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Treatment of High-Risk Neuroblastoma
High-risk neuroblastoma is a highly aggressive solid tumor that most commonly presents in early childhood. Advances in treatment through decades of clinical trials and research have led to improved outcomes. This review provides an overview of the current state of treatment for high-risk neuroblastoma.
Journal Article
Neuroblastoma in the Era of Precision Medicine: A Clinical Review
The latest advances in treatment for patients with neuroblastoma are constantly being incorporated into clinical trials and clinical practice standards, resulting in incremental improvements in the survival of patients over time. Survivors of high-risk neuroblastoma (HRNBL), however, continue to develop treatment-related late effects. Additionally, for the majority of the nearly 50% of patients with HRNBL who experience relapse, no curative therapy currently exists. As technologies in diagnostic and molecular profiling techniques rapidly advance, so does the discovery of potential treatment targets. Here, we discuss the current clinical landscape of therapies for neuroblastoma in the era of precision medicine.
Journal Article
MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells.
MYCN
amplification is found in half of high-risk NB patients; however, no available therapies directly target MYCN. Using multi-dimensional metabolic profiling in MYCN expression systems and primary patient tumors, we comprehensively characterized the metabolic landscape driven by MYCN in NB.
MYCN
amplification leads to glycerolipid accumulation by promoting fatty acid (FA) uptake and biosynthesis. We found that cells expressing amplified
MYCN
depend highly on FA uptake for survival. Mechanistically, MYCN directly upregulates FA transport protein 2 (FATP2), encoded by
SLC27A2
. Genetic depletion of
SLC27A2
impairs NB survival, and pharmacological
SLC27A2
inhibition selectively suppresses tumor growth, prolongs animal survival, and exerts synergistic anti-tumor effects when combined with conventional chemotherapies in multiple preclinical NB models. This study identifies FA uptake as a critical metabolic dependency for
MYCN
-amplified tumors. Inhibiting FA uptake is an effective approach for improving current treatment regimens.
Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.
Journal Article
No Horses in the House! The Audacious Life of Artist Rosa Bonheur
written by Mireille Messier illustrated by Anna Bron Orca Book Publishers, 2023 978-1-4598-3352 -4 (he) $21.95 978-1-4598-3354-8 (eBook) $16.99 for Grades 1 to 3 Non-Fiction Picture Book | Biography | Artists | Gender Expectations | Inclusion and Diversity | Feminism | LGBTQ2S+1 Perseverance | Self-Reliance No Horses in the House!, written by award-winning author Mireille Messier and illustrated by acclaimed artist Anna Bron, is a charming and engaging fictionalized biography based on the true story of the early life of Rosa Bonheur, a trailblazing 19th-century French artist who readily challenged gender expectations and forever changed the world of art with her often-oversized realistic paintings of animals. Complete with an author's note and a full page listing the artist's impressive milestones (Who knew she was the first woman artist to receive the Legion of Honour in France (in 1865) and she became friends with Buffalo Bill?), these two end-of-the-book resources offer readers additional glimpses into the ever-inspiring world of Rosa Bonheur, further educating and no doubt encouraging them to explore for themselves the fascinating world of this feisty, queer, gifted and boundary-breaking female role model. Destined to become a go-to on any bookshelf, No Horses in the House! (also available in French) is a touchstone, an irreplaceable resource for school, home and public libraries, sparking meaningful discussion, understanding and compassion, and acting as an enjoyable and accessible point of reference for myriad themes.
Journal Article
Babble! And How Punctuation Saved It
written by Caroline Adderson illustrated by Roman Muradov Tundra Books, 2022 978-0-7352-6583-7 (he) $19.99 978-0-7352-6584-4 (eBook) $10.99 for Grades 2 and up Early Chapter Book | Language, Communication and Punctuation | Listening | Gratitude | Respect and Sharing | Community and Teamwork Babble! Enter an energetic and gregarious stranger, a young girl who distributes strange-looking things from her bag -peculiar symbols that slowly but surely help the distressed villagers transform their thoughts into clear sentences and bring order to their lives, helping them finally make sense of themselves and one another. Each punctuation mark is introduced in red boldface type and used throughout the sentences in various chapters, showing readers how to correctly use each mark and how each one helps words convey meaning and bring about understanding. [...]How Punctuation Saved It is an invaluable resource for home, public and school libraries, inspiring meaningful conversation and acting as an acces- sible touchpoint for intergenerational learning and enjoyment.
Journal Article
Dear Peter, Dear Ulla
written by Barbara Nickel illustrated by Ian Hampton Thistledown Press, 2021 978-1-77187-217-1 (pb) $16.95 for Grades 4 and up Historical Fiction | Second World War | Family and Love | Fear, Courage, Resilience | Prejudice and Racial Violence Dear Peter, Dear Ulla, written by award-winning, British Columbia-based children's author Barbara Nickel and peppered with illustrations by Ian Hampton, is an insightful, affecting historical middle-grade fiction novel about the deep pull of family and friendship, the cataclysmic effects of conflict and racism, and the immeasurable value of courage, hope, loyalty and resilience-all set against the backdrop of the outbreak of the Second World War, in September 1939. [...]party narration is skillfully woven throughout the correspondence, adding vivid, vital information about Peter and Ulla, their families, the war and the communities involved. A must-read for introducing young readers to the nuances and optics of the Second World War and Mennonite history, this richly layered and ultimately life-affirming book is complete with a table of contents and addenda, including multiple postscripts, an author's note, black-and-white illustrations, maps, photos, etchings and two German recipes for food featured in the book: one for Oma's Pepper-nuts and one for Aunt Malgorzata's Polish Apple Cake with Meringue.
Journal Article
Unstoppable: Women with Disabilities
written by Helen Wolfe illustrated by Karen Patkau Second Story Press, 2021 978-1-77260-209-8 (he) $19.95 for Grades 5 to 7 Non-fiction | Feminism | Challenges, Perseverance and Courage | Prejudice and Tolerance | Self-Esteem | Abilities | Cultural and Ethnic Diversity Unstoppable: Women with Disabilities, authored by Helen Wolfe and illustrated by Karen Patkau, is an eye-opening and inspirational non-fiction book about overcoming physical and mental health challenges, diversity and self-esteem, and the indomitable power of courage and perseverance. A dynamic and motivating 24-page read, Wolfe, who has a lifelong physical disability that requires her to use crutches, a wheelchair and a scooter, has crafted an outstanding narrative that focuses on 10 women worldwide who have realized amazing accomplishments, some up against seemingly insurmountable odds, such as Dr. Karin Muraszko, an American neurosurgeon who was born with spina bifida and who now performs live-saving operations, training and teaching other doctors to do the same. [...]for the first time in Ethiopian history, women and people with disabilities are now able to earn their own living. Complete with a handy table of contents, a one-page introduction by Wolfe and mini-bios of both the author and the illustrator, Unstoppable is not only a stirring, memorable must-read but also a spirit-lifting resource and invaluable educational tool for all home, school and public libraries that's sure to build empathy and determination, and encourage all who read it to help make a difference in the world.
Journal Article