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Following the explosive growth in chemical and biological data, the shift from traditional methods of drug discovery to computer-aided means has made data mining and machine learning methods integral parts of today’s drug discovery process. In this paper, extreme gradient boosting (Xgboost), which is an ensemble of Classification and Regression Tree (CART) and a variant of the Gradient Boosting Machine, was investigated for the prediction of biological activity based on quantitative description of the compound’s molecular structure. Seven datasets, well known in the literature were used in this paper and experimental results show that Xgboost can outperform machine learning algorithms like Random Forest (RF), Support Vector Machines (LSVM), Radial Basis Function Neural Network (RBFN) and Naïve Bayes (NB) for the prediction of biological activities. In addition to its ability to detect minority activity classes in highly imbalanced datasets, it showed remarkable performance on both high and low diversity datasets.

AimsSeminal vesicle invasion (SVI) in prostatic adenocarcinoma (PCa) is a high-risk feature associated with lymph node (LN) metastasis and adverse outcomes. However, the impact of SVI laterality on LN metastasis patterns, nodal burden, metastatic focus size and extranodal extension (ENE) remains underexplored.MethodsWe retrospectively analysed 225 PCa patients with SVI who underwent radical prostatectomy with LN dissection. Associations between SVI laterality, tumour grade, volume and nodal parameters were assessed using univariable and multivariable models.ResultsLN metastases were identified in 97 of 225 (43.1%) patients. Bilateral SVI was significantly associated with higher odds of LN metastasis (OR=2.01; p=0.040), nodal burden (IRR=1.89; p=0.004) and ENE (OR=3.76; p=0.013), independent of tumour volume, grade, age and race. Tumour volume and grade independently predicted LN metastasis (p=0.004 and p=0.048, respectively) and were associated with metastatic focus size (p=0.003 and p<0.001, respectively) and nodal burden (p=0.061 and p=0.045, respectively). LN spread mirrored SVI extent: unilateral SVI primarily led to ipsilateral involvement (22/36; 61.1%; p<0.001), while bilateral SVI increased the risk of bilateral spread (OR=3.81; p=0.003). White patients had significantly higher LN metastasis rates than black patients (p=0.010).ConclusionsBilateral SVI is a strong, independent predictor of LN metastasis, nodal burden and ENE. SVI laterality also correlates with LN spread patterns and could inform future risk stratification, though further validation is needed.

Emotions are an essential part of daily human communication. The emotional states and dynamics of the brain can be linked by electroencephalography (EEG) signals that can be used by the Brain–Computer Interface (BCI), to provide better human–machine interactions. Several studies have been conducted in the field of emotion recognition. However, one of the most important issues facing the emotion recognition process, using EEG signals, is the accuracy of recognition. This paper proposes a deep learning-based approach for emotion recognition through EEG signals, which includes data selection, feature extraction, feature selection and classification phases. This research serves the medical field, as the emotion recognition model helps diagnose psychological and behavioral disorders. The research contributes to improving the performance of the emotion recognition model to obtain more accurate results, which, in turn, aids in making the correct medical decisions. A standard pre-processed Database of Emotion Analysis using Physiological signaling (DEAP) was used in this work. The statistical features, wavelet features, and Hurst exponent were extracted from the dataset. The feature selection task was implemented through the Binary Gray Wolf Optimizer. At the classification stage, the stacked bi-directional Long Short-Term Memory (Bi-LSTM) Model was used to recognize human emotions. In this paper, emotions are classified into three main classes: arousal, valence and liking. The proposed approach achieved high accuracy compared to the methods used in past studies, with an average accuracy of 99.45%, 96.87% and 99.68% of valence, arousal, and liking, respectively, which is considered a high performance for the emotion recognition model.

Web applications have become ubiquitous for many business sectors due to their platform independence and low operation cost. Billions of users are visiting these applications to accomplish their daily tasks. However, many of these applications are either vulnerable to web defacement attacks or created and managed by hackers such as fraudulent and phishing websites. Detecting malicious websites is essential to prevent the spreading of malware and protect end-users from being victims. However, most existing solutions rely on extracting features from the website’s content which can be harmful to the detection machines themselves and subject to obfuscations. Detecting malicious Uniform Resource Locators (URLs) is safer and more efficient than content analysis. However, the detection of malicious URLs is still not well addressed due to insufficient features and inaccurate classification. This study aims at improving the detection accuracy of malicious URL detection by designing and developing a cyber threat intelligence-based malicious URL detection model using two-stage ensemble learning. The cyber threat intelligence-based features are extracted from web searches to improve detection accuracy. Cybersecurity analysts and users reports around the globe can provide important information regarding malicious websites. Therefore, cyber threat intelligence-based (CTI) features extracted from Google searches and Whois websites are used to improve detection performance. The study also proposed a two-stage ensemble learning model that combines the random forest (RF) algorithm for preclassification with multilayer perceptron (MLP) for final decision making. The trained MLP classifier has replaced the majority voting scheme of the three trained random forest classifiers for decision making. The probabilistic output of the weak classifiers of the random forest was aggregated and used as input for the MLP classifier for adequate classification. Results show that the extracted CTI-based features with the two-stage classification outperform other studies’ detection models. The proposed CTI-based detection model achieved a 7.8% accuracy improvement and 6.7% reduction in false-positive rates compared with the traditional URL-based model.

