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Modern geophysics highlights that the slip behaviour response of faults is variable in space and time and can result in slow or fast ruptures. However, the origin of this variation of the rupture velocity in nature as well as the physics behind it is still debated. Here, we first highlight how the different types of fault slip observed in nature appear to stem from the same physical mechanism. Second, we reproduce at the scale of the laboratory the complete spectrum of rupture velocities observed in nature. Our results show that the rupture velocity can range from a few millimetres to kilometres per second, depending on the available energy at the onset of slip, in agreement with theoretical predictions. This combined set of observations bring a new explanation of the dominance of slow rupture fronts in the shallow part of the crust or in areas suspected to present large fluid pressure. The authors show that seismogenic faults can be activated by stress perturbations by all possible modes of slip independently of the frictional properties. They demonstrate, that the nature of seismicity is mostly governed by the initial stress level along the faults.

Poroelastic coupling between fractures and the surrounding rock is important to numerous applications in geosciences. We measure the in‐situ fluid pressure and local strain response of a fractured carbonate sample to hydrostatic pressure oscillations. A linear poroelastic model that represents the rock sample is parameterized using X‐ray imaging and ultrasonic wave transmission measurements. The numerical solution, based on Biot's quasistatic equations, is consistent with the measured frequency dependent dispersion of the apparent bulk modulus of the background matrix and the in‐situ pore pressure response, which is caused by fluid pressure diffusion from the compliant fractures into the stiffer matrix. The observed fluid pressure diffusion is causally related to the numerically quantified intrinsic attenuation at seismic frequencies, which is a major contributor to the dissipation of seismic waves. Our analysis supports the use of a simple approximation of fractures as compliant and planar inclusions in numerical simulations based on linear poroelasticity. Plain Language Summary Fractures control the flow of fluids through rocks as well as their mechanical properties. Finding ways to accurately simulate coupled hydro‐mechanical processes in fractured rock is important to a variety of applications in geosciences (e.g., subsurface storage of carbon dioxide or enhanced geothermal energy extraction). Physics‐based simulations require accurate parameterization and validation against experiments. In our experiment on a fluid saturated fractured rock sample, we applied an oscillating confining pressure to the sample and measured the corresponding deformation and the change in the pore fluid pressure in a fracture and the porous matrix. By adjusting the frequency of the oscillations, we observed a divergence in the pore pressure amplitude in the fracture and the matrix, which is a consequence of flow from the fracture into the porous matrix becoming restricted at elevated frequencies. The laboratory measurements were in close agreement with the results of our simulations, which were based on a simplified model of the rock sample. The outcome of our work supports the use of a widely applied approximation of fractures as simple planar inclusions in numerical simulations based on linear poroelasticity. Key Points We observe the poroelastic coupling of fractures to the rock matrix in in‐situ fluid pressure measurements during stress oscillations The geometrically complex fractures can be modeled as compliant and planar poroelastic inclusions The numerically quantified intrinsic seismic (<100 Hz) attenuation is due to fluid pressure diffusion, which is experimentally observed

Myeloid cells contribute to tumor progression, but how the constellation of receptors they express regulates their functions within the tumor microenvironment (TME) is unclear. We demonstrate that Fcmr (Toso), the putative receptor for soluble IgM, modulates myeloid cell responses to cancer. In a syngeneic melanoma model, Fcmr ablation in myeloid cells suppressed tumor growth and extended mouse survival. Fcmr deficiency increased myeloid cell population density in this malignancy and enhanced anti-tumor immunity. Single-cell RNA sequencing of Fcmr-deficient tumor-associated mononuclear phagocytes revealed a unique subset with enhanced antigen processing/presenting properties. Conversely, Fcmr activity negatively regulated the activation and migratory capacity of myeloid cells in vivo, and T cell activation by bone marrow-derived dendritic cells in vitro. Therapeutic targeting of Fcmr during oncogenesis decreased tumor growth when used as a single agent or in combination with anti-PD-1. Thus, Fcmr regulates myeloid cell activation within the TME and may be a potential therapeutic target. Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti-tumour immunity.

