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result(s) for
"Eyrich, W"
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Evaluation of Social Determinants of Health and Prostate Cancer Outcomes Among Black and White Patients
by
Seymore, Mariana
,
Zaorsky, Nicholas G.
,
Stensland, Kristian
in
Aged
,
Black or African American
,
Humans
2023
As the field of medicine strives for equity in care, research showing the association of social determinants of health (SDOH) with poorer health care outcomes is needed to better inform quality improvement strategies.
To evaluate the association of SDOH with prostate cancer-specific mortality (PCSM) and overall survival (OS) among Black and White patients with prostate cancer.
A MEDLINE search was performed of prostate cancer comparative effectiveness research from January 1, 1960, to June 5, 2020.
Two authors independently selected studies conducted among patients within the United States and performed comparative outcome analysis between Black and White patients. Studies were required to report time-to-event outcomes. A total of 251 studies were identified for review.
Three authors independently screened and extracted data. End point meta-analyses were performed using both fixed-effects and random-effects models. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline was followed, and 2 authors independently reviewed all steps. All conflicts were resolved by consensus.
The primary outcome was PCSM, and the secondary outcome was OS. With the US Department of Health and Human Services Healthy People 2030 initiative, an SDOH scoring system was incorporated to evaluate the association of SDOH with the predefined end points. The covariables included in the scoring system were age, comorbidities, insurance status, income status, extent of disease, geography, standardized treatment, and equitable and harmonized insurance benefits. The scoring system was discretized into 3 categories: high (≥10 points), intermediate (5-9 points), and low (<5 points).
The 47 studies identified comprised 1 019 908 patients (176 028 Black men and 843 880 White men; median age, 66.4 years [IQR, 64.8-69.0 years]). The median follow-up was 66.0 months (IQR, 41.5-91.4 months). Pooled estimates found no statistically significant difference in PCSM for Black patients compared with White patients (hazard ratio [HR], 1.08 [95% CI, 0.99-1.19]; P = .08); results were similar for OS (HR, 1.01 [95% CI, 0.95-1.07]; P = .68). There was a significant race-SDOH interaction for both PCSM (regression coefficient, -0.041 [95% CI, -0.059 to 0.023]; P < .001) and OS (meta-regression coefficient, -0.017 [95% CI, -0.033 to -0.002]; P = .03). In studies with minimal accounting for SDOH (<5-point score), Black patients had significantly higher PCSM compared with White patients (HR, 1.29; 95% CI, 1.17-1.41; P < .001). In studies with greater accounting for SDOH variables (≥10-point score), PCSM was significantly lower among Black patients compared with White patients (HR, 0.86; 95% CI, 0.77-0.96; P = .02).
The findings of this meta-analysis suggest that there is a significant interaction between race and SDOH with respect to PCSM and OS among men with prostate cancer. Incorporating SDOH variables into data collection and analyses are vital to developing strategies for achieving equity.
Journal Article
Polarization analysis of p̄ produced in pA collisions
2019
A quite simple procedure for the generation of a polarized antiproton beam could be worked out if antiprotons are produced with some polarization. In order to investigate this possibility measurements of the polarization of produced antiprotons have been started at a CERN/PS test beam. The polarization will be determined from the asymmetry of the elastic antiproton scattering at a liquid hydrogen target in the CNI region for which the analyzing power is well known. The data are under analysis and an additional measurement is done in 2018. Details on the experiment and the ongoing data analysis will be given.
Journal Article
Drift chamber calibration and particle identification in the P-349 experiment
2019
The goal of the P-349 experiment is to test whether 3.5 GeV/c antiprotons produced in high-energy proton-proton collisions are polarized in view of the preparation of a polarized antiproton beam. In this article, we present the details of the ongoing analysis focused on the drift chambers calibration and particle identification with DIRC.
Journal Article
Status of the analysis for the search of polarization in the antiproton production process
2016
The P-349 experiment aims to test whether for antiprotons the production process itself can be a source of polarization in view of the preparation of a polarized antiproton beam. In this article we present the details of performed measurements and report on the status of the ongoing analysis.
Journal Article
Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/c
by
Crespo, M. L.
,
Mallot, G. K.
,
Sapozhnikov, M. G.
in
Astronomy
,
Astrophysics and Cosmology
,
Elementary Particles
2013
Multiplicities of charged hadrons produced in deep inelastic muon scattering off a
6
LiD target have been measured as a function of the DIS variables
x
Bj
,
Q
2
,
W
2
and the final state hadron variables
p
T
and
z
. The
distributions are fitted with a single exponential function at low values of
to determine the dependence of
on
x
Bj
,
Q
2
,
W
2
and
z
. The
z
-dependence of
is shown to be a potential tool to extract the average intrinsic transverse momentum squared of partons,
, as a function of
x
Bj
and
Q
2
in a leading order QCD parton model.
Journal Article
Erratum to: Azimuthal asymmetries of charged hadrons produced in high-energy muon scattering off longitudinally polarised deuterons
by
Crespo, M. L.
,
Mallot, G. K.
,
Srnka, A.
in
Astronomy
,
Astrophysics and Cosmology
,
Elementary Particles
2020
The original version of this article unfortunately contained a mistake.
Journal Article
Azimuthal asymmetries of charged hadrons produced by high-energy muons scattered off longitudinally polarised deuterons
2010
Azimuthal asymmetries in semi-inclusive production of positive (
h
+
) and negative hadrons (
h
−
) have been measured by scattering 160 GeV muons off longitudinally polarised deuterons at CERN. The asymmetries were decomposed in several terms according to their expected modulation in the azimuthal angle
φ
of the outgoing hadron. Each term receives contributions from one or several spin and transverse-momentum-dependent parton distribution and fragmentation functions. The amplitudes of all
φ
-modulation terms of the hadron asymmetries integrated over the kinematic variables are found to be consistent with zero within statistical errors, while the constant terms are nonzero and equal for
h
+
and
h
−
within the statistical errors. The dependencies of the
φ
-modulated terms versus the Bjorken momentum fraction
x
, the hadron fractional momentum
z
, and the hadron transverse momentum
were studied. The
x
dependence of the constant terms for both positive and negative hadrons is in agreement with the longitudinal double-spin hadron asymmetries, measured in semi-inclusive deep-inelastic scattering. The
x
dependence of the sin
φ
-modulation term is less pronounced than that in the corresponding HERMES data. All other dependencies of the
φ
-modulation amplitudes are consistent with zero within the statistical errors.
Journal Article
Study of Σ(1385) and Ξ(1321) hyperon and antihyperon production in deep inelastic muon scattering
by
Crespo, M. L.
,
Mallot, G. K.
,
Sapozhnikov, M. G.
in
Astronomy
,
Astrophysics and Cosmology
,
Elementary Particles
2013
Large samples of
Λ
,
Σ
(1385) and
Ξ
(1321) hyperons produced in the deep-inelastic muon scattering off a
6
LiD target were collected with the COMPASS experimental setup at CERN. The relative yields of
Σ
(1385)
+
,
Σ
(1385)
−
,
,
,
Ξ
(1321)
−
, and
hyperons decaying into
were measured. The ratios of heavy-hyperon to
Λ
and heavy-antihyperon to
were found to be in the range 3.8 % to 5.6 % with a relative uncertainty of about 10 %. They were used to tune the parameters relevant for strange particle production of the LEPTO Monte Carlo generator.
Journal Article