Explore the vast range of titles available.

In the search to reduce the side effects, toxicity and assuring the desired effectiveness of the drugs, many efforts has been made to improve specific drugs’ delivery characteristics. Several carrier nanoparticles have been used to assist the drugs incorporation, absorption and transport through the bloodstream. However, most chemical synthesis routes are multistep and time-consuming treatments and, also, many carrier nanoparticles have toxic effects. In this work, we report a simple one-pot approach for the synthesis of CoFe2O4 nanoparticles (20 to 100 nm). The magnetic measurements revealed nanoparticles with a magnetic saturation nearly one third of that for bulk CoFe2O4. In vitro assays showed no hemolytic potential and negligible toxicity. By in vivo experiments using adult male mice we found no potential risk alterations by the nanoparticles administration. Therefore, the CoFe2O4 nanoparticles, synthesized by the current approach, can be a model drug-carrier, which makes them useful for the biomedical applications.

We present COPAINS (Code for Orbital Parametrisation of Astrometrically Inferred New Systems), an innovative tool developed to identify previously undiscovered companions detectable via direct imaging, based on changes in stellar proper motions across multiple astrometric catalogues. This powerful procedure allows for dynamical predictions of the possible masses and separations of unseen companions compatible with observed astrometric trends, marginalised over unknown orbital elements. Validating our approach using well-constrained systems, we found that our tool provides a good indication of the region of the parameter space where undetected secondaries may be located. Comparing the output of the code to the measured or expected sensitivity from various imaging instruments, this in turn enables us to robustly select the most promising targets for direct imaging campaigns searching for low-mass companions. Such an informed selection method promises to reduce the null detection rates from current programs and will significantly increase the current census of wide brown dwarfs and planetary companions to stars, which remain extremely rare in the surveys conducted so far.

Located at less than 2pc away, Luhman16AB (WISE.J104915.57-531906.1) is the closest pair of brown dwarfs and third closest `stellar' system to Earth. An exoplanet candidate in the Luhman16 binary system was reported in 2017 based on a weak astrometric signature in the analysis of 12 HST epochs. An additional epoch collected in 2018 and re-analysis of the data with more advanced methods further increased the significance level of the candidate, consistent with a Neptune-mass exoplanet orbiting one of the Luhman16 brown dwarf components. We report the joint analysis of these previous data together with two new astrometric HST epochs we obtained to confirm or disprove this astrometric signature. Our new analysis rules out presence of a planet orbiting one component of the Luhman16AB system for masses M > 1.5 M_Nep (Neptune masses) and periods between 400 and 5000 days. However, the presence of third bodies with masses M < 3 M_Nep and periods between 2 and 400 days (~1.1yrs) can not be excluded. Our measurements make significant improvements to the characterization of this sub-stellar binary, including its mass-ratio 0.8305+/-0.0006, individual component masses 35.4+/-0.2 M_Jup and 29.4+/-0.2 M_Jup (Jupiter masses), and parallax distance 1.9960pc +/- 50AU. Comparison of the masses and luminosities of Luhman16AB to several evolutionary models shows persistent discrepancies in the ages of the two components, but strengthens the case that this system is a member of the 510+/-95 Myr Oceanus Moving Group.

In the second paper of this series we perfected our method of linking high precision Hubble Space Telescope astrometry to the high-accuracy Gaia DR2 absolute reference system to overcome the limitations of relative astrometry with narrow-field cameras. Our test case here is the Y brown dwarf WISE J163940.83-684738.6, observed at different epochs spread over a 6-yr time baseline with the Infra-Red channel of the Wide Field Camera 3. We derived significantly improved astrometric parameters compared to previous determinations, finding: (mu_RAcosDc,mu_DC,parallax) = (577.21+/-0.24mas/yr,-3108.39+/-0.27mas/yr,210.4+/-1.8mas). In particular, our derived absolute parallax corresponds to a distance of 4.75+/-0.05pc for the faint ultracool dwarf.