Cardiovascular diseases present a significant global health challenge that emphasizes the critical need for developing accurate and more effective detection methods. Several studies have contributed valuable insights in this field, but it is still necessary to advance the predictive models and address the gaps in the existing detection approaches. For instance, some of the previous studies have not considered the challenge of imbalanced datasets, which can lead to biased predictions, especially when the datasets include minority classes. This study’s primary focus is the early detection of heart diseases, particularly myocardial infarction, using machine learning techniques. It tackles the challenge of imbalanced datasets by conducting a comprehensive literature review to identify effective strategies. Seven machine learning and deep learning classifiers, including K-Nearest Neighbors, Support Vector Machine, Logistic Regression, Convolutional Neural Network, Gradient Boost, XGBoost, and Random Forest, were deployed to enhance the accuracy of heart disease predictions. The research explores different classifiers and their performance, providing valuable insights for developing robust prediction models for myocardial infarction. The study’s outcomes emphasize the effectiveness of meticulously fine-tuning an XGBoost model for cardiovascular diseases. This optimization yields remarkable results: 98.50% accuracy, 99.14% precision, 98.29% recall, and a 98.71% F1 score. Such optimization significantly enhances the model’s diagnostic accuracy for heart disease.

The detection of manmade disasters particularly fire is valuable because it causes many damages in terms of human lives. Research on fire detection using wireless sensor network and video-based methods is a very hot research topic. However, the WSN based detection model need fire happens and a lot of smoke and fire for detection. Similarly, video-based models also have some drawbacks because conventional algorithms need feature vectors and high rule-based models for detection. In this paper, we proposed a fire detection method which is based on powerful machine learning and deep learning algorithms. We used both sensors data as well as images data for fire prevention. Our proposed model has three main deep neural networks i.e. a hybrid model which consists of Adaboost and many MLP neural networks, Adaboost-LBP model and finally convolutional neural network. We used Adaboost-MLP model to predict the fire. After the prediction, we proposed two neural networks i.e. Adaboost-LBP model and convolutional neural network for detection of fire using the videos and images taken from the cameras installed for the surveillance. Adaboost-LBP model is to generate the ROIs from the image where emergencies exist Our proposed model results are quite good, and the accuracy is almost 99%. The false alarming rate is very low and can be reduced more using further training.

In the era of interconnected and intelligent cyber-physical systems, preserving privacy has become a paramount concern. This paper aims a groundbreaking proof-of-concept (PoC) design that leverages consortium blockchain technology to address privacy challenges in cyber-physical systems (CPSs). The proposed design introduces a novel approach to safeguarding sensitive information and ensuring data integrity while maintaining a high level of trust among stakeholders. By harnessing the power of consortium blockchain, the design establishes a decentralized and tamper-resistant framework for privacy preservation. However, ensuring the security and privacy of sensitive information within CPSs poses significant challenges. This paper proposes a cutting-edge privacy approach that leverages consortium blockchain technology to secure secrets in CPSs. Consortium blockchain, with its permissioned nature, provides a trusted framework for governing the network and validating transactions. By employing consortium blockchain, secrets in CPSs can be securely stored, shared, and accessed by authorized entities only, mitigating the risks of unauthorized access and data breaches. The proposed approach offers enhanced security, privacy preservation, increased trust and accountability, as well as interoperability and scalability. This paper aims to address the limitations of traditional security mechanisms in CPSs and harness the potential of consortium blockchain to revolutionize the management of secrets, contributing to the advancement of CPS security and privacy. The effectiveness of the design is demonstrated through extensive simulations and performance evaluations. The results indicate that the proposed approach offers significant advancements in privacy protection, paving the way for secure and trustworthy cyber-physical systems in various domains.

