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Evaluation of three families with hereditary retinoblastoma demonstrates close linkage of the gene for this tumor with the genetic locus for esterase D. These results assign the gene for the hereditary form of retinoblastoma to band q14 on chromosome 13, the same region which is affected in the chromosome deletion form of this eye tumor, and therefore suggest a common underlying mechanism in the pathogenesis of these two forms of retinoblastoma.

Much of what we know about terrestrial life during the Carboniferous Period comes from Middle Pennsylvanian (~315–307 Mya) Coal Measures deposited in low-lying wetland environments 1 – 5 . We know relatively little about terrestrial ecosystems from the Early Pennsylvanian, which was a critical interval for the diversification of insects, arachnids, tetrapods, and seed plants 6 – 10 . Here we report a diverse Early Pennsylvanian trace and body fossil Lagerstätte (~320–318 Mya) from the Wamsutta Formation of eastern North America, distinct from coal-bearing deposits, preserved in clastic substrates within basin margin conglomerates. The exceptionally preserved trace fossils and body fossils document a range of vertebrates, invertebrates and plant taxa ( n  = 131), with 83 distinct foliage morphotypes. Plant-insect interactions include what may be the earliest evidence of insect oviposition. This site expands our knowledge of early terrestrial ecosystems and organismal interactions and provides ground truth for future phylogenetic reconstructions of key plant, arthropod, and vertebrate groups. Our knowledge of life in the Carboniferous Period is largely restricted to low-lying wetlands dated to 315–310 million years ago. Here, the authors present an older Lagerstätte on an alluvial fan 320–318 million years ago, preserving a diverse ecosystem of vertebrates, invertebrates, plants, and plant-insect interactions.

Evidence-based psychotherapies (EBPs) are underused in health care settings. Aligning implementation of EBPs with the needs of health care leaders (i.e., operational stakeholders) can potentially accelerate their uptake into routine practice. Operational stakeholders (such as hospital leaders, clinical directors, and national program officers) can influence development and oversight of clinical programs as well as policy directives at local, regional, and national levels. Thus, engaging these stakeholders during the implementation and dissemination of EBPs is critical when targeting wider use in health care settings. This article describes how research–operations partnerships were leveraged to increase implementation of an empirically supported psychotherapy – brief Cognitive Behavioral Therapy (brief CBT) – in Veterans Health Administration (VA) primary care settings. The partnered implementation and dissemination efforts were informed by the empirically derived World Health Organization’s ExpandNet framework. A steering committee was formed and included several VA operational stakeholders who helped align the brief CBT program with the implementation needs of VA primary care settings. During the first 18 months of the project, partnerships facilitated rapid implementation of brief CBT at eight VA facilities, including training of 12 providers who saw 120 patients, in addition to expanded program elements to better support sustainability (e.g., train-the-trainer procedures).

A push-pull strategy for reducing populations of the thrips Frankliniella occidentalis (Pergande), F. bispinosa (Morgan) and F. tritici (Fitch) in tomato was evaluated. Push components consisted of ultraviolet (UV)-reflective mulch and foliar applications of kaolin and the pull component consisted of the companion plant Bidens alba (L.). Replicated field experiments were conducted in 2011 and 2012. Adult and larval thrips were reduced by UV-reflective mulch during early and mid-flowering of tomato. Spray applications of kaolin were effective in reducing adult and larval thrips during early, mid- and late-flowering. The pull effects of the B. alba companion plants were additive and sometimes interactive with the push effects of UV-reflective mulch and kaolin in reducing the adult males of each thrips species and the females of F. bispinosa. The strategy was not effective in reducing the adult females of F. tritici and F. occidentalis. In addition to attracting the Frankliniella species adults, the companion plants were hosts for the thrips predator Orius insidiosus (Say). The companion plants combined with UV-reflective mulch and kaolin proved effective as a push-pull system for suppressing flower thrips, including F. occidentalis which is a serious pest of tomato worldwide.

