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Large earthquakes are usually assumed to release all of the strain accumulated since the previous event, implying a reduced seismic hazard after them. However, long records of seismic history at several subduction zones suggest supercycle behaviour, where centuries-long accumulated strain is released through clustered large earthquakes, resulting in an extended period of enhanced seismic hazard. Here we combine historical seismology results, present-day geodesy data, and dense local observations of the recent M w 7.8 2016 Pedernales earthquake to reconstruct the strain budget at the Ecuador subduction zone since the great 1906 earthquake. We show that the Pedernales earthquake involved the successive rupture of two patches on the plate interface that were locked prior to the earthquake and most probably overlaps the area already ruptured in 1942 by a similar earthquake. However, we find that coseismic slip in 2016 exceeds the deficit accumulated since 1942. The seismic moment of every large earthquake during the twentieth century further exceeds the moment deficit accumulated since 1906. These results, together with the seismic quiescence before 1906 highlighted by historical records and marine palaeoseismology, argue for an earthquake supercycle at the Ecuador–Colombia margin. This behaviour, which has led to an enhanced seismic hazard for 110 years, is possibly still going on and may apply to other subduction zones that recently experienced a great earthquake. Large earthquakes are often assumed to reset the seismic hazard of a region. Analysis of recent and historical seismicity in Ecuador suggests that this region may experience clusters of large earthquakes and extended periods of high seismic hazard.

Regions of intense continental deformation, termed continental slivers, have been identified in Chile, Bolivia and Ecuador. Analyses of GPS data now identify another large sliver in Peru, the Inca Sliver, that is moving away from a neighbouring sliver in Ecuador—implying that moving continental slivers control the deformation of almost the entire Andean mountain range. Along the western margin of South America, plate convergence is accommodated by slip on the subduction interface and deformation of the overriding continent 1 , 2 , 3 , 4 , 5 , 6 . In Chile 1 , 2 , 3 , 4 , Bolivia 6 , Ecuador and Colombia 5 , 7 , continental deformation occurs mostly through the motion of discrete domains, hundreds to thousands of kilometres in scale. These continental slivers are wedged between the Nazca and stable South American plates. Here we use geodetic data to identify another large continental sliver in Peru that is about 300–400 km wide and 1,500 km long, which we call the Inca Sliver. We show that movement of the slivers parallel to the subduction trench is controlled by the obliquity of plate convergence and is linked to prominent features of the Andes Mountains. For example, the Altiplano is located at the boundary of converging slivers at the concave bend of the central Andes, and the extending Gulf of Guayaquil is located at the boundary of diverging slivers at the convex bend of the northern Andes. Motion of a few large continental slivers therefore controls the present-day deformation of nearly the entire Andes mountain range. We also show that a 1,000-km-long section of the plate interface in northern Peru and southern Ecuador slips predominantly aseismically, a behaviour that contrasts with the highly seismic neighbouring segments. The primary characteristics of this low-coupled segment are shared by ∼ 20% of the subduction zones in the eastern Pacific Rim.

Objective To determine the extent of mitochondrial DNA (mtDNA) damage in systemic lupus erythematosus (SLE) patients compared to healthy subjects and to determine the factors associated with mtDNA damage among SLE patients. Methods A cross-sectional study was performed in 86 SLE patients (per American College of Rheumatology classification criteria) and 86 healthy individuals matched for age and gender. Peripheral blood mononuclear cells (PBMCs) were collected from subjects to assess the relative amounts of mtDNA damage. Quantitative polymerase chain reaction assay was used to measure the frequency of mtDNA lesions and mtDNA abundance. Socioeconomic-demographic features, clinical manifestations, pharmacologic treatment, disease activity, and damage accrual were determined. Statistical analyses were performed using t test, pairwise correlation, and Pearson’s chi-square test (or Fisher’s exact test) as appropriate. Results Among SLE patients, 93.0% were women. The mean (SD) age was 38.0 (10.4) years and the mean (SD) disease duration was 8.7 (7.5) years. SLE patients exhibited increased levels of mtDNA damage as shown by higher levels of mtDNA lesions and decreased mtDNA abundance as compared to healthy individuals. There was a negative correlation between disease damage and mtDNA abundance and a positive correlation between mtDNA lesions and disease duration. No association was found between disease activity and mtDNA damage. Conclusion PBMCs from SLE patients exhibited more mtDNA damage compared to healthy subjects. Higher levels of mtDNA damage were observed among SLE patients with major organ involvement and damage accrual. These results suggest that mtDNA damage have a potential role in the pathogenesis of SLE.

