidWorks software. The product, called ConceptWorks, lets design engineers transfer solid models over the Internet.
Magazine Article
An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold
The mature mammalian cortex is composed of 6 architecturally and functionally distinct layers. Two key steps in the assembly of this layered structure are the initial establishment of the glial scaffold and the subsequent migration of postmitotic neurons to their final position. These processes involve the precise and timely regulation of adhesion and detachment of neural cells from their substrates. Although much is known about the roles of adhesive substrates during neuronal migration and the formation of the glial scaffold, less is understood about how these signals are interpreted and integrated within these neural cells. Here, we provide in vivo evidence that Cas proteins, a family of cytoplasmic adaptors, serve a functional and redundant role during cortical lamination. Cas triple conditional knock-out ( Cas TcKO) mice display severe cortical phenotypes that feature cobblestone malformations. Molecular epistasis and genetic experiments suggest that Cas proteins act downstream of transmembrane Dystroglycan and β1-Integrin in a radial glial cell-autonomous manner. Overall, these data establish a new and essential role for Cas adaptor proteins during the formation of cortical circuits and reveal a signaling axis controlling cortical scaffold formation.
Journal Article
Ecological assessment of the marine ecosystems of Barbuda, West Indies: Using rapid scientific assessment to inform ocean zoning and fisheries management
To inform a community-based ocean zoning initiative, we conducted an intensive ecological assessment of the marine ecosystems of Barbuda, West Indies. We conducted 116 fish and 108 benthic surveys around the island, and measured the abundance and size structure of lobsters and conch at 52 and 35 sites, respectively. We found that both coral cover and fish biomass were similar to or lower than levels observed across the greater Caribbean; live coral cover and abundance of fishery target species, such as large snappers and groupers, was generally low. However, Barbuda lacks many of the high-relief forereef areas where similar work has been conducted in other Caribbean locations. The distribution of lobsters was patchy, making it difficult to quantify density at the island scale. However, the maximum size of lobsters was generally larger than in other locations in the Caribbean and similar to the maximum size reported 40 years ago. While the lobster population has clearly been heavily exploited, our data suggest that it is not as overexploited as in much of the rest of the Caribbean. Surveys of Barbuda's Codrington Lagoon revealed many juvenile lobsters, but none of legal size (95 mm carapace length), suggesting that the lagoon functions primarily as nursery habitat. Conch abundance and size on Barbuda were similar to that of other Caribbean islands. Our data suggest that many of the regional threats observed on other Caribbean islands are present on Barbuda, but some resources-particularly lobster and conch-may be less overexploited than on other Caribbean islands. Local management has the potential to provide sustainability for at least some of the island's marine resources. We show that a rapid, thorough ecological assessment can reveal clear conservation opportunities and facilitate rapid conservation action by providing the foundation for a community-driven policymaking process at the island scale.
Journal Article
An adhesion signaling axis involving Dystroglycan, beta1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold
The mature mammalian cortex is composed of 6 architecturally and functionally distinct layers. Two key steps in the assembly of this layered structure are the initial establishment of the glial scaffold and the subsequent migration of postmitotic neurons to their final position. These processes involve the precise and timely regulation of adhesion and detachment of neural cells from their substrates. Although much is known about the roles of adhesive substrates during neuronal migration and the formation of the glial scaffold, less is understood about how these signals are interpreted and integrated within these neural cells. Here, we provide in vivo evidence that Cas proteins, a family of cytoplasmic adaptors, serve a functional and redundant role during cortical lamination. Cas triple conditional knock-out (Cas TcKO) mice display severe cortical phenotypes that feature cobblestone malformations. Molecular epistasis and genetic experiments suggest that Cas proteins act downstream of transmembrane Dystroglycan and [beta]1-Integrin in a radial glial cell-autonomous manner. Overall, these data establish a new and essential role for Cas adaptor proteins during the formation of cortical circuits and reveal a signaling axis controlling cortical scaffold formation.
Journal Article
Benthic assemblages are more predictable than fish assemblages at an island scale
Decades of research have revealed relationships between the abundance of coral reef taxa and local conditions, especially at small scales. However, a rigorous test of covariation requires a robust dataset collected across wide environmental or experimental gradients. Here, we surveyed spatial variability in the densities of major coral reef functional groups at 122 sites along a 70 km expanse of the leeward, forereef habitat of Curaçao in the southern Caribbean. These data were used to test the degree to which spatial variability in community composition could be predicted based on assumed functional relationships and site-specific anthropogenic, physical, and ecological conditions. In general, models revealed less power to describe the spatial variability of fish biomass than cover of reef builders (R2 of best-fit models: 0.25 [fish] and 0.64 [reef builders]). The variability in total benthic cover of reef builders was best described by physical (wave exposure and reef relief) and ecological (turf algal height and coral recruit density) predictors. No metric of anthropogenic pressure was related to spatial variation in reef builder cover. In contrast, total fish biomass showed a consistent (albeit weak) association with anthropogenic predictors (fishing and diving pressure). As is typical of most environmental gradients, the spatial patterns of both fish biomass density and reef builder cover were spatially autocorrelated. Residuals from the best-fit model for fish biomass retained a signature of spatial autocorrelation while the best-fit model for reef builder cover removed spatial autocorrelation, thus reinforcing our finding that environmental predictors were better able to describe the spatial variability of reef builders than that of fish biomass. As we seek to understand spatial variability of coral reef communities at the scale of most management units (i.e., at kilometer- to island-scales), distinct and scale-dependent perspectives will be needed when considering different functional groups.
Journal Article