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"Ferrari, P"
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Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort
Background/Objectives:
We aimed to investigate the differences in plasma concentrations and in intakes of amino acids between male meat-eaters, fish-eaters, vegetarians and vegans in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition.
Subjects/Methods:
This cross-sectional analysis included 392 men, aged 30–49 years. Plasma amino acid concentrations were measured with a targeted metabolomic approach using mass spectrometry, and dietary intake was assessed using a food frequency questionnaire. Differences between diet groups in mean plasma concentrations and intakes of amino acids were examined using analysis of variance, controlling for potential confounding factors and multiple testing.
Results:
In plasma, concentrations of 6 out of 21 amino acids varied significantly by diet group, with differences of −13% to +16% between meat-eaters and vegans. Concentrations of methionine, tryptophan and tyrosine were highest in fish-eaters and vegetarians, followed by meat-eaters, and lowest in vegans. A broadly similar pattern was seen for lysine, whereas alanine concentration was highest in fish-eaters and lowest in meat-eaters. For glycine, vegans had the highest concentration and meat-eaters the lowest. Intakes of all 18 dietary amino acids differed by diet group; for the majority of these, intake was highest in meat-eaters followed by fish-eaters, then vegetarians and lowest in vegans (up to 47% lower than in meat-eaters).
Conclusions:
Men belonging to different habitual diet groups have significantly different plasma concentrations of lysine, methionine, tryptophan, alanine, glycine and tyrosine. However, the differences in plasma concentrations were less marked than and did not necessarily mirror those seen for amino acid intakes.
Journal Article
Similarities and differences in the functional architecture of mother- infant communication in rhesus macaque and British mother-infant dyads
Similarly to humans, rhesus macaques engage in mother-infant face-to-face interactions. However, no previous studies have described the naturally occurring structure and development of mother-infant interactions in this population and used a comparative-developmental perspective to directly compare them to the ones reported in humans. Here, we investigate the development of infant communication, and maternal responsiveness in the two groups. We video-recorded mother-infant interactions in both groups in naturalistic settings and analysed them with the same micro-analytic coding scheme. Results show that infant social expressiveness and maternal responsiveness are similarly structured in humans and macaques. Both human and macaque mothers use specific mirroring responses to specific infant social behaviours (modified mirroring to communicative signals, enriched mirroring to affiliative gestures). However, important differences were identified in the development of infant social expressiveness, and in forms of maternal responsiveness, with vocal responses and marking behaviours being predominantly human. Results indicate a common
functional architecture
of mother-infant communication in humans and monkeys, and contribute to theories concerning the evolution of specific traits of human behaviour.
Journal Article
Contagious Yawning in Gelada Baboons as a Possible Expression of Empathy
Yawn contagion in humans has been proposed to be related to our capacity for empathy. It is presently unclear whether this capacity is uniquely human or shared with other primates, especially monkeys. Here, we show that in gelada baboons (Theropithecus gelada) yawning is contagious between individuals, especially those that are socially close, i.e., the contagiousness of yawning correlated with the level of grooming contact between individuals. This correlation persisted after controlling for the effect of spatial association. Thus, emotional proximity rather than spatial proximity best predicts yawn contagion. Adult females showed precise matching of different yawning types, which suggests a mirroring mechanism that activates shared representations. The present study also suggests that females have an enhanced sensitivity and emotional tuning toward companions. These findings are consistent with the view that contagious yawning reveals an emotional connection between individuals. This phenomenon, here demonstrated in monkeys, could be a building block for full-blown empathy.
Journal Article
Reasons for therapeutic inertia when managing hypertension in clinical practice in non-Western countries
Insufficient awareness of hypertension guidelines by physicians may be an impediment to achieving adequate blood pressure (BP) control rates in clinical practice. We therefore conducted an open intervention survey among primary care physicians in 1596 centres from 16 countries in four different continents to prospectively assess what is the BP goal defined by physicians for individual patients and what are the reasons for not intensifying antihypertensive treatment when BP goals are not achieved. Enrolled patients (
N
=35 302) were either not treated to goal (
N
=22 887) or previously untreated (
N
=12 250). Baseline systolic and diastolic BP averaged 159/95±15/12 mm Hg. BP goals defined by physicians averaged 136±6 mm Hg for systolic and 86±5 mm Hg for diastolic BP. Patients' individual risk stratification determined BP goals. At last visit BP averaged 132/81±11/8 mm Hg and values of ⩽140/90 were reached in 92% of untreated and 80% of previously uncontrolled treated hypertensives. The main reasons for not intensifying antihypertensive treatment when BP remained above goal were the assumption that the time after starting the new drug was too short to attain its full effect, the satisfaction with a clear improvement of BP or with a BP nearing the goal, and the acceptance of good self-measurements. In this open intervention program in primary care, a large proportion of patients achieved recommended BP goals. The belief that a clear improvement in BP is acceptable and that the full drug effect may take up to several weeks to be reached are frequent reasons for treatment inertia when goals are not achieved.
