Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
2,671
result(s) for
"Fang, Di"
Sort by:
روح مطمئنة
بين الضحك، والبكاء، والبكاء الضاحك تدور حياة الإنسان، ومن هنا تبدأ سطور رواية «روح مطمئنة» تنقل لنا هذا المزج الذي يصنع التجربة والحكمة. تصور هذه الرواية مأساة أن يكون لديك قلب يحمل دفء الأسرة والعائلة، ويصاب ذلك القلب بألم الفقد الذي يجعل من التعامل معه وتخطيه أمرا حتميا لكي تستمر الحياة. الرواية للأديب الصيني : تشو دا شين، وترجمتها عن الصينية : د. شيماء كمال ود. رشا كمال.
BOOK
Photodegradation of carbon dots cause cytotoxicity
Carbon dots (CDs) are photoluminescent nanomaterials with wide-ranging applications. Despite their photoactivity, it remains unknown whether CDs degrade under illumination and whether such photodegradation poses any cytotoxic effects. Here, we show laboratory-synthesized CDs irradiated with light degrade into molecules that are toxic to both normal (HEK-293) and cancerous (HeLa and HepG2) human cells. Eight days of irradiation photolyzes 28.6-59.8% of the CDs to <3 kilo Dalton molecules, 1431 of which are detected by high-throughput, non-target high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. Molecular network and community analysis further reveal 499 cytotoxicity-related molecules, 212 of which contain polyethylene glycol, glucose, or benzene-related structures. Photo-induced production of hydroxyl and alkyl radicals play important roles in CD degradation as affected by temperature, pH, light intensity and wavelength. Commercial CDs show similar photodegraded products and cytotoxicity profiles, demonstrating that photodegradation-induced cytotoxicity is likely common to CDs regardless of their chemical composition. Our results highlight the importance of light in cytocompatibility studies of CDs.
Carbon dots have attracted much attention for biomedical applications but potential degradation and associated toxicity are still poorly understood. Here, the authors report on a study into the photo-degradation of carbon dots, the products produced and associated cytotoxicity.
Journal Article
The association between food insecurity and mental health during the COVID-19 pandemic
Objective
To explore the association between food insecurity and mental health outcomes among low-income Americans during the COVID-19 pandemic.
Methods
We conducted a survey of 2714 low-income respondents nationwide from June 29, 2020 to July 21, 2020. A proportional odds logit model was employed to estimate the associations between food insecurity and anxiety and between food insecurity and depression.
Results
Food insecurity is associated with a 257% higher risk of anxiety and a 253% higher risk of depression. Losing a job during the pandemic is associated with a 32% increase in risk for anxiety and a 27% increase in risk for depression.
Conclusions
Food insecurity caused by the pandemic was associated with increased risk of mental illness. The relative risk of mental illness from being food insecure is almost three-fold that of losing a job during the pandemic. Public health measures should focus on getting direct subsidies of food purchases to poor families, especially families with children. They should also reduce the stigma and shame that is associated with accepting charitable foods.
