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"Fulton, Bruce"
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Introduction A Heartfelt Future : The Stories of Kim Ch’oyŏp
One of the more ironic cultural developments in Korea in the new millennium is a noticeable decline in the consumption of Korean literature. Ironic because much of the appeal of the performance dimensions of elements of popular culture such as film, television dramas, K-pop, and street theater derives from Korean oral literature (kubi munhak). Korean recorded literature (kirok munhak), by contrast, since its origins in hansi mere centuries after the advent of Korean recorded history, has been regarded as an elite, conservative, and patriarchal form of literary art. Fortunately, Korean literature survives in the new millennium in large part because of the increasing attention among readers to, and perhaps grudging acknowledgment by the influential Korean literature power structure (mundan) of, genre fiction. Fiction writers increasingly straddle the boundaries between mainstream and genre fiction, finding their way into print both with the leading publishers of literary fiction and with publishing houses focusing on genre fiction.
Journal Article
Lost souls : stories
These captivating short stories portray three major periods in modern Korean history: the forces of colonial modernity during the late 1930s; the postcolonial struggle to rebuild society after four decades of oppression, emasculation, and cultural exile (1945 to 1950); and the attempt to reconstruct a shattered land and a traumatized nation after the Korean War. Lost Souls echoes the exceptional work of China's Shen Congwen and Japan's Kawabata Yasunari. Modernist narratives set in the metropolises of Tokyo and Pyongyang alternate with starkly realistic portraits of rural life. Surrealist tales suggest the unsettling sensation of colonial domination, while stories of the outcast embody the thrill and terror of independence and survival in a land dominated by tradition and devastated by war. Written during the chaos of 1945, \"Booze\" recounts a fight between Koreans for control of a former Japanese-owned distillery. \"Toad\" relates the suffering created by hundreds of thousands of returning refugees, and stories from the 1950s confront the catastrophes of the Korean War and the problematic desire for autonomy. Visceral and versatile, Lost Souls is a classic work on the possibilities of transition that showcases the innovation and craftsmanship of a consummate -- and widely celebrated -- storyteller.
Book
In Memoriam : Professor Kevin O’Rourke (1939–2020)
An obituary for Professor Kevin O'Rourke is presented. O'Rourke is the most accomplished translator of Korean literature past and present, prose and poetry. His published translations span a period of nearly fifty years. His first book-length translation was Ten Korean Short Stories, published by Yonsei University Press in 1971, a mere seven years after he arrived in Korea in 1964, in his mid-twenties, as one of the Columban Fathers. This volume of stories ranging from the 1920s to the 1970s was republished as A Washed-Out Dream, with the addition of an eleventh story, in 1980.
Journal Article
The human jungle : a novel
\"This sprawling novel was consolidated into one volume from three novels in original Korean. It follows a large cast of characters through business, manufacturing, and university life in China as the country shifts from a manufacturing to consumer economy. Most of the characters are Koreans trying to make their way in China, providing a unique viewpoint on the superpower\"-- Provided by publisher.
Book
CYP76M7 Is an ent -Cassadiene C11α-Hydroxylase Defining a Second Multifunctional Diterpenoid Biosynthetic Gene Cluster in Rice
Biosynthetic gene clusters are common in microbial organisms, but rare in plants, raising questions regarding the evolutionary forces that drive their assembly in multicellular eukaryotes. Here, we characterize the biochemical function of a rice (Oryza sativa) cytochrome P450 monooxygenase, CYP76M7, which seems to act in the production of antifungal phytocassanes and defines a second diterpenoid biosynthetic gene cluster in rice. This cluster is uniquely multifunctional, containing enzymatic genes involved in the production of two distinct sets of phytoalexins, the antifungal phytocassanes and antibacterial oryzalides/oryzadiones, with the corresponding genes being subject to distinct transcriptional regulation. The lack of uniform coregulation of the genes within this multifunctional cluster suggests that this was not a primary driving force in its assembly. However, the cluster is dedicated to specialized metabolism, as all genes in the cluster are involved in phytoalexin metabolism. We hypothesize that this dedication to specialized metabolism led to the assembly of the corresponding biosynthetic gene cluster. Consistent with this hypothesis, molecular phylogenetic comparison demonstrates that the two rice diterpenoid biosynthetic gene clusters have undergone independent elaboration to their present-day forms, indicating continued evolutionary pressure for coclustering of enzymatic genes encoding components of related biosynthetic pathways.
Journal Article
Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases
The pleckstrin homology (PH) domain is well known for its phospholipid targeting function. The PH-TEC homology (PHTH) domain within the TEC family of tyrosine kinases is also a crucial component of the autoinhibitory apparatus. The autoinhibitory surface on the PHTH domain has been previously defined, and biochemical investigations have shown that PHTH-mediated inhibition is mutually exclusive with phosphatidylinositol binding. Here we use hydrogen/deuterium exchange mass spectrometry, nuclear magnetic resonance (NMR), and evolutionary sequence comparisons to map where and how the PHTH domain affects the Bruton’s tyrosine kinase (BTK) domain. The data map a PHTH-binding site on the activation loop face of the kinase C lobe, suggesting that the PHTH domain masks the activation loop and the substrate-docking site. Moreover, localized NMR spectral changes are observed for non–surface-exposed residues in the active site and on the distal side of the kinase domain. These data suggest that the association of PHTH induces allosteric conformational shifts in regions of the kinase domain that are critical for catalysis. Through statistical comparisons of diverse tyrosine kinase sequences, we identify residues unique to BTK that coincide with the experimentally determined PHTH-binding surface on the kinase domain. Our data provide a more complete picture of the autoinhibitory conformation adopted by full-length TEC kinases, creating opportunities to target the regulatory domains to control the function of these kinases in a biological setting.
Journal Article