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We present the active galactic nucleus (AGN) catalog and optical spectroscopy for the second data release of the Swift BAT AGN Spectroscopic Survey (BASS DR2). With this DR2 release we provide 1449 optical spectra, of which 1182 are released for the first time, for the 858 hard-X-ray-selected AGNs in the Swift BAT 70-month sample. The majority of the spectra (801/1449, 55%) are newly obtained from Very Large Telescope (VLT)/X-shooter or Palomar/Doublespec. Many of the spectra have both higher resolution (R > 2500, N ∼ 450) and/or very wide wavelength coverage (3200–10000 Å, N ∼ 600) that are important for a variety of AGN and host galaxy studies. We include newly revised AGN counterparts for the full sample and review important issues for population studies, with 47 AGN redshifts determined for the first time and 790 black hole mass and accretion rate estimates. This release is spectroscopically complete for all AGNs (100%, 858/858), with 99.8% having redshift measurements (857/858) and 96% completion in black hole mass estimates of unbeamed AGNs (722/752). This AGN sample represents a unique census of the brightest hard-X-ray-selected AGNs in the sky, spanning many orders of magnitude in Eddington ratio (L/L Edd = 10−5–100), black hole mass (M BH = 105–1010 M ⊙), and AGN bolometric luminosity (L bol = 1040–1047 erg s−1 ).

Epigenetics describes mechanisms which control gene expression and cellular processes without changing the DNA sequence. The main mechanisms in epigenetics are DNA methylation in CpG-rich promoters, histone modifications and non-coding RNAs (ncRNAs). DNA methylation modifies the function of the DNA and correlates with gene silencing. Histone modifications including acetylation/deacetylation and phosphorylation act in diverse biological processes such as transcriptional activation/inactivation and DNA repair. Non-coding RNAs play a large part in epigenetic regulation of gene expression in addition to their roles at the transcriptional and post-transcriptional level. Osteoporosis is the most common skeletal disorder, characterized by compromised bone strength and bone micro-architectural deterioration that predisposes the bones to an increased risk of fracture. It is most often caused by an increase in bone resorption that is not sufficiently compensated by a corresponding increase in bone formation. Nowadays it is well accepted that osteoporosis is a multifactorial disorder and there are genetic risk factors for osteoporosis and bone fractures. Here we review emerging evidence that epigenetics contributes to the machinery that can alter DNA structure, gene expression, and cellular differentiation during physiological and pathological bone remodeling.

Vera C. Rubin Observatory is a ground-based astronomical facility under construction, a joint project of the National Science Foundation and the U.S. Department of Energy, designed to conduct a multipurpose 10 yr optical survey of the Southern Hemisphere sky: the Legacy Survey of Space and Time. Significant flexibility in survey strategy remains within the constraints imposed by the core science goals of probing dark energy and dark matter, cataloging the solar system, exploring the transient optical sky, and mapping the Milky Way. The survey’s massive data throughput will be transformational for many other astrophysics domains and Rubin’s data access policy sets the stage for a huge community of potential users. To ensure that the survey science potential is maximized while serving as broad a community as possible, Rubin Observatory has involved the scientific community at large in the process of setting and refining the details of the observing strategy. The motivation, history, and decision-making process of this strategy optimization are detailed in this paper, giving context to the science-driven proposals and recommendations for the survey strategy included in this Focus Issue.

Clinical decision rules can help to determine the need for CT imaging in children with head injuries. We aimed to validate three clinical decision rules (PECARN, CATCH, and CHALICE) in a large sample of children. In this prospective observational study, we included children and adolescents (aged <18 years) with head injuries of any severity who presented to the emergency departments of ten Australian and New Zealand hospitals. We assessed the diagnostic accuracy of PECARN (stratified into children aged <2 years and ≥2 years), CATCH, and CHALICE in predicting each rule-specific outcome measure (clinically important traumatic brain injury [TBI], need for neurological intervention, and clinically significant intracranial injury, respectively). For each calculation we used rule-specific predictor variables in populations that satisfied inclusion and exclusion criteria for each rule (validation cohort). In a secondary analysis, we compiled a comparison cohort of patients with mild head injuries (Glasgow Coma Scale score 13–15) and calculated accuracy using rule-specific predictor variables for the standardised outcome of clinically important TBI. This study is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12614000463673. Between April 11, 2011, and Nov 30, 2014, we analysed 20 137 children and adolescents attending with head injuries. CTs were obtained for 2106 (10%) patients, 4544 (23%) were admitted, 83 (<1%) underwent neurosurgery, and 15 (<1%) died. PECARN was applicable for 4011 (75%) of 5374 patients younger than 2 years and 11 152 (76%) of 14 763 patients aged 2 years and older. CATCH was applicable for 4957 (25%) patients and CHALICE for 20 029 (99%). The highest point validation sensitivities were shown for PECARN in children younger than 2 years (100·0%, 95% CI 90·7–100·0; 38 patients identified of 38 with outcome [38/38]) and PECARN in children 2 years and older (99·0%, 94·4–100·0; 97/98), followed by CATCH (high-risk predictors only; 95·2%; 76·2–99·9; 20/21; medium-risk and high-risk predictors 88·7%; 82·2–93·4; 125/141) and CHALICE (92·3%, 89·2–94·7; 370/401). In the comparison cohort of 18 913 patients with mild injuries, sensitivities for clinically important TBI were similar. Negative predictive values in both analyses were higher than 99% for all rules. The sensitivities of three clinical decision rules for head injuries in children were high when used as designed. The findings are an important starting point for clinicians considering the introduction of one of the rules. National Health and Medical Research Council, Emergency Medicine Foundation, Perpetual Philanthropic Services, WA Health Targeted Research Funds, Townsville Hospital Private Practice Fund, Auckland Medical Research Foundation, A + Trust.

