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Rin's story continues in this acclaimed sequel to The poppy war--an epic fantasy combining the history of 20th-century China with a gripping world of gods and monsters. Nikan is on the run from the murderous commands of the fiery Phoenix--the vengeful god who has blessed Rin with her fearsome power. Though she does not want to live, she refuses to die until she avenges the traitorous Empress who betrayed Rin's homeland to its enemies.

Attosecond-scale electron localization The primary event in photoexcitation — involved in processes such as photosynthesis and photoisomerization — is an electronic response that occurs on attosecond (1 as = 10 −18 s) timescales, a realm recently made accessible to spectroscopic investigation by the development of attosecond-scale light pulses. Sansone et al . report an experimental study in which electron localization in molecules is measured on attosecond timescales using pump–probe spectroscopy. H 2 and D 2 are dissociatively ionized by the sequence of an isolated attosecond ultraviolet pulse and an intense few-cycle infrared pulse, and a localization of the electronic charge distribution within the molecule is measured that depends on the delay between the pump and probe pulses. This work demonstrates that combined experimental and computational efforts enable the use of attosecond pulses for the exploration of electron localization. Attosecond (10 −18 s) laser pulses make it possible to peer into the inner workings of atoms and molecules on the electronic timescale — phenomena in solids have already been investigated in this way. Here, an attosecond pump–probe experiment is reported that investigates the ionization and dissociation of hydrogen molecules, illustrating that attosecond techniques can also help explore the prompt charge redistribution and charge localization that accompany photoexcitation processes in molecular systems. For the past several decades, we have been able to directly probe the motion of atoms that is associated with chemical transformations and which occurs on the femtosecond (10 −15 -s) timescale. However, studying the inner workings of atoms and molecules on the electronic timescale 1 , 2 , 3 , 4 has become possible only with the recent development of isolated attosecond (10 −18 -s) laser pulses 5 . Such pulses have been used to investigate atomic photoexcitation and photoionization 6 , 7 and electron dynamics in solids 8 , and in molecules could help explore the prompt charge redistribution and localization that accompany photoexcitation processes. In recent work, the dissociative ionization of H 2 and D 2 was monitored on femtosecond timescales 9 and controlled using few-cycle near-infrared laser pulses 10 . Here we report a molecular attosecond pump–probe experiment based on that work: H 2 and D 2 are dissociatively ionized by a sequence comprising an isolated attosecond ultraviolet pulse and an intense few-cycle infrared pulse, and a localization of the electronic charge distribution within the molecule is measured that depends—with attosecond time resolution—on the delay between the pump and probe pulses. The localization occurs by means of two mechanisms, where the infrared laser influences the photoionization or the dissociation of the molecular ion. In the first case, charge localization arises from quantum mechanical interference involving autoionizing states and the laser-altered wavefunction of the departing electron. In the second case, charge localization arises owing to laser-driven population transfer between different electronic states of the molecular ion. These results establish attosecond pump–probe strategies as a powerful tool for investigating the complex molecular dynamics that result from the coupling between electronic and nuclear motions beyond the usual Born–Oppenheimer approximation.

\"In Church and Society in Hungary and in the Hungarian Diaspora, Nâandor Dreisziger tells the story of Christianity in Hungary and the Hungarian diaspora from its earliest years until the present. Beginning with the arrival of Christianity in the middle Danube basin, Dreisziger follows the fortunes of the Hungarians' churches through the troubled times of the Middle Ages, the years of Ottoman and Habsburg domination, and the turmoil of the twentieth century: wars, revolutions, foreign occupations, and totalitarian rule. Complementing this detailed history of religious life in Hungary, Dreisziger describes the fate of the churches of Hungarian minorities in countries that received territories from the old Kingdom of Hungary after the First World War. He also tells the story of the rise, halcyon days, and decline of organized religious life among Hungarian immigrants to Western Europe, the Americas, and elsewhere.\"-- Provided by publisher.

