Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
26
result(s) for
"Fein, Eric"
Sort by:
Skateboard breakdown
\"Ty has the talent to take first place, but lately he's been skating angry. His temper is getting him into trouble and making him miss easy tricks. If Ty wants to win, he'll have to keep his cool, or his red-hot temper will puthis first place hopes on ice.\"--Page 4 of cover.
BOOK
Engaging Community and Academic Partners to Explore Adolescent Emotional Well-Being
In an under-resourced area of the South Bay of Los Angeles, partnerships were formed between community advocates with extensive research experience, less experienced academic investigators, and an urban public high school without partnered research experience. This article outlines the process of developing these partnerships through a community-academic research conference addressing a priority area identified by the local community to define and understand the importance and relevance of adolescent emotional well-being. Teen participants from the high school identified support from the community as the most crucial ingredient for achieving adolescent emotional well-being.
Journal Article
Parasite's power drain
As the sun sets in Metropolis, the electricity suddenly goes out, and crime wave erupts throughout the darkened city. This is a job for Superman! But as the man of steel restores order, an even bigger problem arrives-- the evil Parasite. This power-hungry monster won't let Superman save the day without a fight. If the Man of Steel isn't careful, it'll be lights out for him as well.
Book
Characterization of cationic glucocorticoids as gene delivery, antimicrobial, and anti-inflammatory agents
Cationic lipids facilitate gene delivery and some cationic sterol-based compounds have antimicrobial activity due to their amphiphilic character. These dual functions are relevant in local infection during intrapulmonary gene transfer for cystic fibrosis. The transfection activities of two cationic lipids, dexamethasone spermine (DS) and disubstituted spermine (D2S), displayed up to a 7-fold improvement in transgene expression for mixtures of DS/D2S. D2S demonstrated strong bactericidal activity against E. coli MG 1655, B. subtilis, and P. aeruginosa PAO1 with complete killing demonstrated at 5 μM and a two order of magnitude higher tolerance before eukaryotic membrane disruption. D2S exhibited LPS scavenging activity, resulting in significant inhibition of LPS-mediated activation of human neutrophils with 85% lower IL-8 released at 12 hrs, as well as in vivo antibacterial activity against a mucoid strain of P. aeruginosa (Xen5). We have demonstrated that DS and D2S can interact with viral vectors altering the surface properties of the particles by decreasing the net surface charge density. In vitro transduction showed a 6-fold and 7-fold increase in transgene expression with AAV2/6.2 and AAV2/9, respectively, when these viral vectors were pre-formulated with cationic lipids. Transduction of human airway epithelium with AAV2/6.2-lipid formulations showed greater than 2-fold increase in GFP positive cells and increases in total fluorescence compared to control. Intranasal administration of 1011 genome copies (GC) of AAV with lipid formulations resulted in an average 4-fold increase in transgene expression for both AAV2/6.2 and AAV2/9. Histological examination of lung cross-sections displayed increased transduction of conducting airway for formulations of AAV2/9 with DS compared to AAV2/9 alone. An inflammatory model of arthritis and bone remodeling was used to assess the pharmacological activity since prolonged glucocorticoid treatment can reduce inflammation but also lead to a profound impact on skeletal remodeling. Our results show that both DS and D2S reduce receptor activator of nuclear factor κ B ligand (RANKL), increase osteoprotegerin (OPG), and reduce inflammatory cytokine transcripts (IL-6) in vitro. Local and systemic in vivo pharmacological activities for both compounds in a collagen-induced arthritis model indicate D2S has comparable systemic anti-inflammatory activity to dexamethasone and possible dissociated glucocorticoid character in the bone microenvironment.
Dissertation
Autism Spectrum Disorders
The book's emphasis on types of assessment, genetic testing and counseling, and medical and psychological treatment will be exceedingly useful to health care providers navigating the new diagnostic criteria introduced in DSM-5.
eBook
Venom. Along came a spider
\"It's Venom vs. Spider-Man once again ... for the first time! Eddie Brock takes on a very different web-slinger: Ben Reilly! With Venom a wanted man and Eddie's ex-wife Anne Weying caught in the middle, a deadly rivalry is reborn! And when the symbiote-hunting alien Xenophage targets Venom, this time it's Eddie's brain in danger of being eaten! Meanwhile, four imprisoned symbiotes join together to become Hybrid - but how will this unstable new hero be judged by the Jury? And as Venom's hunger threatens to overwhelm him, can Eddie keep his \"other\" in check - or will everyone's favorite symbiote become a crazed cannibal killer? Either way, Venom's in for a world of hurt - courtesy of Dr. Paine!\"--Page 4 of cover.
BOOK
The Effects of Compensatory Auditory Stimulation and High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Tinnitus Perception – A Randomized Pilot Study
Tinnitus correlates with elevated hearing thresholds and reduced cochlear compression. We hypothesized that reduced peripheral input leads to elevated neuronal gain resulting in the perception of a phantom sound.
