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"Ferguson, E"
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A taxometric analysis of health anxiety
A long-standing issue in the health anxiety literature is the extent to which health anxiety is a dimensional or a categorical construct. This study explores this question directly using taxometric procedures.
Seven hundred and eleven working adults completed an index of health anxiety [the Whiteley Index (WI)] and indicated their current health status. Data from those who were currently healthy (n=501) and receiving no medical treatment were examined using three taxometric procedures: mean above minus below a cut (MAMBAC), maximum eigenvalue (MAXEIGEN) and L-mode factor analysis (L-MODE).
Graphical representations (comparing actual to simulated data) and fit indices indicate that health anxiety is more accurately represented as a dimensional rather than a categorical construct.
Health anxiety is better represented as a dimensional construct. Implications for theory development and clinical practice are examined.
Journal Article
A global overview of cassava genetic diversity
Although numerous studies of diversity have been conducted in cassava, there is no comprehensive assessment of global genetic diversity. Here we draw on previous studies and breeders' knowledge to select diversity sets from the International Institute of Tropical Agriculture (IITA) and the International Center for Tropical Agriculture (CIAT) genebanks and breeders' germplasm, as well as elite germplasm and landraces from eastern, southern and central (ESC) Africa to make a global assessment of diversity in cassava, using a SNP based GoldenGate (Illumina Inc.) assay. A synthesis of results from genetic distance and ADMIXTURE analysis essentially revealed four populations (i) South American germplasm characterised by relatively higher genetic diversity with hypothetical ancestral founder genotypes from Brazil, (ii) a smaller group of African introduction germplasm which is more distantly related to all other germplasm, (iii) West Africa germplasm dominated by IITA breeding lines, containing sources of cassava mosaic disease resistance, and IITA genebank accessions from West Africa, both characterised by slightly lower diversity, and (iv) a less cohesive group of African germplasm, termed 'Other', with moderate levels of diversity and a majority of germplasm from ESC Africa. This study highlights opportunities for heterosis breeding, purging of duplicates in genebanks and the need for conservation of ESC Africa landraces.
Journal Article
Relicensing as a Secondary Market Strategy
Secondary markets in the information technology industry, where used or refurbished equipment is traded, have been growing steadily. For original equipment manufacturers (OEMs) in this industry, the importance of secondary markets has grown in parallel, not only as a source of revenue, but also because of their impact on these firms' competitive advantage and market strategy. Recent articles in the press have severely criticized some OEMs who are perceived to be actively trying to eliminate the secondary market for their products. Other OEMs have policies that enhance their secondary markets. The goal of this paper is to understand how an OEM's incentives and optimal strategies vis-à-vis the secondary market are shaped contingent on her relative competitive advantage, product characteristics, and consumer preferences. The critical trade-off that we examine is whether the indirect benefit from maintaining an active secondary market (the resale value effect) can outweigh the potentially negative effect of the sales of used products at the expense of new product sales (the cannibalization effect). To that end, we develop a durable good model where the OEM can directly affect the resale value of her product through a relicensing fee charged to the buyer of the refurbished equipment. We analyze the OEM's strategy in both the monopoly and the duopoly cases, characterize the optimal relicensing fee set by the OEM, and draw conclusions on the conditions that favor stimulating or deterring the secondary market.
This paper was accepted by Candace A. Yano, operations and supply chain management.
Journal Article
A Rising Tide Does Not Lift All Boats: Intersectional Analysis Reveals Inequitable Impacts of the Seafood Trade in Fishing Communities
Seafood is the world’s most traded food commodity, and the international trade in seafood is promoted as a development strategy in low-income coastal communities across the globe. However, the seafood trade can drive negative social and environmental impacts in fishing communities, and whether the benefits of trade actually reach fishers is a subject of ongoing scholarship. Furthermore, scholars and policymakers have tended to treat fishing communities as homogeneous, assuming that trade policies will impact all members equally. Yet individual community members have different roles, statuses, and entitlements according to their intersecting identities, meaning that different fishers will be differently impacted by the seafood trade. In particular, women occupy different positions than men in seafood value chains and in fishing communities. There are also important within-group differences among men and among women depending on their nationality, marital status, and other identity markers. Through 205 surveys, 54 interviews, and ethnographic field methods conducted in fifteen rural Palauan fishing communities between November 2019 and March 2020, this case study of the sea cucumber trade in Palau brings together theories of gender, intersectionality, and access to answer the question, “How are the harms and benefits of the seafood trade distributed in fishing communities?” In this case, men benefited more than women from the export of sea cucumbers by leveraging access to technology; knowledge; and authority, and the trade depleted resources relied on primarily by women for their food security and livelihoods. An intersectional analysis revealed that marital status and nationality determined access among women, with married women having greater access than unmarried women and immigrant women having greater access than immigrant men, demonstrating the importance of intersectionality as an analytical tool.