Journal Article
Relationship Between Body Mass Index and Low Skeletal Muscle Mass in Adults Based on NHANES 2011–2018
Sarcopenia, a syndrome characterized by declining muscle mass and function, is associated with various adverse health outcomes. While body mass index (BMI) is a fundamental health indicator, its relationship with sarcopenia is complex and remains inadequately explored. Low BMI has been linked to muscle loss, but the role of other demographic and clinical factors in this relationship is unclear. This cross-sectional study analyzed data from the NHANES 2011–2018 cohort, including 7,455 adults aged ≥ 20 years. Low muscle mass was diagnosed based on appendicular skeletal muscle mass using DXA criteria. BMI was categorized into quartiles for analysis. Weighted multivariable logistic regression assessed associations between BMI and low muscle mass, adjusting for confounders such as age, gender, ethnicity, income-to-poverty ratio, and chronic diseases (e.g., diabetes and hypertension). Variance inflation factors (VIF) confirmed the absence of multicollinearity. Lower BMI was significantly associated with higher odds of low muscle mass (adjusted OR: 0.508, 95% CI: 0.483–0.533, p < 0.001), while higher BMI exhibited a protective effect. Age (OR: 1.035, 95% CI: 1.025–1.045, p < 0.001) and female gender (OR: 1.570, 95% CI: 1.267–1.949, p < 0.001) were independent risk factors. Racial disparities were noted, with non-Hispanic Black individuals at lower risk compared to non-Hispanic Whites (OR: 0.242, 95% CI: 0.152–0.384, p < 0.001). Other significant factors included diabetes and alcohol consumption, while education and smoking status were not significantly associated. BMI is inversely associated with low muscle mass prevalence, with lower BMI posing a higher odds. The findings underscore the clinical importance of monitoring BMI and addressing multifactorial risk profiles for low muscle mass management and prevention.
Journal Article
Simulation and analysis of firing accuracy of remote control weapon station
Muzzle disturbance and fire control system error are the main factors affecting the firing accuracy of remote control weapon stations. In order to study the influence of muzzle disturbance on firing accuracy, this paper establishes a rigid-flexible coupling dynamic virtual prototype model of a remote control weapon station based on finite element theory. On this basis, the firing accuracy of the weapon station under the effect of muzzle disturbance is simulated and analyzed, the fire control system error is calculated, and then the firing accuracy of the weapon system is obtained. Further on, compared with the firing accuracy test, the rationality of the system structure design and the accuracy of the fire control system design are verified.
Journal Article
Efficient Quantum Algorithm for Nonlinear Reaction–Diffusion Equations and Energy Estimation
Nonlinear differential equations exhibit rich phenomena in many fields but are notoriously challenging to solve. Recently, Liu et al. (in: Proceedings of the National Academy of Sciences 118(35), 2021) demonstrated the first efficient quantum algorithm for dissipative quadratic differential equations under the condition
R
<
1
, where
R
measures the ratio of nonlinearity to dissipation using the
ℓ
2
norm. Here we develop an efficient quantum algorithm based on Liu et al. (2021) for reaction–diffusion equations, a class of nonlinear partial differential equations (PDEs). To achieve this, we improve upon the Carleman linearization approach introduced in Liu et al. (2021) to obtain a faster convergence rate under the condition
R
D
<
1
, where
R
D
measures the ratio of nonlinearity to dissipation using the
ℓ
∞
norm. Since
R
D
is independent of the number of spatial grid points
n
while
R
increases with
n
, the criterion
R
D
<
1
is significantly milder than
R
<
1
for high-dimensional systems and can stay convergent under grid refinement for approximating PDEs. As applications of our quantum algorithm we consider the Fisher-KPP and Allen-Cahn equations, which have interpretations in classical physics. In particular, we show how to estimate the mean square kinetic energy in the solution by postprocessing the quantum state that encodes it to extract derivative information.
Journal Article
Propagation Phenomena for a Nonlocal Dispersal Lotka–Volterra Competition Model in Shifting Habitats
This paper is concerned with the propagation phenomena for a nonlocal dispersal Lotka–Volterra competition model with shifting habitats. It is assumed that the growth rate of each species is nondecreasing along the
x
-axis, positive near
∞
and nonpositive near
-
∞
, and shifting rightward with a speed
c
>
0
. In the case where both species coexist near
∞
, we established three types of forced waves connecting the origin, respectively to the coexistence state with any forced speed
c
; to itself with forced speed
c
>
c
∗
(
∞
)
; and to a semi-trivial steady state with forced speed
c
>
c
¯
(
∞
)
, where
c
∗
(
∞
)
and
c
¯
(
∞
)
are two positive numbers. In the case where one species is competitively stronger near
∞
, we also obtain the existence and nonexistence of forced waves connecting the origin to the semi-trivial steady state. Our results show the existence of multiple types of forced waves with the same forced speed. The mathematical proofs involve integral equations and Schauder’s fixed point theorem, and heavily rely on the construction of various upper-lower solutions, which adds new techniques to deal with the “shifting environments” problem.
