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Extraction of uranium from seawater is critical for the sustainable development of nuclear energy. However, the currently available uranium adsorbents are hampered by co-existing metal ion interference. DNAzymes exhibit high selectivity to specific metal ions, yet there is no DNA-based adsorbent for extraction of soluble minerals from seawater. Herein, the uranyl-binding DNA strand from the DNAzyme is polymerized into DNA-based uranium extraction hydrogel (DNA-UEH) that exhibits a high uranium adsorption capacity of 6.06 mg g −1 with 18.95 times high selectivity for uranium against vanadium in natural seawater. The uranium is found to be bound by oxygen atoms from the phosphate groups and the carbonyl groups, which formed the specific nano-pocket that empowers DNA-UEH with high selectivity and high binding affinity. This study both provides an adsorbent for uranium extraction from seawater and broadens the application of DNA for being used in recovery of high-value soluble minerals from seawater. The extraction of metals from seawater is an area of great potential; especially for the extraction of uranium. Here, the authors report on the synthesis of a DNA based uranium adsorbent with high selectivity and demonstrate the potential for the DNA based extraction of high-value soluble minerals from seawater.

Synthesis of framework materials possessing specific spatial structures or containing functional ligands has attracted tremendous attention. Herein, a halogen hydrogen-bonded organic framework (XHOF) is fabricated by using Cl − ions as central connection nodes to connect organic ligands, 7,7,8,8-tetraaminoquinodimethane (TAQ), by forming a Cl − ···H 3 hydrogen bond structure. Unlike metallic node-linked MOFs, covalent bond-linked COFs, and intermolecular hydrogen bond-linked HOFs, XHOFs represent a different kind of crystalline framework. The electron-withdrawing effect of Cl − combined with the electron-rich property of the organic ligand TAQ strengthens the hydrogen bonds and endows XHOF-TAQ with high stability. Due to the production of excited electrons by TAQ under light irradiation, XHOF-TAQ can efficiently catalyze the reduction of soluble U(VI) to insoluble U(IV) with a capacity of 1708 mg-U g −1 -material. This study fabricates a material for uranium immobilization for the sustainability of the environment and opens up a new direction for synthesizing crystalline framework materials. While hydrogen bonded organic frameworks are well covered in the scientific literature, halogen hydrogen-bonded organic framework (XHOF) remain less explored. Here, the authors demonstrate a highly stable diradical-based XHOF and demonstrate photoreduction of uranyl ions and high capacity of uranyl immobilization.

A novel 2D visible-light-driven TiO2@Ti3C2/g-C3N4 ternary heterojunction photocatalyst with modified interfacial microstructure and electronic properties was synthesized by ultrasonic-assisted calcination method. The remarkably active g-C3N4 could provide high productivity of photogenerated electrons and holes. Meanwhile, the O/OH-terminated Ti3C2 and by-product TiO2 could act as excellent supporters by migrating electrons in TiO2@Ti3C2/g-C3N4 hybrids. As a result, the highest photocatalytic activities in the degradation of aniline and RhB were increased to 5 and 1.33 times higher than that of pristine g-C3N4 under visible-light irradiation, respectively. Furthermore, we proposed that n–n heterojunction and n-type Schottky heterojunction were built up across their interfaces, which efficiently improve the transition of electrons and further promote the photocatalytic activity of TiO2@Ti3C2/g-C3N4 hybrids. More appealingly, all the results highlight that the environment-friendly TiO2@Ti3C2/g-C3N4 heterojunction hybrids would be desirable candidates for pollutants degradation.

Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in the N-terminal tail of histone H3 and affect the function of polycomb repressor complexes 1 and 2 (PRC1 and PRC2). However, the prevalence and function of histone mutations in other tumour contexts is unknown. Here we show that somatic histone mutations occur in approximately 4% (at a conservative estimate) of diverse tumour types and in crucial regions of histone proteins. Mutations occur in all four core histones, in both the N-terminal tails and globular histone fold domains, and at or near residues that contain important post-translational modifications. Many globular domain mutations are homologous to yeast mutants that abrogate the need for SWI/SNF function, occur in the key regulatory ‘acidic patch’ of histones H2A and H2B, or are predicted to disrupt the H2B–H4 interface. The histone mutation dataset and the hypotheses presented here on the effect of the mutations on important chromatin functions should serve as a resource and starting point for the chromatin and cancer biology fields in exploring an expanding role of histone mutations in cancer. The characterization of missense histone mutations that occur across several cancer types provides insight into the potential role of these mutations in altering chromatin structure and potentially contributing to tumour development.

