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يتحدث الكتاب عن مشكلة الإرهاق النفسي الناتج عن الضغوط الحياتية والذي يودي بالإنسان إلى مضاعفات نفسية جمة قد تصل إلى حد الاحتراق النفسي والذي عرفه الكتاب وضرب له الأمثلة، ثم يتوسع الكتاب بالفكرة ويقدم نصائح واسعة الطيف متطرقاً إلى جوانب الحياة المتعددة مع الأمثلة المستوحاة من واقع كل منا من خلال مئة رسالة موجهة للمرهقين والمتعبين حيث سنجد حلولاً لمشكلات كثيرة تمر بنا ومخارج الأوقات الضيق التي نعيشها في حياتنا اليومية والمواقف التي لابد وقد عاشها الجميع وأثرت بهم بطريقة سلبية. الكتاب تنموي تعمق بأثر الإرهاق على النفس وقـدم نصائح وخطوات للوصول إلى بر الأمان المتمثل بالراحة النفسية والقدرة على التعامل مع المواقف الحياتية دون أن يهلكنا التعب ويمحونا قدراتنا الضغط.

A partial-wave analysis (PWA) for the photoproduction of pseudoscalar mesons on a nucleon using truncation in total angular momentum j is discussed. A formalism is described that can be used for investigating discrete ambiguities. Considerable attention is devoted to the connection of this type of PWA with that based on the truncation in orbital angular momentum l .

During four aircraft field experiments with the DLR research aircraft Falcon in 1998 (LACE), 2006 (SAMUM-1) and 2008 (SAMUM-2 and EUCAARI), airborne High Spectral Resolution Lidar (HSRL) and in situ measurements of aerosol microphysical and optical properties were performed. Altogether, the properties of six different aerosol types and aerosol mixtures – Saharan mineral dust, Saharan dust mixtures, Canadian biomass burning aerosol, African biomass burning mixture, anthropogenic pollution aerosol, and marine aerosol have been studied. On the basis of this extensive HSRL data set, we present an aerosol classification scheme which is also capable to identify mixtures of different aerosol types. We calculated mixing lines that allowed us to determine the contributing aerosol types. The aerosol classification scheme was supported by backward trajectory analysis and validated with in-situ measurements. Our results demonstrate that the developed aerosol mask is capable to identify complex stratifications with different aerosol types throughout the atmosphere.

Enterotoxigenic Escherichia coli causes diarrhoea, leading to substantial mortality and morbidity in children, but no specific vaccine exists. This trial tested an oral, inactivated, enterotoxigenic E coli vaccine (ETVAX), which has been previously shown to be safe and highly immuongenic in Swedish and Bangladeshi adults. We tested the safety and immunogenicity of ETVAX, consisting of four E coli strains overexpressing the most prevalent colonisation factors (CFA/I, CS3, CS5, and CS6) and a toxoid (LCTBA) administered with or without a double-mutant heat-labile enterotoxin (dmLT) as an adjuvant, in Bangladeshi children. We did a randomised, double-blind, placebo-controlled, dose-escalation, age-descending, phase 1/2 trial in Dhaka, Bangladesh. Healthy children in one of three age groups (24–59 months, 12–23 months, and 6–11 months) were eligible. Children were randomly assigned with block randomisation to receive either ETVAX, with or without dmLT, or placebo. ETVAX (half [5·5 × 1010 cells], quarter [2·5 × 1010 cells], or eighth [1·25 × 1010 cells] adult dose), with or without dmLT adjuvant (2·5 μg, 5·0 μg, or 10·0 μg), or placebo were administered orally in two doses 2 weeks apart. Investigators and participants were masked to treatment allocation. The primary endpoint was safety and tolerability, assessed in all children who received at least one dose of vaccine. Antibody responses to vaccine antigens, defined as at least a two-times increase in antibody levels between baseline and post-immunisation, were assessed as secondary endpoints. This trial is registered with ClinicalTrials.gov, NCT02531802. Between Dec 7, 2015, and Jan 10, 2017, we screened 1500 children across the three age groups, of whom 430 were enrolled and randomly assigned to the different treatment groups (130 aged 24–59 months, 100 aged 12–23 months, and 200 aged 6–11 months). All participants received at least one dose of vaccine. No solicited adverse events occurred that were greater than moderate in severity, and most were mild. The most common solicited event was vomiting (ten [8%] of 130 patients aged 24–59 months, 13 [13%] of 100 aged 12–23 months, and 29 [15%] of 200 aged 6–11 months; mostly of mild severity), which appeared related to dose and age. The addition of dmLT did not modify the safety profile. Three serious adverse events occurred but they were not considered related to the study drug. Mucosal IgA antibody responses in lymphocyte secretions were detected against all primary vaccine antigens (CFA/I, CS3, CS5, CS6, and the LCTBA toxoid) in most participants in the two older age groups, whereas such responses to four of the five antigens were less frequent and of lower magnitude in infants aged 6–11 months than in older children. Faecal secretory IgA immune responses were recorded against all vaccine antigens in infants aged 6–11 months. 78 (56%) of 139 infants aged 6–11 months who were vaccinated developed mucosal responses against at least three of the vaccine antigens versus 14 (29%) of 49 of the infants given placebo. Addition of the adjuvant dmLT enhanced the magnitude, breadth, and kinetics (based on number of responders after the first dose of vaccine) of immune responses in infants. The encouraging safety and immunogenicity of ETVAX and benefit of dmLT adjuvant in young children support its further assessment for protective efficacy in children in enterotoxigenic E coli-endemic areas. PATH (Bill & Melinda Gates Foundation and the UK's Department for International Development), the Swedish Research Council, and The Swedish Foundation for Strategic Research.

