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Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor. Conventional treatments for GBM include surgery, chemotherapy, radiotherapy, or a combination of these. However, emerging therapies, such as hyperthermia treatments, are being developed. One of these new therapies is nanoparticle-mediated photothermal therapy (PTT), a non-invasive treatment that converts light into heat using photoagents such as plasmonic nanoparticles. High molecular weight hyaluronic acid (HA) has been described as a potential inhibitor of tumor progression and exhibits a high affinity for the CD44 receptor, which is present in GBM cells. The in vivo efficacy of gold nanorods (GNRs) biofunctionalized with HA-700kDa in PTT has been evaluated in a murine GBM model. Adult male C57/BL-6 mice (N=15), 3-8-month-old, were used for PTT experiments. CT2A cells were injected into the mouse brain to establish a GBM model. Tumor-bearing mice were randomly divided into three groups: Control (untreated, n=5), GNRs (injected with GNRs, n=5) and PTT-treated (injected with GNRs and treated with laser, n=5). After GNR injection, mice were irradiated with a laser at 0.98 A (250mW) for 25 min over three consecutive days. As observed in the analysis of tumor sizes from all MR images, animals treated with a laser following GNR injection exhibited significantly smaller tumor sizes compared to control and GNR-treated animals one week after the treatment. In addition, PTT treatment led to a notable improvement in the exploratory behavior of the treated animals and an increase in their life expectancy compared to untreated control mice. This study demonstrates the efficacy of GNR-based-PTT, applied to an orthotopic tumor model, using GNRs biofunctionalized with HA to target GBM CT2A cells. The treatment resulted in a reduction in tumor mass and an extension of life expectancy in GNR-PTT treated mice.

An innovative technique to access the nuclear matrix elements entering the expression of the life time of the double beta decay by relevant cross sections of double charge exchange reactions is proposed. The basic point is the coincidence of the initial and final state wave-functions in the two classes of processes and the similarity of the transition operators, which in both cases present a superposition of Fermi, Gamow-Teller and rank-two tensor components with a relevant implicit momentum transfer. First pioneering experimental results obtained at the INFN-LNS laboratory for the 40Ca(18O,18Ne)40Ar reaction at 270 MeV, give encouraging indication on the capability of the proposed technique to access relevant quantitative information. A key aspect of the project is the use of the K800 Superconducting Cyclotron (CS) for the acceleration of the required high resolution and low emittance heavy- ion beams and of the MAGNEX large acceptance magnetic spectrometer for the detection of the ejectiles. The use of the high-order trajectory reconstruction technique, implemented in MAGNEX, allows to reach the high mass, angular and energy resolution required even at very low cross section. The LNS set-up is today an ideal one for this research even in a worldwide perspective. However a main limitation on the beam current delivered by the accelerator and the maximum rate accepted by the MAGNEX focal plane detector must be sensibly overcome in order to systematically provide accurate numbers to the neutrino physics community in all the studied cases. The upgrade of the LNS facilities in this view is part of this project.

The 18O+48Ti reaction was studied at the energy of 275 MeV for the first time under the NUMEN and NURE experimental campaigns with the aim of investigating the complete reaction network potentially involved in the 48Ti→48Ca double charge exchange transition. Understanding the degree of competition between successive nucleon transfer and double charge exchange reactions is crucial for the description of the meson exchange mechanism. Into this context, angular distribution measurements for one- and two-nucleon transfer reactions for the system 18O+48Ti were performed at the MAGNEX facility of INFN-LNS in Catania. An overview of the status of the analysis for the two-proton transfer reaction will be given.

