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"Ferrari, Alessandro"
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Star wars, the prequel trilogy : a graphic novel
\"Relive the beginnings of the ultimate tale of good versus evil! Join Anakin Skywalker, Obi-Wan Kenobi, Padmâe Amidala, Yoda, Darth Maul, and the rest of the heroes and villains from the Star Wars universe in this graphic novel collection that retells the prequel trilogy.\"-- Back cover.
Book
SARS-CoV-2 vaccine breakthrough infections with the alpha variant are asymptomatic or mildly symptomatic among health care workers
Vaccine breakthrough SARS-CoV-2 infection has been monitored in 3720 healthcare workers receiving 2 doses of BNT162b2. SARS-CoV-2 infection is detected in 33 subjects, with a 100-day cumulative incidence of 0.93%. Vaccine protection against acquisition of SARS-CoV-2 infection is 83% (95%CI: 58–93%) in the overall population and 93% (95%CI: 69-99%) in SARS-CoV-2-experienced subjects, when compared with a non-vaccinated control group from the same Institution, in which SARS-CoV-2 infection occurs in 20/346 subjects (100-day cumulative incidence: 5.78%). The infection is symptomatic in 16 (48%) vaccinated subjects
vs
17 (85%) controls (p = 0.01). All analyzed patients, in whom the amount of viral RNA was sufficient for genome sequencing, results infected by the alpha variant. Antibody and T-cell responses are not reduced in subjects with breakthrough infection. Evidence of virus transmission, determined by contact tracing, is observed in two (6.1%) cases. This real-world data support the protective effect of BNT162b2 vaccine. A triple antigenic exposure, such as two-dose vaccine schedule in experienced subjects, may confer a higher protection.
Several COVID-19 vaccines have shown good efficacy in clinical trials. Here, the authors provide real world effectiveness data in a group of BNT162b2 vaccinated health care workers and find that breakthrough infections are asymptomatic or mild.
Journal Article
Star wars. Episode IV
\"Capturing the galaxy-spanning action of A New Hope, experience Episode IV as a beautiful graphic novel combining the epic wonder of Star Wars with streamlined, young-reader friendly designs. This all-ages graphic novel is a must-read for longtime fans and a great introduction for newcomers!\"-- Provided by publisher.
Book
Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology
Full Laboratory Automation is revolutionizing work habits in an increasing number of clinical microbiology facilities worldwide, generating huge streams of digital images for interpretation. Contextually, deep learning architectures are leading to paradigm shifts in the way computers can assist with difficult visual interpretation tasks in several domains. At the crossroads of these epochal trends, we present a system able to tackle a core task in clinical microbiology, namely the global interpretation of diagnostic bacterial culture plates, including presumptive pathogen identification. This is achieved by decomposing the problem into a hierarchy of complex subtasks and addressing them with a multi-network architecture we call
DeepColony
. Working on a large stream of clinical data and a complete set of 32 pathogens, the proposed system is capable of effectively assist plate interpretation with a surprising degree of accuracy in the widespread and demanding framework of Urinary Tract Infections. Moreover, thanks to the rich species-related generated information,
DeepColony
can be used for developing trustworthy clinical decision support services in laboratory automation ecosystems from local to global scale.
DeepColony is a multi-level AI solution for the interpretation of bacterial culturing images in clinical microbiology laboratory automations. Here, the authors show it allows presumptive identification and quantitation of relevant pathogens at both colony- and plate-level.
Journal Article
Injected Fuel Mass and Flow Rate Control in Internal Combustion Engines: A Systematic Literature Review
Advancements in fuel injection systems have dramatically improved the precision of controlling injected fuel mass or flow rate; a key factor in optimizing internal combustion engine (ICE) performance, emissions control, and fuel efficiency. This review systematically analyzes 145 scientific research papers from the last two decades, including older foundational works, tracing the evolution of injected mass control from early Bosch and Zeuch meters to advanced machine learning or physical models. This study draws upon research collected from the most reputable databases. Through both qualitative and quantitative analyses, the state-of-the-art of these systems is presented, and key innovations are highlighted regarding advanced control algorithms and real-time feedback mechanisms under various operational conditions such as high or transient loads and multi-stage injection strategies. Special attention is given to challenges in maintaining precise control with alternative fuels like biodiesel, hydrogen, or synthetic fuels, which exhibit different physical properties compared to traditional fuels. The findings emphasize the need for further research on injection control, especially in light of stringent emissions regulations. Improving these systems for next-generation ICEs is a key point for achieving cleaner, more efficient combustion and bridging the sustainability gap between traditional and future mobility solutions.
Journal Article
Human type I interferons protect Vero E6 and ARPE-19 cells against West Nile virus and are neutralized by pathogenic autoantibodies
Auto-antibodies (auto-Abs) that neutralize type I interferons (IFNs) have been implicated in severe viral infections, including ~ 40% of cases of West Nile virus (WNV) neuroinvasive disease (WNND). Developing robust in vitro models to evaluate the protective effects of type I IFNs against viral infection, as well as the disruptive effects of auto-Abs, is essential for understanding disease pathogenesis and identifying patients at risk. In this study, we used Vero E6 and ARPE-19 cell lines to investigate the ability of type I (IFN-α, IFN-β, IFN-ω), type II (IFN-γ), and type III (IFN-λ1) IFNs to restrict WNV infection. Our results demonstrate that IFN-α, IFN-β, and IFN-ω effectively protect ARPE-19 cells from WNV infection, with IFN-β exhibiting the strongest antiviral effect. In contrast, Vero E6 cells required higher concentrations of IFN-ω to achieve comparable protection. Neither IFN-γ nor IFN-λ1 conferred protection in either cell line. We further screened serum samples from WNV-infected patients for auto-Abs neutralizing type I IFNs. Our findings confirm that the ARPE-19-based assay is consistent with other established methods for detecting neutralizing auto-Abs against type I IFNs. This simple and reliable assay offers a valuable tool for assessing the antiviral effects of type I IFNs and the neutralizing activity of auto-Abs in both research and clinical settings. Future studies should aim to validate the clinical utility of the ARPE-19-WNV infection model on a larger scale.
