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The restrictions put in place to contain the COVID-19 virus have led to widespread social isolation, impacting mental health worldwide. These restrictions may be particularly difficult for adolescents, who rely heavily on their peer connections for emotional support. However, there has been no longitudinal research examining the psychological impact of the COVID-19 pandemic among adolescents. This study addresses this gap by investigating the impact of the COVID-19 pandemic on adolescents’ mental health, and moderators of change, as well as assessing the factors perceived as causing the most distress. Two hundred and forty eight adolescents (Mage = 14.4; 51% girls; 81.8% Caucasian) were surveyed over two time points; in the 12 months leading up to the COVID-19 outbreak (T1), and again two months following the implementation of government restrictions and online learning (T2). Online surveys assessed depressive symptoms, anxiety, and life satisfaction at T1 and T2, and participants’ schooling, peer and family relationships, social connection, media exposure, COVID-19 related stress, and adherence to government stay-at-home directives at T2 only. In line with predictions, adolescents experienced significant increases in depressive symptoms and anxiety, and a significant decrease in life satisfaction from T1 to T2, which was particularly pronounced among girls. Moderation analyses revealed that COVID-19 related worries, online learning difficulties, and increased conflict with parents predicted increases in mental health problems from T1 to T2, whereas adherence to stay-at-home orders and feeling socially connected during the COVID-19 lockdown protected against poor mental health. This study provides initial longitudinal evidence for the decline of adolescent’s mental health during the COVID-19 pandemic. The results suggest that adolescents are more concerned about the government restrictions designed to contain the spread of the virus, than the virus itself, and that those concerns are associated with increased anxiety and depressive symptoms, and decreased life satisfaction.

Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-resident phagocytes also harbor enzymes and transporters along the endocytic pathway that orchestrate the resolution of ingested macromolecules from the phagolysosome. Solutes fluxed from the endocytic pathway and into the cytosol can then be reutilized by the phagocyte or exported for their use by neighboring cells. Such a fundamental metabolic coupling between resident phagocytes and the tissue in which they reside is well-emphasized in the case of retinal pigment epithelial (RPE) cells; specialized phagocytes that are responsible for the turnover of photoreceptor outer segments (POS). Photoreceptors are prone to photo-oxidative damage and their long-term health depends enormously on the disposal of aged portions of the outer segment. The phagocytosis of the POS by the RPE is the sole means of this turnover and clearance. RPE are themselves mitotically quiescent and therefore must resolve the ingested material to prevent their toxic accumulation in the lysosome that otherwise leads to retinal disorders. Here we describe the sequence of events underlying the healthy turnover of photoreceptors by the RPE with an emphasis on the signaling that ensures the phagocytosis of the distal POS and on the transport of solutes from the phagosome that supersedes its resolution. While other systems may utilize different receptors and transporters, the biophysical and metabolic manifestations of such events are expected to apply to all tissue-resident phagocytes that perform regular phagocytic programs.

Undergraduate diversity is fostered across many contexts Ethnic minorities comprise rapidly growing portions of the populations of most developed countries ( 1 ) but are underrepresented in fields of science, technology, engineering, and mathematics (STEM) ( 2 , 3 ). Efforts to increase diversity in the STEM workforce, important for developing more effective approaches to group problem-solving ( 4 – 6 ), have been under way in the United States for decades, but widespread impact remains relatively low ( 3 ). The Meyerhoff Scholars Program (MYS) at the University of Maryland, Baltimore County (UMBC), provides a promising model for increasing retention and academic performance of underrepresented minority (URM) undergraduates in STEM and for preparing those undergraduates to pursue and succeed in graduate and professional programs ( 7 , 8 ). Although MYS is nearly 30 years old and outcomes for African-American STEM majors have been extensively documented [see ( 7 , 8 ) and references therein], no other majority university [not meeting the definition of being a minority-serving institution (MSI) ( 9 )] has achieved similar outcomes ( 10 ). We describe here some promising early indicators that an interinstitutional partnership approach can help enable MYS-like outcomes at majority universities with different URM compositions, geographies, and institutional sizes and cultures: The University of North Carolina at Chapel Hill (UNC) and Pennsylvania State University at University Park (PSU).

