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"Fu, Li"
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Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms
Nervonic acid (NA) is a major very long-chain monounsaturated fatty acid found in the white matter of mammalian brains, which plays a critical role in the treatment of psychotic disorders and neurological development. In the nature, NA has been synthesized by a handful plants, fungi, and microalgae. Although the metabolism of fatty acid has been studied for decades, the biosynthesis of NA has yet to be illustrated. Generally, the biosynthesis of NA is considered starting from oleic acid through fatty acid elongation, in which malonyl-CoA and long-chain acyl-CoA are firstly condensed by a rate-limiting enzyme 3-ketoacyl-CoA synthase (KCS). Heterologous expression of kcs gene from high NA producing species in plants and yeast has led to synthesis of NA. Nevertheless, it has also been reported that desaturases in a few plants can catalyze very long-chain saturated fatty acid into NA. This review highlights recent advances in the biosynthesis, the sources, and the biotechnological aspects of NA.
Journal Article
Emerging technologies for the pretreatment of lignocellulosic materials for bio-based products
Exploring a cheap and clean renewable energy has become a common destination round the world with the depletion of oil resources and the concerns of increasing energy demands. Lignocellulosic biomass is the most abundant renewable resource in the biosphere, and the total biomass formed by plant photosynthesis reached more than 200 billion tons every year. Cellulase and hemicellulose and lignin degradation enzymes, the efficient biocatalyst, could efficiently convert the lignocellulosic biomass into sugars that could be further processed into biofuels, biochemical, and biomaterial for human requirement. The utilization and conversion of cellulosic biomass has great significance to solve the problems such as environmental pollution and energy crisis. Lignocellulosic materials are widely considered as important sources to produce sugar streams that can be fermented into ethanol and other organic chemicals. Pretreatment is a necessary step to overcome its intrinsic recalcitrant nature prior to the production of important biomaterial that has been investigated for nearly 200 years. Emerging research has focused in order of economical, eco-friendly, and time-effective solutions, for large-scale operational approach. These new mentioned technologies are promising for lignocellulosic biomass degradation in a huge scale biorefinery. This review article has briefly explained the emerging technologies especially the consolidated bioprocessing, chemistry, and physical base pretreatment and their importance in the valorization of lignocellulosic biomass conversion.
Journal Article
Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Cardiac pressure overload resulting from trans-aortic constriction in mice leads to cardiac fibrosis and increased Wnt/β-catenin signaling in cardiac fibroblasts. Here, we conditionally induce β-catenin loss of function in resident cardiac fibroblasts using
Tcf21
MerCreMer
or in activated cardiac fibroblasts using periostin (
Postn
)
MerCreMer
. We show that β-catenin loss of function in cardiac fibroblasts after trans-aortic constriction significantly preserves cardiac function, and reduces interstitial fibrosis but does not alter the numbers of activated or differentiated cardiac fibroblasts in vivo. However, β-catenin is specifically required in resident cardiac fibroblasts for fibrotic excessive extracellular matrix gene expression and binds
Col3a1
and
Postn
gene sequences in cultured cardiac fibroblasts after induction of Wnt signaling. Moreover, cardiomyocyte hypertrophy is blunted with cardiac fibroblast-specific loss of β-catenin after trans-aortic constriction in vivo. Thus, Wnt/β-catenin signaling in resident cardiac fibroblasts is required for excessive extracellular matrix gene expression and collagen deposition after trans-aortic constriction.
Understanding the mechanisms causing cardiac fibrosis is key to prevention and therapy development of many heart diseases. Here, the authors show that Wnt/β-catenin signaling in resident cardiac fibroblasts is required for deposition of fibrotic extracellular matrix and the regulation of cardiomyocyte hypertrophy in a mouse model of heart fibrosis.
Journal Article
Generating synthetic magnetism via Floquet engineering auxiliary qubits in phonon-cavity-based lattice
Gauge magnetic fields have a close relation to breaking time-reversal symmetry in condensed matter. In the presence of the gauge fields, we might observe nonreciprocal and topological transport. Inspired by these, there is a growing effort to realize exotic transport phenomena in optical and acoustic systems. However, due to charge neutrality, realizing analog magnetic flux for phonons in nanoscale systems is still challenging in both theoretical and experimental studies. Here we propose a novel mechanism to generate synthetic magnetic field for phonon lattice by Floquet engineering auxiliary qubits. We find that, a longitudinal Floquet drive on the qubit will produce a resonant coupling between two detuned acoustic cavities. Specially, the phase encoded into the longitudinal drive can exactly be transformed into the phonon-phonon hopping. Our proposal is general and can be realized in various types of artificial hybrid quantum systems. Moreover, by taking surface-acoustic-wave (SAW) cavities for example, we propose how to generate synthetic magnetic flux for phonon transport. In the presence of synthetic magnetic flux, the time-reversal symmetry will be broken, which allows one to realize the circulator transport and analog Aharonov-Bohm effects for acoustic waves. Last, we demonstrate that our proposal can be scaled to simulate topological states of matter in quantum acoustodynamics system.
Journal Article
A silicon-on-insulator slab for topological valley transport
Backscattering suppression in silicon-on-insulator (SOI) is one of the central issues to reduce energy loss and signal distortion, enabling for capability improvement of modern information processing systems. Valley physics provides an intriguing way for robust information transfer and unidirectional coupling in topological nanophotonics. Here we realize topological transport in a SOI valley photonic crystal slab. Localized Berry curvature near zone corners guarantees the existence of valley-dependent edge states below light cone, maintaining in-plane robustness and light confinement simultaneously. Topologically robust transport at telecommunication is observed along two sharp-bend interfaces in subwavelength scale, showing flat-top high transmission of ~10% bandwidth. Topological photonic routing is achieved in a bearded-stack interface, due to unidirectional excitation of valley-chirality-locked edge state from the phase vortex of a nanoscale microdisk. These findings show the prototype of robustly integrated devices, and open a new door towards the observation of non-trivial states even in non-Hermitian systems.
Backscattering is one of the major factors that limit the performance of integrated nanophotonics. Here, He et al. realize topologically protected, robust and unidirectional coupling as well as optical transport on a silicon-on-insulator platform by exploiting the valley degree of freedom.
Journal Article