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Plant physiological status is the interaction between the plant genome and the prevailing growth conditions. Accurate characterization of plant physiology is, therefore, fundamental to effective plant phenotyping studies; particularly those focused on identifying traits associated with improved yield, lower input requirements, and climate resilience. Here, we outline the approaches used to assess plant physiology and how these techniques of direct empirical observations of processes such as photosynthetic CO2 assimilation, stomatal conductance, photosystem II electron transport, or the effectiveness of protective energy dissipation mechanisms are unsuited to high-throughput phenotyping applications. Novel optical sensors, remote/proximal sensing (multi- and hyperspectral reflectance, infrared thermography, sun-induced fluorescence), LiDAR, and automated analyses of below-ground development offer the possibility to infer plant physiological status and growth. However, there are limitations to such ‘indirect’ approaches to gauging plant physiology. These methodologies that are appropriate for the rapid high temporal screening of a number of crop varieties over a wide spatial scale do still require ‘calibration’ or ‘validation’ with direct empirical measurement of plant physiological status. The use of deep-learning and artificial intelligence approaches may enable the effective synthesis of large multivariate datasets to more accurately quantify physiological characters rapidly in high numbers of replicate plants. Advances in automated data collection and subsequent data processing represent an opportunity for plant phenotyping efforts to fully integrate fundamental physiological data into vital efforts to ensure food and agro-economic sustainability.

This paper deals with sliding games, which are a variant of the better known pushpush game. On a given structure (grid, torus...), a robot can move in a specific set of directions, and stops when it hits a block or boundary of the structure. The objective is to place the minimum number of blocks such that the robot can visit all the possible positions of the structure. In particular, we give the exact value of this number when playing on a rectangular grid and a torus. Other variants of this game are also considered, by constraining the robot to stop on each case, or by replacing blocks by walls.

This paper deals with sliding games, which are a variant of the better known pushpush game. On a given structure (grid, torus...), a robot can move in a specific set of directions, and stops when it hits a block or boundary of the structure. The objective is to place the minimum number of blocks such that the robot can visit all the possible positions of the structure. In particular, we give the exact value of this number when playing on a rectangular grid and a torus. Other variants of this game are also considered, by constraining the robot to stop on each case, or by replacing blocks by walls.

Background It remains elusive how the characteristics, the course of disease, the clinical management and the outcomes of critically ill COVID-19 patients admitted to intensive care units (ICU) worldwide have changed over the course of the pandemic. Methods Prospective, observational registry constituted by 90 ICUs across 22 countries worldwide including patients with a laboratory-confirmed, critical presentation of COVID-19 requiring advanced organ support. Hierarchical, generalized linear mixed-effect models accounting for hospital and country variability were employed to analyse the continuous evolution of the studied variables over the pandemic. Results Four thousand forty-one patients were included from March 2020 to September 2021. Over this period, the age of the admitted patients (62 [95% CI 60–63] years vs 64 [62–66] years, p  < 0.001) and the severity of organ dysfunction at ICU admission decreased (Sequential Organ Failure Assessment 8.2 [7.6–9.0] vs 5.8 [5.3–6.4], p  < 0.001) and increased, while more female patients (26 [23–29]% vs 41 [35–48]%, p  < 0.001) were admitted. The time span between symptom onset and hospitalization as well as ICU admission became longer later in the pandemic (6.7 [6.2–7.2| days vs 9.7 [8.9–10.5] days, p  < 0.001). The PaO 2 /FiO 2 at admission was lower (132 [123–141] mmHg vs 101 [91–113] mmHg, p  < 0.001) but showed faster improvements over the initial 5 days of ICU stay in late 2021 compared to early 2020 (34 [20–48] mmHg vs 70 [41–100] mmHg, p  = 0.05). The number of patients treated with steroids and tocilizumab increased, while the use of therapeutic anticoagulation presented an inverse U-shaped behaviour over the course of the pandemic. The proportion of patients treated with high-flow oxygen (5 [4–7]% vs 20 [14–29], p  < 0.001) and non-invasive mechanical ventilation (14 [11–18]% vs 24 [17–33]%, p  < 0.001) throughout the pandemic increased concomitant to a decrease in invasive mechanical ventilation (82 [76–86]% vs 74 [64–82]%, p  < 0.001). The ICU mortality (23 [19–26]% vs 17 [12–25]%, p  < 0.001) and length of stay (14 [13–16] days vs 11 [10–13] days, p  < 0.001) decreased over 19 months of the pandemic. Conclusion Characteristics and disease course of critically ill COVID-19 patients have continuously evolved, concomitant to the clinical management, throughout the pandemic leading to a younger, less severely ill ICU population with distinctly different clinical, pulmonary and inflammatory presentations than at the onset of the pandemic.

