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"Fleming, Piper"
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Piper Morgan in charge!
\"After saying good-bye to her circus friends, Piper Morgan and her mom are on the move again, this time returning to Mom's hometown and to Piper's beloved grandmother's house after Piper's mom takes a job in the local elementary school principal's office. Piper is excited for a new school and new friends and is thrilled when she is made an office helper. But there is one girl who seems determined to prove she is a better helper than Piper--and she just so happens to be the principal's daughter. Can Piper figure out how to handle being the new girl in town once more?\"--Provided by publisher.
Book
New Pseudomonas infections drive Pf phage transmission in CF airways
Pf bacteriophages, lysogenic viruses that infect Pseudomonas aeruginosa (Pa), are implicated in the pathogenesis of chronic Pa infections; phage-infected (Pf+) strains are known to predominate in people with cystic fibrosis (pwCF) who are older and have more severe disease. However, the transmission patterns of Pf underlying the progressive dominance of Pf+ strains are unclear. In particular, it is unknown whether phage transmission commonly occurs horizontally between bacteria via viral particles within the airway or whether Pf+ bacteria are mostly acquired via de novo Pseudomonas infections. Here, we studied Pa genomic sequences from 3 patient cohorts totaling 662 clinical isolates from 105 pwCF. We identified Pf+ isolates and analyzed transmission patterns of Pf within patients between genetically similar groups of bacteria called \"clone types.\" We found that Pf was predominantly passed down vertically within Pa clone types and rarely via horizontal transfer between clone types within the airway. Conversely, we found extensive evidence of Pa de novo infection by a new, genetically distinct Pf+ Pa. Finally, we observed that clinical isolates showed reduced activity of type IV pili and reduced susceptibility to Pf in vitro. These results cast light on the transmission of virulence-associated phages in the clinical setting.
Journal Article
Piper Morgan plans a party
Piper is excited to help her mom plan a big party for another girl her age. After all, who doesn t love a good party? But when Piper and her mom arrive, they are in for an unpleasant surprise: A spoiled little girl, a huge mansion, and a list of impossible demands from the birthday girl that includes a real-life princess and grape jelly beans. How will they ever pull off the show-stopping party that Emmy is demanding? It seems like no matter what they suggest, Emmy is never happy. Can Piper help her mom pull off the best party ever? Or will the party turn into a big fat mess?
Book
Pseudomonas superinfection drives Pf phage transmission within airway infections in patients with cystic fibrosis
Pf bacteriophages, lysogenic viruses that infect
, are implicated in the pathogenesis of chronic
infections; phage-infected (Pf+) strains are known to predominate in people with cystic fibrosis (pwCF) who are older and have more severe disease. However, the transmission patterns of Pf underlying the progressive dominance of Pf+ strains are unclear. In particular, it is unknown whether phage transmission commonly occurs horizontally between bacteria within the airway via viral particles or if Pf+ bacteria are mostly acquired via new
infections. Here, we have studied
genomic sequences from 3 patient cohorts totaling 663 clinical isolates from 105 pwCF. We identify Pf+ isolates and analyze transmission patterns of Pf within patients between genetically similar groups of bacteria called \"clone types\". We find that Pf is predominantly passed down vertically within
lineages and rarely via horizontal transfer between clone types within the airway. Conversely, we find extensive evidence of
superinfection by a new, genetically distinct
that is Pf+. Finally, we find that clinical isolates show reduced activity of the type IV pilus and reduced susceptibility to Pf
. These results cast new light on the transmission of virulence-associated phages in the clinical setting.
Journal Article
A clinical grade neurostimulation implant for hierarchical control of physiological activity
Bioelectronic implants for neurostimulation aim to steer disordered neurophysiological processes back towards a healthy state. However, physiology is subject to biological rhythms, including the circadian rhythm and the sleep-wake cycle. These predictable rhythms affect disease symptomatology, biomarkers used in closed-loop therapies, and a physiological system's expected response to stimulation. Therefore, therapeutic devices should incorporate feedforward elements to align algorithm parameters with predictable changes in physiological state, as a parallel of physiological rheostatic control. Here we introduce the DyNeuMo-2c, the first clinical-grade implant capable of delivering closed-loop neurostimulation while flexibly changing its functional configuration according to time of day. The device can chronically measure brain activity and motion state to track potential biomarker patterns in natural, out-of-clinic settings, allowing identification and targeting of patient-specific chronotypes. The system implements a hierarchical control flow, with baseline therapy set by a circadian scheduler, and adaptive policies layered to take effect based on specific biomarkers indicating patient and disease state. Using a benchtop validation setup, we demonstrate that the system has the required capabilities for delivering time-contingent closed-loop therapy in two established clinical use cases: Parkinson's disease and epilepsy. Next, we deploy the system
to deliver closed-loop deep brain stimulation in a healthy non-human primate model of vigilance, highlighting the importance of synchronisation between device operation and physiological state in various conditions (task performance, unconstrained behaviour, and sleep). Time-of-day-dependent adaptation of closed-loop stimulation enabled modulation of both vigilance and behaviour. Overall, the novel device architecture provides a proof-of-concept for delivering time-contingent therapy in chronic therapeutic settings where biological rhythms are of key importance.
Journal Article
New resource-management approach targets long-term liability of drilling wastes
A new project-planning methodology for declassifying drilling wastes can minimize the long-term liability associated with the disposal of contaminated drill cuttings and fluids. Superfund legislation in the US and duty-of-care laws in the European Union are two examples of government programs designed to minimize future environmental contamination. These and other laws stipulate that a company disposing of its waste in an approved fashion today could face remediation liability in the future. A comprehensive survey of more than 100 operator representatives and key governmental regulators across 11 mature and developing regions illustrates the economic impact of managing drilling wastes. Those surveyed suggested that, while the rate of increase is uncertain, waste management spending in relation to the cost of drilling fluids will continue to rise over the foreseeable future.
Magazine Article