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We present a list of photometricVRIcomparison sequences in the fields of 16 blazars. For six of these objects, comparison stars were calibrated for the first time during the present work. For most of the other 10 blazars, we improved the old sequences by either calibrating stars in theRandIbands or adding new comparison stars. Finding charts for 15 of these sequences are also reported.

We present a list of photometric VRI comparison sequences in the fields of 16 blazars. For six of these objects, comparison stars were calibrated for the first time during the present work. For most of the other 10 blazars, we improved the old sequences by either calibrating stars in the R and I bands or adding new comparison stars. Finding charts for 15 of these sequences are also reported. (Author)

The Asiago Database on Photometric Systems (ADPS) is a compilation of basic information and reference data on 201 photometric systems (both ground-based and space-born), available in book format (Moro and Munari, 2000) and electronically (http://ulisse.pd.astro.it/ADPS). It is a relevant source of information to address the legacy of existing photometric systems to the one being designed for the GAIA mission. Its use in such a context and the planned developments are briefly discussed.

In this paper we describe the hardware and software architecture of the Automatic Imaging Telescope (AIT), recently developed at the Perugia University Observatory. It is based on an existing 0.4-m telescope which was transformed into an automatic device. During the night, all the observatory functions are controlled by two PCs in an unattended mode. The system is equipped with an autoguider and the software was designed to allow the automatic reduction of the data at the end of the night. Since 1994 October the AIT has been collecting a large amount of BVR C I C data for about 30 blazars.

Rainfall-induced landslides represent a major threat to human activities, and thus an improved understanding of their triggering mechanisms is needed. The paper reports some preliminary inferences on this topic, based on the data recorded over a 2-year period by a multi-parametric monitoring station located on one of the slopes of the Monterosso catchment (Cinque Terre, north-western Italy). This catchment has experienced multiple, concurrent shallow landslides after intense rainfall events. After defining a soil hydraulic model through data interpretation and numerical simulations, slope stability analyses were performed to elucidate several aspects related to shallow landslide occurrence. Both long-term climate conditions and single rainfall events were simulated via physically based approaches. The findings from these simulations enabled us to assume the pattern of infiltration and quantify the impact of soil hydraulic behavior on landslide triggering conditions. In this regard, various analyses were carried out on the same triggering event both at local scale and in the overall catchment, with a view to highlighting the role of initial soil moisture and soil hysteretic behavior in slope stability.

Timely and systematic collection of landslide information after a triggering event is pivotal for the definition of landslide trends in response to climate change. On September 15, 2022, a large part of central Italy, particularly Marche and Umbria regions, was struck by an anomalous rainfall event that showed characteristics of a persistent convective system. An extraordinary cumulated rainfall of 419 mm was recorded by a rain gauge in the area in only 9 h. The rainfall triggered 1687 landslides in the area affected by the peak rainfall intensity and caused widespread flash floods and floods in the central and lower parts of the catchments. In this work, we describe the characteristics of the landslides identified during a field survey started immediately after the event. Most of the mass movements are shallow, and many are rapid (i.e., debris flows, earth flows) and widely affecting the road network. Landslide area spans from a few tens of square meters to 105 m2, with a median value of 87 m2. Field evidence revealed diffuse residual risk conditions, being a large proportion of landslides located in the immediate vicinity of infrastructures. Besides reporting the spatial distribution of landslides triggered by an extreme rainfall event, the data collected on landslides can be used to make comparisons with the distribution of landslides in the past, validation of landslide susceptibility models, and definition of the general interaction between landslides and structures/infrastructures.

Purpose Human papillomaviruses (HPVs) are the causative agents of cervical cancer and are also associated with other types of cancers. HPVs can modulate microRNAs (miRNAs) expressed by infected cells. The production of extracellular vesicles is deregulated in cancer, and their cargo delivered to the microenvironment can promote tumorigenesis. The involvement of HPV oncoproteins on miRNA expression in cells and exosomes was analyzed in keratinocytes transduced with E6 and E7 from mucosal HPV-16 or cutaneous HPV-38 (K16 and K38). Methods MiRNAs were investigated through the TaqMan Array Human MicroRNA Cards, followed by real-time RT-PCR assay for specific miRNAs. Selected miRNA targets were analyzed by Western blot and correlated to the HPV oncoproteins by specifically silencing E6 and E7 expression. Exosomes, isolated from K16 and K38 supernatants by differential centrifugations, were quantified through the vesicle-associated acetylcholinesterase activity. Results MiRNAs deregulated in K16 and K38 cells were identified. HPV-16 and/or HPV-38 E6 and E7 single proteins can modify the expression of selected miRNAs involved in the tumorigenesis, in particular miR-18a, -19a, -34a and -590-5p. The analysis of the content of exosomes isolated from HPV-positive cells revealed the presence of E6 and E7 mRNAs and few miRNAs. MiR-222, a key miRNA deregulated in many cancers, was identified in exosomes from K16 cells. Conclusions HPV E6 and/or E7 oncoprotein expression can induce the deregulation of some miRNAs. Through the production and function of exosomes, HPV oncogenes as well as HPV-deregulated miRNAs can potentiate the virus oncogenic effects in the tumor cell microenvironment.

