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Soft γ-ray repeaters exhibit bursting emission in hard X-rays and soft γ-rays. During the active phase, they emit random short (milliseconds to several seconds long), hard-X-ray bursts, with peak luminosities 1 of 10 36 to 10 43 erg per second. Occasionally, a giant flare with an energy of around 10 44 to 10 46 erg is emitted 2 . These phenomena are thought to arise from neutron stars with extremely high magnetic fields (10 14 to 10 15 gauss), called magnetars 1 , 3 , 4 . A portion of the second-long initial pulse of a giant flare in some respects mimics short γ-ray bursts 5 , 6 , which have recently been identified as resulting from the merger of two neutron stars accompanied by gravitational-wave emission 7 . Two γ-ray bursts, GRB 051103 and GRB 070201, have been associated with giant flares 2 , 8 – 11 . Here we report observations of the γ-ray burst GRB 200415A, which we localized to a 20-square-arcmin region of the starburst galaxy NGC 253, located about 3.5 million parsecs away. The burst had a sharp, millisecond-scale hard spectrum in the initial pulse, which was followed by steady fading and softening over 0.2 seconds. The energy released (roughly 1.3 × 10 46 erg) is similar to that of the superflare 5 , 12 , 13 from the Galactic soft γ-ray repeater SGR 1806−20 (roughly 2.3 × 10 46 erg). We argue that GRB 200415A is a giant flare from a magnetar in NGC 253. The γ-ray burst GRB 200415A is probably a giant flare emitted from a magnetar in the nearby starburst galaxy NGC 253.

We present the catalog of Interplanetary Network (IPN) localizations for 199 short-duration gamma-ray bursts (sGRBs) detected by the Konus-Wind (KW) experiment between 2011 January 1 and 2021 August 31, which extends the initial sample of IPN localized KW sGRBs (arXiv:1301.3740) to 495 events. We present the most comprehensive IPN localization data on these events, including probability sky maps in HEALPix format.

Magnetars are young, highly magnetized neutron stars that produce extremely rare giant flares of gamma-rays, the most luminous astrophysical phenomena in our Galaxy. The detection of these flares from outside the Local Group of galaxies has been predicted, with just two candidates so far. Here we report on the extremely bright gamma-ray flare GRB 200415A of April 15, 2020, which we localize, using the Interplanetary Network, to a tiny (20 sq. arcmin) area on the celestial sphere, that overlaps the central region of the Sculptor galaxy at 3.5 Mpc from the Milky Way. From the Konus-Wind detections, we find a striking similarity between GRB 200415A and GRB 051103, the even more energetic flare that presumably originated from the M81/M82 group of galaxies at nearly the same distance (3.6 Mpc). Both bursts display a sharp, millisecond-scale, hard-spectrum initial pulse, followed by an approximately 0.2 s long steadily fading and softening tail. Apart from the huge initial pulses of magnetar giant flares, no astrophysical signal with this combination of temporal and spectral properties and implied energy has been reported previously. At the inferred distances, the energy released in both flares is on par with that of the December 27, 2004 superflare from the Galactic magnetar SGR 1806-20, but with a higher peak luminosity. Taken all together, this makes GRB 200415A and its twin GRB 051103 the most significant candidates for extragalactic magnetar giant flares, both a factor of five more luminous than the brightest Galactic magnetar flare observed previously, thus providing an important step towards a better understanding of this fascinating phenomenon.

Considerable has been said and written of late concerning an apparent growing tendency to establish age limits in the employment of industrial workers, particularly by employers of the larger groups. Various organizations, including war veterans and women's clubs.

Editor The Chronicle: Sir E. Ambrose of Redding, whose letter was published in the \"Safety Valve\" June 25, 1919, is apparently convinced that the State compensation insurance fund treats ... unfairly. He asks for the name of one injured worker who has been promptly paid...

Editor The Chronicle--Sir, Contrary to expressed belief, incurred losses of the insurance fund conducted by the state are no higher, at most, than the average loss ratio of the corporate companies while the expense of its corporate competitors, only about one-fourth the average...

