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"Fei Wang"
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Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from the brain stem nuclei and ventral roots of the spinal cord, leading to fatal paralysis. Currently, there are no effective therapies for ALS. Increasing evidence indicates that neuroinflammation plays an important role in ALS pathogenesis. The neuroinflammation in ALS is characterized by infiltration of lymphocytes and macrophages, activation of microglia and reactive astrocytes, as well as the involvement of complement. In this review, we focus on the key cellular players of neuroinflammation during the pathogenesis of ALS by discussing not only their detrimental roles but also their immunomodulatory actions. We will summarize the pharmacological therapies for ALS that target neuroinflammation, as well as recent advances in the field of stem cell therapy aimed at modulating the inflammatory environment to preserve the remaining MNs in ALS patients and animal models of the disease.
Journal Article
The China order : Centralia, world empire, and the nature of Chinese power
\"Examines the rising power of China and Chinese foreign policy through a revisionist analysis of Chinese civilization. What does the rise of China represent, and how should the international community respond? With a holistic rereading of Chinese longue durâee history, Fei-Ling Wang provides a simple but powerful framework for understanding the nature of persistent and rising Chinese power and its implications for the current global order. He argues that the Chinese ideation and tradition of political governance and world order--the China Order--is based on an imperial state of Confucian-Legalism as historically exemplified by the Qin-Han polity. Claiming a Mandate of Heaven to unify and govern the whole known world or tianxia (all under heaven), the China Order dominated Eastern Eurasia as a world empire for more than two millennia, until the late nineteenth century. Since 1949, the People's Republic of China has been a reincarnated Qin-Han polity without the traditional China Order, finding itself stuck in the endless struggle against the current world order and the ever-changing Chinese society for its regime survival and security. Wang also offers new discoveries and assessments about the true golden eras of Chinese civilization, explains the great East-West divergence between China and Europe, and analyzes the China Dream that drives much of current Chinese foreign policy\"--Publisher description.
Book
Second-order spectral lineshapes from charged interfaces
Second-order nonlinear spectroscopy has proven to be a powerful tool in elucidating key chemical and structural characteristics at a variety of interfaces. However, the presence of interfacial potentials may lead to complications regarding the interpretation of second harmonic and vibrational sum frequency generation responses from charged interfaces due to mixing of absorptive and dispersive contributions. Here, we examine by means of mathematical modeling how this interaction influences second-order spectral lineshapes. We discuss our findings in the context of reported nonlinear optical spectra obtained from charged water/air and solid/liquid interfaces and demonstrate the importance of accounting for the interfacial potential-dependent
χ
(3)
term in interpreting lineshapes when seeking molecular information from charged interfaces using second-order spectroscopy.
Charged interfaces are important in chemical systems, but the influence of charge on vibrational sum frequency spectra has only recently been considered. Here the authors show the importance of accounting for the interfacial potential-dependent χ
(3)
term in interpreting spectral lineshapes from charged interfaces.
Journal Article
Parallel population and parallel human : a cyber-physical social approach
\"This book is a result of an ambitious research agenda I made for myself almost 30 years ago after reading Karl Popper's The Open Society and its Enemies. To me, the open society should have no enemies, we must find a way to build the bridge between Popper's utopian social engineering and piecemeal social engineering, perhaps through the Cyber-enabled Social Movement Organizations and Operations (CeSMO), and that would be my research for the rest of my professional career. I had promised myself to write a book entitled The Open Society and its Friends, and even created a new name for my ambition, Bemonad, for Becoming and Being Gottfried Leibniz's Monad, which was redefined as the atom of intelligence for Popper's Artificial World in the sense of ancient Greek philosopher Democritus' atom for matters in the Physical World. Of course, I realized very soon that it is simply a dream and a mission impossible. However, this had dramatically changed my career path from intelligent control for robotic systems to a mixture of science, technology, engineering, and social studies for complex intelligent systems, or an interdisciplinary approach by today's term, starting from my technical report at NASA/UA Space Engineering Research Center (SERC) on Shadow Systems in 1994 and ending up with the creation of the Program for Advanced Research in Complex Systems (PARCS) at the University of Arizona, Tucson, Arizona in 1999.\"-- Provided by publisher.
Book
Mechanisms underlying antidepressant effect of transcutaneous auricular vagus nerve stimulation on CUMS model rats based on hippocampal α7nAchR/NF-κB signal pathway
Background
Stress-induced neuroinflammation was considered to play a critical role in the pathogenesis of depression. Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder. The anti-inflammatory signal of vagus nerve is mediated by α7 nicotinic acetylcholine receptor (α7nAchR), and the hippocampus, the region with the most distribution of α7nAchR, regulates emotions. Here, we investigated the role of α7nAchR mediating hippocampal neuroinflammation in taVNS antidepressant effect though homozygous α7nAChR (−/−) gene knockout and α7nAchR antagonist (methyllycaconitine, MLA).
Methods
There were control, model, taVNS, α7nAChR(−/−) + taVNS, hippocampus (Hi) MLA + taVNS and Hi saline + taVNS groups. We used the chronic unpredicted mild stress (CUMS) method to establish depressive model rats for 42 days, excepting control group. After the successful modeling, except the control and model, the rats in the other groups were given taVNS, which was applied through an electroacupuncture apparatus at the auricular concha (2/15 Hz, 2 mA, 30 min/days) for 21 days. Behavioral tests were conducted at baseline, after modeling and after taVNS intervention, including sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST). These tests are widely used to evaluate depression-like behavior in rats. The samples were taken after experiment, the expressions of α7nAchR, NF-κB p65, IL-1β and the morphology of microglia were detected.