Background Oral supplementation with some amino acids (like methionine, taurine, and cysteine) could be useful in subjects with hair loss conditions such as androgenic alopecia (AGA or FAGA) or telogen effluvium (TE). Hydrolysed collagen (HC) oral supplementation has demonstrated to have beneficial effects on nail and skin health and could improve hair growth. A food supplement in tablet formulation containing hydrolysed fish‐origin collagen (300 mg/dose), taurine, cysteine, methionine, iron, and selenium has been recently available. To date no controlled data are available regarding the clinical efficacy of this product as adjuvant to hair loss specific treatments in these clinical conditions. Study aims To evaluate and compare the efficacy and tolerability of an oral supplementation based on HC and amino acids in subjects with hair loss due to AGA/FAGA or chronic TE in combination with drug treatments in comparison with drug treatments alone. Methods and subjects In a prospective, 12‐week, randomized, assessor‐blinded controlled trial 83 subjects (mean age 41 ± 16 years; 26 men and 57 women) were enrolled in the study. Fifty‐nine subjects suffered from AGA/FAGA (Hamilton I‐VA, Ludwig I‐1, II‐2) and 24 from chronic TE. Subjects were randomized to oral supplementation (1 tablet day) in combination with the specify drug treatment decided by the investigator according to the type of hair loss (AGA/FAGA or TE) (Group A; N = 48) or to specific drugs treatment only (Group B; N = 35). The main outcome of the trial was the clinical efficacy evaluation using a 7‐point global assessment score (GAS) (from +3: Much Improved to ‐3 Much worsened; with score 0 representing no modification). The GAS score was evaluated using standardized photographs by an investigator unaware of the treatment groups at week 6 and at week 12. A secondary outcome was the evaluation of acceptability of the treatment regimen using a 10‐point evaluation score. Results Seventy‐six participants (91.6%) completed the 12‐week study period. The GAS score at week 6 was 0.5 ± 0.2 in group A and 0.0 ± 0.1 in Group B (p < 0.05; Mann‐Whitney). At week 12 the GAS score in Group A was statistically significant higher in comparison with Group B (1.67 ± 0.16 and 0.66 ± 0.20, p < 0.001; Mann–Whitney test). A higher percentage of Group A subjects achieved a GAS score of ≥2 in comparison with group B (50% vs. 23%). The oral supplement was generally well tolerated. Conclusion An oral supplement containing hydrolysed fish‐origin collagen, taurine, cysteine, methionine, iron, and selenium has demonstrated to improve the clinical efficacy of specific anti‐hair loss treatments in subjects with AGA/FAGA or chronic TE.

Interferon (IFN)-β inhibits cell proliferation and affects cell cycle in keratinocytes transformed by both mucosal high risk Human Papilloma Virus (HPV) and cutaneous HPV E6 and E7 proteins. In particular, upon longer IFN-β treatments, cutaneous HPV38 expressing cells undergo senescence. IFN-β appears to induce senescence by upregulating the expression of the tumor suppressor PML, a well known IFN-induced gene. Indeed, experiments in gene silencing via specific siRNAs have shown that PML is essential in the execution of the senescence programme and that both p53 and p21 pathways are involved. IFN-β treatment leads to a modulation of p53 phosphorylation and acetylation status and a reduction in the expression of the p53 dominant negative ΔNp73. These effects allow the recovery of p53 transactivating activity of target genes involved in the control of cell proliferation. Taken together, these studies suggest that signaling through the IFN pathway might play an important role in cellular senescence. This additional understanding of IFN antitumor action and mechanisms influencing tumor responsiveness or resistance appears useful in aiding further promising development of biomolecular strategies in the IFN therapy of cancer.

Purpose The role of oxidative stress is increasingly recognized in cognitive disorders of the elderly, notably Alzheimer’s disease (AD). In these subjects brain 18 F-FDG PET is regarded as a reliable biomarker of neurodegeneration. We hypothesized that oxidative stress could play a role in impairing brain glucose utilization in elderly subjects with increasing severity of cognitive disturbance. Methods The study group comprised 85 subjects with cognitive disturbance of increasing degrees of severity including 23 subjects with subjective cognitive impairment (SCI), 28 patients with mild cognitive impairment and 34 patients with mild AD. In all subjects brain FDG PET was performed and plasma activities of extracellular superoxide dismutase (eSOD), catalase and glutathione peroxidase were measured. Voxel-based analysis (SPM8) was used to compare FDG PET between groups and to evaluate correlations between plasma antioxidants and glucose metabolism in the whole group of subjects, correcting for age and Mini-Mental State Examination score. Results Brain glucose metabolism progressively decreased in the bilateral posterior temporoparietal and cingulate cortices across the three groups, from SCI to mild AD. eSOD activity was positively correlated with glucose metabolism in a large area of the left temporal lobe including the superior, middle and inferior temporal gyri and the fusiform gyrus. Conclusion These results suggest a role of oxidative stress in the impairment of glucose utilization in the left temporal lobe structures in elderly patients with cognitive abnormalities, including AD and conditions predisposing to AD. Further studies exploring the oxidative stress–energy metabolism axis are considered worthwhile in larger groups of these patients in order to identify pivotal pathophysiological mechanisms and innovative therapeutic opportunities.