The OSIRIS-REx Camera Suite (OCAMS) onboard the OSIRIS-REx spacecraft is used to study the shape and surface of the mission’s target, asteroid (101955) Bennu, in support of the selection of a sampling site. We present calibration methods and results for the three OCAMS cameras—MapCam, PolyCam, and SamCam—using data from pre-flight and in-flight calibration campaigns. Pre-flight calibrations established a baseline for a variety of camera properties, including bias and dark behavior, flat fields, stray light, and radiometric calibration. In-flight activities updated these calibrations where possible, allowing us to confidently measure Bennu’s surface. Accurate calibration is critical not only for establishing a global understanding of Bennu, but also for enabling analyses of potential sampling locations and for providing scientific context for the returned sample.

The OSIRIS-REx Camera Suite (OCAMS) will acquire images essential to collecting a sample from the surface of Bennu. During proximity operations, these images will document the presence of satellites and plumes, record spin state, enable an accurate model of the asteroid’s shape, and identify any surface hazards. They will confirm the presence of sampleable regolith on the surface, observe the sampling event itself, and image the sample head in order to verify its readiness to be stowed. They will document Bennu’s history as an example of early solar system material, as a microgravity body with a planetesimal size-scale, and as a carbonaceous object. OCAMS is fitted with three cameras. The MapCam will record color images of Bennu as a point source on approach to the asteroid in order to connect Bennu’s ground-based point-source observational record to later higher-resolution surface spectral imaging. The SamCam will document the sample site before, during, and after it is disturbed by the sample mechanism. The PolyCam, using its focus mechanism, will observe the sample site at sub-centimeter resolutions, revealing surface texture and morphology. While their imaging requirements divide naturally between the three cameras, they preserve a strong degree of functional overlap. OCAMS and the other spacecraft instruments will allow the OSIRIS-REx mission to collect a sample from a microgravity body on the same visit during which it was first optically acquired from long range, a useful capability as humanity reaches out to explore near-Earth, Main-Belt and Jupiter Trojan asteroids.

The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing ecology of the human oral microbiome, we analyzed 124 dental biofilm metagenomes from humans, including Neanderthals and Late Pleistocene to present-day modern humans, chimpanzees, and gorillas, as well as New World howler monkeys for comparison. We find that a core microbiome of primarily biofilm structural taxa has been maintained throughout African hominid evolution, and these microbial groups are also shared with howler monkeys, suggesting that they have been important oral members since before the catarrhine–platyrrhine split ca. 40 Mya. However, community structure and individual microbial phylogenies do not closely reflect host relationships, and the dental biofilms of Homo and chimpanzees are distinguished by major taxonomic and functional differences. Reconstructing oral metagenomes from up to 100 thousand years ago, we show that the microbial profiles of both Neanderthals and modern humans are highly similar, sharing functional adaptations in nutrient metabolism. These include an apparent Homo-specific acquisition of salivary amylase-binding capability by oral streptococci, suggesting microbial coadaptation with host diet. We additionally find evidence of shared genetic diversity in the oral bacteria of Neanderthal and Upper Paleolithic modern humans that is not observed in later modern human populations. Differences in the oral microbiomes of African hominids provide insights into human evolution, the ancestral state of the human microbiome, and a temporal framework for understanding microbial health and disease.

Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the niche, and how it exerts cell-extrinsic control over myeloma cell dormancy and reactivation. In this study, we track individual myeloma cells by intravital imaging as they colonize the endosteal niche, enter a dormant state and subsequently become activated to form colonies. We demonstrate that dormancy is a reversible state that is switched ‘on’ by engagement with bone-lining cells or osteoblasts, and switched ‘off’ by osteoclasts remodelling the endosteal niche. Dormant myeloma cells are resistant to chemotherapy that targets dividing cells. The demonstration that the endosteal niche is pivotal in controlling myeloma cell dormancy highlights the potential for targeting cell-extrinsic mechanisms to overcome cell-intrinsic drug resistance and prevent disease relapse. Therapy resistant dormant myeloma cells contribute to disease relapse. Here, the authors use intravital microscopy to track the location of these cells and demonstrate that they hone to the endosteal niche within the bone.