The last decade of direct imaging (DI) searches for sub-stellar companions has uncovered a widely diverse sample that challenges the current formation models, while highlighting the intrinsically low occurrence rate of wide companions, especially at the lower end of the mass distribution. These results clearly show how blind surveys, crucial to constrain the underlying planet and sub-stellar companion population, are not an efficient way to increase the sample of DI companions. It is therefore becoming clear that efficient target selection methods are essential to ensure a larger number of detections. We present the results of the COPAINS Survey conducted with SPHERE/VLT, searching for sub-stellar companions to stars showing significant proper motion differences (Delta mu) between different astrometric catalogues. We observed twenty-five stars and detected ten companions, including four new brown dwarfs: HIP 21152 B, HIP 29724 B, HD 60584 B and HIP 63734 B. Our results clearly demonstrates how astrometric signatures, in the past only giving access to stellar companions, can now thanks to Gaia reveal companions well in the sub-stellar regime. We also introduce FORECAST (Finley Optimised REtrieval of Companions of Accelerating STars), a tool which allows to check the agreement between position and mass of the detected companions with the measured Delta mu. Given the agreement between the values of the masses of the new sub-stellar companions from the photometry with the model-independent ones obtained with FORECAST, the results of COPAINS represent a significant increase of the number of potential benchmarks for brown dwarf and planet formation and evolution theories.

One field containing WISE J154151.65-225024.9 was observed by Hubble Space Telescope at three different epochs taken in ~5 yrs. We measured positions of sources in all images and successfully linked these positions to the Gaia DR2 absolute system to derive the astrometric parameters for this faint close-by Y1 brown dwarf. The developed procedure avoids traditional limitations of relative imaging-astrometry with narrow-field cameras, extending Gaia DR2 to fainter magnitudes. We found (mu_RA,mu_d,parallax) = (-902.62+/-0.35mas/yr, -88.26+/-0.35mas/yr,168.4+/-2.2mas), which represent a sizable improvement over recent determinations in the literature. Applying a correction from relative to absolute parallax we found an absolute parallax of 169+/-2 mas, corresponding to a distance of 5.9+/-0.1 pc.

During the past decade, state-of-the-art planet-finder instruments like SPHERE@VLT, coupling coronagraphic devices and extreme adaptive optics systems, unveiled, thanks to large surveys, around 20 planetary mass companions at semi-major axis greater than 10 astronomical units. Direct imaging being the only detection technique to be able to probe this outer region of planetary systems, the SPHERE infrared survey for exoplanets (SHINE) was designed and conducted from 2015 to 2021 to study the demographics of such young gas giant planets around 400 young nearby solar-type stars. In this paper, we present the observing strategy, the data quality, and the point sources analysis of the full SHINE statistical sample as well as snapSHINE. Both surveys used the SPHERE@VLT instrument with the IRDIS dual band imager in conjunction with the integral field spectrograph IFS and the angular differential imaging observing technique. All SHINE data (650 datasets), corresponding to 400 stars, including the targets of the F150 survey, are processed in a uniform manner with an advanced post-processing algorithm called PACO ASDI. An emphasis is put on the classification and identification of the most promising candidate companions. Compared to the previous early analysis SHINE F150, the use of advanced post-processing techniques significantly improved by one or 2 magnitudes (x3-x6) the contrast detection limits, which will allow us to put even tighter constraints on the radial distribution of young gas giants. This increased sensitivity directly places SHINE as the largest and deepest direct imaging survey ever conducted. We detected and classified more than 3500 physical sources. One additional substellar companion has been confirmed during the second phase of the survey (HIP 74865 B), and several new promising candidate companions are awaiting second epoch confirmations.

