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To investigate the association between achievement motivation and subjective well-being, as well as the moderating role of self-control and self-management on this relationship, 1017 Chinese college students were surveyed. The main results showed that: The interactive effect of motivation to approach success and self-control on subjective well-being was significant. Specifically, for individuals with high self-control ability, the positive effects of motivation to approach success on subjective well-being, life satisfaction and positive affect tended to be stronger, and meanwhile, the motivation to approach success negatively predicted negative affect. Furthermore, the interactive effect of motivation to avoid failure and self-control on subjective well-being was significant. Specifically, for individuals with high self-control ability, the negative effects of motivation to avoid failure on subjective well-being, life satisfaction and positive affect tended to be weaker, and meanwhile, the effect of motivation to avoid failure on negative affect was relatively weaker. Overall, our study indicated that improving self-control ability could maximize the positive effect of achievement motivation on subjective well-being. Moreover, motivating individuals with high self-control ability to pursue success and reducing motivation to avoid failure for individuals with low self-control ability could have a more positive influence on subjective well-being.

Although the formation control of multi-agent systems has been widely investigated from various aspects, the problem is still not well resolved, especially for the case of distributed output-feedback formation controller design without input information exchange among neighboring agents. Using relative output information, this paper presents a novel distributed reduced-order estimation of the formation error at a predefined time. Based on the proposed distributed observer, a neural-network-based formation controller is then designed for multi-agent systems with connected graphs. The results are verified by both theoretical demonstration and simulation example.

Acute inflammatory storm is a major cause of myocardial ischemia/reperfusion (I/R) injury, with no effective treatment currently available. The excessive aggregation of neutrophils is correlated with an unfavorable prognosis in acute myocardial infarction (AMI) patients. Exosomes derived from mesenchymal stromal cells (MSC-Exo) have certain immunomodulatory potential and might be a therapeutic application. Therefore, we investigated the protective role of MSC-Exo in modulating neutrophil infiltration and formation of neutrophil extracellular traps (NETs) following myocardial I/R injury. Exosomes were isolated from the supernatant of MSCs using a gradient centrifugation method. We used flow cytometry, histochemistry, and immunofluorescence to detect the changes of neutrophils post-intravenous MSC-Exo injection. Additionally, cardiac magnetic resonance (CMR) and thioflavin S experiments were applied to detect microvascular obstruction (MVO). The NLR family pyrin domain containing 3 (NLRP3) inflammasome was examined for mechanism exploration. Primary neutrophils were extracted for in vitro experiment. Antibody of Ly6G was given to depleting the neutrophils in mice for verification the effect of MSC-Exo. Finally, we analyzed the MiRNA sequence of MSC-Exo and verified it in vitro. MSC-Exo administration reduced neutrophil infiltration and NETs formation after myocardial I/R. MSC-Exo treatment also could attenuate the activation of NLRP3 inflammasome both in vivo and in vitro. At the same time, the infarction size and MVO following I/R injury were reduced by MSC-Exo. Moreover, systemic depletion of neutrophils partly negated the therapeutic effects of MSC-Exo. Up-regulation of miR-199 in neutrophils has been shown to decrease the expression of NETs formation after stimulation. Our results demonstrated that MSC-Exo mitigated myocardial I/R injury in mice by modulating neutrophil infiltration and NETs formation. This study provides novel insights into the potential therapeutic application of MSC-Exo for myocardial ischemia/reperfusion injury.

Intermediate-mass black holes (IMBHs) may be the link between stellar mass holes and the supermassive variety in the nuclei of galaxies, and globular clusters (GCs) may be one of the most promising environments for their formation. Here, we carry out a pilot study of the observability of tidal disruption events (TDEs) from 103 M ⊙ < M • < 105 M ⊙ IMBHs embedded in stellar cusps at the center of GCs. We model the long super-Eddington accretion phase and ensuing optical flare, and derive the disruption rate of main-sequence stars as a function of black hole mass and GC properties with the help of a 1D Fokker–Planck approach. The photospheric emission of the adiabatically expanding outflow dominates the observable radiation and peaks in the near-ultraviolet/optical bands, outshining the brightness of the (old) stellar population of GCs in Virgo for a period of months to years. A search for TDE events in a sample of nearly 4000 GCs observed at multiple epochs by the Next Generation Virgo Cluster Survey yields null results. Given our model predictions, this sample is too small to set stringent constraints on the present-day occupation fraction of GCs hosting IMBHs. Naturally, better simulations of the properties of the cluster central stellar distribution, TDE light curves, and rates, together with larger surveys of GCs are all needed to gain deeper insights into the presence of IMBHs in GCs.

