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The game on! diet : kick your friend's butt while shrinking your own
Outlines a competitive method for losing weight and pursuing fitness goals without extreme methods, in a guide that provides meal plans, exercises, and recommended lifestyle changes.
Book
Molecular Cloning and Characterization of a Calmodulin-Dependent Phosphodiesterase Enriched in Olfactory Sensory Neurons
The sensing of an odorant by an animal must be a rapid but transient process, requiring an instant response and also a speedy termination of the signal. Previous biochemical and electrophysiological studies suggest that one or more phosphodiesterases (PDEs) may play an essential role in the rapid termination of the odorant-induced cAMP signal. Here we report the molecular cloning, expression, and characterization of a cDNA from rat olfactory epithelium that encodes a member of the calmodulin-dependent PDE family designated as PDE1C. This enzyme shows high affinity for cAMP and cGMP, having a Kmfor cAMP much lower than that of any other neuronal Ca2+/calmodulin-dependent PDE. The mRNA encoding this enzyme is highly enriched in olfactory epithelium and is not detected in six other tissues tested. However, RNase protection analyses indicate that other alternative splice variants related to this enzyme are expressed in several other tissues. Within the olfactory epithelium, this enzyme appears to be expressed exclusively in the sensory neurons. The high affinity for cAMP of this Ca2+/calmodulin-dependent PDE and the fact that its mRNA is highly concentrated in olfactory sensory neurons suggest an important role for it in a Ca2+-regulated olfactory signal termination.
Journal Article
The Control of Schistosomiasis in Patillas, Puerto Rico
A joint effort of the Puerto Rico Department of Health and the San Juan Laboratories of the Public Health Service to control schistosomiasis in Patillas, P.R., was started in 1952 as an interdisciplinary effort involving biologists, engineers, and physicians. Snails were controlled with a molluscicide, sodium pentachlorophenate, or by drainage of snail habitats. Fuadin chemotherapy was given to children. By 1962 the prevalence of schistosomiasis among 7-year-old children in Patillas decreased to zero from the original 21.5 percent in 1952, and the snail population was virtually exterminated. The successful program in Patillas, at an average yearly cost of $8,600, provided an estimate of less than $5 million for the snail control phase of an island-wide program in Puerto Rico.
Journal Article