Results
Depression-like behavior and hippocampal neuroinflammation in CUMS model rats were manifested by down-regulated expression of α7nAchR, up-regulated expression of NF-κB p65 and IL-1β, and the morphology of microglia was in amoebic-like activated state. TaVNS could significantly reverse the above-mentioned phenomena, but had rare improvement effect for α7nAChR(−/−) rats and Hi MLA rats.
Conclusion
The antidepressant effect of taVNS is related to hippocampal α7nAchR/NF-κB signal pathway.
Journal Article
Higher-order quantum spin Hall effect in a photonic crystal
The quantum spin Hall effect lays the foundation for the topologically protected manipulation of waves, but is restricted to one-dimensional-lower boundaries of systems and hence limits the diversity and integration of topological photonic devices. Recently, the conventional bulk-boundary correspondence of band topology has been extended to higher-order cases that enable explorations of topological states with codimensions larger than one such as hinge and corner states. Here, we demonstrate a higher-order quantum spin Hall effect in a two-dimensional photonic crystal. Owing to the non-trivial higher-order topology and the pseudospin-pseudospin coupling, we observe a directional localization of photons at corners with opposite pseudospin polarizations through pseudospin-momentum-locked edge waves, resembling the quantum spin Hall effect in a higher-order manner. Our work inspires an unprecedented route to transport and trap spinful waves, supporting potential applications in topological photonic devices such as spinful topological lasers and chiral quantum emitters.
The quantum spin Hall effect is limited to one-dimensional lower boundary states which limits the possibilities for its exploitation in photonic devices. Here, the authors demonstrate a higher-order quantum spin Hall effect in a photonic crystal and observe opposite pseudospin corner states.
Journal Article
Regulating interfacial reaction through electrolyte chemistry enables gradient interphase for low-temperature zinc metal batteries
In situ formation of a stable interphase layer on zinc surface is an effective solution to suppress dendrite growth. However, the fast transport of bivalent Zn-ions within the solid interlayer remains very challenging. Herein, we engineer the SEI components and enable superior kinetics of Zn metal batteries under harsh conditions through regulating the sequence of interfacial chemical reaction. With the differences in chemical reactivity of trimethyl phosphate co-solvent and trifluoromethanesulfonate anions in the Zn
2+
-solvation shell, Zn
3
(PO
4
)
2
and ZnF
2
are successively generated on Zn metal surface to form a gradient ZnF
2
–Zn
3
(PO
4
)
2
interphase. Mechanistic studies reveal the outer ZnF
2
facilitates Zn
2+
desolvation and inner Zn
3
(PO
4
)
2
serves as channels for fast Zn
2+
transport, contributing to long-term cycling at subzero temperatures. Impressively, the gradient SEI enables a high lifespan over 7000 hours in Zn symmetric cell and a capacity retention of 86.1% after 12000 cycles in Zn–KVOH full cell at –50 °C.
Zinc batteries have received intense attentions but suffer from inferior low-temperature performance. Here, the authors constructed a gradient phosphatized interphase in situ on zinc surface to accelerate zinc-ion desolvation and transport, greatly enhancing the cycling performance at subzero temperatures.
Journal Article
Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement
Myeloid cells, such as resident microglia (MG), infiltrating monocytes (Mo), macrophages (MΦ), and CNS border-associated macrophages (BAM) in the brain, participate in aged brain injury. Aged microglial replacement is protective against brain injury in aged mice; however, whether/how the molecular changes in myeloid cells are affected by this replacement in injured brains remains unclear.
Aged microglia in mice were eliminated by PLX3397 for 21 consecutive days and repopulated following withdrawal for 21 days; then, intracerebral hemorrhage (ICH) models were constructed. Then, a single-nucleus transcriptomic analysis of acutely injured brains in aged mice with microglial replacement was performed.
We observed similarities but strong divergence in the composition and molecular change features of myeloid cells between the replacement (Rep) and control (Con) groups, indicating retention of the core transcriptome and development of differential genes in myeloid cells after microglial replacement in response to brain injury. Both MG and Mo/MΦ experience modification of immune responses after microglial repopulation, with more prominent changes in MG. Gene Ontology (GO) analysis showed that one term directly related to the \"immune response\" was shared between upregulated genes in Rep-MG and Rep-Mo/MΦ, while the other terms related to immune functions and other biofunctions were different between Rep-MG and Rep-Mo/MΦ, indicative of significantly different immune responses to brain injury between MG and MΦ. Furthermore, the trajectory analysis showed a significant transition from aged to young state in Rep-MG compared to only a modest youthful shift in Rep-Mo/MΦ, suggesting a rejuvenation process of aged microglia and macrophages toward young ones in response to brain injury after the treatment of microglial replacement.
Our data indicate that microglial replacement-induced changes in the molecular heterogeneity and state transition of myeloid cells may be neuroprotective against acute brain injury.
Journal Article
Biological characteristics of IL-6 and related intestinal diseases
The intestine serves as an important digestive and the largest immune organ in the body. Interleukin-6(IL-6), an important mediator of various pathways, participates in the interactions between different kinds of cells and closely correlates with intestinal physiological and pathological condition. In this review we summarize the signaling pathways of IL-6 and its functions in maintaining intestinal homeostasis. We also explored its relation with nervous system and highlight its potential role in Parkinson's disease. Based on its specialty of the double-side influences on intestinal tumors and inflammation, we summarize how they are done through distinctive process.
Journal Article