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195 result(s) for "Flack, R."
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Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy
Treatment of gestational diabetes before 20 weeks’ gestation led to a modestly lower incidence of a composite of adverse neonatal outcomes but no material differences in pregnancy-related hypertension or neonatal lean body mass.
Oral health knowledge, attitudes and care practices of people with diabetes: a systematic review
Background People with uncontrolled diabetes are at greater risk for several oral health problems, particularly periodontal (gum) disease. Periodontal disease also impacts diabetes control. Good oral hygiene and regular dental visits are recommended to prevent and manage oral health problems. Several studies have been conducted to assess the oral health knowledge, attitudes, and practices of people with diabetes yet a review of these findings has not yet been undertaken. The aim of this systematic review was to synthesize current evidence on the knowledge, attitudes and practices of people with diabetes in relation to their oral health care. Methods A systematic search of all literature was carried out in five databases using key search terms. The inclusion criteria were: 1) published in the English language; 2) from 2000 to November, 2017; 3) conducted on persons with any type of diabetes and of all ages; 4) explored at least one study outcome (knowledge or attitude or practices toward oral health care); and 5) used quantitative methods of data collection. No restrictions were placed on the quality and setting of the study. Results A total of 28 studies met the inclusion criteria. The studies included a total of 27,894 people with diabetes and were conducted in 14 countries. The review found that people with diabetes have inadequate oral health knowledge, poor oral health attitudes, and fewer dental visits. They rarely receive oral health education and dental referrals from their care providers. Provision of oral health education by diabetes care providers and referral to dentists when required, was associated with improved oral health behaviours among patients. Conclusions Overall, people with diabetes have limited oral health knowledge and poor oral health behaviours. It is therefore essential to educate patients about their increased risk for oral health problems, motivate them for good oral health behaviours and facilitate access to dental care.
Measurement of double-$\\beta$ decay of $^{150}$Nd to the 0$^+_1$ excited state of $^{150}$Sm in NEMO-3
The NEMO-3 results for the double-$\\beta $ decay of $^{150}$Nd to the 0$^+_1$ and 2$^+_1$ excited states of $^{150}$Sm are reported. The data recorded during 5.25 year with 36.6 g of the isotope $^{150}$Nd are used in the analysis. The signal of the $2\\nu \\beta \\beta $ transition to the 0$^+_1$ excited state is detected with a statistical significance exceeding 5$\\sigma $. The half-life is measured to be $T_{1/2}^{2\\nu \\beta \\beta }(0^+_1) = \\left[ 1.11 ^{+0.19}_{-0.14} \\,\\left( \\hbox {stat}\\right) ^{+0.17}_{-0.15}\\,\\left( \\hbox {syst}\\right) \\right] \\times 10^{20}$ year, which is the most precise value that has been measured to date. 90% confidence-level limits are set for the other decay modes. For the $2\\nu \\beta \\beta $ decay to the 2$^+_1$ level the limit is $T^{2\\nu \\beta \\beta }_{1/2}(2^+_1) > 2.42 \\times 10^{20}~\\hbox {year}$. The limits on the $0\\nu \\beta \\beta $ decay to the 0$^+_1$ and 2$^+_1$ levels of $^{150}$Sm are significantly improved to $T_{1/2}^{0\\nu \\beta \\beta }(0^+_1) > 1.36 \\times 10^{22}~\\hbox {year}$ and $T_{1/2}^{0\\nu \\beta \\beta }(2^+_1) > 1.26 \\times 10^{22}~\\hbox {year}$.
Weak measurement and its experimental realisation
The relationship between the real part of the weak value of the momentum operator at a post selected position is discussed and the meaning of the experimentally determined stream-lines in the Toronto experiment of Kocsis et al is re-examined. We argue against interpreting the energy flow lines as photon trajectories. The possibility of performing an analogous experiment using atoms is proposed in order that a direct comparison can be made with the trajectories calculated by Philippidis, Dewdney and Hiley using the Bohm approach.
Probing new physics models of neutrinoless double beta decay with SuperNEMO
The possibility to probe new physics scenarios of light Majorana neutrino exchange and right-handed currents at the planned next generation neutrinoless double β decay experiment SuperNEMO is discussed. Its ability to study different isotopes and track the outgoing electrons provides the means to discriminate different underlying mechanisms for the neutrinoless double β decay by measuring the decay half-life and the electron angular and energy distributions.
Face morphing attacks: Investigating detection with humans and computers
Background In recent years, fraudsters have begun to use readily accessible digital manipulation techniques in order to carry out face morphing attacks. By submitting a morph image (a 50/50 average of two people’s faces) for inclusion in an official document such as a passport, it might be possible that both people sufficiently resemble the morph that they are each able to use the resulting genuine ID document. Limited research with low-quality morphs has shown that human detection rates were poor but that training methods can improve performance. Here, we investigate human and computer performance with high-quality morphs, comparable with those expected to be used by criminals. Results Over four experiments, we found that people were highly error-prone when detecting morphs and that training did not produce improvements. In a live matching task, morphs were accepted at levels suggesting they represent a significant concern for security agencies and detection was again error-prone. Finally, we found that a simple computer model outperformed our human participants. Conclusions Taken together, these results reinforce the idea that advanced computational techniques could prove more reliable than training people when fighting these types of morphing attacks. Our findings have important implications for security authorities worldwide.