Journal Article
LIMIT DISTRIBUTIONS FOR KPZ GROWTH MODELS WITH SPATIALLY HOMOGENEOUS RANDOM INITIAL CONDITIONS
For stationary KPZ growth in 1 + 1 dimensions, the height fluctuations are governed by the Baik–Rains distribution. Using the totally asymmetric single step growth model, alias TASEP, we investigate height fluctuations for a general class of spatially homogeneous random initial conditions. We prove that for TASEP there is a one-parameter family of limit distributions, labeled by the diffusion coefficient of the initial conditions. The distributions are defined through a variational formula. We use Monte Carlo simulations to obtain their numerical plots. Also discussed is the connection to the six-vertex model at its conical point.
Journal Article
Ventricular arrhythmias among patients with implantable cardioverter‐defibrillator during the COVID‐19 pandemic
Background Coronavirus Disease‐2019 (COVID‐19) has been associated with myocardial injury and higher risk of arrhythmic complications. However, no reports are available about the effect of the ongoing pandemic on arrhythmias in patients at risk. Objective To describe the effect of COVID‐19 pandemic on arrhythmic burden among high‐risk patients. Methods This is a cross‐sectional study on the incidence of ventricular arrhythmia (VA) during the pandemic outbreak (study period), compared to the same timeframe in 2019 (reference period). Inclusion criteria were age (>18 years) and having an implantable cardiac defibrillator (ICD). Results Among 455 patients enrolled (mean age 64.9 ± 15.7 years; 25.1% females and 39.6% with CRTD), in the study period, 45 (9.9%) patients experienced a total of 86 VA; 8 patients (1.7%) required antitachycardia‐pacing (ATP) and 6 (1.3%) at least one shock. In the reference period, a total of 69 events occurred in 36 patients (7.9%). Six patients (1.3%) required ATP and three (0.7%) at least one shock. The number of patients that suffered from any arrhythmic events in the study period (9.9% vs 7.9%) did not significantly differ from the reference period (χ2 = 1.09, P = .29). The main predictor of VA during the COVID‐19 pandemic was the previous history of any ICD therapy (OR = 3.84, P < .001). Conclusions No evidence of an increase of arrhythmic burden was found during the COVID‐19 pandemic among patients with an ICD. Among 455 patients (mean age 64.9 ± 15.7 years), 25.1% were females and 39.6% had a CRTD. The number of patients that suffered from any arrhythmic events in the study period (9.9 vs 7.9%) did not significantly differ from the reference period (χ2 = 1.09, P = .29). No evidence of an increase of arrhythmic burden was found during the COVID‐19 epidemic.
Journal Article
Inflated beta distributions
This paper considers the issue of modeling fractional data observed on [0,1), (0,1] or [0,1]. Mixed continuous-discrete distributions are proposed. The beta distribution is used to describe the continuous component of the model since its density can have quite different shapes depending on the values of the two parameters that index the distribution. Properties of the proposed distributions are examined. Also, estimation based on maximum likelihood and conditional moments is discussed. Finally, practical applications that employ real data are presented.
Journal Article
From monkey mirror neurons to primate behaviours: possible 'direct' and 'indirect' pathways
The discovery of mirror neurons (MNs), deemed to be at the basis of action understanding, could constitute the potential solution to the 'correspondence problem' between one's own and others' action that is crucial for of imitative behaviours. However, it is still to be clarified whether, and how, several imitative phenomena, differing in terms of complexity and cognitive effort, could be explained within a unified framework based on MNs. Here we propose that MNs could differently contribute to distinct imitative behaviours by means of two anatomo-functional pathways, subjected to changes during development. A 'direct mirror pathway', directly influencing the descending motor output, would be responsible for neonatal and automatic imitation. This proposal is corroborated by some new behavioural evidences provided here. During development, the increased control of voluntary movements and the capacity to efficiently suppress automatic motor activation during action observation assign to the core MNs regions essentially perceptuo-cognitive functions. These functions would be exploited by an 'indirect mirror pathway' from the core regions of the MN system to prefrontal cortex. This latter would play a key role in parsing, storing and organizing motor representations, allowing the emergence of more efficient and complex imitative behaviours such as response facilitation and true imitation.
Journal Article
TRANSFORMING EARTH INTO HOUSES: A METHODOLOGY FOR DOCUMENTING CONSTRUCTION PROCESSES AS AN APPRENTICE IN THE IRANIAN DESERT, SOUTH KHORASAN
This article presents a methodology for recording and documenting building processes using an anthropological approach. The village of Esfahak, in the region of South Khorasan (Iran) is situated in an arid environment scarce in water and trees. These conditions have resulted in the development of building forms that are almost entirely made out of earth. For centuries houses have been erected by local master masons utilizing only mud bricks and without the use of any architectural drawings. This research seeks to document how building processes unfold and are implemented in the village, for both restoration and new constructions. The researcher undertakes ethnographic fieldwork examining the relationship between villagers and their architecture. This approach is based on participant observation, engaging the local community to study how buildings were and are conceived, constructed, inhabited, maintained and restored. Moreover, the research employs an apprentice-style fieldwork method to access building sites. Thus, the researcher learns by doing with masons as a way to embody local knowledge, and not merely through passive observation. The work on site, given its processual nature, is documented through audio-visual recordings from both an external and first-person perspective. The use of head-mounted cameras facilitates review and discussion of building processes with the masons allowing for an in-depth understanding of this craft practice.
Journal Article