Understanding the coupling between rock permeability, pore pressure, and fluid flow is crucial, as fluids play an important role in the Earth's crustal dynamics. We measured the distribution of fluid pressure during fluid‐flow experiments on two typical crustal lithologies, granite and basalt. Our results demonstrate that the pore‐pressure distribution transitions from a linear to a non‐linear profile as the imposed pore‐pressure gradient is increased (from 2.5 to 60 MPa) across the specimen. This non‐linearity results from the effective pressure dependence of permeability, for which two analytical formulations were considered: an empirical exponential and a new micromechanics‐based model. In both cases, the non‐linearity of pore pressure distribution is predicted. Using a compilation of permeability versus Terzaghi's effective pressure data for granites and basalts, we show that our micromechanics‐based model has the potential to predict the pore pressure distribution over the range of effective pressures expected within the brittle crust. Plain Language Summary Fluids distributions and fluid migrations play an important role in the Earth's crustal dynamics and how fluids migrate through a rock will depend primarily on permeability. However, the permeability of crustal rocks may exhibit important pressure dependence, because cracks and fractures will increasingly close with increasing tectonic pressure. In this experimental study, we show that the couplings between increasing pressure, crack closure, and permeability reduction may result in non‐linear pore pressure distributions on a rock specimen at the laboratory scale, which confirms for the first time pioneering theoretical and experimental works. Two simple analytical expressions of the pressure dependence of permeability predict this non‐linearity. One empirical expression, most commonly used in the literature, takes the form of an exponential. The second one, a new model, based on crack micromechanics, was developed within this work and shown to outperform the exponential formulation at low Terzaghi's effective pressure. Key Points Pore pressure was measured locally in rocks exhibiting pressure‐dependent permeability We observed a transition from linear to nonlinear pore pressure distribution with increasing fluid pressure gradients A new, micromechanics‐based, analytical model was developed for the pressure dependence of permeability in microcracked rocks

On the Island of Samos (East Aegean region, Greece), two sedimentary basins are filled by thick continental series dated to the Late Miocene to Early Pliocene. A multidisciplinary study has been performed including (1) the definition of 21 sedimentary facies, (2) a review of the biological components and (3) carbon, oxygen and strontium stable isotope analyses. The succession is characterised by various depositional settings and hydrochemical compositions. Five main stages of basin evolution have been identified: (1) The Late Serravallian is marked by the development of alluvial fans and fan delta; (2) during the Lower Tortonian, isolated shallow lakes with variable salinity, from fresh to brackish, developed under warm and relatively humid conditions; (3) the Middle to Upper Tortonian is marked by the development of a large and deep lake with saline and alkaline waters, under colder and drier conditions; (4) the Latest Tortonian to Messinian period is represented by an ephemeral alluvial system, developed under a dry climate; (5) during the Zanclean, a palustrine and paludal wetland system, dominated by tufa carbonates, developed under moderately humid conditions. This succession is of particular interest for the reconstruction of the palaeoenvironmental evolution of the transition zone between the Mediterranean domain, and the Paratethys and circum‐Paratethys areas. The geochemical data and the presence of flora (diatoms) and fauna (gastropods) of marine affinity suggest transient ingressions of marine‐related water or groundwater inflows as early as the Lower Tortonian. The Samos succession records the complex interaction between the regional geodynamics and climate. The extensional regime of the Eastern Aegean zone generates subsidence, interrupted in the mid‐Tortonian (9 Ma) by a brief compressive event and a major exposure of the basins. Furthermore, the Late Miocene progressive aridification, followed by a change to a more humid climate (Pliocene) is also a major driver of the sedimentation.