How university leaders' empowering approach to resiliency was tested by the dual crises of the COVID-19 pandemic and racial unrest.In 2020, some higher education leaders successfully navigated the unprecedented challenges the year presented and emerged as resilient agents of change in their academic communities. Freeman A. Hrabowski III was one of many leaders who followed the science during the pandemic and followed his heart in the fight for racial justice, even though the science was often playing catch-up with the virus, and campuses were playing catch-up on the history of race in our country. This precarious position often left higher education leaders in the disquieting position of making decisions with only partial or changing information. Drawing from lessons learned in real scenarios, the authors provide practical recommendations for empowering colleagues, cultivating resilience and courage, and sustaining purpose and inclusion within institutions. Building on Hrabowski's previous book The Empowered University, The Resilient University offers university leaders invaluable insight into how the qualities of openness, resilience, courage, passion, and hope can be harnessed in times of crisis to guide their institutions to thrive.

Present-day coral reef ecosystem monitoring techniques can be costly, labor-intensive point measurements that can potentially introduce intractable sampling bias and error. Here we report correlations between visually obtained ecological assessment metrics and concurrently recorded aspects of the underwater biological soundscape over coral reefs at 23 sites spanning the Hawaiian Islands archipelago. Sites from the ‘cool tropics’ oceanographic habitat grouped along a principal component defined by an acoustic sliding scale: from protected or more remote sites at which lower frequencies were more dominant, to degraded sites which produced soundscapes dominated by higher frequency sound. Positive correlations between ambient biological sounds below 2 kHz and the density of benthic invertebrates (Pearson’s ρ = 0.61–0.76), their predators (ρ = 0.65−0.8), organism-scale bathymetric complexity (ρ = 0.6–0.62) and the quantity of crustose coralline algae (ρ = 0.6–0.62) suggest a connection between this part of the spectrum, habitat complexity and the density of benthic fauna. A positive correlation was also observed between the daytime soundscape in the 2 to 20 kHz band and the proportion of benthic fleshy macroalgal cover (ρ = 0.63–0.7), an indicator of reef degradation. This study indicates the possibility of rapid, inexpensive and spatially integrative remote sensing of the ecological state of coral reefs. Such quantitative methods could be used to ecologically assess vast areas of reef habitat autonomously in near real-time and could be important for remote in situ detection and characterization of subtle but significant ecological changes brought about by climate change and other more localized anthropogenic impacts.

The effect of climate change on agriculture in the UK is here assessed using a comprehensive series of policy-relevant agro-climate indicators characterising changes to climate resources and hazards affecting productivity and operations. This paper presents projections of these indicators across the UK with gridded observed data and UKCP18 climate projections representing a range of greenhouse gas emissions scenarios. The projections can be used to inform climate change mitigation and adaptation policy. There will be substantial changes in the climate resource and hazard across the UK during the twenty-first century if emissions continue to follow a high trajectory, and there will still be some changes if emissions reduce to achieve international climate policy targets. Growing seasons for certain crops will lengthen, crop growth will be accelerated, and both drought and heat risks (for some types of production) will increase. Soils will become drier in autumn, although there will be less change in winter and spring. The longer growing seasons and warmer temperatures provide opportunities for new crops, subject to the effects of increasing challenges to production. Most of the changes are relatively consistent across the UK, although drought risk and heat stress risk increase most rapidly in the south and east. The climate change trend is superimposed onto considerable year to year variability. Although there is strong consensus across climate projections on the direction of change, there is considerable uncertainty in the rate and magnitude of change for a given emissions scenario. For the temperature-based indicators, this reflects uncertainty in climate sensitivity, whilst for the precipitation-based indicators largely reflects uncertainty in projected changes in the weather systems affecting the UK.

The circadian clock coordinates physiology and metabolism. mTOR (mammalian/mechanistic target of rapamycin) is a major intracellular sensor that integrates nutrient and energy status to regulate protein synthesis, metabolism, and cell growth. Previous studies have identified a key role for mTOR in regulating photic entrainment and synchrony of the central circadian clock in the suprachiasmatic nucleus (SCN). Given that mTOR activities exhibit robust circadian oscillations in a variety of tissues and cells including the SCN, here we continued to investigate the role of mTOR in orchestrating autonomous clock functions in central and peripheral circadian oscillators. Using a combination of genetic and pharmacological approaches we show that mTOR regulates intrinsic clock properties including period and amplitude. In peripheral clock models of hepatocytes and adipocytes, mTOR inhibition lengthens period and dampens amplitude, whereas mTOR activation shortens period and augments amplitude. Constitutive activation of mTOR in Tsc2-/-fibroblasts elevates levels of core clock proteins, including CRY1, BMAL1 and CLOCK. Serum stimulation induces CRY1 upregulation in fibroblasts in an mTOR-dependent but Bmal1- and Period-independent manner. Consistent with results from cellular clock models, mTOR perturbation also regulates period and amplitude in the ex vivo SCN and liver clocks. Further, mTOR heterozygous mice show lengthened circadian period of locomotor activity in both constant darkness and constant light. Together, these results support a significant role for mTOR in circadian timekeeping and in linking metabolic states to circadian clock functions.

