Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
1,204
result(s) for
"Fischer, Kim"
Sort by:
Randy Kazandy, where are your glasses?
Randy Kazandy's Mom keeps replacing the glasses he breaks, loses, or tosses away until Randy suddenly wants to wear glasses to look just like his Dad.
Book
Locally renewing resident synovial macrophages provide a protective barrier for the joint
Macrophages are considered to contribute to chronic inflammatory diseases such as rheumatoid arthritis
1
. However, both the exact origin and the role of macrophages in inflammatory joint disease remain unclear. Here we use fate-mapping approaches in conjunction with three-dimensional light-sheet fluorescence microscopy and single-cell RNA sequencing to perform a comprehensive spatiotemporal analysis of the composition, origin and differentiation of subsets of macrophages within healthy and inflamed joints, and study the roles of these macrophages during arthritis. We find that dynamic membrane-like structures, consisting of a distinct population of CX
3
CR1
+
tissue-resident macrophages, form an internal immunological barrier at the synovial lining and physically seclude the joint. These barrier-forming macrophages display features that are otherwise typical of epithelial cells, and maintain their numbers through a pool of locally proliferating CX
3
CR1
−
mononuclear cells that are embedded into the synovial tissue. Unlike recruited monocyte-derived macrophages, which actively contribute to joint inflammation, these epithelial-like CX
3
CR1
+
lining macrophages restrict the inflammatory reaction by providing a tight-junction-mediated shield for intra-articular structures. Our data reveal an unexpected functional diversification among synovial macrophages and have important implications for the general role of macrophages in health and disease.
Analysis of macrophage subsets within joints reveals a population of CX
3
CR1
+
tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.
Journal Article
The HADES Yield Prediction System – A Case Study on the Turkish Hazelnut Sector
Crop yield forecasting activities are essential to support decision making of farmers, private companies and public entities. While standard systems use georeferenced agro-climatic data as input to process-based simulation models, new trends entail the application of machine learning for yield prediction. In this paper we present HADES (HAzelnut yielD forEcaSt), a hazelnut yield prediction system, in which process-based modeling and machine learning techniques are hybridized and applied in Turkey. Official yields in the top hazelnut producing municipalities in 2004–2019 are used as reference data, whereas ground observations of phenology and weather data represent the main HADES inputs. A statistical analysis allows inferring the occurrence and magnitude of biennial bearing in official yields and is used to aid the calibration of a process-based hazelnut simulation model. Then, a Random Forest algorithm is deployed in regression mode using the outputs of the process-based model as predictors, together with information on hazelnut varieties, the presence of alternate bearing in the yield series, and agro-meteorological indicators. HADES predictive ability in calibration and validation was balanced, with relative root mean square error below 20%, and R 2 and Nash-Sutcliffe modeling efficiency above 0.7 considering all municipalities together. HADES paves the way for a next-generation yield prediction system, to deliver timely and robust information and enhance the sustainability of the hazelnut sector across the globe.
Journal Article
Rotten Hazelnuts Prediction via Simulation Modeling—A Case Study on the Turkish Hazelnut Sector
The quality defects of hazelnut fruits comprise changes in morphology and taste, and their intensity mainly depends on seasonal environmental conditions. The strongest off-flavor of hazelnuts is known as rotten defect, whose candidate causal agents are a complex of fungal pathogens, with Diaporthe as the dominant genus. Timely indications on the expected incidence of rotten defect would be essential for buyers to identify areas where hazelnut quality will be superior, other than being useful for farmers to have the timely indications of the risk of pathogens infection. Here, we propose a rotten defect forecasting model, and we apply it in the seven main hazelnut producing municipalities in Turkey. We modulate plant susceptibility to fungal infection according to simulated hazelnut phenology, and we reproduce the key components of the Diaporthe spp. epidemiological cycle via a process-based simulation model. A model sensitivity analysis has been performed under contrasting weather conditions to select most relevant parameters for calibration, which relied on weekly phenological observations and the post-harvest analyses of rotten incidence in the period 2016–2019, conducted in 22 orchards. The rotten simulation model reproduced rotten incidence data in calibration and validation datasets with a mean absolute error below 1.8%. The dataset used for model validation (321 additional sampling locations) has been characterized by large variability of rotten incidence, in turn contributing to decrease the correlation between reference and simulated data ( R 2 = 0.4 and 0.21 in West and East Black Sea region, respectively). This denotes the key effect of other environmental and agronomic factors on rotten incidence, which are not yet taken into account by the predictive workflow and will be considered in further improvements. When applied in spatially distributed simulations, the model differentiated the rotten incidence across municipalities, and reproduced the interannual variability of rotten incidence. Our results confirmed that the rotten defect is strictly dependent on precipitation amount and timing, and that plant susceptibility is crucial to trigger fungal infections. Future steps will envisage the application of the rotten simulation model to other hazelnut producing regions, before being operationally used for in-season forecasting activities.