Pathogenic SOX11 variants have been associated with intellectual developmental disorder with microcephaly, and with or without ocular malformations or hypogonadotropic hypogonadism (HH) (IDDMOH, OMIM # 615866). In this article, we report seven new patients with de novo SOX11 variants. Five of the variants are missense, one nonsense, and one whole-gene deletion, most of them are novel variants. The main clinical features included neurodevelopmental delay (7/7) and intellectual disability (5/7), autism/attention deficit hyperactivity disorder (5/7), microcephaly (4/7), short stature (4/7), hypotonia (4/7), and clinodactyly of the 5th fingers (5/7). HH was confirmed in two female patients with primary amenorrhea, nonvisualized/prepubertal size of the uterus, and nonvisualized ovaries. Two of the male patients presented with micropenis, two had cryptorchidism, and one had decreased testicular size, which are suggestive findings of HH. This article contributes to the clinical characterization of patients with SOX11 variants and supports the role of this gene in HH.

Introduction A textbook outcome patient is one in which the operative course passes uneventful, without complications, readmission or mortality. There is a lack of publications in terms of TO on acute cholecystitis. Objetive The objective of this study is to analyze the achievement of TO in patients with urgent early cholecystectomy (UEC) for Acute Cholecystitis. and to identify which factors are related to achieving TO. Materials and methods This is a post hoc study of the SPRiMACC study. It´s a prospective multicenter observational study run by WSES. The criteria to define TO in urgent early cholecystectomy (TOUEC) were no 30-day mortality, no 30-day postoperative complications, no readmission within 30 days, and hospital stay ≤ 7 days (75th percentile), and full laparoscopic surgery. Patients who met all these conditions were taken as presenting a TOUEC. Outcomes 1246 urgent early cholecystectomies for ACC were included. In all, 789 patients (63.3%) achieved all TOUEC parameters, while 457 (36.6%) failed to achieve one or more parameters and were considered non-TOUEC. The patients who achieved TOUEC were younger had significantly lower scores on all the risk scales analyzed. In the serological tests, TOUEC patients had lower values for in a lot of variables than non-TOUEC patients. The TOUEC group had lower rates of complicated cholecystitis. Considering operative time, a shorter duration was also associated with a higher probability of reaching TOUEC. Conclusion Knowledge of the factors that influence the TOUEC can allow us to improve our results in terms of textbook outcome.

We consider the Dirac equation, written in polar formalism, in presence of general Coulomb-like potentials, that is potentials arising from the time component of the vector potential and depending only on the radial coordinate, in order to study the conditions of integrability, given as some specific form for the solution: we find that the angular dependence can always be integrated, while the radial dependence is reduced to finding the solution of a Riccati equation so that it is always possible at least in principle. We exhibit the known case of the Coulomb potential and one special generalization as examples to show the versatility of the method.

The Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) is designed to investigate fault mechanics and seismogenesis along a subduction megathrust, with objectives that include characterizing fault slip, strain accumulation, fault and wall rock composition, fault architecture, and state variables throughout an active plate boundary system. Integrated Ocean Drilling Program (IODP) Expedition 338 was planned to extend and case riser Hole C0002F from 856 to 3600 meters below the seafloor (m b.s.f.). Riser operations extended the hole to 2005.5 m b.s.f., collecting logging-while-drilling (LWD) and measurement-while-drilling, mud gas, and cuttings data. Results reveal two lithologic units within the inner wedge of the accretionary prism that are separated by a prominent fault zone at ~ 1640 m b.s.f. Due to damage to the riser during unfavorable winds and strong currents, riser operations were suspended, and Hole C0002F left for re-entry during future riser drilling operations. Contingency riserless operations included coring at the forearc basin site (C0002) and at two slope basin sites (C0021 and C0022), and LWD at one input site (C0012) and at three slope basin sites (C0018, C0021 and C0022). Cores and logs from these sites comprehensively characterize the alteration stage of the oceanic basement input to the subduction zone, the early stage of Kumano Basin evolution, gas hydrates in the forearc basin, and recent activity of the shallow megasplay fault zone system and associated submarine landslides.

Inclusive differential cross sections $d\\sigma_{pA}/dx_F$ and $d\\sigma_{pA}/dp_t^2$ for the production of \\kzeros, \\lambdazero, and \\antilambda particles are measured at HERA in proton-induced reactions on C, Al, Ti, and W targets. The incident beam energy is 920 GeV, corresponding to $\\sqrt {s} = 41.6$ GeV in the proton-nucleon system. The ratios of differential cross sections \\rklpa and \\rllpa are measured to be $6.2\\pm 0.5$ and $0.66\\pm 0.07$, respectively, for \\xf $\\approx-0.06$. No significant dependence upon the target material is observed. Within errors, the slopes of the transverse momentum distributions $d\\sigma_{pA}/dp_t^2$ also show no significant dependence upon the target material. The dependence of the extrapolated total cross sections $\\sigma_{pA}$ on the atomic mass $A$ of the target material is discussed, and the deduced cross sections per nucleon $\\sigma_{pN}$ are compared with results obtained at other energies.