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Nanoparticles-based glues have recently been shown with substantial potential for hydrogel adhesion. Nevertheless, the transformative advance in hydrogel-based application places great challenges on the rapidity, robustness, and universality of achieving hydrogel adhesion, which are rarely accommodated by existing nanoparticles-based glues. Herein, we design a type of nanohesives based on the modulation of hydrogel mechanics and the surface chemical activation of nanoparticles. The nanohesives can form robust hydrogel adhesion in seconds, to the surface of arbitrary engineering solids and biological tissues without any surface pre-treatments. A representative application of hydrogel machine demonstrates the tough and compliant adhesion between dynamic tissues and sensors via nanohesives, guaranteeing accurate and stable blood flow monitoring in vivo. Combined with their biocompatibility and inherent antimicrobial properties, the nanohesives provide a promising strategy in the field of hydrogel based engineering. Achieving rapid, robust, and universal hydrogel adhesion poses challenges for nanoparticle-based glues. Here, the authors present nanohesives that can adhere to diverse surfaces without pre-treatment based on hydrogel mechanics design and interface chemistry modification.

Salicylic acid (SA), an essential regulator of plant defense, is derived from chorismate via either the phenylalanine ammonia lyase (PAL) or the isochorismate synthase (ICS) catalyzed steps. The ICS pathway is thought to be the primary contributor of defense-related SA, at least in Arabidopsis. We investigated the relative contributions of PAL and ICS to defenserelated SA accumulation in soybean (Glycine max). Soybean plants silenced for five PAL isoforms or two ICS isoforms were analyzed for SA concentrations and SA-derived defense responses to the hemibiotrophic pathogens Pseudomonas syringae and Phytophthora sojae. We show that, unlike in Arabidopsis, PAL and ICS pathways are equally important for pathogen-induced SA biosynthesis in soybean. Knock-down of either pathway shuts down SA biosynthesis and abrogates pathogen resistance. Moreover, unlike in Arabidopsis, pathogen infection is associated with the suppression of ICS gene expression. Pathogen-induced biosynthesis of SA via the PAL pathway correlates inversely with phenylalanine concentrations. Although infections with either virulent or avirulent strains of the pathogens increase SA concentrations, resistance protein-mediated response to avirulent P. sojae strains may function in an SA-independent manner. These results show that PAL- and ICS-catalyzed reactions function cooperatively in soybean defense and highlight the importance of PAL in pathogen-induced SA biosynthesis.

The NAC transcription factor (TF) family is one of the largest plant-specific TF families and its members are involved in the regulation of many vital biological processes during plant growth and development. Recent studies have found that NAC TFs play important roles during the ripening of fleshy fruits and the development of quality attributes. This review focuses on the advances in our understanding of the function of NAC TFs in different fruits and their involvement in the biosynthesis and signal transduction of plant hormones, fruit textural changes, color transformation, accumulation of flavor compounds, seed development and fruit senescence. We discuss the theoretical basis and potential regulatory models for NAC TFs action and provide a comprehensive view of their multiple roles in modulating different aspects of fruit ripening and quality.

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, pathologically characterized by TDP‐43 aggregates. Recent evidence has been indicated that phosphorylated TDP‐43 (pTDP‐43) is present not only in motor neurons but also in muscle tissues. However, it is unclear whether testing pTDP‐43 aggregation in muscle tissue would assist in the diagnosis of ALS. We propose three key questions: (i) Is aggregation of pTDP‐43 detectable in routine biopsied muscles? (ii) Can detection of pTDP‐43 aggregation discriminate between ALS and non‐ALS patients? (iii) Can pTDP‐43 aggregation be observed in the early stages of ALS? We conducted a diagnostic study comprising 2 groups: an ALS group in which 18 cases underwent muscle biopsy screened from a registered ALS cohort consisting of 802 patients and a non‐ALS control group, in which we randomly selected 54 muscle samples from a biospecimen bank of 684 patients. Among the 18 ALS patients, 3 patients carried pathological GGGGCC repeats in the C9ORF72 gene, 2 patients carried SOD1 mutations, and 7 patients were at an early stage with only one body region clinically affected. The pTDP‐43 accumulation could be detected in routine biopsied muscles, including biceps brachii, deltoid, tibialis anterior, and quadriceps. Abnormal aggregation of pTDP‐43 was present in 94.4% of ALS patients (17/18) compared to 29.6% of non‐ALS controls (16/54; p < 0.001). The pTDP‐43 aggregates were mainly close to the sarcolemma. Using a semi‐quantified pTDP‐43 aggregates score, we applied a cut‐off value of 3 as a diagnostic biomarker, resulting in a sensitivity of 94.4% and a specificity of 83.3%. Moreover, we observed that accumulation of pTDP‐43 occurred in muscle tissues prior to clinical symptoms and electromyographic lesions. Our study provides proof‐of‐concept for the detection of pTDP‐43 accumulation via routine muscle biopsy which may serve as a novel biomarker for diagnosis of ALS. To explore whether testing pTDP‐43 aggregation in muscle tissue would assist in the diagnosis of ALS, we conducted a diagnostic study in 18 ALS patients and 54 randomly matched controls from ALS and muscular disease cohorts. Our results indicated that pTDP‐43 was more prone to accumulation in ALS patients, enabling differentiation between ALS and non‐ALS patients with high sensitivity and specificity. Moreover, we observed that accumulation of pTDP‐43 occurred in muscle tissues prior to clinical symptoms and electromyographic lesions.

