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I have two objectives in this paper. The first is to investigate whether, and to what extent, truth is valuable. I do this by first isolating the value question from other normative questions. Second, I import into the debate about the nature of truth some key distinctions hailing from value theory. This will help us to clarify the sense in which (and to what extent) truth is valuable. I then argue that there is significant variability in the value of truth in different areas of discourse. I shall call this the axiological variability conjecture (AVC). I illustrate and substantiate AVC by contrasting the occurrence of disagreement in two paradigmatically evaluative areas of discourse, viz. matters of taste, on the one hand, and morality, on the other. I claim that there is a reasonable tendency to care much more about settling moral disagreements than taste disagreements and that this difference has to do, at least partly but significantly, with the different value that truth exhibits in these two areas of discourse. I then turn to the second objective of the paper—namely, to discuss how pluralistic accounts of the nature of truth may deal with the value of truth in light of AVC. I will argue that AVC is a problem for all versions of truth pluralism that are committed to the following two theses: (1) that truth is a value concept; and (2) that this characteristic of the concept has to be reflected in the metaphysical nature of any admissible truth properties—i.e., all the various properties that are admissible (qua truth properties) in the pluralist account are value-conferring properties and thus intrinsically valuable. In so doing, I will focus primarily on Michael Lynch’s functionalist incarnation of truth pluralism. Lynch terms this “Manifestation Alethic Pluralism” (MAP). My reason for this is twofold: first and foremost, MAP is a paradigmatic exemplification of a model of truth pluralism that is committed to both (1) and (2); second, MAP has, to date, enjoyed the most discussion, and currently provides the most developed account of truth pluralism. However, I argue that MAP lacks the resources to account for AVC. Owing to this, I suggest two ways out for an advocate of MAP, which force various structural changes in her view.

Introduction There is a demand for intraoperative diagnostic support and image guidance in oncological surgery. Novel techniques can provide images similar to histopathological slides within a few minutes. Optical coherence tomography (OCT) and full-field OCT (FF-OCT) provide images with resolution greater than a hundred micrometers without the need for exogenous contrast agents or specimen staining. The aim of this systematic review was to assess the current clinical applications of OCT and dynamic cell imaging (DCI) in oncologic surgery, examining the translation challenges and proposing perspectives for improving future clinical applications. Materials and Methods The study adhered to the PRISMA guidelines. PubMed, Google Scholar, and ClinicalTrials.gov were searched up to July 2024. Manuscripts reporting data on OCT and (D)-FF-OCT application in oncologic surgery were included in the qualitative analysis. Results Thirty-one studies met the inclusion criteria. Most were from the fields of dermatologic (25.8%) and breast cancer (29%) surgery, followed by prostate and bladder (9.6%), ovarian (9.6%), head and neck (6.4%), gastrointestinal (6.4%), hepato-biliary (3.2%), and general surgery (9.6%). The majority of articles focused on FF-OCT and DCI (80.6%). Compared with the gold standard of final pathology, the OCT sensitivity ranged between 66.7 and 94%, the specificity between 64 and 100%, and the accuracy between 73 and 96%. Conclusions The medical use of OCT has expanded from ophtalmology to other fields including gastroenterology and oncology and, with techniques such as FF-OCT and DCI, can enable rapid intraoperative diagnosis beyond classic histopathology.

Starting from a proof-theoretic perspective, wheremeaning is determined by the inference rules governing logical operators, in this paper we primarily aim at developing a proof-theoretic alternative to the model-theoretic meaning-invariant logical pluralism discussed in Beall and Restall (Logical pluralism, Oxford University Press, Oxford, 2006). We will also outline how this framework can be easily extended to include a form of meaning-variant logical pluralism. In this respect, the framework developed in this paper—which we label two-level proof-theoretic pluralism—is much broader in scope than the one discussed in Beall and Restall’s book.

Thermalization in quantum many-body systems typically unfolds over timescales governed by intrinsic relaxation mechanisms. Yet, its spatial aspect is less understood. We investigate this phenomenon in the nonequilibrium steady state (NESS) of a Bose-Hubbard chain subject to coherent driving and dissipation at its boundaries, a setup inspired by current designs in circuit quantum electrodynamics. The dynamical fingerprints of chaos in this NESS are probed using semiclassical out-of-time-order correlators within the truncated Wigner approximation. At intermediate drive strengths, we uncover a two-stage thermalization along the spatial dimension: phase coherence is rapidly lost near the drive, while amplitude relaxation occurs over much longer distances. This separation of scales gives rise to an extended hydrodynamic regime exhibiting anomalous temperature profiles, which we designate as a “prethermal” domain. At stronger drives, the system enters a nonthermal, non-chaotic finite-momentum condensate characterized by sub-Poissonian photon statistics and a spatially modulated phase profile, whose stability is undermined by quantum fluctuations. We explore the conditions underlying this protracted thermalization in space and argue that similar mechanisms are likely to emerge in a broad class of extended driven-dissipative systems. Thermalization in quantum many-body systems can unfold across space in surprising ways. The authors reveal nonequilibrium regimes in a driven-dissipative quantum chain, including a spatially emergent prethermal domain and a nonthermal condensate destabilized by quantum fluctuations, with broad implications for driven quantum platforms

