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The last few decades have seen the rise of ‘ecological modernization theory’ (EMT) as a “green capitalist” tradition extending modernization theory into environmental sociology. This article uses a synthesis of political economy, world-systems theory, and political, economic, and environmental sociology to demonstrate that the EMT presumption of growth and profit as economic priorities (alongside its neglect of core-periphery relations) produces many feedback loops which fatally undermine the viability of EMT’s own political, technological, and social prescriptions, alongside creating problems for the fundamental EMT concept of ‘ecological rationality.’ Furthermore, this article attempts to explain why “green capitalist” approaches to environmental analysis have influence within policy and social science circles despite their inadequacies within environmental sociology. Finally, this article argues that in order to address the ecological challenges of our era, environmental sociology needs to reject “green capitalist” traditions like ‘ecological modernization theory’ which presuppose the desirability and maintenance of profit and growth as economic priorities (and predominantly fail to critique power imbalances between core and non-core nations), and instead return to the development of traditions willing to critique the fundamental traits of the capitalist world-system.

Alien and Philosophy: I Infest, Therefore I Am presents a philosophical exploration of the world of Alien, the simultaneously horrifying and thought-provoking sci-fi horror masterpiece, and the film franchise it spawned. - The first book dedicated to exploring the philosophy raised by one of the most successful and influential sci-fi franchises of modern times - Features contributions from an acclaimed team of scholars of philosophy and pop culture, led by highly experienced volume editors - Explores a huge range of topics that include the philosophy of fear, Just Wars, bio-weaponry, feminism and matriarchs, perfect killers, contagion, violation, employee rights and Artificial Intelligence - Includes coverage of H.R. Giger’s aesthetics, the literary influences of H.P. Lovecraft, sci-fi and the legacy of Vietnam, and much more!

Alien and Philosophy: I Infest, Therefore I Am presents a philosophical exploration of the world of Alien, the simultaneously horrifying and thought-provoking sci-fi horror masterpiece, and the film franchise it spawned. The first book dedicated to exploring the philosophy raised by one of the most successful and influential sci-fi franchises of modern times Features contributions from an acclaimed team of scholars of philosophy and pop culture, led by highly experienced volume editors Explores a huge range of topics that include the philosophy of fear, Just Wars, bio-weaponry, feminism and matriarchs, perfect killers, contagion, violation, employee rights and Artificial Intelligence Includes coverage of H.R. Giger s aesthetics, the literary influences of H.P. Lovecraft, sci-fi and the legacy of Vietnam, and much more!

Stenotrophomonas maltophilia is an opportunistic bacterial pathogen found in healthcare settings. During May 2022–September 2023, an acute care hospital in northern California, USA, identified 13 S. maltophilia bloodstream infections among intensive care unit patients. Whole-genome sequencing showed the isolates were highly related. We identified risk factors for infection by conducting a matched case–control study, targeted assessment of infection prevention and control practices, and laboratory testing of suspected environmental reservoirs. Among 13 case-patients and 39 control-patients, patients exposed to iodinated contrast (odds ratio [OR] 12.0; 95% CI 2.1–∞), injectable propofol (OR 12.2; 95% CI 1.5–101.4), or fentanyl (OR 9.2; 95% CI 1.8–∞) had increased odds of S. maltophilia bloodstream infection. Although we did not have culture confirmation of a source, we suspect S. maltophilia was transmitted by exposure to nonsterile water from a common source. We recommended infection prevention and control practices to reduce risk for contamination from nonsterile water.

The challenge of distinguishing genetic drift from selection remains a central focus of population genetics. Time-sampled data may provide a powerful tool for distinguishing these processes, and we here propose approximate Bayesian, maximum likelihood, and analytical methods for the inference of demography and selection from time course data. Utilizing these novel statistical and computational tools, we evaluate whole-genome datasets of an influenza A H1N1 strain in the presence and absence of oseltamivir (an inhibitor of neuraminidase) collected at thirteen time points. Results reveal a striking consistency amongst the three estimation procedures developed, showing strongly increased selection pressure in the presence of drug treatment. Importantly, these approaches re-identify the known oseltamivir resistance site, successfully validating the approaches used. Enticingly, a number of previously unknown variants have also been identified as being positively selected. Results are interpreted in the light of Fisher's Geometric Model, allowing for a quantification of the increased distance to optimum exerted by the presence of drug, and theoretical predictions regarding the distribution of beneficial fitness effects of contending mutations are empirically tested. Further, given the fit to expectations of the Geometric Model, results suggest the ability to predict certain aspects of viral evolution in response to changing host environments and novel selective pressures.