Heavy-ion one-nucleon transfer reactions are promising tools to investigate single-particle configurations in nuclear states, with and without the excitation of the core degrees of freedom. An accurate determination of the spectroscopic amplitudes of these configurations is essential for the study of other direct reactions as well as beta-decays. In this context, the 76Se(18O,17O)77Se one-neutron transfer reaction gives a quantitative access to the relevant single particle orbitals and core polarization transitions built on 76Se. This is particularly relevant, since it provides data-driven information to constrain nuclear structure models for the 76Se nucleus.The excitation energy spectrum and the differential cross section angular distributions of this nucleon transfer reaction was measured at 275 MeV incident energy for the first time using the MAGNEX large acceptance magnetic spectrometer. The data are compared with calculations based on distorted wave Born approximation and coupled channel Born approximation adopting spectroscopic amplitudes for the projectile and target overlaps derived by large-scale shell model calculations and interacting boson-fermion model.These reactions are studied in the frame of the NUMEN project. The NUMEN (NUclear Matrix Elements for Neutrinoless double beta decay) project was conceived at the Istituto Nazionale di Fisica Nucleare–Laboratori Nazionali del Sud (INFN-LNS) in Catania, Italy, aiming at accessing information about the nuclear matrix elements (NME) of neutrinoless double beta decay (0νββ) through the study of the heavy-ion induced double charge exchange (DCE) reactions on various 0νββ decay candidate targets. Among these, the 76Se nucleus is under investigation since it is the daughter nucleus of 76Ge in the 0νββ decay process.

In this contribution, we will illustrate the main results of the R&D activities related to the Silicon Carbide detectors associated with NUMEN project.

Giant resonances are collective excitation modes for many-body systems of fermions governed by a mean field, such as the atomic nuclei. The microscopic origin of such modes is the coherence among elementary particle-hole excitations, where a particle is promoted from an occupied state below the Fermi level (hole) to an empty one above the Fermi level (particle). The same coherence is also predicted for the particle–particle and the hole–hole excitations, because of the basic quantum symmetry between particles and holes. In nuclear physics, the giant modes have been widely reported for the particle–hole sector but, despite several attempts, there is no precedent in the particle–particle and hole–hole ones, thus making questionable the aforementioned symmetry assumption. Here we provide experimental indications of the Giant Pairing Vibration, which is the leading particle–particle giant mode. An immediate implication of it is the validation of the particle–hole symmetry. The Giant Pairing Vibration is a collective mode in an atomic nucleus caused by coherence between particle-particle excitations, which has so far eluded detection. Cappuzzello et al . present signatures for its existence via heavy-ion-induced two-neutron transfer reactions in carbon nuclei.

The project number was missing from the acknowledgement. The correct acknowledgment is as follows

Elastic scattering and breakup angular distribution measurements for the systems 6,7 Li + p were performed at the MAGNEX facility of the I stituto N azionale di F isica N ucleare- L aboratori N azionali del S ud (INFN-LNS) in Catania, in the energy range of (2.3–5.4)AMeV. The breakup channel was identified and quantified adopting the algorithm MULTIP.Within this algorithm which is a Monte Carlo simulation code, the history of the breakup fragments can be tagged from the rest frame of the decay nucleus itself to the laboratory frame. Angular distribution data of both elastic scattering and breakup were analyzed under the same theoretical model and the influence of continuum on the elastic channel was investigated.

Excitation energy spectra and absolute cross section angular distributions were measured for the 13C(18O,16O)15C two-neutron transfer reaction at 84 MeV incident energy. This reaction selectively populates two-neutron configurations in the states of the residual nucleus. Exact finite-range coupled reaction channel calculations are used to analyse the data. Two approaches are discussed: the extreme cluster and the newly introduced microscopic cluster. The latter makes use of spectroscopic amplitudes in the centre of mass reference frame, derived from shell-model calculations using the Moshinsky transformation brackets. The results describe well the experimental cross section and highlight cluster configurations in the involved wave functions.

The NUMEN project proposes to study heavy-ion induced Double Charge Exchange (DCE) reactions with the final goal to get information on the nuclear matrix elements for neutrinoless double beta (0νββ) decay. The knowledge of the nuclear matrix elements is crucial to infer the neutrino average masses from the possible measurement of the half-life of 0νββ decay. DCE reactions and 0νββ decay present some similarities, the initial and final-state wave functions are the same and the transition operators are similar. The experimental measurements of DCE reactions induced by heavy ions present a number of challenging aspects, since they are characterized by very low cross sections.