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"Fischer, Anya"
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CONTEMPLAR LA VIDA: PASEOS, EXCURSIONES Y VIAJES DE CARMEN LAFORET
Tomando como corpus del trabajo los artículos que Carmen Laforet publicó de 1948 a 1953 en el semanario barcelonés Destino, en la sección titulada \"Puntos de vista de una mujer\", y las crónicas de su viaje a Estados Unidos en el otoño de 1965, recogidas en el libro Paralelo 35, estudio una faceta poco conocida de la autora: su perfil de paseante por diversas ciudades, de excursionista que se refugia en la naturaleza y de viajera que visita los más destacados enclaves de ese país norteamericano. Analizo en él cómo la escritora extiende una mirada desprejuiciada sobre la realidad y la vida que la rodea y envuelve, guiada por sus apetencias y gustos, por la curiosidad, atenta a detalles mínimos que estimulan su imaginación, a cualquier novedad o cambio que la impresione e impacte. También analizo la factura narrativa de los mismos: estampas y escenas o relatos articulados en torno a un suceso, una experiencia, un encuentro azaroso o los recuerdos personales. Vemos en ellos a una Carmen Laforet espectadora y oidora -e interlocutora- de la vida contemporánea, atenta siempre a captar esa realidad fluida y en constante movimiento que desfila ante sus ojos
Journal Article
UNAMUNO, PEREGRINO DE LA BELLEZA: ASCENSIÓN Y ASUNCIÓN, O DE UNA ESTÉTICA MONTESINA / Unamuno, Pilgrimage of Beauty: Ascension and Assumption, or about a natural esthetic
Partiendo de la experiencia del viaje en la vida y escritos de Unamuno, analizo los motivos —estéticos, sensuales, cordiales, físicos, intelectivos y políticos— que le impulsan determinados pueblos lugares de España, cuya práctica, ya desde su juventud, le permite transformar la experiencia sentimental en sensitiva, el amar en querer, paso previo a la accion, pues tales andanzas tienen una dimensión tanto estética como política. Estudio, consiguiente, la poderosa presencia e influencia de los lugares recorridos y sentidos por don Miguel, hasta el punto de llegar a constituir constelaciones casi permanentes en su universo literario, atendiendo a la significación de los espacios mas destacados —montaña, cima, llano, cumbre, sierra páramo—, y su importancia en la forja de conceptos claves en el pensamiento de Unamuno, como las parejas Asunción y Ascensión, In-tracción e In-versión. Starting with the travel experiences in the life and works of Unamuno, I analyze the different motifs —esthetic, sensual, emotive, physical, intellectual and political— that led the author to walk and travel around certain places in Spain. These exercises (as he called them), practiced since he was a young man in his native land, taught him how to transform a sentimental experience into a sensual one, love into desire, which was the prelude to action, since Unamuno's andanzas have both an esthetic and a political significance. I therefore point out and describe the presence and influence of the places/ spaces visited and felt by Unamuno, to the degree that they conform to a peculiar and permanent microcosm within his works, paying attention to and analyzing the most significant ones, not always present in the authors studies —mountain, peak, to, flatness mountain range or waste land— , and at the same time I review their importance in Unamuno's thought, especially in concepts such as Asumption, Ascension o In-traction and In-version.