Objective This study aims to investigate the 10-year trends and disparities in underweight, overweight, and obesity among older adults aged 65 years and older in China from 2008 to 2018. Methods We used four waves (2008, 2011, 2014, and 2018) of data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a national community-based cross-sectional survey conducted every 2–3 years. Body weight and height were measured by trained assessors following standardized procedures. BMI was calculated and divided into underweight (< 18.5 kg/m 2 ), normal (18.5–24.9 kg/m 2 ), overweight (25.0-29.9 kg/m 2 ), obese (≥ 30.0 kg/m 2 ) according to WHO reference. Multinomial logistic regression models were used to examine factors related with abnormal BMI groups, after adjusting for potential confounders. Results Among 46,543 older adults in China, the prevalence rates of underweight decreased with each survey year from 2008 to 2018, declining from 20.05 to 7.87% (p < 0.001). In contrast, the prevalence rates of overweight and obesity showed an increasing trend (all p < 0.001). Specifically, the prevalence of overweight rose from 12.82% to 2008 to 28.45% in 2018, and the prevalence of obesity increased from 1.62% to 2008 to 4.95% in 2018. In the multinomial logistic regression model, survey year, gender, residence, marital status, economic status, numbers of chronic diseases, smoking status, sleep quality, and functional disability were factors related with obesity. Conclusion The prevalence rates of overweight and obesity were increasing while the prevalence of underweight and normal weight significantly decreased from 2008 to 2018 among older adults in China, which poses a huge challenge for chronic disease. There is an urgent need for intervention policy planning and early prevention of abnormal body weight for the preparation of an aging society.

The gut microbiota, the body’s richest microbial ecosystem, is essential for maintaining gut function and immune balance. Additionally, microbial-derived metabolites are linked to the onset and progression of various diseases. There is a potential bidirectional gut–lung axis by which the gut and lungs can communicate with each other mediated by microbiota, immune responses, and metabolic products, and thus affect lung cancer occurrence. As the pathological progression of lung cancer advances and treatment methods are optimized, there is a concurrent and continuous alteration in the gut microbiota and its metabolites in lung cancer patients. This review highlights that the composition and structure of the gut microbiota in lung cancer patients undergo dynamic alterations, which are intricately linked to the pathological progression of the disease and the implementation of therapeutic interventions. Longitudinal monitoring of this system may offer unprecedented insights into the early diagnosis, precise treatment, and prognostic evaluation of lung cancer.

Purpose To evaluate the prognostic significance of progesterone receptor (PR) expression and the PIK3CA mutation status in HR+/HER2 − breast cancer patients, with the goal of screening patients who may derive the greatest benefit from PI3K-targeted therapy. Methods A retrospective analysis was conducted on 152 HR+/HER2 − breast cancer patients stratified by PR expression levels and PIK3CA mutation status. The study population was divided into groups on the basis of a median PR threshold of 50% and further subdivided by PIK3CA mutation status. To evaluate the variability of clinicopathologic features among these groups, t tests and ANOVA were employed. The influence of these variables on survival was analyzed via Cox regression. Additionally, a risk prediction model was developed using the PR expression level and PIK3CA mutation status. The prognostic utility of this model was examined via both Kaplan‒Meier (KM) survival curves and receiver operating characteristic (ROC) analyses. These methods have also been utilized to explore the associations between clinicopathologic parameters and clinical outcomes with respect to survival prediction and prognosis. Results Significant differences in age, ER expression, and Ki67, HER2, and PIK3CA mutation status were detected between the groups ( P  < 0.05). Specifically, elevated PR expression was correlated with lower levels of Ki67 and low HER2 expression. The presence of a PIK3CA mutation was significantly linked to survival outcomes according to both univariate and multivariate Cox regression analyses. Moreover, ROC analysis revealed that models incorporating both PR expression and PIK3CA mutation status achieved the highest level of diagnostic precision (AUC = 0.82). Conclusion PR expression and PIK3CA mutation status are significant prognostic markers in HR+/HER2 − breast cancer patients. Assessing these biomarkers in combination can enhance prognostic stratification, potentially guiding more informed clinical decision-making.