We investigated initiation and propagation of compaction bands (CB) in six wet and four dry Bentheim sandstone samples deformed in axial compression tests with strain rates ranging from 3.2 × 10 −8  s −1 to 3.2 × 10 −4  s −1 . Circumferential notches with 0.8-mm width and 5-mm depth served to initiate CB at mid-sample length. Wet samples were saturated with distilled water and deformed at 195 MPa confining pressure and 10 MPa pore pressure. Dry samples were deformed at 185 MPa confining pressure. Twelve P-wave sensors, eight S-wave sensors and two pairs of orthogonally oriented strain-gages were glued to the sample surface to monitor acoustic emission (AE), velocities and local strain during the loading process. Nucleation of compaction bands is indicated by AE clusters close to the notch tips. With progressive loading, AE activity increased and AE hypocenters indicated propagation of a single CB normal to the sample axis. CB propagation from the sample periphery towards the centre was monitored. Microstructural analysis of deformed samples shows excellent agreement between location of AE clusters and CBs. In both dry and wet samples the lateral propagation of CBs was about 100 times faster than axial shortening rates. At the slowest displacement rate, AE activity during band propagation was reduced and CB nucleation in wet samples occurred at 20% lower stresses. This may indicate an increasing contribution of stress corrosion processes to the formation of the compaction bands. In dry and wet samples inelastic compaction energy per area ranged between 16 and 80 kJ m −2 . This is in good agreement with previous estimates from laboratory and field studies.

Successful mammalian reproduction depends on proper synthesis of the pituitary-derived glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Several transcription factors cooperate to activate cell-specific and hormone-regulated expression of the gonadotropin beta subunits (Lhb and Fshb). Among these, NR5A1 (steroidogenic factor 1; SF1) has been shown to directly bind to the Lhb promoter, mediate basal and gonadotropin-releasing hormone (GnRH)-stimulated Lhb transcription, and possibly directly regulate Fshb expression. Recently, the closely-related NR5A2 was shown to activate the rat Lhb promoter in vitro. Here, we further characterized the role of NR5A2 in regulating gonadotropin synthesis. Ectopically expressed NR5A2 directly activated the murine Lhb promoter in a manner identical to that of NR5A1, whereas neither factor activated the murine Fshb promoter. In LβT2 gonadotrope-like cells, depletion of endogenous NR5A1 or NR5A2 impaired basal and GnRH-stimulated Lhb and Fshb transcription. To analyze the physiological role of NR5A2 in gonadotropes in vivo, we generated mice with a gonadotrope-specific deletion of Nr5a2. In contrast with our in vitro data, these mice had normal pituitary Lhb and Fshb expression and intact fertility. Together, our data establish that NR5A2 can act in a non-redundant manner to regulate Lhb and Fshb transcription in vitro, but is dispensable in vivo.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Although different fluid pressure diffusion mechanisms caused by fractures have been extensively studied using analytical and numerical methods, there is little to no experimental work completed on them in laboratory conditions. In this paper, hydrostatic-stress oscillations (frequency − 0.04 to 1 Hz) are used on an intact and saw cut sample, in dry and water saturated conditions, in a triaxial cell at different effective pressures in undrained conditions. The objective is to study the fracture’s effect on the elastic properties of the sample and validate some computational fracture models, that have been explored in the literature. Experimental results highlight dispersion and attenuation in saturated conditions due to the fracture, which diminishes in amplitude as the effective pressure is increased, i.e. as the fracture is closed. From local strain gauge measurements, it is found that there is a local negative phase shift between stress and strain in water saturated conditions for the fractured sample, due to the location of the strain measurements. No attenuation observed in dry conditions. A simple 1D model using mass balance and mechanical equilibrium equations for a linear isotropic poroelastic homogeneous medium give prediction in very good agreement with the experimental results. A 3D model was also developed to allow a comparison between analytic, numerical and experimental results.HighlightsUsing innovative microvalves in an experimental setup on a fractured rock sample, to reach undrained conditions, in seismic frequency range.Local strain measurements, for the first time experimentally, show local negative phase shift between stress and strain in water saturated conditions.A 1D analytical and 3D numerical model were created which are in good agreement with the experimental results.

Between 1975 and 1996, the Centre d’Expérimentation du Pacifique (CEP) carried out French underground nuclear tests under the atoll of Mururoa (French Polynesia). The deformation of its coral rim was extensively monitored in order to assess the stability of the outer slopes, in particular since a flank collapsed in 1979, triggering a landslide-generated tsunami. The atoll has attracted the attention of experts since the beginning of the nuclear tests because of the mechanical behavior of porous and weak chalky limestones at depth. In this study, samples of these rocks, which were extracted from the atoll’s rim through drilling, have been deformed in the laboratory. The implications of the experiments provide a new perspective on the deformation of the Mururoa atoll since the end of nuclear tests—and, by extension, on the micromechanics of chalks for several other geological contexts.