Journal Article
Closed-Loop Supply Chains
Written by academic experts, in language that is accessible to practitioners, this authoritative resource examines recent research and case studies of companies running profitable reuse/remanufacture operations in various industries.
eBook
The Effect of Competition on Recovery Strategies
Manufacturers often face a choice of whether to recover the value in their end‐of‐life products through remanufacturing. In many cases, firms choose not to remanufacture, as they are (rightly) concerned that the remanufactured product will cannibalize sales of the higher‐margin new product. However, such a strategy may backfire for manufacturers operating in industries where their end‐of‐life products (cell phones, tires, computers, automotive parts, etc.) are attractive to third‐party remanufacturers, who may seriously cannibalize sales of the original manufacturer. In this paper, we develop models to support a manufacturer's recovery strategy in the face of a competitive threat on the remanufactured product market. We first analyze the competition between new and remanufactured products produced by a monopolist manufacturer and identify conditions under which the firm would choose not to remanufacture its products. We then characterize the potential profit loss due to external remanufacturing competition and analyze two entry‐deterrent strategies: remanufacturing and preemptive collection. We find that a firm may choose to remanufacture or preemptively collect its used products to deter entry, even when the firm would not have chosen to do so under a pure monopoly environment. Finally, we discuss conditions under which each strategy is more beneficial.
Journal Article
We need to talk about error: causes and types of error in veterinary practice
Patient safety research in human medicine has identified the causes and common types of medical error and subsequently informed the development of interventions which mitigate harm, such as the WHO's safe surgery checklist. There is no such evidence available to the veterinary profession. This study therefore aims to identify the causes and types of errors in veterinary practice, and presents an evidence based system for their classification. Causes of error were identified from retrospective record review of 678 claims to the profession's leading indemnity insurer and nine focus groups (average N per group=8) with vets, nurses and support staff were performed using critical incident technique. Reason's (2000) Swiss cheese model of error was used to inform the interpretation of the data. Types of error were extracted from 2978 claims records reported between the years 2009 and 2013. The major classes of error causation were identified with mistakes involving surgery the most common type of error. The results were triangulated with findings from the medical literature and highlight the importance of cognitive limitations, deficiencies in non-technical skills and a systems approach to veterinary error.
Journal Article
Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events
Patients 65 or older with hypertension who switched from hydrochlorothiazide to chlorthalidone did not have fewer major cardiovascular events or non–cancer-related deaths than those who continued receiving hydrochlorothiazide.
Journal Article
Inhibition of Protease–Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways
Abstract
Rationale
In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises mucociliary clearance, favoring mucus plugging and chronic bacterial infection. Inhibitors of the epithelial sodium channel (ENaC) have therapeutic potential in CF airways to reduce hyperstimulated sodium and fluid absorption to levels that can restore airway hydration.
Objectives
To determine whether a novel compound (QUB-TL1) designed to inhibit protease/ENaC signaling in CF airways restores ASL volume and mucociliary function.
Methods
Protease activity was measured using fluorogenic activity assays. Differentiated primary airway epithelial cell cultures (F508del homozygotes) were used to determined ENaC activity (Ussing chamber recordings), ASL height (confocal microscopy), and mucociliary function (by tracking the surface flow of apically applied microbeads). Cell toxicity was measured using a lactate dehydrogenase assay.
Measurements and Main Results
QUB-TL1 inhibits extracellularly located channel activating proteases (CAPs), including prostasin, matriptase, and furin, the activities of which are observed at excessive levels at the apical surface of CF airway epithelial cells. QUB-TL1–mediated CAP inhibition results in diminished ENaC-mediated Na+ absorption in CF airway epithelial cells caused by internalization of a prominent pool of cleaved (active) ENaCγ from the cell surface. Importantly, diminished ENaC activity correlates with improved airway hydration status and mucociliary clearance. We further demonstrate QUB-TL1–mediated furin inhibition, which is in contrast to other serine protease inhibitors (camostat mesylate and aprotinin), affords protection against neutrophil elastase–mediated ENaC activation and Pseudomonas aeruginosa exotoxin A–induced cell death.
Conclusions
QUB-TL1 corrects aberrant CAP activities, providing a mechanism to delay or prevent the development of CF lung disease in a manner independent of CF transmembrane conductance regulator mutation.
Journal Article