Due to the wide availability and usage of connected devices in Internet of Things (IoT) networks, the number of attacks on these networks is continually increasing. A particularly serious and dangerous type of attack in the IoT environment is the botnet attack, where the attackers can control the IoT systems to generate enormous networks of “bot” devices for generating malicious activities. To detect this type of attack, several Intrusion Detection Systems (IDSs) have been proposed for IoT networks based on machine learning and deep learning methods. As the main characteristics of IoT systems include their limited battery power and processor capacity, maximizing the efficiency of intrusion detection systems for IoT networks is still a research challenge. It is important to provide efficient and effective methods that use lower computational time and have high detection rates. This paper proposes an aggregated mutual information-based feature selection approach with machine learning methods to enhance detection of IoT botnet attacks. In this study, the N-BaIoT benchmark dataset was used to detect botnet attack types using real traffic data gathered from nine commercial IoT devices. The dataset includes binary and multi-class classifications. The feature selection method incorporates Mutual Information (MI) technique, Principal Component Analysis (PCA) and ANOVA f-test at finely-granulated detection level to select the relevant features for improving the performance of IoT Botnet classifiers. In the classification step, several ensemble and individual classifiers were used, including Random Forest (RF), XGBoost (XGB), Gaussian Naïve Bayes (GNB), k-Nearest Neighbor (k-NN), Logistic Regression (LR) and Support Vector Machine (SVM). The experimental results showed the efficiency and effectiveness of the proposed approach, which outperformed other techniques using various evaluation metrics.

The Internet of Things (IoT) concept has emerged to improve people’s lives by providing a wide range of smart and connected devices and applications in several domains, such as green IoT-based agriculture, smart farming, smart homes, smart transportation, smart health, smart grid, smart cities, and smart environment. However, IoT devices are at risk of cyber attacks. The use of deep learning techniques has been adequately adopted by researchers as a solution in securing the IoT environment. Deep learning has also successfully been implemented in various fields, proving its superiority in tackling intrusion detection attacks. Due to the limitation of signature-based detection for unknown attacks, the anomaly-based Intrusion Detection System (IDS) gains advantages to detect zero-day attacks. In this paper, a systematic literature review (SLR) is presented to analyze the existing published literature regarding anomaly-based intrusion detection, using deep learning techniques in securing IoT environments. Data from the published studies were retrieved from five databases (IEEE Xplore, Scopus, Web of Science, Science Direct, and MDPI). Out of 2116 identified records, 26 relevant studies were selected to answer the research questions. This review has explored seven deep learning techniques practiced in IoT security, and the results showed their effectiveness in dealing with security challenges in the IoT ecosystem. It is also found that supervised deep learning techniques offer better performance, compared to unsupervised and semi-supervised learning. This analysis provides an insight into how the use of data types and learning methods will affect the performance of deep learning techniques for further contribution to enhancing a novel model for anomaly intrusion detection and prediction.

Precision medicine has emerged as a transformative approach to healthcare, aiming to deliver personalized treatments and therapies tailored to individual patients. However, the realization of precision medicine relies heavily on the availability of comprehensive and diverse medical data. In this context, blockchain-enabled federated learning, coupled with electronic medical records (EMRs), presents a groundbreaking solution to unlock revolutionary insights in precision medicine. This abstract explores the potential of blockchain technology to empower precision medicine by enabling secure and decentralized data sharing and analysis. By leveraging blockchain’s immutability, transparency, and cryptographic protocols, federated learning can be conducted on distributed EMR datasets without compromising patient privacy. The integration of blockchain technology ensures data integrity, traceability, and consent management, thereby addressing critical concerns associated with data privacy and security. Through the federated learning paradigm, healthcare institutions and research organizations can collaboratively train machine learning models on locally stored EMR data, without the need for data centralization. The blockchain acts as a decentralized ledger, securely recording the training process and aggregating model updates while preserving data privacy at its source. This approach allows the discovery of patterns, correlations, and novel insights across a wide range of medical conditions and patient populations. By unlocking revolutionary insights through blockchain-enabled federated learning and EMRs, precision medicine can revolutionize healthcare delivery. This paradigm shift has the potential to improve diagnosis accuracy, optimize treatment plans, identify subpopulations for clinical trials, and expedite the development of novel therapies. Furthermore, the transparent and auditable nature of blockchain technology enhances trust among stakeholders, enabling greater collaboration, data sharing, and collective intelligence in the pursuit of advancing precision medicine. In conclusion, this abstract highlights the transformative potential of blockchain-enabled federated learning in empowering precision medicine. By unlocking revolutionary insights from diverse and distributed EMR datasets, this approach paves the way for a future where healthcare is personalized, efficient, and tailored to the unique needs of each patient.