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The world faces urgent sustainability challenges and international agreements call for policy change. CO2 pricing is an effective way to reduce greenhouse gas emissions and allows us to find innovative ways to cover these emission sources, addressing environmental, economic, and social sustainability through the targeted use of revenues. In order to design a publicly acceptable pricing concept, this study empirically examines the public perceptions of CO2 pricing in Germany, preferred revenue recycling schemes, and socio-psychological differences following its national implementation. In a choice-based conjoint measurement, we simulated the interplay of influencing factors (revenue reinvestment, climate effects, and scale of action) in a comprehensible choice task (n = 1209). The results show that revenue reinvestment has the highest importance for the acceptance of CO2 pricing, followed by the climate effect, and confirm that the individual financial burden is a significant obstacle to achieving government climate goals. The findings help policymakers to understand the public’s motives and demands for accepted carbon pricing options, and support management recommendations for policy and governance to work towards a sustainable transformation. However, to achieve global sustainability outcomes, it is imperative that such studies are conducted worldwide, as comparisons with previous studies reveal local differences in needs and preferences.

The world faces urgent sustainability challenges and international agreements call for policy change. CO[sub.2] pricing is an effective way to reduce greenhouse gas emissions and allows us to find innovative ways to cover these emission sources, addressing environmental, economic, and social sustainability through the targeted use of revenues. In order to design a publicly acceptable pricing concept, this study empirically examines the public perceptions of CO[sub.2] pricing in Germany, preferred revenue recycling schemes, and socio-psychological differences following its national implementation. In a choice-based conjoint measurement, we simulated the interplay of influencing factors (revenue reinvestment, climate effects, and scale of action) in a comprehensible choice task (n = 1209). The results show that revenue reinvestment has the highest importance for the acceptance of CO[sub.2] pricing, followed by the climate effect, and confirm that the individual financial burden is a significant obstacle to achieving government climate goals. The findings help policymakers to understand the public’s motives and demands for accepted carbon pricing options, and support management recommendations for policy and governance to work towards a sustainable transformation. However, to achieve global sustainability outcomes, it is imperative that such studies are conducted worldwide, as comparisons with previous studies reveal local differences in needs and preferences.

The outbreak of COVID-19 has posed formidable challenges to the food industry, exacerbating threats to food security worldwide. In response to this crisis, this comprehensive review systematically maps the existing literature concerning sustainability and resilience within the realm of food security. A meticulous categorization of the identified papers is performed, focusing on elucidating the underlying causes of food insecurity, assessing their profound impacts on public health, delineating the requisite strategies and actions, and discerning the commonalities and distinctions between sustainability and resilience. Systematic searches across reputable databases, including PubMed, Google Scholar, Scopus, and Springer, were conducted to retrieve pertinent papers published from 2019 to 2022, specifically addressing the threats to food security in the post-pandemic landscape. From an initial pool of 105 papers, 26 met the stringent inclusion criteria for subsequent in-depth analysis and categorization, employing thematic content analysis to elucidate their thematic focus on causative factors, repercussions, mitigation strategies, and intersections between sustainability and resilience. Drawing insights from the amalgamated findings, this study proposes a holistic, systematic conceptualization for integrating sustainability and resilience principles within the food sector. This structure offers a roadmap for fortifying food security, ultimately advancing the cause of public health and well-being. It is poised to serve as a valuable resource for researchers, facilitating the exploration of sustainability and resilience in the context of food supply chains and providing policymakers with actionable insights for implementing these vital approaches.

