Search Results Heading

MBRLSearchResults

mbrl.module.common.modules.added.book.to.shelf
Title added to your shelf!
View what I already have on My Shelf.
Oops! Something went wrong.
Oops! Something went wrong.
While trying to add the title to your shelf something went wrong :( Kindly try again later!
Are you sure you want to remove the book from the shelf?
Oops! Something went wrong.
Oops! Something went wrong.
While trying to remove the title from your shelf something went wrong :( Kindly try again later!
    Done
    Filters
    Reset
  • Discipline
      Discipline
      Clear All
      Discipline
  • Is Peer Reviewed
      Is Peer Reviewed
      Clear All
      Is Peer Reviewed
  • Item Type
      Item Type
      Clear All
      Item Type
  • Subject
      Subject
      Clear All
      Subject
  • Year
      Year
      Clear All
      From:
      -
      To:
  • More Filters
2 result(s) for "Gözen, İlhan"
Sort by:
The Emotional Impact of Sports Sponsorships: A Sentiment Analysis of Public Reactions on Reddit
This article discusses the role of sports sponsorships and the impact of sponsorship agreements on various stakeholders, along with the emotional reactions they evoke in the public. Sponsorship is viewed as a strategic partnership between companies and sports organizations, with the primary goal of increasing brand visibility and ensuring financial growth. The sentiment analyses presented in the article reveal a complex interaction between sponsorships and public opinion, examining the influence of emotions such as anger, anticipation, disgust, fear, joy, sadness, surprise and trust. These emotions are significantly affected by factors such as the commercialization of sports, manipulative practices in sponsorship agreements and ethical concerns. In this respect, the study approaches the phenomenon of sports sponsorship from a sports economics perspective, drawing attention to the balance between economic interests and societal values. The study emphasizes that while sponsorships can enhance sports experiences, they can lead to negative perceptions if financial interests overshadow the values and integrity of sports. The article highlights the importance of transparency and ethical practices in sponsorship agreements and suggests that future research should delve deeper into the emotional effects of sponsorships. Additionally, it stresses the need for research that extends beyond platforms like Reddit to include other social media channels.
Novel regulation mechanism of adrenal cortisol and DHEA biosynthesis via the endogen ERAD inhibitor small VCP-interacting protein
Endoplasmic reticulum-associated degradation (ERAD) is a well-characterized mechanism of protein quality control by removal of misfolded or unfolded proteins. The tight regulation of ERAD is critical for protein homeostasis as well as lipid metabolism. Although the mechanism is complex, all ERAD branches converge on p97/VCP, a key protein in the retrotranslocation step. The multifunctionality of p97/VCP relies on its multiple binding partners, one of which is the endogenous ERAD inhibitor, SVIP (small VCP-interacting protein). As SVIP is a promising target for the regulation of ERAD, we aimed to assess its novel physiological roles. We revealed that SVIP is highly expressed in the rat adrenal gland, especially in the cortex region, at a consistently high level during postnatal development, unlike the gradual increase in expression seen in developing nerves. Steroidogenic stimulators caused a decrease in SVIP mRNA expression and increase in SVIP protein degradation in human adrenocortical H295R cells. Interestingly, silencing of SVIP diminished cortisol secretion along with downregulation of steroidogenic enzymes and proteins involved in cholesterol uptake and cholesterol biosynthesis. A certain degree of SVIP overexpression mainly increased the biosynthesis of cortisol as well as DHEA by enhancing the expression of key steroidogenic proteins, whereas exaggerated overexpression led to apoptosis, phosphorylation of eIF2α, and diminished adrenal steroid hormone biosynthesis. In conclusion, SVIP is a novel regulator of adrenal cortisol and DHEA biosynthesis, suggesting that alterations in SVIP expression levels may be involved in the deregulation of steroidogenic stimulator signaling and abnormal adrenal hormone secretion.