Journal Article
Effects of long-term hydrogen intervention on the physiological function of rats
The potential therapeutic effects of molecular hydrogen (H
2
) have now been confirmed in various human and animal-disease models. However, the effects of H
2
on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW intake and HI remains elusive. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. Among the 13 parameters, the most striking alterations induced by hydrogen treatment were observed in serum myocardial enzymes spectrum. The results also showed that the changes in these parameters occurred at different time points, and the alterations in most of the parameters were much more significant in HI than HRW. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future.
Journal Article
Effect of different origins on genes encoding key enzymes involved in the polysaccharide biosynthetic pathway in Hedysarum polybotrys Hand.-Mazz
Radix Hedysari (HP) is a traditional Chinese medicine that has gained widespread attention for its tonic effects. Environmental factors significantly influence the active components in HP, notably Radix Hedysari polysaccharides (HPS), which are the principal active constituents. To date, no studies have reported on the environmental impact on the accumulation and biosynthesis of HPS. This research aims to evaluate the HPS accumulation and its biosynthetic pathways across different environments. We measured the HPS levels in samples from the core geographic area (geo-authentic product region) in Wudu, Gansu Province (WD), and a non-core geographic area (non-geo-authentic product region) in Tanchang, Gansu Province (TC), and conducted transcriptomic analyses. The HPS content in HP from WD (HP-WD, 12.14 ± 0.17 mg/g) was significantly higher than that in HP from TC (HP-TC, 5.48 ± 0.29 mg/g). Our investigation into the biosynthetic pathways of HPS showed that 21 enzymes, encoded by 198 unigenes, are involved. We identified 50 unigenes encoding 15 enzymes as differentially expressed genes (DEGs), indicating that approximately 71.4% of these enzymes are substantially affected by environmental factors. Heat map analysis of these 50 DEGs clearly differentiates HP-WD from HP-TC. Pearson correlation analysis revealed that the regulatory genes for 11 key enzymes have a significant positive correlation with HPS content ( P < 0.05, r > 0.8). Consequently, the HP-WD is more likely to accumulate polysaccharides than HP-TC, potentially due to the activity of the aforementioned 11 key enzymes. This study provides theoretical support for the enhanced HPS content and quality assessment of HP sourced from the geo-authentic product region.
Journal Article
HGF/c-Met signaling promotes the migration and proliferation of deer antler MSCs
The complete regeneration of deer antlers is based on the proliferation and differentiation of stem cells. Mesenchymal stem cells (MSCs) of antlers have an important role in antler regeneration and rapid growth and development. HGF is mainly synthesized and secreted by mesenchymal cells. After binding to its receptor c-Met, which transduces signals into cells to stimulate cell proliferation and migration in various organs to promote tissue morphogenesis and angiogenesis. However, the role and mechanism of the HGF/c-Met signaling pathway on antler MSCs are still unclear. In this study, we established antler MSCs with overexpression and interference of HGF gene by lentivirus and small interference RNA, observed the effect of HGF/c-Met signal pathway on the proliferation and migration of antler MSCs, and detected the expression of downstream related signal pathway genes, to explore the mechanism of HGF/c-MET signal pathway on the proliferation and migration of antler MSCs. The results showed that the HGF/c-Met signal affects the expression of
RAS
,
ERK
and
MEK
genes, regulates the proliferation of pilose antler MSCs through Ras/Raf, MEK/ERK pathway, affects the expression of
Gab1
,
Grb2
,
AKT
and
PI3K
genes, and regulates the migration of MSCs of pilose antler through Gab1/Grb2 and PI3K/AKT pathway.
Journal Article