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"Fox, Sarah"
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Understanding how comprehensive geriatric assessment works: the importance of varied methodological approaches
Comprehensive geriatric assessment (CGA) is the gold standard model of care for older adults with frailty. However, despite a large number of published clinical trials, there remain many unanswered questions about how CGA works in different circumstances. This uncertainty stems from CGA being a deeply complex intervention that is heavily modified by context. This review describes recent and novel methodological approaches that explore the active ingredients of CGA and their interaction with context. Future research should continue to embrace broad methodologies that can help us better understand this intervention, in such a way that it can be implemented with fidelity and associated with positive outcomes for older adults.
Journal Article
Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β–related pathway in macrophages
Neuropathic pain remains poorly managed by current therapies, highlighting the need to improve our knowledge of chronic pain mechanisms. In neuropathic pain models, dorsal root ganglia (DRG) nociceptive neurons transfer miR-21 packaged in extracellular vesicles to macrophages that promote a proinflammatory phenotype and contribute to allodynia. Here we show that miR-21 conditional deletion in DRG neurons was coupled with lack of upregulation of chemokine CCL2 after nerve injury and reduced accumulation of CCR2-expressing macrophages, which showed TGF-β-related pathway activation and acquired an M2-like antinociceptive phenotype. Indeed, neuropathic allodynia was attenuated after conditional knockout of miR-21 and restored by TGF-βR inhibitor (SB431542) administration. Since TGF-βR2 and TGF-β1 are known miR-21 targets, we suggest that miR-21 transfer from injured neurons to macrophages maintains a proinflammatory phenotype via suppression of such an antiinflammatory pathway. These data support miR-21 inhibition as a possible approach to maintain polarization of DRG macrophages at an M2-like state and attenuate neuropathic pain.
Journal Article
An ale of two cities
\"The Winter Carnival always brings holiday cheer, Christmas joy--and tourists with cash--to picturesque Shady Creek, Vermont. At the center of the glittering decorations and twinkling lights is booklover and pub owner Sadie Coleman, creating original cocktails, hosting a literary trivia evening, and cheering on her loyal employee Melanie 'Mel' Costas as she competes in the ice carving competition. But holiday cheer can't compete with former resident and renowned chef Freddy Mancini, who arrives with his nose in the air, showing off his ice-sculpting skills like a modern-day Michelangelo. During the artists' break in the night-long contest, Mel's tools disappear... and Freddy is found dead with her missing pick in his chest. Although the police turn their attention to Mel, it seems everyone in town had a grudge against Freddy, including his assistant, his mentor, his former flame, and even his half-brother. Faster than she can fling a Huckleberry Gin, Sadie finds herself racing to make sure the police don't arrest the wrong suspect--all while sharing a flirtation with local brewery owner Grayson Blake. Their chemistry leads to a heated rivalry at the hockey rink--and to the hot pursuit of a killer.\" -- Provided by publisher.
Book
Anticipating the ageing trajectories of superheroes in the Marvel cinematic universe
Ruth Hubbard and colleagues examine the personal traits and health behaviours of five of Marvel's superheroes and envisage the challenges this extraordinary cohort might experience during ageing
Journal Article
Cryptocurrencies in public and private law
This book examines how cryptocurrencies based on blockchain technologies fit into existing general law categories of public and private law. The book takes the common law systems of the United Kingdom as the centre of its study but extends beyond the UK to show how cryptocurrencies would be accommodated in some Western European and East Asian legal systems outside the common law tradition.0By investigating traditional conceptions of money in public law and private law the work examines the difficulties of fitting cryptocurrencies within those approaches and models. Fundamental questions regarding issues of ownership, transfer, conflict of laws, and taxation are addressed with a view to equipping the reader with the tools to answer common transactional questions about cryptocurrencies. The international contributor team uses the common law systems of the United Kingdom as a basis for the analysis, but also looks comparatively to other systems across the wider common law and civil law world to provide detailed examination of the legal problems encountered.
Book
Sharing the Sidewalk: Observing Delivery Robot Interactions with Pedestrians during a Pilot in Pittsburgh, PA
Sidewalk delivery robots are being deployed as a form of last-mile delivery. While many such robots have been deployed on college campuses, fewer have been piloted on public sidewalks. Furthermore, there have been few observational studies of robots and their interactions with pedestrians. To better understand how sidewalk robots might integrate into public spaces, the City of Pittsburgh, Pennsylvania conducted a pilot of sidewalk delivery robots to understand possible uses and the challenges that could arise in interacting with people in the city. Our team conducted ethnographic observations and intercept interviews to understand how residents perceived of and interacted with sidewalk delivery robots over the course of the public pilot. We found that people with limited knowledge about the robots crafted stories about their purpose and function. We observed the robots causing distractions and obstructions with different sidewalk users (including children and dogs), witnessed people helping immobilized robots, and learned about potential accessibility issues that the robots may pose. Based on our findings, we contribute a set of recommendations for future pilots, as well as questions to guide future design for robots in public spaces.
Journal Article
The tree of life
This is a film about the conflict between nature and grace, the agonizing mystery of God, and the meaning of life itself. The death of his brother forces Jack O'Brien to confront his past, which is dominated by his difficult relationship with his father. Jack's father was a stern authoritarian whose no-nonsense demeanor masked a host of unfulfilled dreams. His mother was a gentle, kind woman who often allowed her own needs and desires to give way to those of her husband and children. As Jack's memories come flooding back--of the course of a Texas summer in the 1950s--viewers observe Jack's evolving relationship with his parents, his younger brother, and God, while adult Jack questions the meanings of life, love, and family.
DVD
Downwind
Downwindis an unflinching tale of the atomic West that reveals the intentional disregard for human and animal life through nuclear testing by the federal government and uranium extraction by mining corporations during and after the Cold War.
Sarah Alisabeth Fox highlights the personal cost of nuclear testing and uranium extraction in the American West through extensive interviews with \"downwinders,\" the Native American and non-Native residents of the Great Basin region affected by nuclear environmental contamination and nuclear-testing fallout. These downwinders tell tales of communities ravaged by cancer epidemics, farmers and ranchers economically ruined by massive crop and animal deaths, and Native miners working in dangerous conditions without proper safety equipment so that the government could surreptitiously study the effects of radiation on humans.
In chilling detailDownwindbrings to light the stories and concerns of these groups whose voices have been silenced and marginalized for decades in the name of \"patriotism\" and \"national security.\"
With the renewed boom in mining in the American West, Fox's look at this hidden history, unearthed from years of field interviews, archival research, and epidemiological studies, is a must-read for every American concerned about the fate of our western lands and communities.
eBook