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Background Nowadays, nanoparticles (NPs) have evolved as multifunctional systems combining different custom anchorages which opens a wide range of applications in biomedical research. Thus, their pharmacological involvements require more comprehensive analysis and novel nanodrugs should be characterized by both chemically and biological point of view. Within the wide variety of biocompatible nanosystems, iron oxide nanoparticles (IONPs) present mostly of the required features which make them suitable for multifunctional NPs with many biopharmaceutical applications. Results Cisplatin-IONPs and different functionalization stages have been broadly evaluated. The potential application of these nanodrugs in onco-therapies has been assessed by studying in vitro biocompatibility (interactions with environment) by proteomics characterization the determination of protein corona in different proximal fluids (human plasma, rabbit plasma and fetal bovine serum),. Moreover, protein labeling and LC–MS/MS analysis provided more than 4000 proteins de novo synthetized as consequence of the nanodrugs presence defending cell signaling in different tumor cell types (data available via ProteomeXchanges with identified PXD026615). Further in vivo studies have provided a more integrative view of the biopharmaceutical perspectives of IONPs. Conclusions Pharmacological proteomic profile different behavior between species and different affinity of protein coating layers (soft and hard corona). Also, intracellular signaling exposed differences between tumor cell lines studied. First approaches in animal model reveal the potential of theses NPs as drug delivery vehicles and confirm cisplatin compounds as strengthened antitumoral agents.

This paper provides a summary of the investigations carried out for the preliminary assessment of potential geohazards affecting the archaeological site of Dadan in the Kingdom of Saudi Arabia. The site is characterized by the presence of Cambro-Ordovician sandstone cliffs (Siq formation), which were quarried in ancient times (Dadan/Lihyan kingdom) for building materials. Both the steep quarried portion (Upper Siq) and the gentler underlying slope (Middle Siq) contain tombs of significant archaeological value. Landsliding and erosion are the main geomorphological processes affecting the site, posing risks to the safety of visitors, archaeological workers, and the preservation of the site. The primary processes affecting the rock cliffs, the underlying slope talus, and the tombs were identified using geological and geomechanical surveys, in addition to various geomatic acquisitions. The mechanical properties of the rock formations and discontinuity sets were identified through laboratory testing and in situ surveying, respectively. This information represents the first step in promoting further actions for risk mitigation and site management.

The early immune kinetics after SARS-CoV-2 vaccination remain poorly understood, particularly among individuals with low-count monoclonal B-cell lymphocytosis (MBLlo). We investigated the cellular and humoral kinetics in the blood of 50 non-MBL healthy donors (HD) vs. 16 MBLlo subjects after SARS-CoV-2 vaccination, who were subclassified according to their history of previous exposure to SARS-CoV-2 into SARS-CoV-2 naïve and previously infected subjects. Overall, we found decreased neutrophil and lymphocyte counts at day +4 following each dose in non-MBL HD, together with an earlier and higher increase in plasma cell (PC) counts and SARS-CoV-2-specific antibody levels after the first vaccine in previously infected non-MBL HD. MBLlo subjects showed a similar profile, except for lower B-cell and higher PC counts after vaccination, and a trend towards a higher (but delayed) antibody response. In summary, we found different cell-kinetic profiles following vaccination in SARS-CoV-2 naïve vs. previously infected non-MBL HD (earlier PC and antibody responses in the latter group); additionally, MBLlo subjects had significantly lower B-cell and higher PC counts after vaccination, and a delayed SARS-CoV-2-specific antibody response.

This thesis aims to compare the novel Crematorio by Rafael Chirbes with the television series of the same title, focusing on political corruption, land speculation and environmental damage associated with these activities. This study demonstrates that uncontrolled construction, covered by the corruption of politicians, generates social and environmental damage that reduces the quality of life. It also illustrates that ecological issues, despite the severity thereof, are not a major concern for the public and authors, but environmental problems are so prevalent in today's society that it is almost impossible not to reflect it directly or indirectly.

IntroductionThe NeVa stent retriever has proven it’s safety and performance for treating large vessel occlusion (LVO) in acute ischemic stroke (AIS) across multiple clinical studies including the most recently published CLEAR Trial. This trial was conducted under rigorous scrutiny, with independent boards adjudicating outcomes. Real-world data is helpful in assessing the reproducibility of patient outcomes.Aim of StudyNeVa ONE is a multicenter, international, prospective registry designed to assess outcomes in a real-world cohort of patients.MethodsAIS LVO patients treated with NeVa either as first-line or as a rescue device are included. This interim analysis reports performance results of 175 subjects from 15 centers in 7 countries treated with NeVa used as first-line device. Study endpoints are successful (TICI2b-3) and/or complete (TICI 2c-3) recanalization at first pass (mFPE/FPE), up to three passes, and at procedure end. Secondary endpoints include neurological deterioration at 24 hours and device/procedure-related adverse events.ResultsMean patient age was 71±14 years. Most frequently reported conditions in medical history included: Hypertension (39%); Dyslipidemia (19%); Diabetes (14%) and Atrial Fibrillation (14%). Median admission-NIHSS was 16 (IQR:12–20). IV-tPA was administered in 43,1% of subjects. Occlusion sites were: ICA (23%), MCA (71%), posterior circulation (5%), and ACA (1%). Recanalization rates were: mFPE: 72.6%; FPE: 58.3%; ≤3pass eTICI 2b-3: 90.9%; ≤3pass eTICI 2c-3: 76.0%; Final eTICI 2b-3: 98.9% and final eTICI 2c-3: 83.4%.ConclusionNeVa ONE Registry represents real-world data obtained from LVO AIS subjects treated with NeVa.Disclosure of InterestNothing to disclose

