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Mathematical models of energy systems have been mostly represented by either linear or nonlinear ordinary differential equations. This is consistent with lumped-parameter dynamic system modeling, where dynamics of system state variables can be fully described only in the time domain. However, when dynamic processes of energy systems display both temporal and spatial evolutions (as is the case of distributed-parameter systems), the use of partial differential equations is necessary. Distributed-parameter systems, being described by partial differential equations, are mathematically (and computationally) much more difficult for modeling, analysis, simulation, and control. Despite these difficulties in recent years, quite a significant number of papers that use partial differential equations to model and control energy processes and systems have appeared in journal and conference publications and in some books. As a matter of fact, distributed-parameter systems are a modern trend in the areas of control systems engineering and some energy systems. In this overview, we will limit our attention mostly to renewable energy systems, particularly to partial differential equation modeling, simulation, analysis, and control papers published on fuel cells, wind turbines, solar energy, batteries, and wave energy. In addition, we will indicate the state of some papers published on tidal energy systems that can be modelled, analyzed, simulated, and controlled using either lumped or distributed-parameter models. This paper will first of all provide a review of several important research topics and results obtained for several classes of renewable energy systems using partial differential equations. Due to a substantial number of papers published on these topics in the past decade, the time has come for an overview paper that will help researchers in these areas to develop a systematic approach to modeling, analysis, simulation, and control of energy processes and systems whose time–space evolutions are described by partial differential equations. The presented overview was written after the authors surveyed more than five hundred publications available in well-known databases such as IEEE, ASME, Wiley, Google, Scopus, and Web of Science. To the authors’ best knowledge, no such overview on PDEs for energy systems is available in the scientific and engineering literature. Throughout the paper, the authors emphasize novelties, originalities, and new ideas, and identify open problems for future research. To achieve this goal, the authors reviewed more than five hundred journal articles and conference papers.

Immune checkpoint blockade (ICB) has transformed the treatment of metastatic cancer but is hindered by variable response rates. A key unmet need is the identification of biomarkers that predict treatment response. To address this, we analyzed six whole exome sequencing cohorts with matched disease outcomes to identify genes and pathways predictive of ICB response. To increase detection power, we focus on genes and pathways that are significantly mutated following correction for epigenetic, replication timing, and sequence-based covariates. Using this technique, we identify several genes ( BCLAF1, KRAS, BRAF , and TP53) and pathways (MAPK signaling, p53 associated, and immunomodulatory) as predictors of ICB response and develop the Cancer Immunotherapy Response CLassifiEr (CIRCLE). Compared to tumor mutational burden alone, CIRCLE led to superior prediction of ICB response with a 10.5% increase in sensitivity and a 11% increase in specificity. We envision that CIRCLE and more broadly the analysis of recurrently mutated cancer genes will pave the way for better prognostic tools for cancer immunotherapy. Few genetic biomarkers are known for cancer immunotherapy. Here the authors identify recurrently-mutated genes and pathways associated with treatment response and develop a classifier using tumour whole exome sequencing and clinical features.

Full- and reduced-order observers have been used in many engineering applications, particularly for energy systems. Applications of observers to energy systems are twofold: (1) the use of observed variables of dynamic systems for the purpose of feedback control and (2) the use of observers in their own right to observe (estimate) state variables of particular energy processes and systems. In addition to the classical Luenberger-type observers, we will review some papers on functional, fractional, and disturbance observers, as well as sliding-mode observers used for energy systems. Observers have been applied to energy systems in both continuous and discrete time domains and in both deterministic and stochastic problem formulations to observe (estimate) state variables over either finite or infinite time (steady-state) intervals. This overview paper will provide a detailed overview of observers used for linear and linearized mathematical models of energy systems and review the most important and most recent papers on the use of observers for nonlinear lumped (concentrated)-parameter systems. The emphasis will be on applications of observers to renewable energy systems, such as fuel cells, batteries, solar cells, and wind turbines. In addition, we will present recent research results on the use of observers for distributed-parameter systems and comment on their actual and potential applications in energy processes and systems. Due to the large number of papers that have been published on this topic, we will concentrate our attention mostly on papers published in high-quality journals in recent years, mostly in the past decade.

