Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
2,134
result(s) for
"Fu, Na"
Sort by:
التخفيف من حدة الفقر في الصين المعاصرة
استنادا إلى نظرة عامة على أوضاع الفقر، يقدم هذا الكتاب مسار التخفيف من حدة الفقر والتنمية في الصين، ويشرح نموذج التنمية والتخفي من حدة الفقر بخصائص صينية والتمسك بمباديء (سيطرة الحكومة ومشاركة المجتمع والاعتماد على الذات والتنمية الموجهة والتنمية الشاملة) كما يقدم الكتاب تلخيصا شاملا لإنجازات الصين العظيمة وخبراتها الهامة وإسهاماتها الرئيسية في قضية التخفيف من حدة الفقر في العالم، ويعرض بإيجاز نظرات وممارسات التخفيف المستهدف من الفقر في العصر الجديد من أجل توفير مراجع لكسب المعركة ضد الفقر في الصين وقضية التخفيف من حدة الفقر في العالم.
Book
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
Reversible post-translational modifications represent a mechanism to control tumor metabolism. Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and demalonylation, plays a role in colorectal cancer (CRC) glutamine metabolic rewiring. Metabolic profiling identifies that deletion of SIRT5 causes a marked decrease in
13
C-glutamine incorporation into tricarboxylic-acid (TCA) cycle intermediates and glutamine-derived non-essential amino acids. This reduces the building blocks required for rapid growth. Mechanistically, the direct interaction between SIRT5 and glutamate dehydrogenase 1 (GLUD1) causes deglutarylation and functional activation of GLUD1, a critical regulator of cellular glutaminolysis. Consistently, GLUD1 knockdown diminishes SIRT5-induced proliferation, both in vivo and in vitro. Clinically, overexpression of SIRT5 is significantly correlated with poor prognosis in CRC. Thus, SIRT5 supports the anaplerotic entry of glutamine into the TCA cycle in malignant phenotypes of CRC via activating GLUD1.
Tumour metabolism can be controlled through post-translational modifications. Here the authors show that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical regulator of glutaminolysis, inducing its deglutarylation and functional activation.
Journal Article
Ordering Policy of Two-Stage Newsvendor Model for Fresh Retailer under RFID Investment
Fresh products have a strong dependence on time and a large loss rate in the circulation process. Applying RFID technology to the supply chain of fresh products, through the real-time tracking technology, can not only reduce the products’ time dependence but also realize the second order within the whole sales period. This paper takes a two-echelon fresh supply chain of a single fresh retailer as the research object, constructs a two-stage Newsvendor model with or without RFID technology, compares the difference in profits, and provides decision-making reference for fresh retailers whether to invest in RFID or not.
Journal Article
Comprehensive review on zinc‐ion battery anode: Challenges and strategies
Zinc‐ion batteries (ZIBs) have been extensively investigated and discussed as promising energy storage devices in recent years owing to their low cost, high energy density, inherent safety, and low environmental impact. Nevertheless, several challenges remain that need to be prioritized before realizing the widespread application of ZIBs. In particular, the development of zinc anodes has been hindered by many challenges, such as inevitable zinc dendrites, corrosion passivation, and the hydrogen evolution reaction (HER), which have severely limited the practical application of high‐performance ZIBs. This review starts with a systematic discussion of the origins of zinc dendrites, corrosion passivation, and the HER, as well as their effects on battery performance. Subsequently, we discuss solutions to the above problems to protect the zinc anode, including the improvement of zinc anode materials, modification of the anode–electrolyte interface, and optimization of the electrolyte. In particular, this review emphasizes design strategies to protect zinc anodes from an integrated perspective with broad interest rather than a view with limited focus. In the final section, comments and perspectives are provided for the future design of high‐performance zinc anodes. A systematic and detailed summary of the research progress on zinc ion battery anodes is presented, including the causes of zinc dendrites, corrosion passivation and hydrogen evolution reaction on zinc anodes along with the existing strategies. Perspectives are provided for the future design of high‐performance zinc anodes.
Journal Article
Astragaloside IV Improves High-Fat Diet–Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway
Objective : Astragaloside IV (AS-IV) is the primary bioactive component purified from Astragalus membranaceus which is one of the traditional Chinese medicines. Research studies found that AS-IV has significant pharmacological effects on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver cirrhosis, and diabetic nephropathy, but little is known about the effects of AS-IV on nonalcoholic fatty liver disease (NAFLD). In this study, we investigated whether AS-IV has beneficial effects on NAFLD in rats and its potential mechanisms. Methods : Male SD rats were fed with high-fat diet (HFD) for 12 weeks to establish NAFLD rat model, and then, the rats were divided into five groups. The control group rats were fed with normal diet for 12 weeks and then were given normal saline (1.0 ml kg −1 day −1 ) by intragastric administration for 4 weeks. The model group rats were fed with HFD for 12 weeks and then were given normal saline (1.0 ml kg −1 day −1 ) by intragastric administration for 4 weeks. The AS-IV-L, AS-IV-M, and AS-IV-H groups were treated with 20, 40, and 80 mg kg −1 day −1 of AS-IV by intragastric administration for 4 weeks and given HFD diet. Then, we detected serum transaminase (ALT, AST), blood lipid (TG, TC), inflammatory cytokines (IL-6, IL-8 and TNF-α), liver histology(NAFLD activity score), TLR4/MyD88 signaling pathway in liver tissue. Results : We found AS-IV significantly reduced serum levels of AST, ALT, TG, TNF-α, IL-6, and IL-8 in NAFLD rats and downregulate the expression of TLR4 mRNA, MyD88 mRNA, NF-κB mRNA, and proteins in liver tissue. Moreover, AS-IV could significantly reduce the NAFLD activity score of NAFLD rat liver. Conclusion : In this study, we demonstrated that AS-IV have a protective effect on NAFLD by inhibiting TNF-α, IL-6 and IL-8 levels and down-regulating TLR4, MyD88 and NF-κB expression in rat liver tissues.