Newer, selective insecticides with few negative impacts on natural enemies and competitor species are needed for effective, sustainable management of the western flower thrips, Frankliniella occidentalis (Pergande). The purpose of this study was to evaluate the impacts on natural enemies and competitor thrips species of insecticides used for control of western flower thrips in fruiting vegetables. Trials with tomato (Solanum lycopersicum L.) and with pepper (Capsicum annuum L.) were conducted to evaluate insecticide treatment effects on western flower thrips and natural enemies at the North Florida in 2008, 2009, 2010 and 2011. A number of insecticides from different classes showed moderate to high efficacy against western flower thrips. The broad-spectrum insecticides acetamiprid, methomyl, and tolfenpyrad demonstrated activity against the pest, while also reducing populations of the key predator of thrips in pepper, Orius insidiosus (Say) (Hemiptera: Anthocoridae). Insecticides that showed little impact on populations of O. insidiosus were cyantraniliprole, flonicamid, spirotetramat, and terpenes. Although only moderately active against the western flower thrips, they would be valuable additions to existing management programs for pepper. Insecticides with activity against western flower thrips also showed activity against Frankliniella tritici (Fitch). This non-damaging congener species is a beneficial because it out-competes the western flower thrips, especially in tomato where O. insidiosus is not a major factor in western flower thrips management. Numerous insecticides were identified with activity against the western flower thrips that are suitable for use in integrated pest management programs of fruiting vegetables.

Anthophilous flower thrips in the genus Frankliniella (Thysanoptera: Thripidae) exploit ephemeral plant resources and therefore must be capable of successfully locating appropriate hosts on a repeated basis, yet little is known of interspecific and intraspecific variation in responses to host plant type and nutritional quality. Field trials were conducted over two seasons to determine if the abundance of males and females of three common Frankliniella species, F. occidentalis (Pergande), F. tritici (Fitch) and F. bispinosa (Morgan), their larvae, and a key predator, Orius insidiosus (Say) (Hemiptera: Anthocoridae) were affected by host plant type and plant nutritional quality. Two host plants, pepper, Capsicum annuum L. (Solanales: Solanaceae) and tomato, Solanum lycopersicum L. that vary in suitability for these species were examined, and their nutritional quality was manipulated by applying three levels of nitrogen fertilization (101 kg/ha, 202 kg/ha, 404 kg/ha). F. occidentalis females were more abundant in pepper than in tomato, but males did not show a differential response. Both sexes of F. tritici and F. bispinosa were more abundant in tomato than in pepper. Larval thrips were more abundant in pepper than in tomato. Likewise, O. insidiosus females and nymphs were more abundant in pepper than in tomato. Only F. occidentalis females showed a distinct response to nitrogen fertilization, with abundance increasing with fertilization. These results show that host plant utilization patterns vary among Frankliniella spp. and should not be generalized from results of the intensively studied F. occidentalis. Given the different pest status of these species and their differential abundance in pepper and tomato, it is critical that scouting programs include species identifications for proper management.

Newer, selective insecticides with few negative impacts on natural enemies and competitor species are needed for effective, sustainable management of the western flower thrips, Frankliniella occidentalis (Pergande). The purpose of this study was to evaluate the impacts on natural enemies and competitor thrips species of insecticides used for control of western flower thrips in fruiting vegetables. Trials with tomato (Solanum lycopersicum L.) and with pepper (Capsicum annuum L.) were conducted to evaluate insecticide treatment effects on western flower thrips and natural enemies at the North Florida in 2008, 2009, 2010 and 2011. A number of insecticides from different classes showed moderate to high efficacy against western flower thrips. The broad-spectrum insecticides acetamiprid, methomyl, and tolfenpyrad demonstrated activity against the pest, while also reducing populations of the key predator of thrips in pepper, Orius insidiosus (Say) (Hemiptera: Anthocoridae). Insecticides that showed little impact on populations of O. insidiosus were cyantraniliprole, flonicamid, spirotetramat, and terpenes. Although only moderately active against the western flower thrips, they would be valuable additions to existing management programs for pepper. Insecticides with activity against western flower thrips also showed activity against Frankliniella tritici (Fitch). This non-damaging congener species is a beneficial because it out-competes the western flower thrips, especially in tomato where O. insidiosus is not a major factor in western flower thrips management. Numerous insecticides were identified with activity against the western flower thrips that are suitable for use in integrated pest management programs of fruiting vegetables.