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result(s) for
"Flynn, Riley"
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Booker T. Washington
\"Simple text and photographs present the life of Booker T. Washington\"-- Provided by publisher.
BOOK
Sewers stink! : how does waste go down?
\"Ever wonder how the sewer system works? Look no further! Discover the story behind the pipes beneath our feet. From facts on the first plumbing systems to information about how wastewater gets treated and cleaned. Readers will learn about why we need sanitation and the journey our waste and used water takes through the pipes\"-- Provided by publisher.
Book
Toilets tank! : their inner workings
\"Get ready for some literal bathroom reading. Discover the story behind their home's most under appreciated feature. From facts on how much bodily waste the average person releases a day to information on what the first \"toilets\" were like. Readers will learn about why we need sanitation and where our waste goes when we flush.\"-- Provided by publisher.
Book
Multi-targeted, NOT gated CAR-T cells as a strategy to protect normal lineages for blood cancer therapy
Despite advances in treatment of blood cancers, several-including acute myeloid leukemia (AML)-continue to be recalcitrant. Cell therapies based on chimeric antigen receptors (CARs) have emerged as promising approaches for blood cancers. However, current CAR-T treatments suffer from on-target, off-tumor toxicity, because most familiar blood cancer targets are also expressed in normal lineages. In addition, they face the common problem of relapse due to target-antigen loss. Cell therapeutics engineered to integrate more than one signal, often called logic-gated cells, can in principle achieve greater selectivity for tumors.
We applied such a technology, a NOT gated system called Tmod™ that is being developed to treat solid-tumor patients, to the problem of therapeutic selectivity for blood cancer cells.
Here we show that Tmod cells can be designed to target 2-4 antigens to provide different practical and conceptual options for a blood cancer therapy: (i) mono- and bispecific activating receptors that target CD33, a well-known AML antigen expressed on the majority of AML tumors (as well as healthy myeloid cells) and CD43 (SPN), an antigen expressed on many hematopoietic cancers (and normal blood lineages); and (ii) mono- and bispecific inhibitory receptors that target CD16b (FCGR3B) and CLEC9A, antigens expressed on key normal blood cells but not on most blood cancers.
These results further demonstrate the robust modularity of the Tmod system and generalize the Tmod approach beyond solid tumors.
Journal Article
Team science: A syllabus for success on big projects
Interdisciplinary teams are on the rise as scientists attempt to address complex environmental issues. While the benefits of team science approaches are clear, researchers often struggle with its implementation, particularly for new team members. The challenges of large projects often weigh on the most vulnerable members of a team: trainees, including undergraduate students, graduate students, and post‐doctoral researchers. Trainees on big projects have to navigate their role on the team, with learning project policies, procedures, and goals, all while also training in key scientific tasks such as co‐authoring papers. To address these challenges, we created and participated in a project‐specific, graduate‐level team science course. The purposes of this course were to: (1) introduce students to the goals of the project, (2) build trainees' understanding of how big projects operate, and (3) allow trainees to explore how their research interests dovetailed with the overall project. Additionally, trainees received training regarding: (1) diversity, equity & inclusion, (2) giving and receiving feedback, and (3) effective communication. Onboarding through the team science course cultivated psychological safety and a collaborative student community across disciplines and institutions. Thus, we recommend a team science course for onboarding students to big projects to help students establish the skills necessary for collaborative research. Project‐based team science classes can benefit student advancement, enhance the productivity of the project, and accelerate the discovery of solutions to ecological issues by building community, establishing a shared project vocabulary, and building a workforce with collaborative skills to better answer ecological research questions. Team Science is on the rise to address complex ecological issues which cannot be tackled in individual research labs or management programs. Students on big projects often struggle with a clear understanding of the projects goals, their role on the team, project policies and procedures, and knowing how to engage in key scientific tasks such as co‐authoring papers. We recommend that big, collaborative projects begin with formal Team Science courses for trainees, which benefits student advancement, enhances the productivity of the project, and accelerates the discovery of solutions to ecological issues.
Journal Article