Journal Article
A genome-wide association study of red-blood cell fatty acids and ratios incorporating dietary covariates: Framingham Heart Study Offspring Cohort
Recent analyses have suggested a strong heritable component to circulating fatty acid (FA) levels; however, only a limited number of genes have been identified which associate with FA levels. In order to expand upon a previous genome wide association study done on participants in the Framingham Heart Study Offspring Cohort and FA levels, we used data from 2,400 of these individuals for whom red blood cell FA profiles, dietary information and genotypes are available, and then conducted a genome-wide evaluation of potential genetic variants associated with 22 FAs and 15 FA ratios, after adjusting for relevant dietary covariates. Our analysis found nine previously identified loci associated with FA levels (FADS, ELOVL2, PCOLCE2, LPCAT3, AGPAT4, NTAN1/PDXDC1, PKD2L1, HBS1L/MYB and RAB3GAP1/MCM6), while identifying four novel loci. The latter include an association between variants in CALN1 (Chromosome 7) and eicosapentaenoic acid (EPA), DHRS4L2 (Chromosome 14) and a FA ratio measuring delta-9-desaturase activity, as well as two loci associated with less well understood proteins. Thus, the inclusion of dietary covariates had a modest impact, helping to uncover four additional loci. While genome-wide association studies continue to uncover additional genes associated with circulating FA levels, much of the heritable risk is yet to be explained, suggesting the potential role of rare genetic variation, epistasis and gene-environment interactions on FA levels as well. Further studies are needed to continue to understand the complex genetic picture of FA metabolism and synthesis.
Journal Article
Unamuno, peregrino de la belleza: Ascensión y Asunción, o de una estética montesina
Starting with the travel experience in the life and works of
Unamuno, I analize the different rehaznos esthetic, sensual, emotive, physical,
intellectual and political that led the autor to walk and travel around certain
places of Spain. Theseexercices (as he called them), practiced since he was a
young man in his native land, taught him how to transform the sentimental experience
in a sensual one, the love in desire, which was the first step for action,
since Unamuno s andanzas have both a esthetical and a political significance.According to this, I point out and describe the presence and influence of the
places/spaces visited and felt by Unamuno, so that they conform a peculiar and
permanent microcosmos within his Works, paying attention and analyzing the
most significant ones, not always present in the author s studies mountain,
peak, top, flatness, mountain range or waste land , and at the same time I review
their importance in Unamuno s Thought, specially in concpts such as Asunción,
Ascensión, In-tracción or In-versión. Partiendo de la experiencia del viaje en la vida y escritos de
Unamuno, analizo los motivos estéticos, sensuales, cordiales, físicos, intelectivos
y políticos que le impulsan a recorrer determinados pueblos y lugares de
España, cuya práctica, ya desde su juventud, le permite transformar la experiencia
sentimental en sensitiva, el amar en querer, paso previo a la acción, pues tales
andanzas tienen una dimensión tanto estética como política. Estudio, por consiguiente,
la poderosa presencia e influencia de los lugares recorridos y sentidos
por don Miguel, hasta el punto de llegar a constituir constelaciones casi permanentes
en su universo literario, atendiendo a la significación de los espacios más
destacados montaña, cima, llano, cumbre, sierra o páramo , y su importancia
en la forja de conceptos claves en el pensamiento de Unamuno, como las
parejas Asunción y Ascensión, o In-tracción e In-versión.
Journal Article
Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin
Nucleolar stress, characterized by loss of nucleolar integrity, has not been described in the cardiac context. In addition to ribosome biogenesis, nucleoli are critical for control of cell proliferation and stress responses. Our group previously demonstrated induction of the nucleolar protein nucleostemin (NS) in response to cardiac pathological insult. NS interacts with nucleophosmin (NPM), a marker of nucleolar stress with cytoprotective properties. The dynamic behavior of NS and NPM reveal that nucleolar disruption is an early event associated with stress response in cardiac cells. Rapid translocation of NS and NPM to the nucleoplasm and suppression of new preribosomal RNA synthesis occurs in both neonatal rat cardiomyocytes (NRCM) and cardiac progenitor cells (CPC) upon exposure to doxorubicin or actinomycin D. Silencing of NS significantly increases cell death resulting from doxorubicin treatment in CPC, whereas NPM knockdown alone induces cell death. Overexpression of either NS or NPM significantly decreases caspase 8 activity in cultured cardiomyocytes challenged with doxorubicin. The presence of altered nucleolar structures resulting from myocardial infarction in mice supports the model of nucleolar stress as a general response to pathological injury. Collectively, these findings serve as the initial description of myocardial nucleolar stress and establish the postulate that nucleoli acts as sensors of stress, regulating the cellular response to pathological insults.
Journal Article