Cells living in geometrically confined microenvironments are ubiquitous in various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-host interactions. Here, we reveal that interactions between bacteria and spatially constrained cell monolayers exhibit strong spatial heterogeneity, and that bacteria tend to adhere to these cells near the outer edges of confined monolayers. The bacterial adhesion force near the edges of the micropatterned monolayers is up to 75 nN, which is ~3 times higher than that at the centers, depending on the underlying substrate rigidities. Single-cell RNA sequencing experiments indicate that spatially heterogeneous expression of collagen IV with significant edge effects is responsible for the location-dependent bacterial adhesion. Finally, we show that collagen IV inhibitors can potentially be utilized as adjuvants to reduce bacterial adhesion and thus markedly enhance the efficacy of antibiotics, as demonstrated in animal experiments. Cells in the body live in geometrically constrained microenvironments. Here, Feng at al report that these constraints induce collagen IV expression which is responsible for location dependent bacterial adhesion.

Background Despite the growing application of the Dual-factor model of mental health (DFM), there is a paucity of research on military personnel. Additionally, existing cross-sectional studies indicate that resilience and perceived social support are associated with military mental health, but the lack of cross-lagged studies precludes researchers from making causal interpretations. This study aimed to explore the longitudinal relationship between resilience, perceived social support, negative dimension of mental health (depressive symptom), and positive dimension (life satisfaction) among military personnel using cross-lagged analysis. Methods A total of 215 military personnel were investigated longitudinally over a 12-week, two-phase period. The Connor-Davidson Resilience Scale (CD-RISC), Perceived Social Support Scale (PSSS), Patients’ Health Questionnaire Depression Scale-9 Item (PHQ-9), and Satisfaction with Life Scale (SWLS) were employed to measure their resilience, perceived social support, depression symptoms, and life satisfaction, respectively. Pearson correlation analysis was used to examine the correlations between the aforementioned variables, and a paired t-test was employed to ascertain whether the variables changed over time. A cross-lagged panel analysis was employed to explore cross-lagged relationships between these variables in military personnel. Results All participants in this study were male. At Time 1, the mean age of all participants was 22.98 years ( SD  = 2.99), and the mean scores for the CD-RISC, PSSS, PHQ-9, and SWLS were 71.61 ( SD  = 14.86), 68.60 ( SD  = 10.22), 1.74 ( SD  = 2.89), and 28.08 ( SD  = 5.51), respectively. Cross-lagged analysis showed that prior resilience significantly predicted later depression symptoms ( β = -0.19, p  = 0.028) and life satisfaction ( β  = 0.17, p  = 0.038). Prior perceived social support significantly predicted later life satisfaction ( β  = 0.15, p  = 0.040) but not depression symptoms ( β = -0.04, p  = 0.652). Prior depression symptoms significantly predicted later life satisfaction ( β = -0.26, p < 0.001), and prior life satisfaction also predicted later depression symptoms ( β = -0.23, p  = 0.002). Conclusions The negative and positive dimensions of military mental health can interact with each other. Moreover, enhancing resilience and perceived social support may be a novel perspective for improving the mental health of military personnel.

Bone regeneration of oral and maxillofacial defects in situ remains a significant clinical challenge. This study investigates the synergistic effects of phosphorus (P) and zinc (Zn) co-doping in wollastonite bioceramics to enhance osteogenic activity and antibacterial potential for bone repair. Cylindrical bioceramic granules with varying P/Zn ratios (CSi-P8: CSi-Zn6 = 3:0, 2:1, 1:2 and 0:3) were fabricated via co-precipitation and evaluated for in-vitro bioactivity, cell proliferation, osteogenic differentiation, and antibacterial performance. The experimental results demonstrated that the co-doped groups (8P/6Zn-2:1 and 8P/6Zn-1:2) exhibited superior hydroxyapatite formation in simulated body fluid (SBF), sustained Ca²⁺/Si⁴⁺ ion release, and synergistic osteogenic effects, as evidenced by elevated RUNX2/β-catenin expression and BMSC proliferation. Zn doping conferred dose-dependent antibacterial activity against Staphylococcus aureus (93% inhibition for 8P/6Zn-0:3). In vivo cranial defect experiments in rabbits revealed that the 8P/6Zn-2:1 granules significantly promoted new bone trabeculae formation and defect closure within 16 weeks, outperforming single-doped and control groups. Histological and micro-CT analyses confirmed enhanced bone volume fraction (BV/TV%) and trabecular density (Tb.N) in the co-doped groups. These findings highlight the dual functionality of P/Zn co-doped wollastonite (e.g. 8P/6Zn-2:1), where P enhances osteogenesis via increasing the expression of RUNX2/β-catenin and apatite deposition, while Zn provides antibacterial protection, offering more promising implants for infected oral bone defects.