Background and Objectives: To summarize the evidence on in vivo uterine pelvic lymphatic drainage. Materials and Methods: A literature search was performed in multiple electronic databases from inception to December 2024. We included all the studies that compared two different uterine injection sites in the mapping of pelvic sentinel lymph nodes by injecting two different tracers into two distinct injection sites. The primary outcomes included the concordance and discordance rates in the mapped pelvic sentinel lymph nodes between the pairs of injection sites. The secondary outcomes were the detection rates per injection site and tracer. Four reviewers independently reviewed the records for inclusion, assessed the risk of bias, and extracted the data. Pooled concordance, discordance, and detection rates with 95% confidence intervals (CIs) were estimated using the random effects model. Heterogeneity was quantified using the I2 tests. Results: Out of 2512 records, we included 4 studies (172 patients and 344 hemipelves). Three studies injected the cervix with the technetium-99m and the uterine corpus with methylene blue; one study injected the cervix with indocyanine green and the utero-ovarian ligament with methylene blue. Both tracers/injection sites successfully identified a sentinel lymph node in 132 hemipelves (132/344; 38.4%), identifying the same sentinel lymph node in 116 cases (116/132; 87.9%). The pooled concordance rate per hemipelvis was 91.8% (95% CI 0.665–1.000; I2 = 92%; chi2 p-value < 0.01). Two different sentinel lymph nodes were identified in the remaining 16 hemipelves, with a pooled hemipelvis discordance rate of 8.2% (95% CI 0.000–0.335; I2 = 92%; chi2 p-value < 0.01). The cervix and technetium-99m were the injection site and tracer with the highest pooled detection rate. Conclusions: Different uterine injection sites appear to share a common pelvic lymphatic pathway and sentinel lymph node in most cases, consistent with the current practice in endometrial cancer. Future research will confirm whether cervical injections might be proposed for pelvic sentinel lymph node mapping in all gynecological cancers.

PurposeThis research paper aims to integrate the employee-related factors that empirical literature considers antecedents of performance (skills, work motivation, personal characteristics) into a multiple linear regression model, and to test such a model in order to measure the level of each individual factor on the performance.Design/methodology/approachQuantitative, multisource research approach. After testing the validity of the model with a Confirmatory Factor Analysis, this research applies the multiple linear regression model Work performance = a(Skills) + b(Work Motivation) + c(Personal Characteristics) + e(constant) to two different samples of workers: chemical technicians (N = 63) and salespeople (N = 61).FindingsThis study confirms the factorial structure of the antecedents of work performance, showing that skills, motivation, and personal characteristics are three general employee-related factors underlying work performance. The statistical analysis highlights a variance in performance between 40 and 65% explained by employee-related factors, hence leaving 35–60% as due to factors outside the model (firm/environment-related and/or job-related factors, or other skills and personal characteristics not considered in the model). The study also highlights that employee-related factors sometimes affect performance differently than job designers' expectations, and sometimes even negatively.Research limitations/implicationsThe equation was tested on two case studies, so further explorations are needed. Furthermore, the approach adopted is inductive thus describing performance as it is, not as it should be. Therefore, it explains the best actual performance of workers, not the ideal performance.Practical implicationsThe equation tested here represents a simple and valid tool to guide many Human Resource Management practices, such as; selection, training, development, and career orientation.Social implicationsFindings provide a valid indication for designing and managing human resource management systems more even-handedly, from an organizational and employee point of view. In doing so, it drives organizations towards a better Person/Job fit.Originality/valueThe study represents one of the first attempts to take into consideration multiple factors simultaneously in explaining work performance.