The relationship between body mass index and sleep in women with risk factors for gestational diabetes mellitus
Background Both obesity and sleep disorders are common among women during pregnancy. Although prior research has identified a relationship between obesity and sleep disorders, those findings are from women later in pregnancy. Objective To explore the relationships between self‐reported sleep duration, insufficient sleep and snoring with body mass index (BMI) among multiethnic women at risk of gestational diabetes mellitus (GDM)in early pregnancy. Methods Cross‐sectional study of baseline data from women at risk of GDM enrolled in the Treatment of BOoking Gestational diabetes Mellitus (TOBOGM) multicentre trial across 12 Australian/Austrian sites. Participants completed a questionnaire before 20 weeks’ gestation to evaluate sleep. BMI <25 kg/m2 served as the reference group in multivariable logistic regression. Results Among the 2865 women included, the prevalence of overweight and obesity classes I‐III was 28%, 19%, 11% and 12%, respectively. There was no relationship between sleep duration and BMI. The risk of insufficient sleep >5 days/month was higher in class II and class III obesity (1.38 (1.03–1.85) and 1.34 (1.01–1.80), respectively), and the risk of snoring increased as BMI increased (1.59 (1.25–2.02), 2.68 (2.07–3.48), 4.35 (3.21–5.88) to 4.96 (3.65–6.74), respectively)). Conclusions Obesity is associated with insufficient sleep among pregnant women at risk of GDM. Snoring is more prevalent with increasing BMI.
The weak value of spin for atomic systems
A system is being designed and constructed in order to measure the weak value of spin for atomic systems. The experiment utilises spin-1 metastable helium atoms in the 23 S 1 state. This paper outlines the experiment and its features.
Age, age at diagnosis and diabetes duration are all associated with vascular complications in type 2 diabetes
Type 2 diabetes (T2DM) is increasingly diagnosed in younger patients. The trajectory of complications in patients diagnosed at a younger or older age is not well understood. We examine the associations between age, age at diagnosis and diabetes duration and vascular complications in patients with T2DM. A cross-sectional study of pre-specified demographic and clinical data, from 3419 adults with T2DM participating in the Australian National Diabetes Audit (2015). Factors associated with diabetes complications were analysed using logistic regression. Mean (±SD) current age was 62.9±12.5years, age at diagnosis was 49.4±12.3years and mean diabetes duration was 13.5±9.4years. Macrovascular complications were more prevalent in patients who were older at diabetes diagnosis whereas microvascular complications were more prevalent in patients who were younger at diabetes diagnosis. Age, age at diagnosis and diabetes duration were all independently associated with increased risk of macrovascular complications after adjustment for sex, smoking, BMI and microvascular complications (all p<0.001). In contrast, only diabetes duration was independently associated with microvascular complications after adjustment for sex, smoking, BMI and macrovascular complications (p<0.001). Age, age at diagnosis, and diabetes duration were all independently associated with macrovascular complications whereas only diabetes duration was independently associated with microvascular complications.
Sprint Training Increases Muscle Oxidative Metabolism During High-Intensity Exercise in Patients With Type 1 Diabetes
Sprint Training Increases Muscle Oxidative Metabolism During High-Intensity Exercise in Patients With Type 1 Diabetes Alison R. Harmer , PHD 1 2 , Donald J. Chisholm , MD 3 , Michael J. McKenna , PHD 4 , Sandra K. Hunter , PHD 2 , Patricia A. Ruell , PHD 2 , Justine M. Naylor , PHD 1 , Lyndal J. Maxwell , PHD 1 and Jeff R. Flack , MD 5 1 Discipline of Physiotherapy, University of Sydney, Lidcombe, New South Wales, Australia 2 Discipline of Exercise and Sports Science, University of Sydney, Lidcombe, New South Wales, Australia 3 Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia 4 School of Human Movement, Recreation, and Performance, Centre for Aging, Rehabilitation, Exercise, and Sport, Victoria University, Melbourne, Victoria, Australia 5 Diabetes Centre, Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia Corresponding author: Alison Harmer, a.harmer{at}usyd.edu.au Abstract OBJECTIVE —To investigate sprint-training effects on muscle metabolism during exercise in subjects with (type 1 diabetic group) and without (control group) type 1 diabetes. RESEARCH DESIGN AND METHODS —Eight subjects with type 1 diabetes and seven control subjects, matched for age, BMI, and maximum oxygen uptake ( V̇ o 2peak ), undertook 7 weeks of sprint training. Pretraining, subjects cycled to exhaustion at 130% V̇ o 2peak . Posttraining subjects performed an identical test. Vastus lateralis biopsies at rest and immediately after exercise were assayed for metabolites, high-energy phosphates, and enzymes. Arterialized venous blood drawn at rest and after exercise was analyzed for lactate and [H + ]. Respiratory measures were obtained on separate days during identical tests and during submaximal tests before and after training. RESULTS —Pretraining, maximal resting activities of hexokinase, citrate synthase, and pyruvate dehydrogenase did not differ between groups. Muscle lactate accumulation with exercise was higher in type 1 diabetic than nondiabetic subjects and corresponded to indexes of glycemia (A1C, fasting plasma glucose); however, glycogenolytic and glycolytic rates were similar. Posttraining, at rest, hexokinase activity increased in type 1 diabetic subjects; in both groups, citrate synthase activity increased and pyruvate dehydrogenase activity decreased; during submaximal exercise, fat oxidation was higher; and during intense exercise, peak ventilation and carbon dioxide output, plasma lactate and [H + ], muscle lactate, glycogenolytic and glycolytic rates, and ATP degradation were lower in both groups. CONCLUSIONS —High-intensity exercise training was well tolerated, reduced metabolic destabilization (of lactate, H + , glycogenolysis/glycolysis, and ATP) during intense exercise, and enhanced muscle oxidative metabolism in young adults with type 1 diabetes. The latter may have clinically important health benefits. Footnotes Published ahead of print at http://care.diabetesjournals.org on 20 August 2008. Clinical trial reg. no. ACTRN012606000368538, clinicaltrials.org Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact. Accepted August 12, 2008. Received February 13, 2008. DIABETES CARE