INTRODUCTION:Older adults with inflammatory bowel disease (IBD) are at higher risk for postoperative complications as compared to their younger counterparts; however, factors contributing to this are unknown. We assessed risk factors associated with adverse IBD-related surgical outcomes, evaluated trends in emergency surgery, and explored differential risks by age.METHODS:Using the American College of Surgeons National Surgical Quality Improvement Program database, we identified adults ≥18 years of age who underwent an IBD-related intestinal resection from 2005 to 2019. Our primary outcome included a 30-day composite of mortality, readmission, reoperation, and/or major postoperative complication.RESULTS:Overall, 49,746 intestinal resections were performed with 9,390 (18.8%) occurring among older adults with IBD. Nearly 37% of older adults experienced an adverse outcome as compared to 28.1% among younger adults with IBD (P < 0.01). Among all adults with IBD, the presence of preoperative sepsis (adjusted odds ratio [aOR], 2.08; 95% confidence interval [CI] 1.94-2.24), malnutrition (aOR, 1.22; 95% CI 1.14-1.31), dependent functional status (aOR, 6.92; 95% CI 4.36-11.57), and requiring emergency surgery (aOR, 1.50; 95% CI 1.38-1.64) increased the odds of an adverse postoperative outcome, with similar results observed when stratifying by age. Furthermore, 8.8% of surgeries among older adults were emergent, with no change observed over time (P = 0.16).DISCUSSION:Preoperative factors contributing to the risk of an adverse surgical outcome are similar between younger and older individuals with IBD, and include elements such as malnutrition and functional status. Incorporating these measures into surgical decision-making can reduce surgical delays in older individuals at low risk and help target interventions in those at high risk, transforming care for thousands of older adults with IBD.

In this paper, we design an optimal controller for a wind turbine (WT) with doubly-fed induction generator (DFIG) by decomposing the algebraic Riccati equation (ARE) of the singularly perturbed wind turbine system into two reduced-order AREs that correspond to the slow and fast time scales. In addition, we derive a mathematical expression to obtain the optimal regulator gains with respect to the optimal pure-slow and pure-fast, reduced-order Kalman filters and linear quadratic Gaussian (LQG) controllers. Using this method allows the design of the linear controllers for slow and fast subsystems independently, thus, achieving complete separation and parallelism in the design process. This solves the corresponding ill-conditioned problem and reduces the complexity that arises when the number of wind turbines integrated to the power system increases. The reduced-order systems are compared to the original full-order system to validate the performance of the proposed method when a wind turbulence and a large-signal disturbance are applied to the system. In addition, we show that the similarity transformation does not preserve the performance index value in case of Kalman filter and the corresponding LQG controller.

In recent years, the tremendous increase in data traffic carried by wireless communication networks has generated the urgent need for establishing more energy-efficient wireless communication systems. Recent advances in semiconductor and light devices have triggered remarkable research interest to the development of these optical wireless communication (OWC) links. Among them, free-space optical (FSO) links and, more recently, ultraviolet links which operate within the (UV-C) spectral band, have been considered as prime candidates to create both high speed and power effective line-of-sight (LOS) and non-light-of-sight (NLOS) free-air communication links, respectively. Moreover, transdermal optical wireless (TOW) links for telemetry with medical implants minimize the expense of power for the implant. In the current review, a background on the energy efficiency challenges in wireless communication is presented. Each of these OWC technologies is mainly discussed in terms of key energy consumption requirements and major limiting factors that affect their power performance. Energy-efficient modulation formats as well as other powerful techniques for performance enhancement such as diversity and relaying are assessed. The survey is concluded with a discussion regarding their future energy consumption requirements and trends.

Low-resolution face images can be found in many practical applications. For example, faces captured from surveillance videos are typically in small sizes. Existing face recognition deep networks, trained on high-resolution images, perform poorly in recognizing low-resolution faces. In this work, an improved multi-branch network is proposed by combining ResNet and feature super-resolution modules. ResNet is for recognizing high-resolution facial images and extracting features from both high- and low-resolution images. Feature super-resolution modules are inserted before the classifier of ResNet for low-resolution facial images. They are used to increase feature resolution. The proposed method is effective and simple. Experimental results show that the recognition accuracy for high-resolution face images is high, and the recognition accuracy for low-resolution face images is improved.