PurposeTo summarize available evidence comparing the transdermal and the oral administration routes of hormone replacement therapy (HRT) in postmenopausal women.MethodsWe performed a systematic review of the literature on multiple databases between January 1990 and December 2021. We included randomized controlled trials and observational studies comparing the transdermal and oral administration routes of estrogens for HRT in postmenopausal women regarding at least one of the outcomes of interest: cardiovascular risk, venous thromboembolism (VTE), lipid metabolism, carbohydrate metabolism, bone mineral density (BMD), and risk of pre-malignant and malignant endometrial lesions, or breast cancer.ResultsThe systematic literature search identified a total of 1369 manuscripts, of which 51 were included. Most studies were observational and of good quality, whereas the majority of randomized controlled trials presented a high or medium risk of bias. Oral and transdermal administration routes are similar regarding BMD, glucose metabolism, and lipid profile improvements, as well as do not appear different regarding breast cancer, endometrial disease, and cardiovascular risk. Identified literature provides clear evidence only for the VTE risk, which is higher with the oral administration route.ConclusionsAvailable evidence comparing the transdermal and oral administration routes for HRT is limited and of low quality, recommending further investigations. VTE risk can be considered the clearest and strongest clinical difference between the two administration routes, supporting the transdermal HRT as safer than the oral administration route.

Purpose Drawing on Bandura’s social learning theory (SLT), the purpose of this paper is to investigate, analytically, the impact that after-training skills level (i.e. perceived skill match) has on change self-efficacy. Moreover, this research also aims to identify which specific skills sets (if any) act as a protective factor during organizational change, supporting the change confidence (CC) level of the people involved. Design/methodology/approach Quantitative research was carried out on a sample of 200 workers in the bank sector. Findings Findings of this study suggest that skill match has a significant impact on the CC level. Furthermore, this study demonstrates that, even in front-office jobs, a perceived skill match of soft skills does not have a significant impact on staff CC, unlike that suggested by common sense and by literature. Research limitations/implications Future research should investigate if and how a training process enables change self-efficacy over time or instead shows its utility only when it is relating to a specific and limited period. Practical implications This study suggests that in designing training, top and middle management should pay specific attention to change recipients’ needs by adopting a bottom-up approach. Moreover, to improve training effectiveness, it would be advisable to also train change recipients’ supervisors. Social implications This study has social implications in suggesting how to foster the adaptive capabilities of change recipients in current turbulent times. In doing so, it suggests how to prevent some undesirable change consequences such as anxiety, intention to quit, work-related stress and change cynicism. Originality/value This paper shows that, from a methodological point of view, it is necessary to evaluate training effectiveness at the level of a specific skill area and not simply by comparing the trained/not trained people, as typically practiced until now.

Background: Laparoscopic surgery for endometriosis presents unique challenges due to the complexity of and variability in lesion appearances within the abdominal cavity. This study investigates the application of deep learning models for object detection in laparoscopic videos, aiming to assist surgeons in accurately identifying and localizing endometriosis lesions and related anatomical structures. A custom dataset was curated, comprising of 199 video sequences and 205,725 frames. Of these, 17,560 frames were meticulously annotated by medical professionals. The dataset includes object detection annotations for 10 object classes relevant to endometriosis, alongside segmentation masks for some classes. Methods: To address the object detection task, we evaluated the performance of two deep learning models—FasterRCNN and YOLOv9—under both stratified and non-stratified training scenarios. Results: The experimental results demonstrated that stratified training significantly reduced the risk of data leakage and improved model generalization. The best-performing FasterRCNN object detection model achieved a high average test precision of 0.9811 ± 0.0084, recall of 0.7083 ± 0.0807, and mAP50 (mean average precision at 50% overlap) of 0.8185 ± 0.0562 across all presented classes. Despite these successes, the study also highlights the challenges posed by the weak annotations and class imbalances in the dataset, which impacted overall model performances. Conclusions: In conclusion, this study provides valuable insights into the application of deep learning for enhancing laparoscopic surgical precision in endometriosis treatment. The findings underscore the importance of robust dataset curation and advanced training strategies in developing reliable AI-assisted tools for surgical interventions. The latter could potentially improve the guidance of surgical interventions and prevent blind spots occurring in difficult to reach abdominal regions. Future work will focus on refining the dataset and exploring more sophisticated model architectures to further improve detection accuracy.

Landau–Zener–Stückelberg–Majorana (LZSM) interference occurs when qubit parameters are periodically modulated across avoided level crossings. We explore this phenomenon in nonlinear multilevel bosonic systems, where interference is influenced by multiple energy levels. We fabricate two superconducting resonators with flux-tunable Josephson junction arrays. The first device, exhibiting weak nonlinearity, behaves like a linear resonator under weak driving but shows LZSM interference akin to two-level systems. With stronger driving, nonlinear effects alter the interference pattern. We theoretically demonstrate that merging LZSM peaks can lead to dissipative quantum chaos. In the second device, where nonlinearity exceeds photon-loss rates, we observe additional LZSM peaks from Kerr multiphoton resonances. Under Floquet theory, these resonances represent synthetic modes of coupled nonlinear cavities, revealing effective coupling as modulation parameters vary. Our findings advance the understanding of LZSM physics and emphasize the control of nonlinear Floquet states and the emergence of chaos in engineered systems, with significant implications for novel applications in quantum dynamics and quantum control.