Journal Article
Effects of accelerated rehabilitation surgical care on the surgical site wound infection and postoperative complications in patients of lung cancer: A meta‐analysis
To comprehensively evaluate the effect of accelerated rehabilitation surgical care on perioperative wound infections and complications in patients undergoing lung cancer surgery. A comprehensive computerised search for randomised controlled trials (RCTs) of accelerated rehabilitative surgical care applied to patients undergoing lung cancer surgery was conducted using the Web of Science, PubMed, Cochrane Library, Embase, Wanfang and China National Knowledge Infrastructure databases from inception to September 2023. The literature was screened and evaluated by two investigators, and data were extracted from the final included literature. Stata software (version 17.0) was used for data analysis. Overall, 21 RCTs involving 2187 patients were included, including 1093 cases in the accelerated rehabilitation surgical care group and 1094 cases in the conventional care group. The analyses revealed that patients with lung cancer surgery who implemented accelerated rehabilitation surgical care were significantly less likely to develop postoperative wound infections (odds ratio [OR] = 0.29, 95% confidence interval [CI]: 0.17–0.49, p < 0.001) and postoperative complications (OR = 0.26, 95% CI: 0.20–0.34, p < 0.001) and shortened the hospital length of stay (standardised mean differences [SMD] = −1.93, 95% CI: −2.32 to −1.53, and p < 0.001) compared with conventional care. The effect of accelerated rehabilitation surgical care intervention in the perioperative period of lung cancer surgery patients is remarkable, as it can effectively reduce the incidence of wound infection and complications, shorten hospitalisation time and promote patient recovery.
Journal Article
Investigation of the Stability of Methylammonium Lead Iodide (MAPbI3) Film Doped with Lead Cesium Triiodide (CsPbI3) Quantum Dots under an Oxygen Plasma Atmosphere
In this study, we describe composited perovskite films based on the doping of lead cesium triiodide (CsPbI3) quantum dots (QDs) into methylammonium lead iodide (MAPbI3). CsPbI3 QDs and MAPbI3 were prepared by ligand-assisted re-precipitation and solution mixing, respectively. These films were optimized by oxygen plasma treatment, and the effect of powers from 0 to 80 W on the structural properties of the composited perovskite films is discussed. The experimental results showed that the light-harvesting ability of the films was enhanced at 20 W. The formation of the metastable state (lead(II) oxide and lead tetroxide) was demonstrated by peak differentiation-imitating. A low power enhanced the quality of the films due to the removal of organic impurities, whereas a high power caused surface damage in the films owing to the severe degradation of MAPbI3.
Journal Article
The Mechanism of PEDOT: PSS Films with Organic Additives
This article demonstrates changes in the structures of poly (3,4-ethylene dioxythiophene): polystyrene sulfonate (PEDOT: PSS) with the addition of organic additives. The mechanisms of PEDOT: PSS are analyzed using X-ray photoelectron spectroscopy (XPS), cross-sectional images obtained from scanning electron microscopy (SEM), and contact angles. In this paper, a bond-breaking reaction and phase separation are successfully found to occur between PEDOT: PSS molecules and the organic additives. Our research also finds that this bond-breaking reaction and phase separation exist in the PEDOT: PSS–sorbitol–maltitol film at the same time. The addition of organic additives will improve the optical properties and the moisture stability of PEDOT: PSS films.
Journal Article
Genetic and Clinical Advances of Congenital Muscular Dystrophy
Objective： The aim was to update the genetic and clinical advances of congenital muscular dystrophy （CMD）, based on a systematic review of the literature from 1991 to 2017. Data Sources： Articles in English published in PubMed from 1991 to 2017 English were searched. The terms used in the literature searches were CMD. Study Selection： The task force initially identified citations for 98 published articles. Of the 98 articles, 52 studies were selected after further detailed review. Three articles, which were not written in English, were excluded from the study. This study referred to all the important and English literature in full. Results： CMD is a group of early-onset disorders encompassing great clinical and genetic heterogeneity. Patients present with muscle weakness typically from birth to early infancy, delay or arrest of gross motor development, and joint and/or spinal rigidity. The diagnosis of CMD relies on clinical findings, brain and muscle imaging, muscle biopsy histology, muscle and/or skin immunohistochemical staining, and molecular genetic testing. Conclusions： Advances in next-generation sequencing and histopathological techniques have enabled the recognition of distinct CMD subtypes supported by specific gene identification. Genetic counseling and multidisciplinary management of CMD play an important role in help patients and their family. Further elucidation of the significant clinical and genetic heterogeneity, therapeutic targets, and the clinical care for patients remains our challenge for the future.
Journal Article
Reset-Voltage Controlled Resistance-State and Applications of Forming-Free Fe-Doped SrTiO3 Thin-Film Memristor
In this study, we prepared a strontium ferrite titanate (STF) thin film using a sol–gel process to insulate resistive random-access memory (RRAM) applications. Compared to the typical strontium titanate (STO) RRAM, the improvement in the resistive switching characteristics in STF RRAM is obvious. The Al/STO/ITO/Glass RRAM set/reset voltages of −1.4 V/+3.3 V and the Al/STF/ITO/Glass RRAM set/reset voltages of −0.45 V/+1.55 V presented a memory window larger than 103, a low operating voltage and device stability of more than 104 s. In this study, the influence of Fe on the conducting paths and the bipolar resistive switching properties of Al/STF/ITO/Glass RRAM devices is investigated.
Journal Article