The purpose of this pilot study was to test whether compensating for this peripheral deficit could reduce the tinnitus percept acutely using customized auditory stimulation. To further enhance the effects of auditory stimulation, this intervention was paired with high-definition transcranial direct current stimulation (HD-tDCS).
A randomized sham-controlled, single blind study was conducted in a clinical setting on adult participants with chronic tinnitus (n = 14). Compensatory auditory stimulation (CAS) and HD-tDCS were administered either individually or in combination in order to access the effects of both interventions on tinnitus perception. CAS consisted of sound exposure typical to daily living (20-minute sound-track of a TV show), which was adapted with compressive gain to compensate for deficits in each subject's individual audiograms. Minimum masking levels and the visual analog scale were used to assess the strength of the tinnitus percept immediately before and after the treatment intervention.
CAS reduced minimum masking levels, and visual analog scale trended towards improvement. Effects of HD-tDCS could not be resolved with the current sample size.
The results of this pilot study suggest that providing tailored auditory stimulation with frequency-specific gain and compression may alleviate tinnitus in a clinical population. Further experimentation with longer interventions is warranted in order to optimize effect sizes.
Journal Article
Potential for soil legacy phosphorus release from restored riparian wetlands within an agricultural landscape
Wetlands are valuable ecosystems because they are highly productive, support a wide range of wildlife, and serve as hotspots for biogeochemical cycling. Historically, vast areas of wetlands in the United States (US) were drained and converted to agriculture. Efforts are currently underway to restore wetland and floodplain functioning across the US and elsewhere. Re-wetting historically drained and farmed soils can potentially liberate legacy phosphorus (P) to surface waters as soluble reactive P (SRP), offsetting P retained by sedimentation during floods. A better understanding of the controls on SRP release is needed to estimate net P retention in these settings. Soil P saturation ratio (PSR) and soil P storage capacity (SPSC) are two proxies for SRP runoff risk that have shown promise for characterizing restored wetlands but require further testing. In this study, we examined soils at 42 riparian sites ranging from active farms to mature wetlands in the Vermont portion of the Lake Champlain Basin (USA), where phosphorus load reduction is a critical goal to achieve in-lake water quality targets. We additionally quantified potential SRP release to overlying water using intact soil cores from 20 plots spanning 14 sites. Final SRP concentrations in intact cores spanned two orders of magnitude and were predicted well by SPSC and PSR. SRP release was greatest at more recently and frequently farmed sites. Several soil properties, including PSR and SPSC, were correlated with farming frequency and time since farming, indicating that SRP release could be mapped using existing geodata for soils, hydrology and land use. Our findings confirm that soil SRP release during flooding needs to be considered in estimates of net P balance for restored riparian wetlands in agricultural landscapes.
Journal Article
FFCD-1004 Clinical Trial: Impact of Cytidine Deaminase Activity on Clinical Outcome in Gemcitabine-Monotherapy Treated Patients
Because cytidine deaminase (CDA) is the key enzyme in gemcitabine metabolism, numerous studies have attempted to investigate impact of CDA status (i.e. genotype or phenotype) on clinical outcome. To date, data are still controversial because none of these studies has fully investigated genotype-phenotype CDA status, pharmacokinetics and clinical outcome relationships in gemcitabine-treated patients. Besides, most patients were treated with gemcitabine associated with other drugs, thus adding a confounding factor. We performed a multicenter prospective clinical trial in gemcitabine-treated patients which aimed at investigating the link between CDA deficiency on the occurrence of severe toxicities and on pharmacokinetics, and studying CDA genotype-phenotype relationships.
One hundred twenty patients with resected pancreatic adenocarcinoma eligible for adjuvant gemcitabine monotherapy were enrolled in this study promoted and managed by the Fédération Francophone de Cancérologie Digestive. Toxicities were graded according to National Cancer Institute's Common Terminology Criteria for Adverse Events Version 4. They were considered severe for grade ≥ 3, and early when occurring during the first eight weeks of treatment. CDA status was evaluated using a double approach: genotyping for 79A>C and functional testing. Therapeutic drug monitoring of gemcitabine and its metabolite were performed on the first course of gemcitabine.
Five patients out of 120 (i.e., 4.6%) were found to be CDA deficient (i.e., CDA activity <1.3 U/mg), and only one among them experienced early severe hematological toxicity. There was no statistically significant difference in CDA activity between patients experiencing hematological severe toxicities (28.44%) and patients who tolerated the treatment (71.56%). CDA genetic analysis failed in evidencing an impact in terms of toxicities or in CDA activity. Regarding pharmacokinetics, a wide inter-individual variability has been observed in patients.
This study, which included only 4.6% of CDA-deficient patients, failed in identifying CDA status as a predictive marker of toxicities with gemcitabine. A lack of statistical power because of smoothing effect of CDA variability as compared with real life conditions could explain this absence of impact.
ClinicalTrials.gov NCT01416662.
Journal Article