Remote sensing (RS) technologies are essential for safeguarding cultural heritage sites from geo-hydrogeological threats. Advances in RS methods have improved the accuracy and managing of 3D datasets, creating a growing need for efficient data analysis in geo-hazards prevention. This paper presents two archaeological sites where a geo-hazards assessment was conducted: Hegra (Al-Hijr / Mada in Salih) and Dadan in the Kingdom of Saudi Arabia (KSA), AlUla region. Hegra is the KSA's first UNESCO World Heritage site, while Dadan is the most significant site in the country. These case studies confirm the key role of RS survey outputs in evaluating geo-hazards at rock-carved heritage sites. The integration of on-site surveys with RS methods, especially ALS, TLS and UAV-DP, quickly provides accurate point cloud data for geo-hazards assessment. Additionally, using explainable AI algorithms speeds up the classification of geometrical features, enhancing knowledge and enabling reliable, fast and repeatable monitoring in restoration planning. Keywords Close-range methods, Hazard assessment, Rock-carved cultural heritage.

BackgroundRecent randomized trials have demonstrated the efficacy of mechanical thrombectomy in treating acute ischemic stroke, however, further research is required to optimize this technique. We aimed to evaluate the impact of guide catheter position and clot crossing on revascularization rates using A Direct Aspiration First Pass Technique (ADAPT).MethodsData were collected between January 2018 and August 2019 as part of the Spanish ADAPT Registry on ACE catheters (SARA), a multicenter observational study assessing real-world thrombectomy outcomes. Demographic, clinical, and angiographic data were collected. Subgroup analyses assessed the relationship between guide catheter/microguidewire position and modified Trombolysis in Cerebral Infarction (mTICI) scores. First pass effect (FPE) was defined as mTICI 3 after single pass of the device.ResultsFrom a total of 589 patients, 80.8% underwent frontline aspiration thrombectomy. The median score on the National Institutes of Health Stroke Scale (NIHSS) was 16.0. After adjusting for confounders, the likelihood of achieving FPE (adjusted Odds Ratio (aOR), 0.587; 95% confidence interval (CI), 0.38 to 0.92; p=0.0194) were higher among patients with more distal petrocavernous placement of guide catheter. The likelihood of achieving FPE (aOR, 0.592; 95% CI, 0.39 to 0.90; p=0.0138) and final angiogram complete reperfusion (aOR, 0.465; 95% CI, 0.30 to 0.73; p=0.0008) were higher among patients without microguidewire crossing the clot. No difference was noted for time from arterial puncture to reperfusion in any study group. At the 90-day follow-up, the mortality rate was 9.2% and 65.8% of patients across the entire study cohort were functionally independent (modified Rankin Scale (mRS) 0–2).ConclusionsPetrocavernous guide catheter placement improved first-pass revascularization. Crossing the occlusion with a microguidewire lowered the likelihood of achieving FPE and complete reperfusion after final angiogram.

The importance of the distribution of accommodation businesses over a certain area has grown remarkably, especially if such distribution is mapped using tools and techniques that utilize the territory as a variable in the analysis. The purpose of this paper is to demonstrate, by means of a geographical information system (GIS) and spatial statistics, that it is possible to better define the groupings of rural accommodation available in Extremadura, Spain, especially if these are conceptualized by dint of their lodging capacity. To do so, two specific techniques have been used: hotspot analysis and outlier analysis, which yield results that prove the existence of homogeneous and heterogeneous groups of accommodation businesses, based not only on their spatial proximity but also on their lodging capacity. On the basis of this analysis, the regional administration can devise tourist policies and strategic plans in order to improve the management and efficiency of each business. Despite the applicability of the present results, this study also addresses the difficulties in using these techniques—Where establishing the spatial relationships and the boundary distance are key concepts. In the case study here, the ideal configuration utilizes a fixed distance of six miles.

This study examines the demographic dynamics of Extremadura and Andalusia, two autonomous communities in southern Spain characterized by low income levels and marked territorial differences in terms of ageing and depopulation. Based on the observation of growing demographic pressure associated with low birth rates and emigration to more economically dynamic areas, a methodological approach based on spatial analysis techniques is proposed. In particular, the ageing index and demographic dependency ratio indicators are used, applying tools such as Hot Spot Analysis and Cluster and Outlier Analysis to identify significant spatial patterns and outliers. The results show a high concentration of ageing and dependency in provinces such as Cáceres and Almería, suggesting greater demographic vulnerability. In contrast, urban areas such as Seville and Granada, as well as the Guadalquivir depression, show more favorable indicators, reflecting greater resilience. Likewise, municipalities with demographic behavior that is anomalous with respect to their surroundings are detected, which raises the need for micro-territorial studies aimed at understanding these exceptions and designing more effective public policies adapted to the local context.