The epithelial-mesenchymal transition (EMT) is crucial to cancer progression and metastasis. Although multiple cellular miRNAs have been identified to regulate the EMT and metastasis in cancers, the role of viral miRNAs in cancer progression remains largely unknown. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy typically characterized by its early metastasis. In the present study, we have discovered the involvement of a viral miRNA, EBV-miR-BART7-3p, in the EMT and metastasis of NPC cells. Initially, we observed that EBV-miR-BART7-3p was highly expressed in NPC and positively correlated with lymph node metastasis and clinical stage of NPC. Subsequently, we demonstrated that EBV-miR-BART7-3p enhanced cell migration/invasion in vitro , cancer metastasis in vivo , and particularly the EMT characterized by loss of epithelial markers and gain of mesenchymal features in NPC cells. Furthermore, mechanistic studies disclosed that EBV-miR-BART7-3p targeted a major human tumor suppressor PTEN, modulating PI3K/Akt/GSK-3β signaling and eventually leading to the high expression and nuclear accumulation of Snail and β-catenin, which favor EMT. Knockdown of PTEN could phenocopy the effect of EBV-miR-BART7-3p, whereas re-expression of PTEN resulted in a phenotypic reversion. Moreover, these findings were supported by an observation of an EBV-positive cell model in which silencing of endogenous EBV-miR-BART7-3p partially attenuated cell migration/invasion and altered EMT protein expression pattern via reverting PI3K/Akt, Snail and β-catenin expression. Thus, this study suggests a novel mechanism by which EBV-miR-BART7-3p modulates the EMT and metastasis of NPC cells, and a clinical implication of EBV-miR-BART7-3p as a potential biomarker or therapeutic target.

Patients 70 years of age or younger with previously untreated CLL were randomly assigned to receive ibrutinib plus rituximab or chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab. The ibrutinib-based regimen led to prolonged progression-free and overall survival.

\"What's the harm in a pseudonym? Bestselling sensation Juniper Song is not who she says she is, she didn't write the book she claims she wrote, and she is most certainly not Asian American--in this chilling and hilariously cutting novel from the #1 New York Times bestselling author R. F. Kuang in the vein of White Ivy and The Other Black Girl. Authors June Hayward and Athena Liu were supposed to be twin rising stars: same year at Yale, same debut year in publishing. But Athena's a cross-genre literary darling, and June didn't even get a paperback release. Nobody wants stories about basic white girls, June thinks. So when June witnesses Athena's death in a freak accident, she acts on impulse: she steals Athena's just-finished masterpiece, an experimental novel about the unsung contributions of Chinese laborers to the British and French war efforts during World War I. So what if June edits Athena's novel and sends it to her agent as her own work? So what if she lets her new publisher rebrand her as Juniper Song--complete with an ambiguously ethnic author photo? Doesn't this piece of history deserve to be told, whoever the teller? That's what June claims, and the New York Times bestseller list seems to agree. But June can't get away from Athena's shadow, and emerging evidence threatens to bring June's (stolen) success down around her. As June races to protect her secret, she discovers exactly how far she will go to keep what she thinks she deserves. With its totally immersive first-person voice, Yellowface takes on questions of diversity, racism, and cultural appropriation not only in the publishing industry but the persistent erasure of Asian-American voices and history by Western white society. R. F. Kuang's novel is timely, razor-sharp, and eminently readable.\"-- Provided by publisher.

It is recommended that children aged 3 months to five years of age living in areas of seasonal transmission in the sub-Sahel should receive Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) during the malaria transmission season. The purpose of this study was to evaluate the safety of SMC with SPAQ in children when delivered by community health workers in three districts in Senegal where SMC was introduced over three years, in children from 3 months of age to five years of age in the first year, then in children up to 10 years of age. A surveillance system was established to record all deaths and all malaria cases diagnosed at health facilities and a pharmacovigilance system was established to detect adverse drug reactions. Health posts were randomized to introduce SMC in a stepped wedge design. SMC with SPAQ was administered once per month from September to November, by nine health-posts in 2008, by 27 in 2009 and by 45 in 2010. After three years, 780,000 documented courses of SMC had been administered. High coverage was achieved. No serious adverse events attributable to the intervention were detected, despite a high level of surveillance. SMC is being implemented in countries of the sub-Sahel for children under 5 years of age, but in some areas the age distribution of cases of malaria may justify extending this age limit, as has been done in Senegal. Our results show that SMC is well tolerated in children under five and in older children. However, pharmacovigilance should be maintained where SMC is implemented and provision for strengthening national pharmacovigilance systems should be included in plans for SMC implementation. ClinicalTrials.gov NCT 00712374.

Today's readers of science fiction and fantasy have an appetite for stories that address a wide variety of voices, perspectives, and styles. There is an openness to experiment and pushing boundaries, combined with the classic desire to read about spaceships and dragons, future technology and ancient magic, and the places where they intersect. Contemporary science fiction and fantasy looks to accomplish the same goal as ever - to illuminate what it means to be human.

We introduce and study the notions of hyperbolically embedded and very rotating families of subgroups. The former notion can be thought of as a generalization of the peripheral structure of a relatively hyperbolic group, while the latter one provides a natural framework for developing a geometric version of small cancellation theory. Examples of such families naturally occur in groups acting on hyperbolic spaces including hyperbolic and relatively hyperbolic groups, mapping class groups,