Journal Article
Using Annual Landsat Time Series for the Detection of Dry Forest Degradation Processes in South-Central Angola
Dry tropical forests undergo massive conversion and degradation processes. This also holds true for the extensive Miombo forests that cover large parts of Southern Africa. While the largest proportional area can be found in Angola, the country still struggles with food shortages, insufficient medical and educational supplies, as well as the ongoing reconstruction of infrastructure after 27 years of civil war. Especially in rural areas, the local population is therefore still heavily dependent on the consumption of natural resources, as well as subsistence agriculture. This leads, on one hand, to large areas of Miombo forests being converted for cultivation purposes, but on the other hand, to degradation processes due to the selective use of forest resources. While forest conversion in south-central rural Angola has already been quantitatively described, information about forest degradation is not yet available. This is due to the history of conflicts and the therewith connected research difficulties, as well as the remote location of this area. We apply an annual time series approach using Landsat data in south-central Angola not only to assess the current degradation status of the Miombo forests, but also to derive past developments reaching back to times of armed conflicts. We use the Disturbance Index based on tasseled cap transformation to exclude external influences like inter-annual variation of rainfall. Based on this time series, linear regression is calculated for forest areas unaffected by conversion, but also for the pre-conversion period of those areas that were used for cultivation purposes during the observation time. Metrics derived from linear regression are used to classify the study area according to their dominant modification processes. We compare our results to MODIS latent integral trends and to further products to derive information on underlying drivers. Around 13% of the Miombo forests are affected by degradation processes, especially along streets, in villages, and close to existing agriculture. However, areas in presumably remote and dense forest areas are also affected to a significant extent. A comparison with MODIS derived fire ignition data shows that they are most likely affected by recurring fires and less by selective timber extraction. We confirm that areas that are used for agriculture are more heavily disturbed by selective use beforehand than those that remain unaffected by conversion. The results can be substantiated by the MODIS latent integral trends and we also show that due to extent and location, the assessment of forest conversion is most likely not sufficient to provide good estimates for the loss of natural resources.
Journal Article
Prone Torso Rotation Exercise Using a Stability Ball
MUSCLES INVOLVED Rectus abdominis, externaJ and interna obliques, transversus abdominis, erector spinae, quadratus lumborum, gluteus maximus, hamstrings (biceps femoris, sem itend inosus, semimembranosus) , tibialis anterior, trapezius, rhomboids, rotator cuff, anterior deltoids, pectoralis major, and triceps brachii.
Journal Article
Exercise Technique: Reverse Lunge Into a Step-Up
Proper exercise execution is paramount, and technique should not be sacrificed in lieu of load. [...] some decision making on the part of the strength and conditioning professional and/or personal trainer and athlete must be used to determine the proper initial and subsequent loads.
Journal Article
Alternating Inchworm and Pike from a Plank Exercise Using a Stability Ball
MUSCLES INVOLVED Core stabilizers, abdominal muscles (external and internal obliques and transverse and rectus abdominis), hip flexors (iliopsoas, rectus femoris, and sartorius). EXERCISE DESCRIPTION This exercise for the core stabilizers, abdominals, and hip flexors combines 2 separate exercises, the inchworm from a plank and the pike from a plank, into 1 fluid exercise, performed sequentially and repetitively using a stability ball.
Journal Article
Highly pathogenic avian influenza causes mass mortality in Sandwich Tern Thalasseus sandvicensis breeding colonies across north-western Europe
In 2022, highly pathogenic avian influenza (HPAI) A(H5N1) virus clade 2.3.4.4b became enzootic and caused mass mortality in Sandwich Tern Thalasseus sandvicensis and other seabird species across north-western Europe. We present data on the characteristics of the spread of the virus between and within breeding colonies and the number of dead adult Sandwich Terns recorded at breeding sites throughout north-western Europe. Within two months of the first reported mortalities, 20,531 adult Sandwich Terns were found dead, which is >17% of the total north-western European breeding population. This is probably an under-representation of total mortality, as many carcasses are likely to have gone unnoticed and unreported. Within affected colonies, almost all chicks died. After the peak of the outbreak, in a colony established by late breeders, 25.7% of tested adults showed immunity to HPAI subtype H5. Removal of carcasses was associated with lower levels of mortality at affected colonies. More research on the sources and modes of transmission, incubation times, effective containment, and immunity is urgently needed to combat this major threat for colonial seabirds.
Journal Article