Journal Article
Effects of Rate-Shaped and Multiple Injection Strategies on Pollutant Emissions, Combustion Noise and Fuel Consumption in a Low Compression Ratio Diesel Engine
An experimental investigation has been carried out to highlight the effects of different injection strategies on the performance and emissions of a low compression ratio Euro 5 diesel engine operated with high EGR rates. Rate-shaped main injections, achieved with piezoelectric and solenoid injectors by means of boot and injection fusion, respectively, as well as optimized multiple injection patterns have been compared. The results of the comparisons, performed with reference to a state-of-the-art double pilot-Main (pM) strategy, are presented in terms of engine-out exhaust emissions, combustion noise (CN) and fuel consumption. Rate-shaped main injections, when included in delayed multiple injection patterns, have shown a minor influence on reducing NOx, while a slight deterioration in soot has been found. Both a double pilot and a boot injection schedule have been able to reduce CN at low loads. A higher reduction in CN has been obtained with an injection fusion event. Finally, DoE optimized triple and quadruple injection strategies have led to improved soot-NOx trade-offs, with respect to the pM calibration. In fact, splitting the injection helps to entrain air inside the fuel plumes, thus creating locally leaner mixture (less prone to forming soot) and allowing increasing the EGR rates (reducing NOx formation).
Journal Article
Experimental Measurement and Numerical Validation of the Flow Ripple in Internal Gear Pumps
The flow ripple in an internal gear pump was measured by means of a new instantaneous high-pressure flowmeter. The flowmeter consists of two pressure sensors mounted on a piece of the straight steel pump delivery line, and a variable-diameter orifice was installed along such a line, downstream of the flowmeter, to generate a variable load. Three distinct configurations of the high-pressure flowmeter, characterized by a different distance between the pressure transducers, were analyzed. Furthermore, a comprehensive fluid dynamic 3D model of the pump and of its high-pressure delivery line was developed and validated in terms of both the delivery pressure and the flow ripple for different pump working conditions. For the three examined configurations of the flowmeter, the measured flowrate time histories matched the corresponding numerical distributions at the various operating points. Finally, the validated 3D model was applied to predict the incomplete filling working of the interteeth chambers, and the obtained numerical pressure time histories along the delivery line were used, as input data, to assess the reliability of the flowmeter algorithm even in these severe operating conditions.
Journal Article
Exact solutions for quasi-one-dimensional compressible viscous flows in conical nozzles
New analytical solutions for the one-dimensional steady-state compressible viscous adiabatic flow of an ideal gas through a conical nozzle or diffuser have been obtained. In order to analytically solve the problem, it is essential to determine the correct transformations of the variables and to identify the kinetic energy per unit of mass as the physical variable that appears in the final Abel ordinary differential equation. A dimensionless representation is given of the new solution, which points out the fundamental role exerted by some dimensionless groups in problems where viscous power dissipation and variable flow areas are present simultaneously as driving factors of flow changes. Furthermore, a steady-state fluid dynamics analysis of the compressible viscous flows in conical nozzles and diffusers has been carried out to improve the physical interpretation of the solutions. Finally, the thus determined analytical solutions have been validated for both subsonic and supersonic flows through a comparison with numerical solutions pertaining to the same ordinary differential equation. However, when the exact solution includes shocks, the time-asymptotic numerical solutions of the Euler equations for the quasi-one-dimensional unsteady-state gas dynamics are used for validation and the discretisation is performed by applying a finite volume technique. The proposed analytical solutions are complementary to the Fanno and nozzle models that refer to a viscous adiabatic constant cross-section pipe flow and an inviscid adiabatic variable cross-section pipe flow, respectively, and extend the collection of the exact solutions of gas dynamics.
Journal Article
Experimental Investigation on Gasoline—Water Mixture Fuel Impingement Preparation Method and Spray Characteristics with High Injection Temperatures and Pressures
Gasoline–water mixed injections are of great interest because of their advantages for reduced manufacturing costs and improved atomization, with the potential to alleviate engine detonation and reduce emissions. In this work, based on the principle of impinging flow, a real-time gasoline–water mixture preparation system for internal combustion engines was designed and the preparation system performance was compared with the standard swirl mixing technique. An image processing method was established to quantify the uniformity of the prepared mixture. Based on the flash-boiling spray flash-boiling spray experiment, the spray characteristics of different gasoline–water mixtures were analyzed under different injection temperatures (30–160 °C) and pressures (5–15 MPa). The experiments showed that the impinging pressure was the main factor affecting the emulsification performance of the real-time gasoline–water mixture, and that the proposed real-time mixing system could produce a stable gasoline–water emulsion. For temperatures in the 30–160 °C range, the flash-boiling spray flash-boiling spray experiments showed that the spray penetration distance first decreases and then increases with the injection temperature, while the spray angle shows an opposite trend. The turning point corresponded to the flash-boiling point of each gasoline–water mixture.
Journal Article