•The killed oral ETEC vaccine ETVAX ± dmLT adjuvant was safe in Bangladeshi adults.•All vaccinees responded to all 5 primary vaccine antigens in ALS specimens.•A majority of vaccinees responded to ≥4 antigens in plasma specimens.•A sensitive electrochemiluminescence assay was established for small sample volumes.•ALS responses measured by electrochemiluminescence and ELISA assays correlated well. The safety and immunogenicity of the second generation oral enterotoxigenic Escherichia coli (ETEC) vaccine ETVAX, consisting of inactivated recombinant E. coli strains over-expressing the colonization factors (CFs) CFA/I, CS3, CS5 and CS6 and the heat labile toxoid LCTBA, were evaluated in Bangladeshi volunteers. To enable analysis of antibody responses against multiple vaccine antigens for subsequent use in small sample volumes from children, a sensitive electrochemiluminescence (ECL) assay for analysis of intestine-derived antibody-secreting cell responses using the antibodies in lymphocyte secretions (ALS) assay was established using Meso Scale Discovery technology. Three groups of Bangladeshi adults (n = 15 per group) received two oral doses of ETVAX with or without double mutant LT (dmLT) adjuvant or placebo in the initial part of a randomized, double-blind, placebo-controlled, age-descending, dose-escalation trial. CF- and LTB-specific ALS and plasma IgA responses were analyzed by ECL and/or ELISA. ETVAX was safe and well tolerated in the adults. Magnitudes of IgA ALS responses determined by ECL and ELISA correlated well (r = 0.85 to 0.98 for the five primary antigens, P < 0.001) and ECL was selected as the ALS readout method. ALS IgA responses against each of the primary antigens were detected in 87–100% of vaccinees after the first and in 100% after the second vaccine dose. Plasma IgA responses against different CFs and LTB were observed in 62–93% and 100% of vaccinees, respectively. No statistically significant adjuvant effect of dmLT on antibody responses to any antigen was detected, but the overall antigenic breadth of the plasma IgA response tended to favor the adjuvanted vaccine when responses to 4 or more or 5 vaccine antigens were considered. Responses in placebo recipients were infrequent and mainly detected against single antigens. The promising results in adults supported testing ETVAX in descending age groups of children. ClinicalTrials.gov Identifier: NCT02531802.

The Alt–Grassberger–Sandhas equations for the five-body problem are solved for the case of the driving two-body potentials limited to s-waves. The separable pole expansion method is employed to convert the equations into the effective quasi-two-body form. Numerical results are presented for five identical bosons as well as for the system containing an η-meson and four nucleons. Accuracy of the separable expansion is investigated. It is shown that both in (1+4) and (2+3) fragmentation, the corresponding eigenvalues decrease rather rapidly, what, combined with the alternation of their signs, leads to rather good convergence of the results. For the η-4N system the crucial influence of the subthreshold behavior of the ηN amplitude on the η-nuclear low-energy interaction is discussed.

