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With the rapid development of social economy, the deterioration of environment has become more and more serious; it is urgent to find a balance between economic development and environmental protection. Therefore, enterprises are appealed to invest in environmental protection, and local municipalities are appealed to supervise the environmental behaviors of enterprises, while central government plays a role of regulation. In order to study the preconditions for a better environmental strategy combination of local municipalities and enterprises, an evolutionary game theory was first constructed in this paper, then the evolutionary stable strategy (ESS) of local municipalities and enterprises under different scenarios was examined, and finally a simulation was used to test the results of the analysis. The results indicate that central government’s regulation has influence on the strategies chosen by local municipalities and enterprises, the larger the degree of central government’s incentives are, the more possible local municipalities and enterprises would choose environment-friendly strategies; and the intensity of central government's regulation, the cost and benefits of local municipalities’ supervision, and the cost and benefits of enterprises' environmental investment are the key influence factors.

Dietary fiber is a widely recognized nutrient for human health. Previous studies proved that dietary fiber has significant implications for gastrointestinal health by regulating the gut microbiota. Moreover, mechanistic research showed that the physiological functions of different dietary fibers depend to a great extent on their physicochemical characteristics, one of which is solubility. Compared with insoluble dietary fiber, soluble dietary fiber can be easily accessed and metabolized by fiber-degrading microorganisms in the intestine and produce a series of beneficial and functional metabolites. In this review, we outlined the structures, characteristics, and physiological functions of soluble dietary fibers as important nutrients. We particularly focused on the effects of soluble dietary fiber on human health via regulating the gut microbiota and reviewed their effects on dietary and clinical interventions.

Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.

A considerable number of deep engineering cases show that strain rockbursts occur on both sidewalls of circular caverns and ultimately form a symmetrical V-shaped notch. To investigate the occurrence process and mechanism of strain rockbursts in deep circular cavern under high stresses, simulation experiments under four different three-dimensional (3D) stress conditions were conducted on cubic granite specimens with a prefabricated circular hole using the true-triaxial electro-hydraulic servo mutagenesis testing system. The rock bursting process was monitored on the sidewalls of the hole and recorded in real-time with a wireless microcamera. The results show that the entire rock bursting process on the sidewalls can be divided into four distinct periods for every 3D stress condition: calm period, pellet ejection period, rock fragment exfoliation period, and rock bursting period. Under the conditions that the vertical stress is constant and the horizontal radial stress is equal to the horizontal axial stress, the rockburst severity of the sidewalls clearly decreases with increasing horizontal stress. When the vertical stress is constant and the horizontal axial stress is low, the rockburst severity clearly decreases with the increase of horizontal radial stress. In contrast, when the horizontal axial stress is high, the rockburst severity becomes more serious with increasing horizontal radial stress. During the process of rock fracture and bursting, the damage zones on both sidewalls form two symmetrical V-shaped notches, and the line connecting the centres of the two V-shaped notches is perpendicular to the maximum principal stress direction. The symmetrical V-shaped failure modes on both sidewalls under the four stress conditions are in line with the statistical relationship of the far-field stress state and failure mode of a deep circular cavern without support (Martin et al. in Can Geotech J 36(1):136–151, 1999).

To evaluate the deterioration degree of rock freeze–thaw damage in cold area engineering, it is necessary to establish an accurate freeze–thaw rock damage model and its uniaxial compression numerical simulation method. Therefore, indoor freeze–thaw cycle tests of saturated yellow sandstone were carried out. The porosity and P-wave velocity were measured, and uniaxial compression tests were conducted after different numbers of freeze–thaw cycles. The findings indicate that with an increasing number of freeze–thaw cycles, the elastic modulus, peak strength and wave velocity of the yellow sandstones gradually decrease, while the peak strain and the average porosity increase. The energy evolution law with different numbers of freeze–thaw cycles was analyzed, a freeze–thaw damage model was established according to the relative change in the dissipated energy ratio before and after freezing–thawing, and the accuracy of this damage model and five common damage models was evaluated by the uniaxial compressive strength and peak strain. The functional relationship between mesoscopic parameters and the number of freeze–thaw cycles was formulated to establish a numerical simulation method for saturated sandstones under uniaxial compression after freeze–thaw cycling. The reliability of the numerical method was verified by comparing the stress–strain curve, peak stress, peak strain and energy law with the experimental results.

Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated analysis of spatial and single-cell transcriptomics data across six common cancer types, we identified four distinct functional subgroups of CAFs and described their spatial distribution characteristics. Additionally, the analysis of single-cell RNA sequencing (scRNA-seq) data from three additional common cancer types and two newly generated scRNA-seq datasets of rare cancer types, namely epithelial-myoepithelial carcinoma (EMC) and mucoepidermoid carcinoma (MEC), expanded our understanding of CAF heterogeneity. Cell–cell interaction analysis conducted within the spatial context highlighted the pivotal roles of matrix CAFs (mCAFs) in tumor angiogenesis and inflammatory CAFs (iCAFs) in shaping the immunosuppressive microenvironment. In patients with breast cancer (BRCA) undergoing anti-PD-1 immunotherapy, iCAFs demonstrated heightened capacity in facilitating cancer cell proliferation, promoting epithelial-mesenchymal transition (EMT), and contributing to the establishment of an immunosuppressive microenvironment. Furthermore, a scoring system based on iCAFs showed a significant correlation with immune therapy response in melanoma patients. Lastly, we provided a web interface ( https://chenxisd.shinyapps.io/pancaf/ ) for the research community to investigate CAFs in the context of pan-cancer.

Rock failure generally refers to the process of damaging rock material to the point at which it partially or completely loses its load-carrying capacity. For rock materials, the fracture pattern and mechanical properties, including compressive strength, tensile strength, shear strength, and fracture toughness, under dynamic loads are affected by the loading rate/strain rate. In this study, a series of dynamic indirect tensile tests was conducted on sandstone from Changsha, China.

With the rapid development of social economy and the increasing environmental pollution in China, the government’s environmental investment has been gradually increasing, and an effective evaluation system is required to study the benefits from environmental investment. Based on the literature review and current situation analysis of the benefits from environmental investment, the selection of indicators was determined after the analysis of the economic, environmental, and social benefits of environmental investment. The gray relation analysis (GRA) method was adopted to test the correlation between each indicator and environmental investment, the combination of analytic hierarchy process (AHP) and Delphi method was used to determine the relative weight of each indicator, and a fuzzy comprehensive evaluation model was established for benefits from environmental investment. The study found that benefits from environmental investment in China had been improving over years but still not satisfying, and several suggestions had been proposed according to the analysis.

Lactate is a key metabolite produced from glycolytic metabolism of glucose molecules, yet it also serves as a primary carbon fuel source for many cell types. In the tumor-immune microenvironment, effect of lactate on cancer and immune cells can be highly complex and hard to decipher, which is further confounded by acidic protons, a co-product of glycolysis. Here we show that lactate is able to increase stemness of CD8 + T cells and augments anti-tumor immunity. Subcutaneous administration of sodium lactate but not glucose to mice bearing transplanted MC38 tumors results in CD8 + T cell-dependent tumor growth inhibition. Single cell transcriptomics analysis reveals increased proportion of stem-like TCF-1-expressing CD8 + T cells among intra-tumoral CD3 + cells, a phenotype validated by in vitro lactate treatment of T cells. Mechanistically, lactate inhibits histone deacetylase activity, which results in increased acetylation at H3K27 of the Tcf7 super enhancer locus, leading to increased Tcf7 gene expression. CD8 + T cells in vitro pre-treated with lactate efficiently inhibit tumor growth upon adoptive transfer to tumor-bearing mice. Our results provide evidence for an intrinsic role of lactate in anti-tumor immunity independent of the pH-dependent effect of lactic acid, and might advance cancer immune therapy. Lactic acid from glycolytic metabolism of cancer cells has been associated with immune suppressive functions. Here authors show that lactate, when depart from the acidic protons, inhibits histone deacetylases in CD8 + T cells, which turns them into potent anti-tumour immune cells.