Cycloaddition reaction using CO2 as a starting material to form a cyclic carbonate has been applied to chemical fixation of CO2. In order to further increase the reaction efficiency, herein, a bifunctional catalyst (CPBrs) containing metalloporphyrin and quaternary phosphonium salt groups was prepared, and the related catalytic performance for CO2 conversion was also studied. The catalytic system possesses multiple active sites of zinc porphyrin (Lewis acids) and quaternary phosphonium bromide salts (nucleophilic reagents), which can cooperatively work together to enhance the efficiency of cycloaddition reaction. At the same time, CPBrs (CPBr-1 and CPBr-2) are microporous polymers with permanent microporous pore structure and high specific surface areas (342–370 m2 g−1). Their moderate capacities (5.76 and 8.81% at 1 bar/273 K) to capture carbon dioxide were also beneficial for CO2 conversion. The activity of the bifunctional catalyst is higher than that of the catalyst with a single component. The corresponding highest yield to catalyze cycloaddition reaction between methyl substituented propylene oxide and CO2 is up to 95% (2.5 MPa, 90 °C). What is more, the porous nature of catalysts provides the recoverability of the catalyst, and the efficiency of the catalyst CPBr-2 remains high (above 90% yield) after five catalytic recycle.Graphic abstract

Bladder cancer prognosis is closely linked to the underlying differentiation state of the tumor, ranging from the less aggressive and most-differentiated luminal tumors to the more aggressive and least-differentiated basal tumors. Sequencing of bladder cancer has revealed that loss-of-function mutations in chromatin regulators and mutations that activate receptor tyrosine kinase (RTK) signaling frequently occur in bladder cancer. However, little is known as to whether and how these two types of mutations functionally interact or cooperate to regulate tumor growth and differentiation state. Here, we focus on loss of the histone demethylase UTX (also known as KDM6A) and activation of the RTK FGFR3, two events that commonly cooccur in muscle invasive bladder tumors. We show that UTX loss and FGFR3 activation cooperate to disrupt the balance of luminal and basal gene expression in bladder cells. UTX localized to enhancers surrounding many genes that are important for luminal cell fate, and supported the transcription of these genes in a catalytic-independent manner. In contrast to UTX, FGFR3 activation was associated with lower expression of luminal genes in tumors and FGFR inhibition increased transcription of these same genes in cell culture models. This suggests an antagonistic relationship between UTX and FGFR3. In support of this model, UTX loss-of-function potentiated FGFR3- dependent transcriptional effects and the presence of UTX blocked an FGFR3-mediated increase in the colony formation of bladder cells. Taken together, our study reveals how mutations in UTX and FGFR3 converge to disrupt bladder differentiation programs that could serve as a therapeutic target.

Heterogeneous metal–organic framework composites are widely used to catalyze the synthesis reaction of organic materials. Here, we report the use of a heterogeneous catalyst to catalyze the reaction of alcohols and amines to synthesize imines directly using a one-pot method. A low-dimensional Cu-MOF prepared by a simple surfactant-assisted method shows the morphology of nanorods. Cu-MOF nanorods provide an ideal support for preparing supported metal nanocatalysts. A reduction method was applied to immobilize the ultrafine noble metal Au and Pd nanoparticles on the surface of Cu-MOF nanorods to form a Cu-MOF/Au–Pd composite catalyst. Cu-MOF/Au–Pd catalyst is used to catalyze the reaction between alcohols and amines to form imines. Due to the synergy between different metal nanoparticles, it can effectively catalyze the reaction to form imines. In addition, Cu2+ in Cu-MOF/Au–Pd catalyst facilitates the adsorption of substances by excess electrons and promotes product formation. After 12 h of catalytic reaction, the yield of imine is as high as 95%.