Following the termination of seafloor spreading in the South China Sea (SCS) basin, abundant intraplate volcanism widely spreads in the Indochina block, SCS basin, and Leiqiong area, forming the Southeastern Asian Basalt Province (SABP). The geodynamic origin of the SABP has long been enigmatic and debated. Here, we present a high‐resolution 3‐D upper mantle S‐wave velocity model in the region by conducting earthquake‐based surface wave tomography with seismic data collected across Southeast Asia. The resultant images depict a plume‐like structure beneath the central area of the SABP, characterized by a continuous, sub‐vertical low‐velocity column in the upper mantle. Our new findings, combined with previous geochemical and geodynamic evidence, suggest that the extensive post‐spreading intraplate volcanism within the SABP is likely induced by this focused mantle upwelling, which could be further traced down to the core‐mantle boundary as inferred by existing global velocity models. Plain Language Summary The well‐known Southeastern Asian Basalt Province (SABP), which covers an extensive area of the South China Sea (SCS) and surroundings, is characterized by voluminous volcanism after the cessation of seafloor spreading in the SCS basin. However, the geodynamic mechanism responsible for the formation of the SABP remains debated and not well understood. In this study, we build a high‐resolution 3‐D seismic velocity model in the region utilizing multiple sources of seismic data collected throughout Southeast Asia. We find a distinct plume‐shaped low‐velocity anomaly in the upper mantle beneath the central region of the SABP. Combining with previous geochemical and geodynamic research results, we interpret that the abundant intraplate volcanism within the SABP may be contributed by the underlying focused mantle upwelling. This mantle upwelling, as evidenced in previous global seismic velocity models, could be further traced down to the core‐mantle boundary (∼2,900 km below the Earth's surface). Our tomographic images provide valuable insights into the origin and mantle dynamics related to the young intraplate volcanism that occurred in Southeast Asia. Key Points A high‐resolution 3‐D upper mantle S‐wave velocity model surrounding the South China Sea is constructed A continuous, low‐velocity column is imaged beneath the central region of the Southeastern Asian Basalt Province The post‐spreading intraplate volcanism within the Southeastern Asian Basalt Province is likely induced by the focused mantle upwelling

All extant core-eudicot plants share a common ancestral genome that has experienced cyclic polyploidizations and (re)diploidizations. Reshuffling of the ancestral core-eudicot genome generates abundant genomic diversity, but the role of this diversity in shaping the hierarchical genome architecture, such as chromatin topology and gene expression, remains poorly understood. Here, we assemble chromosome-level genomes of one diploid and three tetraploid Panax species and conduct in-depth comparative genomic and epigenomic analyses. We show that chromosomal interactions within each duplicated ancestral chromosome largely maintain in extant Panax species, albeit experiencing ca. 100–150 million years of evolution from a shared ancestor. Biased genetic fractionation and epigenetic regulation divergence during polyploidization/(re)diploidization processes generate remarkable biochemical diversity of secondary metabolites in the Panax genus. Our study provides a paleopolyploidization perspective of how reshuffling of the ancestral core-eudicot genome leads to a highly dynamic genome and to the metabolic diversification of extant eudicot plants.