We have observed that marine macroalgae produce sound during photosynthesis. The resultant soundscapes correlate with benthic macroalgal cover across shallow Hawaiian coral reefs during the day, despite the presence of other biological noise. Likely ubiquitous but previously overlooked, this source of ambient biological noise in the coastal ocean is driven by local supersaturation of oxygen near the surface of macroalgal filaments, and the resultant formation and release of oxygen-containing bubbles into the water column. During release, relaxation of the bubble to a spherical shape creates a monopole sound source that 'rings' at the Minnaert frequency. Many such bubbles create a large, distributed sound source over the sea floor. Reef soundscapes contain vast quantities of biological information, making passive acoustic ecosystem evaluation a tantalizing prospect if the sources are known. Our observations introduce the possibility of a general, volumetrically integrative, noninvasive, rapid and remote technique for evaluating algal abundance and rates of primary productivity in littoral aquatic communities. Increased algal cover is one of the strongest indicators for coral reef ecosystem stress. Visually determining variations in algal abundance is a time-consuming and expensive process. This technique could therefore provide a valuable tool for ecosystem management but also for industrial monitoring of primary production, such as in algae-based biofuel synthesis.

Coral reef ecosystems are under dual threat from climate change. Increasing sea surface temperatures and thermal stress create environmental limits at low latitudes, and decreasing aragonite saturation state creates environmental limits at high latitudes. This study examines the response of unique coral reef habitats to climate change in the remote Pacific, using the National Center for Atmospheric Research Community Earth System Model version 1 alongside the species distribution algorithm Maxent. Narrow ranges of physico-chemical variables are used to define unique coral habitats and their performance is tested in future climate scenarios. General loss of coral reef habitat is expected in future climate scenarios and has been shown in previous studies. This study found exactly that for most of the predominant physico-chemical environments. However, certain coral reef habitats considered marginal today at high latitude, along the equator and in the eastern tropical Pacific were found to be quite robust in climate change scenarios. Furthermore, an environmental coral reef refuge previously identified in the central south Pacific near French Polynesia was further reinforced. Studying the response of specific habitats showed that the prevailing conditions of this refuge during the 20th century shift to a new set of conditions, more characteristic of higher latitude coral reefs in the 20th century, in future climate scenarios projected to 2100.

The UK is vulnerable to wildfire, and vulnerability is likely to increase due to climate change. Whilst the risk is small compared with many other countries, recent fires have raised awareness and highlighted the potential for environmental damage and loss of property and key infrastructure. Most UK wildfires are a result of inadvertent or deliberate human action, but the environmental conditions depend on antecedent and current weather. This paper presents projections of the effects of climate change on UK wildfire danger, using a version of an operational fire danger model, UKCP18 climate projections representing low and high emissions, and several indicators of fire danger. Fire danger will increase across the whole of the UK, but the extent and variability in change varies with indicator. The absolute danger now and into the future is greatest in the south and east (the average number of danger days increases 3–4 times by the 2080s), but danger increases further north from a lower base. The variation in change across the UK for indicators based on absolute thresholds is determined by how often those thresholds are exceeded now, whilst the (lesser) variability in percentile-based indicators reflects variability in the projected change in climate. Half of the increase in danger is due to increased temperature, and most of the rest is due to projected reductions in relative humidity. Uncertainty in the magnitude of the change is due to uncertainty in changes in temperature, relative humidity, and rainfall, and there is a large difference between two of the UKCP18 climate model ensembles. Reducing emissions to levels consistent with achieving international climate policy targets significantly reduces, but does not eliminate, the increase in fire danger. The results imply that greater attention needs to be given to wildfire danger in both emergency and spatial planning, and in the development of guidelines for activities that may trigger fires. They suggest the need for the development of a fire danger system more tailored to UK conditions, and the combination of fire danger modelling with projections of sources of ignition to better estimate the change in wildfire risk.