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"Fischer, M."
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A poverty of rights : citizenship and inequality in twentieth-century Rio de Janeiro
A Poverty of Rights is an investigation of the knotty ties between citizenship and inequality during the years when the legal and institutional bases for modern Brazilian citizenship originated. Between 1930 and 1964, Brazilian law dramatically extended its range and power, and citizenship began to signify real political, economic, and civil rights for common people. And yet, even in Rio de Janeiro - Brazil's national capital until 1960 - this process did not include everyone. Rio's poorest residents sought with hope, imagination, and will to claim myriad forms of citizenship as their own. Yet, blocked by bureaucratic obstacles or ignored by unrealistic laws, they found that their poverty remained one of rights as well as resources. At the end of a period most notable for citizenship's expansion, Rio's poor still found themselves akin to illegal immigrants in their own land, negotiating important components of their lives outside of the boundaries and protections of laws and rights, their vulnerability increasingly critical to important networks of profit and political power. In exploring this process, Brodwyn Fischer offers a critical re-interpretation not only of Brazil's Vargas regime, but also of Rio's twentieth-century urban history and of the broader significance of law, rights, and informality in the lives of the very poor.
Book
Census and evaluation of p53 target genes
The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the
TP53
gene alters its response pathway, and is central to the development of many cancers. The discovery of a large number of p53 target genes, which confer p53’s tumor suppressor function, has led to increasingly complex models of p53 function. Recent meta-analysis approaches, however, are simplifying our understanding of how p53 functions as a transcription factor. In the survey presented here, a total set of 3661 direct p53 target genes is identified that comprise 3509 potential targets from 13 high-throughput studies, and 346 target genes from individual gene analyses. Comparison of the p53 target genes reported in individual studies with those identified in 13 high-throughput studies reveals limited consistency. Here, p53 target genes have been evaluated based on the meta-analysis data, and the results show that high-confidence p53 target genes are involved in multiple cellular responses, including cell cycle arrest, DNA repair, apoptosis, metabolism, autophagy, mRNA translation and feedback mechanisms. However, many p53 target genes are identified only in a small number of studies and have a higher likelihood of being false positives. While numerous mechanisms have been proposed for mediating gene regulation in response to p53, recent advances in our understanding of p53 function show that p53 itself is solely an activator of transcription, and gene downregulation by p53 is indirect and requires p21. Taking into account the function of p53 as an activator of transcription, recent results point to an unsophisticated means of regulation.
Journal Article
Jump!
From bugs and frogs to alligators and whales, frightened animals always move out of the way of a larger opponent.
Book
Storylines for unprecedented heatwaves based on ensemble boosting
Recent temperature extremes have shattered previously observed records, reaching intensities that were inconceivable before the events. Could the possibility of an event with such unprecedented intensity as the 2021 Pacific Northwest heatwave have been foreseen, based on climate model information available before the event? Could the scientific community have quantified its potential intensity based on the current generation of climate models? Here, we demonstrate how an ensemble boosting approach can be used to generate physically plausible storylines of a heatwave hotter than observed in the Pacific Northwest. We also show that heatwaves of much greater intensities than ever observed are possible in other locations like the Greater Chicago and Paris regions. In order to establish confidence in storylines of ‘black swan’-type events, different lines of evidence need to be combined along with process understanding to make this information robust and actionable for stakeholders.
Climate model ensemble boosting can yield physically coherent storylines for record-shattering climate extremes such as the 2021 Pacific Northwest heatwave. Combining information from storyline approaches with process understanding can inform planning for future extremes of unprecedented intensity.
Journal Article
Peter Pan in scarlet
Fearing for Peter Pan's life, Wendy and the Lost Boys go back to Neverland-- with the help of the fairy Fireflyer-- only to discover their worst nightmares coming true!
Book
Variability conceals emerging trend in 100yr projections of UK local hourly rainfall extremes
Extreme precipitation is projected to intensify with warming, but how this will manifest locally through time is uncertain. Here, we exploit an ensemble of convection-permitting transient simulations to examine the emerging signal in local hourly rainfall extremes over 100-years. We show rainfall events in the UK exceeding 20 mm/h that can cause flash floods are 4-times as frequent by 2070s under high emissions; in contrast, a coarser resolution regional model shows only a 2.6x increase. With every degree of regional warming, the intensity of extreme downpours increases by 5-15%. Regional records of local hourly rainfall occur 40% more often than in the absence of warming. However, these changes are not realised as a smooth trend. Instead, as a result of internal variability, extreme years with record-breaking events may be followed by multiple decades with no new local rainfall records. The tendency for extreme years to cluster poses key challenges for communities trying to adapt.
Climate projections at km-scale show that local hourly precipitation extremes in the UK become 4-times more frequent by 2070, while they do not intensify gradually with warming, but tend to cluster in time.
Journal Article
Top ten European heatwaves since 1950 and their occurrence in the coming decades
The Russian heatwave in 2010 killed tens of thousands of people, and was by far the worst event in Europe since at least 1950, according to recent studies and a novel universal heatwave index capturing both the duration and magnitude of heatwaves. Here, by taking an improved version of this index, namely the heat wave magnitude index daily, we rank the top ten European heatwaves that occurred in the period 1950–2014, and show the spatial distribution of the magnitude of the most recent heatwave in summer 2015. We demonstrate that all these events had a strong impact reported in historical newspapers. We further reveal that the 1972 heatwave in Finland had a comparable spatial extent and magnitude as the European heatwave of 2003, considered the second strongest heatwave of the observational era. In the next two decades(2021–2040), regional climate projections suggest that Europe experiences an enhanced probability for heatwaves comparable to or greater than the magnitude, extent and duration of the Russian heatwave in 2010. We demonstrate that the probability of experiencing a major European heatwave in the coming decades is higher in RCP8.5 than RCP4.5 even though global mean temperature projections do not differ substantially. This calls for a proactive vulnerability assessment in Europe in support of formulating heatwave adaptation strategies to reduce the adverse impacts of heatwaves.
Journal Article
Lottie Paris lives here
Relates a day in the life of a little girl who lives with her Papa Pete in a house across from a park.
Book
Robust spatially aggregated projections of climate extremes
There are large uncertainties associated with the projection of climate extremes. This study shows that the uncertainties are mainly due to internal climate variability. However, model projections are consistent when averaged across regions, allowing robust projection of future extremes.
Many climatic extremes are changing
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,
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,
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,
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, and decision-makers express a strong need for reliable information on further changes over the coming decades as a basis for adaptation strategies. Here, we demonstrate that for extremes stakeholders will have to deal with large irreducible uncertainties on local to regional scales as a result of internal variability, even if climate models improve rapidly. A multimember initial condition ensemble carried out with an Earth system model shows that trends towards more intense hot and less intense cold extremes may be masked or even reversed locally for the coming three to five decades even if greenhouse gas emissions rapidly increase. Likewise, despite a long-term trend towards more intense precipitation and longer dry spells, multidecadal trends of opposite sign cannot be excluded over many land points. However, extremes may dramatically change at a rate much larger than anticipated from the long-term signal. Despite these large irreducible uncertainties on the local scale, projections are remarkably consistent from an aggregated spatial probability perspective. Models agree that within only three decades about half of the land fraction will see significantly more intense hot extremes. We show that even in the short term the land fraction experiencing more intense precipitation events is larger than expected from internal variability. The proposed perspective yields valuable information for decision-makers and stakeholders at the international level.
Journal Article