Deep low‐frequency earthquakes (DLFE) are observed beneath volcanoes worldwide but are limited to island arc volcanoes, hotspot volcanoes, and rift zones. Here we show DLFEs in the Tengchong Volcano Field, southeast Tibet, located ∼300 km from the Indo‐Burma volcanic arc, by analyzing a 12‐year continuous seismic data set. The earthquakes were at a depth of ∼12 km, near the sidewall of the magma body detected by the magnetotelluric survey. The features of isotropic focal mechanism, episodic occurrence, and possible non‐power‐law scaling, with no detectable geodetic deformation, as well as the petrological signatures of the Holocene eruption product, suggest that the earthquakes were likely associated with the weak intermittent magma flows near the magma body. This finding may demonstrate the existence of unsteady magmatic processes in the margin of the Indo‐Eurasia collision zone, which could indicate unneglectable volcanic hazards, underestimated geothermal resources, and mineralization processes in similar regions. Plain Language Summary Magmatic systems in the subduction arc, rift zone, and hotspot region are often active when magma stalls in the crust, indicative of unsteady magma dynamics and potential hazards. Holocene eruptions, present‐day structure anomaly, and geochemical signatures exist in some intra‐continent volcanos far away from the well‐predicted regions by plate tectonics. However, the magmatic systems there are thought to be relatively inactive. In this report, we show the first evidence of deep low‐frequency earthquakes occurring in the continental land on the edge of the Tibet Plateau, without any of the arc, hotspot, and rift volcanism involved. The observations' systematic characterization indicates weak but unsteady fluid flow currently occurring in this region. This finding demonstrates an unexpected behavior of the magmatic system in the continental collision zone, which may be underpredicted by the classic theory of plate tectonics on volcanism. Key Points We report the discovery of deep low‐frequency earthquakes in the margin of the Tibet Plateau Deep origin, isotropic mechanism, low occurrence, and non‐power‐law scaling of the earthquakes are likely related to an unsteady fluid flow Seismic, petrological, and geochemical observations suggest the existence of juvenile magma flow beneath the Tengchong Volcanic Field

North Korea conducted its sixth underground nuclear weapons test in September 2017. The seismic waves generated from the test allow for triangulation and explosive yield estimates. However, Wang et al. show that synthetic aperture radar (SAR) should be added to the arsenal of techniques used to detect and characterize nuclear tests. SAR tracks deformation from space, which resulted in a better constraint of source parameters by using deformation from the nuclear test and the subsequent collapse of Mount Mantap. The test occurred at a depth of about half a kilometer, with an explosive yield around 10 times that of the Hiroshima explosion. Science , this issue p. 166 Space-based synthetic aperture radar satellites can detect underground nuclear weapons tests. Surveillance of clandestine nuclear tests relies on a global seismic network, but the potential of spaceborne monitoring has been underexploited. We used satellite radar imagery to determine the complete surface displacement field of up to 3.5 meters of divergent horizontal motion with 0.5 meters of subsidence associated with North Korea’s largest underground nuclear test. Combining insight from geodetic and seismological remote sensing, we found that the aftermath of the initial explosive deformation involved subsidence associated with subsurface collapse and aseismic compaction of the damaged rocks of the test site. The explosive yield from the nuclear detonation with best-fitting source parameters for 450-meter depth was 191 kilotonnes of TNT equivalent. Our results demonstrate the capability of spaceborne remote sensing to help characterize large underground nuclear tests.

Oceanic lithosphere descends into Earth’s mantle at subduction zones and drives material exchange between Earth’s surface and its deep interior. The subduction process creates chemical and thermal heterogeneities in the mantle, with the strongest gradients located at the interfaces between subducted slabs and the surrounding mantle. Seismic imaging of slab interfaces is key to understanding slab compositional layering, deep-water cycling and melting, yet the existence of slab interfaces below 200 km remains unconfirmed. Here, we observe two sharp and slightly dipping seismic discontinuities within the mantle transition zone beneath the western Pacific subduction zone that coincide spatially with the upper and lower bounds of the high-velocity slab. Based on a multi-frequency receiver function waveform modelling, we found the upper discontinuity to be consistent with the Mohorovičić discontinuity of the subducted oceanic lithosphere in the mantle transition zone. The lower discontinuity could be caused by partial melting of sub-slab asthenosphere under hydrous conditions in the seaward portion of the slab. Our observations show distinct slab–mantle boundaries at depths between 410 and 660 km, deeper than previously observed, suggesting a compositionally layered slab and high water contents beneath the slab.Two seismic discontinuities in the mantle transition zone beneath the western Pacific represent subducted slab interfaces that could be the slab Moho and partially molten sub-slab asthenosphere, according to an analysis of seismic data.

This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baroreflx sensitivity during a rapid (i.e., within seconds) hypertensive stimulus, but baroreflex sensitivity is similar between the sexes during a hypotensive stimulus. Normal aging decreases cardiovagal baroreflex sensitivity and the rate of decline is similar in men and women. Cardiovagal baroreflex sensitivity is reduced in pathological conditions such as hypertension and type II diabetes, and the reduction is greater in female patients than male patients. There is no clear sex difference in sympathetic baroreflex sensitivity among young individuals, however, with women of more advanced age, sympathetic baroreflex sensitivity decreases, which appears to be associated with greater arterial stiffness compared with similarly aged men. The blunted sympathetic baroreflex sensitivity in older women may predispose them to an increased prevalence of hypertension and cardiovascular disease.