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"Furgang, Kathy"
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Adapting to plant and animal extinctions
Explains what causes climate change and the consequences of plant and animal extinctions, and includes advice on saving endangered species and what individuals can do to help.
Book
Tight-Adherence Genes of Actinobacillus actinomycetemcomitans Are Required for Virulence in a Rat Model
Actinobacillus actinomycetemcomitans is a Gram-negative coccobacillus that has been associated with localized aggressive periodontitis and infections of the heart, brain, and urinary tract. Wild-type clinical isolates have the remarkable ability to adhere tenaciously and nonspecifically to solid surfaces such as glass, plastic, and hydroxyapatite. Adherence by A. actinomycetemcomitans is mediated by the tight-adherence (tad) gene locus, which consists of 14 genes (flp-1-flp-2-tadV-rcpCAB-tadZABCDEFG). All but 2 of the genes have been shown to be required for the secretion and assembly of long, bundled Flp1 fibrils. To test whether the tad locus is required for colonization and disease, we developed a rat model for periodontal disease. To mimic the natural route of infection, Sprague-Dawley rats were inoculated orally by adding bacteria directly to their food for 8 days. After inoculation with wild-type or mutant strains defective in adherence (flp-1 and tadA), the rats were assessed for colonization of the oral cavity and pathogenesis. Wild-type A. actinomycetemcomitans was able to colonize and persist for at least 12 weeks in the oral cavity, elicit a humoral immune response, and cause significant bone loss in rats. In contrast, rats fed flp-1 or tadA mutant strains showed no bone loss and their immune responses were indistinguishable from those of the uninoculated controls. These results demonstrate the critical importance of the tad locus in the colonization and pathogenesis of A. actinomycetemcomitans.
Journal Article
Brown v. Board of Education
The Brown v. Board of Education decision comes to mind whenever the topic of landmarks of the American civil rights movement is discussed. The 1954 Supreme Court decision declared it unconstitutional to segregate public school students, opening the door for many other civil rights advances after that. This thoughtful and informative book details the history of the case as well as its impact on the quickly changing America of the 1950s and 1960s. The book also describes how schools and civil rights have changed since this important Supreme Court case.
Book
20 great career-building activities using Twitter
This book shows students how to use Twitter to their advantage, for creative expression, academics, research, reporting, college searches, or promoting a business. Twenty activities help readers create a portfolio and build a digital footprint that can open doors professionally, academically, and creatively.
Book
Jeff Kinney : children's book author and cartoonist
Introduces the reader to acclaimed children's author and cartoonist Jeff Kinney.
BOOK