Folk art is a kind of visual art and arts and crafts formed under the background of folk culture, which is considered as the symbol of traditional culture. But all forms of traditional arts and crafts are threatened by a globalized culture. Many scholars have made multidimensional analysis of folk art from different perspectives. There is a significant gap in the comprehensive literature review on folk art. In order to bridge this gap, this paper adopts the method of bibliometrics to review the existing research on folk art based on Scopus database. With the impact of modern industrial design on folk art and craft, folk art has become a hot topic of cultural communication in recent years. Therefore, this study has two main purposes: (i) to analyze the nature and evolution of academic articles related to folk art. (ii) To identify thematic areas related to the study of folk art and their links with interdisciplinary fields. To achieve this goal, we performed a bibliometric analysis of the 2353 journal articles, books and related international conference articles listed in Scopus. Through the analysis, research activities related to folk art have increased significantly, and the multidimensional, interdisciplinary nature of research is also illustrated. However, there is still room for further research into the impact of interdisciplinary collaboration and how folk art and craft can be activated and applied in modern design.

Background Prunus cistena is an excellent color leaf configuration tree for urban landscaping in the world, which has purplish red leaves, light pink flowers, plant shape and high ornamental value. Genomic resources for P. cistena are scarce, and a clear phylogenetic and evolutionary history for this species has yet to be elucidated. Here, we sequenced and analyzed the complete chloroplast genome of P. cistena and compared it with related species of the genus Prunus based on the chloroplast genome. Results The complete chloroplast genome of P. cistena is a 157,935 bp long typical tetrad structure, with an overall GC content of 36.72% and higher GC content in the in the inverted repeats (IR) regions than in the large single-copy (LSC) and small single-copy (SSC) regions. It contains 130 genes, including 85 protein-coding genes, 37 tRNA genes, and 8 rRNA genes. The ycf3 and clpP genes have two introns, with the longest intron in the trnK-UUU gene in the LSC region. Moreover, the genome has a total of 253SSRs, with the mononucleotide SSRs being the most abundant. The chloroplast sequences and gene arrangements of P. cistena are highly conserved, with the overall structure and gene order similar to other Prunus species. The atpE , ccsA , petA , rps8 , and matK genes have undergone significant positive selection in Prunus species. P. cistena has a close evolutionary relationship with P. jamasakura . The coding and IR regions are more conserved than the noncoding regions, and the chloroplast DNA sequences are highly conserved throughout the genus Prunus . Conclusions The current genomic datasets provide valuable information for further species identification, evolution, and phylogenetic research of the genus Prunus .

It has been demonstrated that Parkinson's disease (PD) is closely associated with endoplasmic reticulum stress (ERS) and ferroptosis. However, the specific mechanisms underlying these associations remain unclear. Consequently, this study investigated the mechanisms connecting these factors and explored potential biomarkers for PD. Data for PD and ERS, as well as information on ferroptosis, were sourced from public databases and relevant literature. Candidate genes were identified through differential expression analysis and weighted gene co-expression network analysis. Further investigations included functional enrichment analysis, the construction of a protein-protein interaction (PPI) network, and the examination of related genes. Subsequently, biomarkers were validated using the least absolute shrinkage and selection operator regression algorithm. Additionally, correlations among biomarkers, gene set enrichment analysis, chromosomal and subcellular localization, immune cell infiltration, regulatory mechanisms, and drug predictions were conducted. Initially, seven candidate genes were identified, predominantly associated with type II diabetes mellitus. Furthermore, five interacting associations within the PPI network and twenty related genes were identified, primarily engaged in the physical interactions pathway. Subsequently, three biomarkers were screened: N-myc downstream-regulated gene 1 (NDRG1), dihydrolipoamide dehydrogenase (DLD), and cold-inducible RNA-binding protein (CIRBP). A detailed analysis revealed a positive correlation between CIRBP and DLD, while NDRG1 exhibited a negative correlation with DLD; all three biomarkers were chiefly enriched in the oxidative phosphorylation pathway and PD. NDRG1 is located on chromosome 8, DLD on chromosome 7, and CIRBP on chromosome 19, with all three primarily localized in the nucleus. A total of 31 differential immune cells were identified between the disease and control groups, with neurons representing the highest proportion and the most significant negative correlation observed between DLD and pro B-cells. The interactions involving NORAD-hsa-miR-1277-5p-DLD, NEAT1-hsa-miR-128-3p-CIRBP, and XIST-hsa-miR-3173-5p-NDRG1 were found to be pivotal. Additionally, these biomarkers were regulated by 15 common transcription factors. Finally, nicotinamide adenine dinucleotide, pyruvic acid, nitric oxide, and phosphates were predicted as potential co-targeted therapeutic agents. NDRG1, DLD, and CIRBP were identified as biomarkers for PD, thereby opening new avenues for elucidating disease mechanisms, facilitating early diagnosis, and identifying potential therapeutic targets.