Stellar multiplicity is believed to influence planetary formation and evolution, although the precise nature and extent of this role remain ambiguous. We present a study aimed at testing the role of stellar multiplicity in the formation and/or evolution of the most massive, close-in planetary and substellar companions. Using direct imaging observations, as well as the Gaia DR2 catalogue, we searched for wide binary companions to 38 stars hosting massive giant planets or brown dwarfs (M > 7 MJup) on orbits shorter than ~1 AU. We report the discovery of a new component in the WASP-14 system, and present an independent confirmation of a comoving companion to WASP-18. From a robust Bayesian statistical analysis, we derived a binary fraction of 79.0+13.2-14.7% between 20-10,000 AU for our sample, twice as high as for field stars with a 3-{\\sigma} significance. This binary frequency was found to be larger than for lower-mass planets on similar orbits, and we observed a marginally higher binary rate for inner companions with periods shorter than 10 days. These results demonstrate that stellar companions greatly influence the formation and/or evolution of these systems, suggesting that the role played by binary companions becomes more important for higher-mass planets, and that this trend may be enhanced for systems with tighter orbits. Our analysis also revealed a peak in binary separation at 250 AU, highlighting a shortfall of close binaries among our sample. This indicates that the mechanisms affecting planet and brown dwarf formation or evolution in binaries must operate from wide separations, although we found that the Kozai-Lidov mechanism is unlikely to be the dominant underlying process. We conclude that binarity plays a crucial role in the existence of very massive short-period giant planets and brown dwarf desert inhabitants, which are almost exclusively observed in multiple systems.

Recent surveys indicate that planets in binary systems are more abundant than previously thought, which is in agreement with theoretical work on disc dynamics and planet formation in binaries. In order to measure the abundance and physical characteristics of wide-orbit giant exoplanets in binary systems, we have designed the 'VIsual Binary Exoplanet survey with Sphere' (VIBES) to search for planets in visual binaries. It uses the SPHERE instrument at VLT to search for planets in 23 visual binary and four visual triple systems with ages of <145 Myr and distances of <150 pc. We used the IRDIS dual-band imager on SPHERE to acquire high-contrast images of the sample targets. For each binary, the two components were observed at the same time with a coronagraph masking only the primary star. For the triple star, the tight components were treated as a single star for data reduction. This enabled us to effectively search for companions around 50 individual stars in binaries and four binaries in triples. We derived upper limits of \\(<\\)13.7\\% for the frequency of sub-stellar companions around primaries in visual binaries, \\(<\\)26.5\\% for the fraction of sub-stellar companions around secondaries in visual binaries, and an occurrence rate of \\(<\\)9.0\\% for giant planets and brown dwarfs around either component of visual binaries. We have combined our observations with literature measurements to astrometrically confirm, for the first time, that 20 binaries and two triple systems, which were previously known, are indeed physically bound. Finally, we discovered a third component of the binary HD~121336. The upper limits we derived are compatible with planet formation through the core accretion and the gravitational instability processes in binaries. These limits are also in line with limits found for single star and circumbinary planet search surveys.

Aims. This work aims at constraining the masses and separations of potential substellar companions to five accelerating stars (HIP 1481, HIP 88399, HIP 96334, HIP 30314 and HIP 116063) using multiple data sets acquired with different techniques. Methods. Our targets were originally observed as part of the SPHERE/SHINE survey, and radial velocity (RV) archive data were also available for four of the five objects. No companions were originally detected in any of these data sets, but the presence of significant proper motion anomalies (PMa) for all the stars strongly suggested the presence of a companion. Combining the information from the PMa with the limits derived from the RV and SPHERE data, we were able to put constraints on the characteristics of the unseen companions. Results. Our analysis led to relatively strong constraints for both HIP 1481 and HIP 88399, narrowing down the companion masses to 2-5 M_Jup and 3-5 M_Jup and separations within 2-15 au and 3-9 au, respectively. Because of the large age uncertainties for HIP 96334, the poor observing conditions for the SPHERE epochs of HIP 30314 and the lack of RV data for HIP 116063, the results for these targets were not as well defined, but we were still able to constrain the properties of the putative companions within a reasonable confidence level. Conclusions. For all five targets, our analysis has revealed that the companions responsible for the PMa signal would be well within reach for future instruments planned for the ELT (e.g., MICADO), which would easily achieve the required contrast and angular resolution. Our results therefore represent yet another confirmation of the power of multi-technique approaches for both the discovery and characterisation of planetary systems.