Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
14,206
result(s) for
"Fern"
Sort by:
Late edition
Toots and the Sisters travel to Charleston, where they search for the murderer of Ida's late husband--and try to protect Ida from similar fate.
Book
The biology and functional importance of MAIT cells
In recent years, a population of unconventional T cells called ‘mucosal-associated invariant T cells’ (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative antigens presented by the major histocompatibility complex (MHC) class I–like protein MR1. MAIT cells use a limited T cell antigen receptor (TCR) repertoire with public antigen specificities that are conserved across species. They can be activated by TCR-dependent and TCR-independent mechanisms and exhibit rapid, innate-like effector responses. Here we review evidence showing that MAIT cells are a key component of the immune system and discuss their basic biology, development, role in disease and immunotherapeutic potential.
Godfrey and colleagues review the basic biology, development, role in disease and immunotherapeutic potential of MAIT cells.
Journal Article
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the best studied of the T cell subsets, but ‘unconventional’ T cells have emerged as being more abundant and influential than has previously been appreciated. Key subsets of unconventional T cells include natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells and γδ T cells; collectively, these make up ~10% of circulating T cells, and often they are the majority of T cells in tissues such as the liver and gut mucosa. Defects and deficiencies in unconventional T cells are associated with autoimmunity, chronic inflammation and cancer, so it is important to understand how their development is regulated. In this Review, we describe the thymic development of NKT cells, MAIT cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.The authors compare the thymic development of several innate-like T cell populations, including natural killer T cells, mucosal-associated invariant T cells and γδ T cells. They focus on the cytokines, surface molecules and transcription factors that are necessary for the development of these cells and highlight some of the key differences from conventional T cell development.
Journal Article
‘If I drop this, I’ll kill the queen’: how I launched a veterinary practice for bees
Elizabeth Hilborn is among just a handful of people in the United States who are medically trained to treat honeybees.
Elizabeth Hilborn is among just a handful of people in the United States who are medically trained to treat honeybees.
Elizabeth Hilborn wearing a beekeeping suit and inspecting a brood frame from a hive
Credit: Kate Medley for
Nature
Journal Article
Deep harbor
\"When Carol Ann 'CJ' Jansen lost her beloved older brother, Kick, in a boating accident, she came adrift. Kick had taken on the role of caring for his little sister after their parents were killed in a car crash. Inheriting half his fortune has left CJ financially secure--yet needing a purpose. As administrative assistant to powerful congressman Snapper Lewis, she's immersed herself in the exciting and often tumultuous world of politics. But suddenly, the career that anchors her life is threatened. CJ stumbles upon information that could implicate her boss in corruption. When the congressman goes missing, the closer CJ gets to uncovering the truth, exposing one shocking secret after another, the more she wonders if she's also in jeopardy. Moving to a small New England town for her own protection, CJ gradually begins to engage with her new surroundings. Her blossoming friendship with the owner of a charter fishing boat offers the promise of much more. But before she can claim happiness, CJ must navigate a course through all her doubts and fears, and trust that this time, the water that took so much from her might just lead her safely home\"-- Provided by publisher.
Book
Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability
Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammatory properties. These crucial properties of vitamin E are beneficial in various aspects of health, especially in neuroprotection and cardiovascular, skin and bone health. However, the poor bioavailability of vitamin E, especially tocotrienols, remains a great limitation for clinical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. This review focuses on the pharmacological properties and pharmacokinetics of vitamin E and current advances in vitamin E nanoformulations for future clinical applications. The limitations and future recommendations are also discussed in this review.
Journal Article
Sweet vengeance
\"Tessa Jamison couldn't have imagined anything worse than losing her beloved twin girls and husband-- until she was convicted of their murder. For ten years, she has counted off the days in Florida's Correctional Center for Women, fully expecting to die behind bars. Fighting to prove her innocence holds little appeal now that her family's gone. But one extraordinary day, her lawyers announce that Tessa's conviction has been overturned on a technicality, and she's released on bail to await a new trial. Hounded by the press, Tessa retreats to the small tropical island owned by her late husband's pharmaceutical company. There, she begins to gather knowledge about her case. For the first time since her nightmare began, Tessa feels a sense of purpose in working to expose the truth and avenge her family. One by one, the guilty will be led to justice, and Tessa can gain closure\"-- Provided by publisher.
Book
A More-than-Human Ecology: Evolving Generative Artificial Intelligence in Higher Education
The significant improvements in generative artificial intelligence (GenAI) observed in recent years present higher education with both an opportunity and a significant challenge. Its successful integration will require careful planning and sound pedagogical underpinnings, both in regard to learning and teaching as well as assessment and feedback. Drawing upon theories from the more-than-human world, as well as concepts such as originality, equality, and sustainability, it is possible to develop a dialogue around GenAI that places the students’ learning journey at the heart of the discussion.
Journal Article