HER2-targeted therapy dramatically improves outcomes in early breast cancer. Here we report the results of two HER2-targeted combinations in the neoadjuvant I-SPY2 phase 2 adaptive platform trial for early breast cancer at high risk of recurrence: ado-trastuzumab emtansine plus pertuzumab (T-DM1/P) and paclitaxel, trastuzumab and pertuzumab (THP). Eligible women have >2.5 cm clinical stage II/III HER2 + breast cancer, adaptively randomized to T-DM1/P, THP, or a common control arm of paclitaxel/trastuzumab (TH), followed by doxorubicin/cyclophosphamide, then surgery. Both T-DM1/P and THP arms ‘graduate’ in all subtypes: predicted pCR rates are 63%, 72% and 33% for T-DM1/P (n = 52), THP (n = 45) and TH (n = 31) respectively. Toxicity burden is similar between arms. Degree of HER2 pathway signaling and phosphorylation in pretreatment biopsy specimens are associated with response to both T-DM1/P and THP and can further identify highly responsive HER2 + tumors to HER2-directed therapy. This may help identify patients who can safely de-escalate cytotoxic chemotherapy without compromising excellent outcome. HER2-targeted therapy improves patient’s outcome in early breast cancer. Here, the authors present the efficacy and biomarker analysis of two HER2-targeted combinations (ado-trastuzumab emtansine plus pertuzumab and paclitaxel, trastuzumab and pertuzumab) in the context of the neoadjuvant I-SPY2 phase 2 adaptive platform trial for early breast cancer at high risk of recurrence.

This article illustrates the value and impact of collaboration among scholars, archivists, and librarians working across universities and government institutions, and how changes in medium—from a born-physical photograph and printed postcard to a digital reproduction to a simultaneously born-digital and printed book—create new possibilities for scholarly analysis, interpretation, and dissemination, which in turn suggest future directions for research and engagement across fields of inquiry. In doing so, this article argues that history matters by illuminating past networks that, through humanistic inquiry, continue to connect people, ideas, and institutions in the present and into the future.

Recent research suggests that dual enrollment programs are a useful recruiting tool for colleges and universities as many high school students remain at their dual enrollment institution after high school graduation. Students staying enrolled at their dual enrollment institution for college may be beneficial for institutions, but is it beneficial for participating dual enrollment students? We find that students who participate in dual enrollment in high school are more likely to experience college undermatch than similar students who do not participate in any postsecondary acceleration opportunities. Students who participate in a dual enrollment program at a 2-year institution and stay at the institution after high school graduation are up to 29% points more likely to undermatch than the average dual enrollment student enrolling in a different postsecondary institution after high school graduation. The difference is reduced to 9% points for dual enrollment students who stay at a four-year institution. Most significantly, our research shows that the decision to stay at a 2-year dual enrollment institution has negative consequences for bachelor’s degree attainment. Students who stay at a 2-year dual enrollment institution where they are undermatched have about a 33% point lower probability of completing a bachelor’s degree when compared to similar 2-year dual enrollment students who move to a 4-year institution where they are not undermatched after high school graduation.

The article deals with the ongoing strategic partnership between the History of Medicine Division at the National Library of Medicine and Virginia Polytechnic Institute and State University (Virginia Tech) to allow researchers, educators, and students access to new forms of cooperative work through a growing network of resources.

Young men who have sex with men (YMSM), particularly those who are partnered, are at unique risk for HIV. YMSM are among those at highest risk for HIV. Meanwhile, despite the fact that primary partners account for many-possibly most-new HIV infections, partnered men who have sex with men perceive themselves to be at much lower risk for HIV infection and therefore test less often than single men. In response to the risk of primary partner HIV transmission, couples HIV testing and counseling (CHTC) procedures have been developed for use in adult populations. Although promising, YMSM couples may require additional support to complete CHTC given their developmental context in which sexual and romantic relationships are relatively new, and communication skills are emergent. The aim of this study was to test the additive benefit of adjunct treatment components tailored for YMSM, which enhance communication skills before the completion of CHTC. The intervention tests a continuum of prevention packages including assertive communication training videos and motivational interviewing focused on assisting with identification and development (MI-AID) before entering into the dyadic intervention components. This protocol is part of the Adolescent Medicine Trials Network (ATN) Scale It Up program described in this issue. This is a comparative effectiveness trial that will be executed in 3 phases. Phase 1 will gather qualitative data related to intervention development and implementation from partnered YMSM at 4 subject recruitment venues (SRVs). Phase 2 will compare a continuum of these interventions in a pilot randomized controlled trial (RCT) at 2 SRVs. Phase 3 will compare the most successful adapted intervention package from phase 2 to CHTC as usual in a larger RCT at 4 SRVs. This phase is focused on implementation and sustainment phases of the Exploration, Preparation, Implementation, and Sustainment framework. Phase 1 data will be drawn from qualitative interviews with partnered YMSM (n=24) and staff from ATN sites (n=20). Baseline enrollment for phase 2 is expected to begin across 2 SRVs in June 2018 (n =36). In phase 2, survey data collection along with HIV and sexually transmitted infection (STI) testing will occur at baseline, and 1- and 3-month (postintervention) follow-ups. Phase 3 will begin enrollment across 4 SRVs in September 2019 (n =144) and follow-ups will occur at 1, 3, 6, and 9 months postintervention. Although MI-AID, video-based assertive communication training, and CHTC have established efficacy when administered on their own, this study will be the first to evaluate the strongest adjunctive version of these interventions to address the specific developmental needs of partnered YMSM. ClinicalTrials.gov NCT03386110; http://clinicaltrials.gov/ct2/show/NCT03386110 (Archived by WebCite at http://www.webcitation.org/75mlO7GCx). DERR1-10.2196/11186.