Observations of 12 X-ray binaries that contain black holes within the central parsec of the Galaxy suggest the existence of hundreds more, and even more isolated black holes. Many black holes in the Galactic Centre Simulations predict that the supermassive black holes near the centres of all large galaxies are surrounded by a concentration of stellar-mass black holes. Such black holes, however, have not previously been detected at the centre of our galaxy. Low-mass X-ray binary systems containing black holes are proxies for single black holes. Charles Hailey and collaborators report finding a dozen such binary systems in the central parsec of the Milky Way. By extrapolating these observations they conclude that the total population of such binary systems in the central parsec of the Galaxy is in the hundreds, with a much greater number of isolated black holes. They cannot, however, rule out the contribution of a sub-dominant population of rotating neutron stars that have become millisecond pulsars through the accretion of gas from close companion stars. The existence of a ‘density cusp’ 1 , 2 —a localized increase in number—of stellar-mass black holes near a supermassive black hole is a fundamental prediction of galactic stellar dynamics 3 . The best place to detect such a cusp is in the Galactic Centre, where the nearest supermassive black hole, Sagittarius A*, resides. As many as 20,000 black holes are predicted to settle into the central parsec of the Galaxy as a result of dynamical friction 3 , 4 , 5 ; however, so far no density cusp of black holes has been detected. Low-mass X-ray binary systems that contain a stellar-mass black hole are natural tracers of isolated black holes. Here we report observations of a dozen quiescent X-ray binaries in a density cusp within one parsec of Sagittarius A*. The lower-energy emission spectra that we observed in these binaries is distinct from the higher-energy spectra associated with the population of accreting white dwarfs that dominates the central eight parsecs of the Galaxy 6 . The properties of these X-ray binaries, in particular their spatial distribution and luminosity function, suggest the existence of hundreds of binary systems in the central parsec of the Galaxy and many more isolated black holes. We cannot rule out a contribution to the observed emission from a population (of up to about one-half the number of X-ray binaries) of rotationally powered, millisecond pulsars. The spatial distribution of the binary systems is a relic of their formation history, either in the stellar disk around Sagittarius A* (ref. 7 ) or through in-fall from globular clusters, and constrains the number density of sources in the modelling of gravitational waves from massive stellar remnants 8 , 9 , such as neutron stars and black holes.

We determine the low-redshift X-ray luminosity function, active black hole mass function (BHMF), and Eddington ratio distribution function (ERDF) for both unobscured (Type 1) and obscured (Type 2) active galactic nuclei (AGNs), using the unprecedented spectroscopic completeness of the BAT AGN Spectroscopic Survey (BASS) data release 2. In addition to a straightforward 1/V max approach, we also compute the intrinsic distributions, accounting for sample truncation by employing a forward-modeling approach to recover the observed BHMF and ERDF. As previous BHMFs and ERDFs have been robustly determined only for samples of bright, broad-line (Type 1) AGNs and/or quasars, ours are the first directly observationally constrained BHMF and ERDF of Type 2 AGNs. We find that after accounting for all observational biases, the intrinsic ERDF of Type 2 AGNs is significantly more skewed toward lower Eddington ratios than the intrinsic ERDF of Type 1 AGNs. This result supports the radiation-regulated unification scenario, in which radiation pressure dictates the geometry of the dusty obscuring structure around an AGN. Calculating the ERDFs in two separate mass bins, we verify that the derived shape is consistent, validating the assumption that the ERDF (shape) is mass-independent. We report the local AGN duty cycle as a function of mass and Eddington ratio, by comparing the BASS active BHMF with the local mass function for all supermassive black holes. We also present the logN−logS of the Swift/BAT 70 month sources.

We present measurements of broad emission lines and virial estimates of supermassive black hole masses (M BH) for a large sample of ultrahard X-ray-selected active galactic nuclei (AGNs) as part of the second data release of the BAT AGN Spectroscopic Survey (BASS/DR2). Our catalog includes M BH estimates for a total of 689 AGNs, determined from the Hα, Hβ, Mg ii λ2798, and/or C iv λ1549 broad emission lines. The core sample includes a total of 512 AGNs drawn from the 70 month Swift/BAT all-sky catalog. We also provide measurements for 177 additional AGNs that are drawn from deeper Swift/BAT survey data. We study the links between M BH estimates and line-of-sight obscuration measured from X-ray spectral analysis. We find that broad Hα emission lines in obscured AGNs ( log(NH/cm−2)>22.0 ) are on average a factor of 8.0−2.4+4.1 weaker relative to ultrahard X-ray emission and about 35−12+7 % narrower than those in unobscured sources (i.e., log(NH/cm−2)<21.5 ). This indicates that the innermost part of the broad-line region is preferentially absorbed. Consequently, current single-epoch M BH prescriptions result in severely underestimated (>1 dex) masses for Type 1.9 sources (AGNs with broad Hα but no broad Hβ) and/or sources with log(NH/cm−2)≳22.0 . We provide simple multiplicative corrections for the observed luminosity and width of the broad Hα component (L[bHα] and FWHM[bHα]) in such sources to account for this effect and to (partially) remedy M BH estimates for Type 1.9 objects. As a key ingredient of BASS/DR2, our work provides the community with the data needed to further study powerful AGNs in the low-redshift universe.