Methane is the third most important greenhouse gas in the atmosphere after water vapour and carbon dioxide. A major handicap to quantify the emissions at the Earth's surface in order to better understand biosphere-atmosphere exchange processes and potential climate feedbacks is the lack of accurate and global observations of methane. Space-based integrated path differential absorption (IPDA) lidar has potential to fill this gap, and a Methane Remote Lidar Mission (MERLIN) on a small satellite in polar orbit was proposed by DLR and CNES in the frame of a German-French climate monitoring initiative. System simulations are used to identify key performance parameters and to find an advantageous instrument configuration, given the environmental, technological, and budget constraints. The sensitivity studies use representative averages of the atmospheric and surface state to estimate the measurement precision, i.e. the random uncertainty due to instrument noise. Key performance parameters for MERLIN are average laser power, telescope size, orbit height, surface reflectance, and detector noise. A modest-size lidar instrument with 0.45 W average laser power and 0.55 m telescope diameter on a 506 km orbit could provide 50-km averaged methane column measurement along the sub-satellite track with a precision of about 1% over vegetation. The use of a methane absorption trough at 1.65 μm improves the near-surface measurement sensitivity and vastly relaxes the wavelength stability requirement that was identified as one of the major technological risks in the pre-phase A studies for A-SCOPE, a space-based IPDA lidar for carbon dioxide at the European Space Agency. Minimal humidity and temperature sensitivity at this wavelength position will enable accurate measurements in tropical wetlands, key regions with largely uncertain methane emissions. In contrast to actual passive remote sensors, measurements in Polar Regions will be possible and biases due to aerosol layers and thin ice clouds will be minimised.

Aerosol and water vapour measurements were performed with the lidar system WALES of Deutsches Zentrum für Luft- und Raumfahrt (DLR) in October and November 2010 during the first mission with the new German research aircraft G55-HALO. Curtains composed of lidar profiles beneath the aircraft show the vertical and horizontal distribution and variability of water vapour mixing ratio and backscatter ratio above Germany. Two missions on 3 and 4 November 2010 were selected to derive the water vapour mixing ratio inside cirrus clouds from the lidar instrument. A good agreement was found with in situ observations performed on a second research aircraft flying below HALO. ECMWF analysis temperature data are used to derive relative humidity fields with respect to ice (RHi) inside and outside of cirrus clouds from the lidar water vapour observations. The RHi variability is dominated by small-scale fluctuations in the water vapour fields while the temperature variation has a minor impact. The most frequent in-cloud RHi value from lidar observations is 98%. The RHi variance is smaller inside the cirrus than outside of the cloud. 2-D histograms of relative humidity and backscatter ratio show significant differences for in-cloud and out-of-cloud situations for two different cirrus cloud regimes. Combined with accurate temperature measurements, the lidar observations have a great potential for detailed statistical cirrus cloud and related humidity studies.

Airborne high spectral resolution lidar observations over Europe during the EUCAARI-LONGREX field experiment in May 2008 are analysed with respect to the optical properties of continental pollution aerosol. Continental pollution aerosol is characterized by its depolarisation and lidar ratio. Over all, the measurements of the lidar ratio and the particle linear depolarization ratio of pollution aerosols provide a narrow range of values. Therefore, this data set allows for a distinct characterization of the aerosol type \"pollution aerosol\" and thus is valuable both to distinguish continental pollution aerosol from other aerosol types and to determine mixtures with other types of aerosols.

An observational dataset from a wintertime field campaign in the Inn Valley, Austria, is analysed in order to study mechanisms of air pollution transport in an Alpine valley. The results illustrate three types of mechanisms: transport by a density current, back-and-forth transport by valley winds, and transport by slope winds. The first type is associated with an air mass difference along the valley. Cooler air located in the lower part of the valley behaves like a density current and produces the advection of pollutants by upvalley winds. In the second type, strong horizontal gradients in pollution concentrations exist close to ground. Multiple wind reversals result in a back-and-forth transport of pollutants by weak valley winds. In the third type, upslope winds during daytime decrease low-level pollution concentrations and cause the formation of elevated pollution layers.