Explore the vast range of titles available.

Oculometric measures have been proven to be useful markers of mind-wandering during visual tasks such as reading. However, little is known about ocular activity during mindfulness meditation, a mental practice naturally involving mind-wandering episodes. In order to explore this issue, we extracted closed-eyes ocular movement measurements via a covert technique (EEG recordings) from expert meditators during two repetitions of a 7-minute mindfulness meditation session, focusing on the breath, and two repetitions of a 7-minute instructed mind-wandering task. Power spectral density was estimated on both the vertical and horizontal components of eye movements. The results show a significantly smaller average amplitude of eye movements in the delta band (1-4 Hz) during mindfulness meditation than instructed mind-wandering. Moreover, participants' meditation expertise correlated significantly with this average amplitude during both tasks, with more experienced meditators generally moving their eyes less than less experienced meditators. These findings suggest the potential use of this measure to detect mind-wandering episodes during mindfulness meditation and to assess meditation performance.

We investigated changes in self-representation depending on language in Friulian–Italian bilinguals. The Temperament and Character Inventory (TCI) and the Junior-TCI were administered respectively to 24 adults and 25 children, both in Friulian and in Italian, at a distance of two weeks from each other. Variations in TCI were detected: both adults and children scored higher in Self-Directedness (a character trait) when using Italian than Friulian. Similar findings were observed for Novelty-Seeking (a temperament trait) in children and Cooperativeness (another character trait) in adults. Results are discussed considering previous studies on bilingualism and within the frame of the Friulian sociolinguistic context.

The aim of the present review is to investigate previous studies concerning the effects of meditation and dispositional mindfulness on conscious and implicit or non-conscious attitudes. First we present a brief perspective on conscious and non-conscious states of mind. Then we introduce the fundamental bases of mindfulness meditation. Third we review studies on dispositional mindfulness and meditation that employed either direct or indirect measures to assess explicit and implicit attitudes. Finally, we briefly present how meditation has been associated with the psychotherapeutic practice of psychoanalysis and, hence, as a therapeutic technique to access the unconscious. Until now, few studies have investigated the impact of meditation on non-conscious states of mind and personality; nevertheless, both scientific studies involving implicit measures and reflections from psychotherapy have underlined the importance of meditation in promoting psychological well-being, leading to de-automatization of automatic patterns of responding and to higher levels of self-awareness.

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized at the molecular level by the expression of Bcr-abl, a 210-kDa fusion protein with deregulated tyrosine kinase activity. Encouraged by the clinical validation of Bcr-abl as the target for the treatment of CML by imatinib, we sought to identify pharmacological agents that could target this kinase by a distinct mechanism. We report the discovery of a new class of Bcr-abl inhibitors using an unbiased differential cytotoxicity screen of a combinatorial kinase-directed heterocycle library. Compounds in this class (exemplified by GNF-2) show exclusive antiproliferative activity toward Bcr-abl–transformed cells, with potencies similar to imatinib, while showing no inhibition of the kinase activity of full-length or catalytic domain of c-abl. We propose that this new class of compounds inhibits Bcr-abl kinase activity through an allosteric non-ATP competitive mechanism.