Tumour addicted to oncomiR MicroRNAs (miRNAs) — small RNA molecules that regulate gene expression and have an important role in establishing cell identity — have been linked to human cancers, where they are referred to as oncomiRs. One model of cancer development proposes that proliferating cells become 'addicted' to activating mutations in an oncogene, and it has been suggested that tumours may also become dependent on oncomiRs. Work in mice that were engineered to conditionally express microRNA-21 (miR-21), which is overexpressed in most tumour types so far analysed, now shows that miR-21 induces pre-B-cell lymphoma. In the absence of miR-21, malignant cells undergo apoptosis and regress, as would be expected if they were addicted to its presence. The pharmacological inactivation of 'oncomiR-21' and other similar miRNAs may therefore be of therapeutic benefit. One model for cancer development posits that the proliferating cells in a tumour can become 'addicted' to activating mutations in an oncogene. With the realization that certain microRNAs promote tumorigenesis, it has been proposed that tumours may also become dependent on such 'oncomiRs'. Here, evidence is provided that the gene encoding microRNA-21 is an oncogene, and that in its absence, tumours undergo apoptosis and regress. Thus tumours can indeed become addicted to oncomiRs. MicroRNAs (miRNAs) belong to a recently discovered class of small RNA molecules that regulate gene expression at the post-transcriptional level. miRNAs have crucial functions in the development and establishment of cell identity, and aberrant metabolism or expression of miRNAs has been linked to human diseases, including cancer 1 . Components of the miRNA machinery and miRNAs themselves are involved in many cellular processes that are altered in cancer, such as differentiation, proliferation and apoptosis. Some miRNAs, referred to as oncomiRs 2 , show differential expression levels in cancer and are able to affect cellular transformation, carcinogenesis and metastasis, acting either as oncogenes or tumour suppressors. The phenomenon of ‘oncogene addiction’ reveals that despite the multistep nature of tumorigenesis, targeting of certain single oncogenes can have therapeutic value 3 , 4 , and the possibility of oncomiR addiction has been proposed but never demonstrated 3 . MicroRNA-21 (miR-21) is a unique miRNA in that it is overexpressed in most tumour types analysed so far. Despite great interest in miR-21, most of the data implicating it in cancer have been obtained through miRNA profiling and limited in vitro functional assays. To explore the role of miR-21 in cancer in vivo , we used Cre and Tet-off technologies to generate mice conditionally expressing miR-21. Here we show that overexpression of miR-21 leads to a pre-B malignant lymphoid-like phenotype, demonstrating that mir-21 is a genuine oncogene. When miR-21 was inactivated, the tumours regressed completely in a few days, partly as a result of apoptosis. These results demonstrate that tumours can become addicted to oncomiRs and support efforts to treat human cancers through pharmacological inactivation of miRNAs such as miR-21.

The risk of sexual HIV transmission in serodiscordant couples when the HIV-positive partner has full virologic suppression on combination antiretroviral therapy (cART) is debated. This study aims to systematically review observational studies and randomized controlled trials (RCTs), evaluating rates of sexual HIV transmission between heterosexual serodiscordant couples when the HIV-positive partner has full suppression on cART. We searched major bibliographic databases to November 2012 for relevant observational studies and RCTs without language restrictions. Conference proceedings, key journals and bibliographies were also searched. Studies reporting HIV transmission rates, cART histories and viral loads of the HIV-positive partners were included. Two reviewers extracted methodologic characteristics and outcomes. Of 20,252 citations, 3 studies met all eligibility criteria with confirmed full virologic suppression in the HIV-positive partner. We included 3 additional studies (2 cohort studies, 1 RCT) that did not confirm viral suppression in the HIV-positive partner at transmission in a secondary meta-analysis. Methodologic quality was reasonable. The rate of transmission in the 3 studies confirming virologic suppression was 0 per 100 person-years (95% CI = 0-0.05), with low heterogeneity (I(2) = 0%). When we included the 3 studies that did not confirm virologic suppression, the rate of transmission was 0.14 per 100 person-years (95%CI = 0.04-0.31) (I(2) = 0%). In a sensitivity analysis including all 6 studies, the rate of transmission was 0 per 100 person-years (95%CI = 0-0.01) after omitting all transmissions with known detectable or unconfirmed viral loads, as full suppression in these cases was unlikely. Limitations included lack of data on same-sex couples, type of sexual intercourse (vaginal vs. anal), direction of HIV transmission, exact viral load at the time of transmission, sexually transmitted infections (STI) rates, and extent of condom use. Our findings suggest minimal risk of sexual HIV transmission for heterosexual serodiscordant couples when the HIV-positive partner has full viral suppression on cART with caveats regarding information on sexual intercourse type, STIs, and condom use. These findings have implications when counseling heterosexual serodiscordant couples on sexual and reproductive health. More research is needed to explore HIV transmission risk between same-sex couples.