The North Ecuadorian-South Colombian subduction zone was the site of the 1906 Mw 8.8 megathrust earthquake. This main shock was followed by three large events in 1942, 1958, and 1979 whose rupture zones were located within the 500 km long 1906 rupture area. A combined onshore and offshore temporary seismic network covering from the trench to the Andes was deployed during 3 months in the area of large earthquakes, in order to obtain a detailed knowledge of the seismic background activity. Resulting earthquakes location and mechanisms bring new insights on interseismic active deformation distribution in the three main tectonic units of the margin, namely, the Interplate Seismogenic Zone, the fore-arc region which is part of the North Andean Block and the downgoing oceanic Nazca plate. The interplate seismic activity presents along strike variations, suggesting that the seismicity and the associated stress buildup along the plate interface depend on the time elapsed since the last large earthquakes. According to our results, the updip and downdip limits of the seismogenic zone appear to be located at 12 and 30 km depth, respectively. Shallow to intermediate depth seismicity indicates a slab dip angle of ≈25°. North of the Carnegie Ridge, the Wadati-Benioff plane is defined beneath the fore arc down to ≈100 km depth. Facing the ridge, the Wadati-Benioff plane extends beneath the Andes, down to ≈140 km depth. This observation conflicts with the hypothesis of the presence of a flat slab at a depth of 100 km facing the ridge. In the overlying fore-arc region, the crustal seismicity occurs down to 40 km depth and is mainly concentrated in a roughly NW-SE 100 km wide stripe stretching from the coast, at about 1°N, to the Andes. The location of this active deformation stripe coincides with observed tectonic segmentation of the coastal domain as evidenced by the presence of an uplifting segment to the south and a subsiding segment to the north of the stripe. It also corresponds to a ≈30° change in the trend of the Andes, suggesting that the curvature of the volcanic arc might play an important role in the deformation of the fore-arc region.

A elaboração deste projeto final de mestrado sugere uma possível resposta à problemática que enfrentam atualmente as cidades aquando a verificação da falência das periferias e o consequente retorno aos centros urbanos. Atualmente é possível encontrar na cidade espaços que necessitam de ser reabilitados, como espaços de antigas zonas industriais, que foram abandonadas devido à especialização da indústria e que se encontram integradas na malha urbana consolidada, devido ao crescimento das cidades. A incorporação de novos modos de ocupação, nestas áreas, pode ser um ponto de partida, para a integração destes espaços na cidade, dotando-os de uma heterogeneidade, bem como para a dinamização do local onde estes se inserem.Este trabalho insere-se numa avaliação no Eixo Xabregas/ Rua Gualdim Pais e Vale de Chelas, na cidade de Lisboa, numa zona que se encontra fragmentada como consequência das sucessivas ocupações e apropriações. Desenvolve-se uma proposta urbanística capaz de integrar e dinamizar uma zona negligenciada do resto da cidade, com o objetivo de a reconverter como elemento de reequilíbrio e distribuição de funções urbanas centrais, entre as áreas de crescimento recente e as estruturas mais antigas da cidade.Desta forma, definem-se estratégias e revela-se uma intenção apta a questionar e estimular um processo de regeneração urbana de adaptação ao tecido urbano envolvente, como contribuição para a renovação e atualização da Paisagem, a redescoberta do património e o redesenho da cidade para uma riqueza de construção e uma qualidade que potencie e promova o tecido urbano.

“Dios quiere que todos los hombres se salven y lleguen al conocimiento de la Verdad”, esta afirmación de la primera carta del apóstol San Pablo a Timoteo, refleja la importancia del conocimiento para la vida del hombre. Este deseo innato por conocer es regulado por la virtud de la studiositas (ST II-II q.166, a.2). Teniendo en cuenta que la naturaleza humana, debido al pecado original, presenta debilidades y pecados que limitan nuestra tendencia natural a orientar nuestra capacidad de conocer hacia el bien y la verdad (tanto en el fin que buscamos al estudiar, como en el modo en que