Post-COVID-19 Syndrome (PCS) is a condition with multiple symptoms partly related to dysregulation of the autonomic nerve system. Assessment of heart rate variability (HRV) using 24 h Holter-ECG may serve as a surrogate to characterize cardiac autonomic activity. A prospective study including 103 PCS patients (time after infection = 252 days, age = 49.0 ± 11.3 years, 45.7% women) was performed and patients underwent detailed clinical screening, cardiopulmonary exercise testing, and 24 h Holter monitoring. Data of PCS patients was compared to 103 CAD patients and a healthy control group (n = 90). After correction for age and sex, frequency-related variables differed in PCS patients compared to controls including LF/HFpower, LF/HFnu, and LF/HF ratio (24 h; p ≤ 0.001). By contrast, these variables were largely comparable between PCS and CAD patients, while sympathetic activation was highest in PCS patients during the 24 h period. Overall, PCS patients showed disturbed diurnal adjustment of HRV, with impaired parasympathetic activity at night. Patients hospitalized during acute infection showed an even more pronounced overactivation of sympathetic activity compared to patients who underwent ambulant care. Our data demonstrate persistent HRV alterations in PCS patients with long-term symptom duration, suggesting a sustained impairment of sympathovagal balance. Moreover, sympathetic overstimulation and diminished parasympathetic response in long-term PCS patients are comparable to findings in CAD patients. Whether HRV variables have a prognostic value in PCS and/or might serve as biomarkers indicating a successful interventional approach warrants further longitudinal studies.

Psoriasis is now classified as an immune-mediated inflammatory disease (IMID) of the skin. It is being recognized that patients with various IMIDs, including psoriasis, are at higher risk of developing “systemic” co-morbidities, e.g., cardiovascular disease (CVD), metabolic syndrome, and overt diabetes. In non-psoriatic individuals, the pathophysiology of obesity, aberrant adipocyte metabolism, diabetes, and CVDs involves immune-mediated or inflammatory pathways. IMIDs may impact these co-morbid conditions through shared genetic risks, common environmental factors, or common inflammatory pathways that are co-expressed in IMIDs and target organs. Given that pathogenic immune pathways in psoriasis are now well worked out and a large number of inflammatory mediators have been identified in skin lesions, in this review we will consider possible mechanistic links between skin inflammation and increased risks of (1) obesity or metabolic alterations and (2) CVD. In particular, we will discuss how well-established risk factors for CVD can originate from inflammation in other tissues.

Richard Trembath, Peter Donnelly and colleagues report a genome-wide association study identifying six new psoriasis susceptibility loci. They also identify a statistical interaction between HLA-C and ERAP1 in psoriasis susceptibility. To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions ( IL28RA , REL, IFIH1, ERAP1, TRAF3IP2 , NFKBIA and TYK2 ). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10 −8 and two loci with a combined P < 5 × 10 −7 ). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 × 10 −6 ). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis.

To date, the effects of endurance exercise training on lymphocyte physiology at the kinome level are largely unknown. Therefore, the present study used a highly sensitive peptide-based kinase activity profiling approach to investigate if the basal activity of tyrosine (Tyr) and serine/threonine (Ser/Thr) kinases of human lymphocytes is affected by the aerobic endurance training status. Results revealed that the activity of various tyrosine kinases of the FGFR family and ZAP70 was increased, whereas the activity of multiple Ser/Thr kinases such as IKK α , CaMK4, PKA α , PKC α+δ (among others) was decreased in lymphocytes of endurance trained athletes (ET). Moreover, functional associations between several differentially regulated kinases in ET-derived lymphocytes were demonstrated by phylogenetic mapping and network analysis. Especially, Ser/Thr kinases of the AGC-kinase (protein kinase A, G, and C) family represent exercise-sensitive key components within the lymphocytes kinase network that may mediate the long-term effects of endurance training. Furthermore, KEGG (Kyoto Encyclopedia of Genes and Genomes) and Reactome pathway analysis indicate that Ras as well as intracellular signaling by second messengers were found to be enriched in the ET individuals. Overall, our data suggest that endurance exercise training improves the adaptive immune competence by modulating the activity of multiple protein kinases in human lymphocytes.